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Stéphane Mancini

@stephanemancini.bsky.social
165 followers 208 following 18 posts

INSERM Research Director, passionate about Science, Immunology, Hematology, lymphocytes, leukemia, microenvironment. Keen on cytometry, imaging, bioinformatics

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Stéphane Mancini @stephanemancini.bsky.social · 25/05/2026
💡The bone marrow niches actively dictate the developmental fate of pre-leukemic cells and shape the secondary mutations that drive the disease forward.
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Stéphane Mancini @stephanemancini.bsky.social · 25/05/2026
⏳ Delayed Onset: Disrupting this signaling delays leukemia development and leads to a more mature B-ALL phenotype. 🧬 Mutational Shift: Without Galectin-1, secondary mutations shift to almost exclusively target the IL-7R pathway.
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Stéphane Mancini @stephanemancini.bsky.social · 25/05/2026
🔬 Niche Signals: Bone marrow microenvironments actively cooperate with driver mutations to trigger B-ALL.  🎯 Targeting Galectin-1: Blocking Galectin-1/pre-BCR signaling limits pre-leukemic cell proliferation and leukemia-initiating capacity.
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Stéphane Mancini @stephanemancini.bsky.social · 25/05/2026
Thrilled to share our latest publication in Oncogene @natureportfolio.nature.com ! 🚀  Our new study reveals the active role of the bone marrow microenvironment in B-ALL leukemogenesis. Huge congrats to Marjorie Delahaye for her incredible work on this project! 🙌  www.nature.com/articles/s41...
nature.com
Signals from the bone marrow B cell niches shape pre-leukemic fate in a murine model of B cell acute lymphoblastic leukemia - Oncogene
Oncogene - Signals from the bone marrow B cell niches shape pre-leukemic fate in a murine model of B cell acute lymphoblastic leukemia
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Pierre sujobert @sujobert.bsky.social · 04/04/2026
Après avoir observé une minute de silence pour un néonazi, l'assemblée nationale auditionne F de Rugy et G Woessner pour parler de journalisme scientifique... Alors merci à Stéphane Foucart pour sa chronique indispensable www.lemonde.fr/idees/articl...
lemonde.fr
« A l’Assemblée nationale, l’information scientifique de France Télévisions et de Radio France a été caricaturée et éreintée sans nuances et sans contradictoire »
CHRONIQUE. L’audition de la commission d’enquête de l’Assemblée nationale sur l’audiovisuel public consacrée à l’information scientifique a vu une accumulation spectaculaire de contrevérités énoncées ...
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Engagement Leucémie @engagementleucemie.bsky.social · 05/04/2026
📣 NOTRE BROCHURE EST DISPONIBLE ! Vous souhaitez parler de l’inscription sur le registre DVMO à vos proches, ou sensibiliser autour de vous Notre brochure regroupe les informations et les messages pour comprendre et partager Téléchargez-la dès maintenant engagement-leucemie.com/brochure
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Stéphane Mancini @stephanemancini.bsky.social · 16/10/2025
Honoured to be part of the summit in immuno-oncology in Yerevan 🇦🇲. Warm welcome from everyone here, such a great pleasure. And what a stunning view! 🤩
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Louise Purton @louisepurton.bsky.social · 23/05/2025
Thanks to @lindemileslab.bsky.social and @challenlab.bsky.social (& team) for writing our first commentary for @isehsociety.bsky.social journal Experimental Hematology! Two recent papers on Clonal Hematopoiesis- want to learn more? Read the link here 👇🏻
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Stéphane Mancini @stephanemancini.bsky.social · 23/05/2025
Such a great day yesterday spent with fantastic people doing amazing science, here in sunny #Glasgow. Thank you so much @keeshanlab.bsky.social for the kind invitation. I can’t wait starting new projects with all of you!
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Mauro Gaya @maurogaya.bsky.social · 30/04/2025
🚨🦠🔬 Last month to register to the EMBO workshop on Adaptive Immunity in Barrier Tissues. 📍 Where: Basel, Switzerland 📅 When: 26th–29th August 2025 📝 Registration deadline: 30th May 2025 Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social #EMBOBarrierTissues
meetings.embo.org
Adaptive immunity in barrier tissues
Immune responses lie at the heart of almost every aspect of human health, including host responses to infection, autoimmunity, cancer, metabolism and aging. While adaptive immune responses by B and T…
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Josep Carreras Leukaemia Research Institute @carrerasijc.bsky.social · 22/04/2025
We're pleased to announce that Dr Ari Melnick has been appointed new Director of the Josep Carreras Institute. Dr Melnick will lead IJC in our mission to advance #research in #leukaemia and other malignant blood diseases. Read the full release here: www.carrerasresearch.org/en/news/dr-a...
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Nina Cabezas-Wallscheid @ninacabezas.bsky.social · 02/04/2025
Extremely happy to share our study on the regulation of HSCs in the context of myocardial infarction published in Nature Cell Biology! Driven by two amazing scientists in my lab - Jasmin and Maricarmen and co-led with the awesome cardiologist Timo! Huge thanks also to all our collaborators 👏🏻👏🏻
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Eric Topol @erictopol.bsky.social · 02/04/2025
The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence "implications are profound" New @nature.com www.nature.com/articles/d41... nature.com/articles/s41...
nature.com
A natural experiment on the effect of herpes zoster vaccination on dementia - Nature
Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...
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Stéphane Mancini @stephanemancini.bsky.social · 21/03/2025
How can something like that happen in the USA? Worrying ☹️ www.theguardian.com/us-news/2025...
theguardian.com
French scientist denied US entry after phone messages critical of Trump found
France’s research minister said the scientist was traveling to Houston for a conference when his phone was searched
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Charlie Hebdo @charliehebdo.fr · 13/03/2025
Licenciements, coupe de budgets, de nombreux scientifiques américains subissent de plein fouet les nouvelles directives de Donald Trump. Une réforme brutale en forme de purge contre tous ceux qui oseraient continuer leurs dans les secteurs qui dérangent. charliehebdo.fr/2025...
charliehebdo.fr
« On entend dire plein de choses » : aux États-Unis, terreur sur la recherche universitaire
Ils sont partout. Selon le nouveau locataire de la Maison-Blanche, les universités américaines ne seraient plus qu’un vaste repaire de gauchistes « wokes », que dis-je, de néobolcheviques aux cheveux bleus. C’est la panique morale au pays des cow-boys. Mais qu’ils soient rassurés, après avoir capitalisé sur le fantasme de l’ennemi de l’intérieur durant toute […]
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ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 12/03/2025
Check out the #ExpHem Special Issue, Making Blood: Mechanisms of Early Hematopoietic Development from guest editors Elaine Dzierzak and Anna Bigas➡️ www.exphem.org/content/edit...
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Stéphane Mancini @stephanemancini.bsky.social · 10/03/2025
www.theguardian.com/us-news/2025...
theguardian.com
‘I hate to predict things’: Trump doesn’t rule out US recession amid trade tariffs
President downplays recent stock market volatility that followed his ducking and weaving over tariff policy
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Stéphane Mancini @stephanemancini.bsky.social · 10/03/2025
‘I hate to predict things’: Trump doesn’t rule out US recession amid trade tariffs Ah ah! 😂 That’s why he has been so successful in sinking daddy’s fortune. Well now the problem is that he is sinking the US and the whole world ☹️
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Stéphane Mancini @stephanemancini.bsky.social · 08/03/2025
Will our leaders be able to react and ensure that France once again becomes the land of enlightenment? That would mean 3% of GDP for research, not for guns and pain
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Eric Chevet @ericchevet.bsky.social · 08/03/2025
www.ouest-france.fr/bretagne/ren...
ouest-france.fr
En solidarité avec leurs homologues américains ciblés par Trump, les scientifiques réunis à Rennes
En réaction à l’offensive menée par l’administration Trump contre le monde de la recherche aux États-Unis, la communauté scientifique française a témoigné de sa solidarité, en multipliant les rassembl...
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Nature @nature.com · 25/02/2025
US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks. go.nature.com/4kd1vIu
go.nature.com
Trump 2.0: an assault on science anywhere is an assault on science everywhere
US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.
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Michalis Averof @michalis-averof.bsky.social · 26/02/2025
As the world of science wakes up to modern fascism, it's worth remembering older generations who stood up for humanity in much harsher circumstances. Jacques Monod worked actively for the resistance in WWII, while pursuing early stages of his research in occupied Paris. @standupforscifr.bsky.social
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HHMI @hhmi-science.bsky.social · 17/02/2025
Bring your samples into focus! A new version of the #Cellpose cell boundary mapping tool, developed at @hhmijanelia.bsky.social by @computingnature.bsky.social and @marius10p.bsky.social, now works on less-than-perfect microscopy images that are noisy, blurry, or undersampled.
buff.ly
Newest version of Cellpose can spot cell boundaries even in cloudy conditions
Picking out individual cells in distorted microscopy images is now as easy as clicking a button. A new version of Cellpose – the popular tool that maps the boundaries of diverse cells in microscopy
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Stéphane Mancini @stephanemancini.bsky.social · 17/02/2025
So happy to share the latest preprint of the lab, with Marjorie Delahaye as the main actor of this great story. This work demonstrates that the bone marrow microenvironment can imprint (pre-)leukemic cell fate and influence the acquisition of secondary mutations
biorxiv.org
Signals from the bone marrow B cell niches shape pre-leukemic fate in murine B cell acute lymphoblastic leukemia
The bone marrow (BM) microenvironment plays a key role in supporting B cell development. In acute lymphoblastic leukemia (B-ALL), the acquisition of oncogenic driver mutations blocks B cell differenti...
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Stéphane Mancini @stephanemancini.bsky.social · 17/02/2025
Great presentation of Marjorie Delahaye, post doc in my team at the #ESHMICRO2025. Now part of the panel of specialists together with great names in the field. Proud of you!
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Stéphane Mancini @stephanemancini.bsky.social · 16/02/2025
ESH haematological tumour microenvironment is just starting! #ESHMICRO2025. So great to be here in London after a two-year wait
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Stéphane Mancini @stephanemancini.bsky.social · 15/02/2025
You've been murdered, who do you want on the case?
media.tenor.com
a man in a blue shirt and tie is sitting in front of a window with his eyes closed
ALT: a man in a blue shirt and tie is sitting in front of a window with his eyes closed
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Thiago Carvalho @cyrilpedia.bsky.social · 15/02/2025
1, 2, 3, 4. "Electronic lab notebooks, despite their popularity, are stored in proprietary formats, incur a recurrent cost, tend to become defunct over time, and have poor interoperability with each other" journals.plos.org/plosbiology/...
journals.plos.org
GitHub enables collaborative and reproducible laboratory research
GitHub, a platform widely used in software development, offers a robust framework for documenting all activities of laboratory research projects. This Community Page highlights the benefits of, and pr...
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Mick Milsom @milsommick.bsky.social · 05/02/2025
New pre-print from Thomas Höfer, Daniel Hübschmann, @haas_lab and myself, with first authors @Esther_RCorrea @FloGrunschlager and Tamar Nizharadze doi.org/10.1101/2025... @DKFZ @NCT_HD @ChariteBerlin @hi_stem_lab BIH & MDC
doi.org
A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells
Residing at the top of the hematopoietic hierarchy, long-term hematopoietic stem cells (HSCs) are capable of self-renewal and sustained blood cell regeneration. Over the past decades, single-cell and ...
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OncoDaily @oncodaily.bsky.social · 04/02/2025
World Cancer Day @uiccofficial.bsky.social oncodaily.com/blog/world-c... #Cancer #OncoDaily #Oncology #UICC #UnitedByUnique #Health #WorldCancerDay #Medicine
oncodaily.com
World Cancer Day - OncoDaily
World Cancer Day / cancer, OncoDaily, Oncology, UICC, United By Unique, World Cancer Day
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Jeremias Lab @jeremiaslab.bsky.social · 03/02/2025
🎉 We’re excited to share our latest research on FLT3-targeted antibody-drug conjugates (ADCs) as a promising strategy to eliminate leukemic stem cells in AML! 🚀🔬Many thanks to all involved in this great BMBF-funded project #leukemia #PDXmodels 📖Read more here: www.nature.com/articles/s41...
nature.com
Effective eradication of acute myeloid leukemia stem cells with FLT3-directed antibody-drug conjugates - Leukemia
Leukemia - Effective eradication of acute myeloid leukemia stem cells with FLT3-directed antibody-drug conjugates
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Stéphane Mancini @stephanemancini.bsky.social · 03/02/2025
You are a scientist and want to expend your scientific network? You are interested in the research held in Rennes? Please share!
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Stéphane Mancini @stephanemancini.bsky.social · 03/02/2025
Thanks Eric!
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Ming Tommy Tang @tommytang.bsky.social · 02/02/2025
In this blog post, I walk you through the steps to download the RNAseq data and make a PCA plot and heatmap divingintogeneticsandgenomics.com/post/pca-tcga/
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Nature @nature.com · 24/01/2025
Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X go.nature.com/42tH8Ai
go.nature.com
Bluesky’s science takeover: 70% of Nature poll respondents use platform
Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X.
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Stéphane Mancini @stephanemancini.bsky.social · 24/01/2025
I’ve done my #eXit! Don't lose any of your followers thanks to #HelloQuitX. Join us on app.helloquitx.com and automatically find your communities on #January20!
app.helloquitx.com
HelloQuitteX
Libérez vos espaces numériques
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Morgan J Freeman @mjfree.bsky.social · 22/01/2025
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Stéphane Mancini @stephanemancini.bsky.social · 08/01/2025
Thanks for this excellent idea. I would be glad to join!
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Oded Rechavi @odedrechavi.bsky.social · 02/01/2025
Every Keynote talk
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