imageimageHypoxia induces a specific NF-κB-dependent gene signature across multiple cell systems. NF-κB is required for over 60% of gene repression occurring in response to hypoxia, controlling oxidat...

We have developed a robust workflow for the identification of proline hydroxylation sites in proteins, using a combination of hydrophilic interaction chromatography (HILIC) enrichment and high-resolut...

Prolyl-hydroxylases (PHDs) are oxygen sensing enzymes that mediate the hydroxylation of proline residues. In mammals, three PHD isoforms (PHD1-3) are responsible for proline hydroxylation of Hypoxia I...

UKRI is increasing the minimum stipend we pay PhD students by 8% to £20,780 from 1 October 2025 and updating our doctoral training grant terms and conditions.

Athena Swan Gold Award for Institute of Systems, Molecular and Integrative Biology

The Institute of Neurophysiopathology (INP) welcomes tenured researchers/lecturers, and junior researchers seeking a permanent position in France to lead or strengthen its research programs RESEARCHER...

Hypoxia is both a physiological and pathological signal in cells. Changes in gene expression play a critical role in the cellular response to hypoxia, enabling cells to adapt to reduced oxygen availab...

Control of αVβ6 integrin and HER2 trafficking drives breast cancer invasion, drug resistance, and therapeutic response.

Scientific questions are universal but the scientific workforce remains skewed, with women and gender minorities still underrepresented. Initiatives such as the Women in Autophagy network promote the ...

SH2 domains are challenging to target using small molecules. Here, the authors develop phosphotyrosine-based covalent ligands of the E3 ligase SOCS2 using structure-based design. A pro-drug approach y...

Pedimos que se faça tudo o que for possível para mitigar o incumprimento do programa do Governo suportado pela Assembleia da República no que diz respeito ao reforço do financiamento da ciência.

Created in 2005 by the Generalitat de Catalunya (Government of Catalonia) and the University of Barcelona, IRB Barcelona is a Severo Ochoa Centre of Excellence—a seal that was awarded in 2011. The ...