The authors explore the potential of changing vaccination schedules combined with ‘germline targeting’ to increase the generation of broadly neutralizing antibodies against HIV. In mice, they find tha...

An HIV envelope trimer mRNA vaccine enables membrane-bound expression and produces a functional immunogen in preclinical mammalian models.

Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies.

We review mechanisms of action underlying the function of vaccine adjuvants and knowledge gaps to be addressed.