iiinova — where your digital self keeps evolving

Reposted by Simone Minnie

E John Wherry @ejohnwherry.bsky.social · 14/08/2025

What's the difference between Trm and exhausted CD8 T cells? Simone Park's new work dissects this important question. These cell types are often confused, but are ontologically and mechanistically distinct with implications for immunotherapy responses. www.biorxiv.org/content/10.1...

biorxiv.org

Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8+ T cells underlies distinct functional potential

Persistent antigen stimulation promotes differentiation of exhausted CD8+ T (TEX) cells. TEX cells are distinct from circulating memory T (TCIRCM) cells but share many features with tissue-resident me...

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Simone Minnie @simone-minnie.bsky.social · 01/07/2025

Contact me directly with your CV if you’re interested. Full disclosure that I may not be able to respond to all messages if this goes anything like my last job ad!

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Simone Minnie @simone-minnie.bsky.social · 01/07/2025

Now that the lab has stuff in it, I’m looking for a postdoc. Must have: - Mouse experience (several years ideally) - Cell culture experience - An interest in T cells - Team player Bonus points for: - any flow experience - any scRNAseq exp (wet or dry) - CAR T manufacturing

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Simone Minnie @simone-minnie.bsky.social · 17/06/2025

Seeing my colleagues succeed brings me so much joy. Can’t wait for the ‘proud PI’ moments to come from my lab. I’ve already asked my trainees how they like to receive recognition and they are both the quiet email types. This will be a challenge…gotta rein it in!

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Simone Minnie @simone-minnie.bsky.social · 11/06/2025

The best advice I received about hiring was always hire people smarter than yourself. I’ve taken that very seriously, plus added my own criteria “vibes”, and I am so excited for the new Minnie Lab team members to start soon!!

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Reposted by Simone Minnie

Formerly Richard Mayhew @dmaanderson.bsky.social · 08/06/2025

Reminder: Not everything thought needs to be said Not everything said needs to be written Not everything written needs to go on social media

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Reposted by Simone Minnie

Eric Topol @erictopol.bsky.social · 07/06/2025

How adding mRNA to code for interleukin-12 markedly increased T cell immune response which could be used for vaccines vs infectious diseases and cancer @sciimmunology.bsky.social www.science.org/doi/10.1126/...

science.org

An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses

IL-12 is dispensable for CD8 T cell responses to mRNA vaccination, but an Il12 mRNA-LNP enhances CD8 T cell memory and protection.

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Simone Minnie @simone-minnie.bsky.social · 17/04/2025

I’m very specifically looking for a tech with mouse experience for my new lab! Message me or apply through the link if you’re interested! aprecruit.ucsf.edu/JPF05438

aprecruit.ucsf.edu

Minnie Lab - Junior, Assistant, or Associate Specialist

University of California, San Francisco is hiring. Apply now!

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Simone Minnie @simone-minnie.bsky.social · 27/03/2025

I also started the hiring process months early - I haven’t even started yet! And it was exceptionally lucky under these circumstances that I did, but I do recommend all new faculty do it anyways!

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Simone Minnie @simone-minnie.bsky.social · 27/03/2025

Hiring freeze at the same time as starting a lab will keep things interesting. Got one hire through the door before it happened at least. This tech really wanted some hands-on training and boy are they going to get it 😂

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Reposted by Simone Minnie

Fred Hutch @fredhutch.org · 13/02/2025

Fred Hutch at #Tandem25: Catch presentations from Drs. Julie Boiko, Rachel Salit, @simone-minnie.bsky.social and Marie Bleakley on cGVHD biology, basic science of GVL and post-HCT immune microenvironment, T cell responses to minor histocompatibility antigens & more 👉 bit.ly/3EAM24L

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Simone Minnie @simone-minnie.bsky.social · 17/01/2025

If you are interested in translational science but also love digging into a good immunology mechanism, please contact me! I'm hiring at all levels. There is a research technician job ad out already (aprecruit.ucsf.edu/JPF05438) but I'll be looking for postdocs too!

aprecruit.ucsf.edu

Minnie Lab - Junior, Assistant, or Associate Specialist

University of California, San Francisco is hiring. Apply now!

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Simone Minnie @simone-minnie.bsky.social · 17/01/2025

I am beyond excited to be starting my lab at UCSF in May 2025. I'll be joining the Hematology/Oncology Division and working with the Myeloma Program (lead by @ajaichari.bsky.social) to advance immunotherapies and cellular therapies for myeloma!

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Simone Minnie @simone-minnie.bsky.social · 01/01/2025

Happy New Year! 2025 is going to be a big one!!

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Simone Minnie @simone-minnie.bsky.social · 19/12/2024

Very exciting news! My COI is that my dad owns a bunch of shares on the Australian side. Bought them years ago and I was a naysayer. So happy to be wrong!!

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Reposted by Simone Minnie

Krishna Komanduri @drkomanduri.bsky.social · 19/12/2024

Hematologists please follow Ajai Chari, the very talented leader of the @ucsfcancer.bsky.social #myeloma program. #hematology bsky.app/profile/ajai...

bsky.app

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Simone Minnie @simone-minnie.bsky.social · 07/12/2024

What a win for myeloma research at Fred Hutch!!! Welcome Madhav!

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Reposted by Simone Minnie

Miguel Perales MD @drmiguelperales.bsky.social · 06/12/2024

Looking forward to this talk by @mskcancercenter.bsky.social Susan Dewolf #637 Cross-Talk between Leukemic Blasts and T Cells Drives Targetable T Cell Dysfunction in the AML Tumor Microenvironment Session: 618. AML: Biomarkers Sunday, Dec 8: 4:30 PM #ASH24 #leusm ash.confex.com/ash/2024/web...

ash.confex.com

Paper: Cross-Talk between Leukemic Blasts and T Cells Drives Targetable T Cell Dysfunction in the AML Tumor Microenvironment

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Simone Minnie @simone-minnie.bsky.social · 04/12/2024

This might just end up being a PNW nature shots account for the next couple of days 😅 It’s so beautiful here!

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Simone Minnie @simone-minnie.bsky.social · 04/12/2024

Break from scientific programming to say that the PNW is truly one of the most beautiful places I’ve ever lived!

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Simone Minnie @simone-minnie.bsky.social · 01/12/2024

This was one of the most useful courses I’ve ever done. Highly recommend. Don’t walk, run!!!

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Reposted by Simone Minnie

Waggoner Lab @labwaggoner.bsky.social · 29/11/2024

Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy www.nature.com/articles/s41...

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Simone Minnie @simone-minnie.bsky.social · 22/11/2024

Idk, I’ve been in restaurants where groups of adults can’t use their inside voice and we can’t have a conversation over the obnoxious laughing and yelling. I don’t take my toddler to restaurants because I personally don’t want to have a bad time, but could we ban those adults too?

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Reposted by Simone Minnie

Miguel Perales MD @drmiguelperales.bsky.social · 22/11/2024

If you're interested in Stem cell transplant and/or Cellular Therapy this is the list #bmtsm #CARTcells #leusm #mmsm #lymsm #MedSky #TcellRx go.bsky.app/7xxh8WW

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Reposted by Simone Minnie

Jason Buenrostro @jbuenrostro.bsky.social · 16/11/2024

Excited to see our T-cell exhaustion preprint published! This work is led by Tristan Tay and collaborators at AstraZeneca. See the sub-thread (reformatted for bluesky) originally composed and posted by the newly minted Dr. Tay www.cell.com/cell-reports...

cell.com

Degradation of IKZF1 prevents epigenetic progression of T cell exhaustion in an antigen-specific assay

Tay et al. demonstrate an antigen-specific assay producing exhausted T cells that reflect those found in human tumors. They identify IKZF1 (IKAROS) as a driver of exhaustion progression and validate t...

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Simone Minnie @simone-minnie.bsky.social · 20/11/2024

Follow me for more mentoring thoughts that I’m literally stealing from parenting books 😂. Apparently just being an empathetic adult goes a long way to fostering collaborative relationships both at home and at work.

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Simone Minnie @simone-minnie.bsky.social · 20/11/2024

Finally, it doesn’t take away anything from anyone to acknowledge feelings/perceptions before offering advice. Sometimes people don’t want advice, just a “yeah that sucks.” Anyways, that’s my yet to be tested 2 cents so take it with a grain of salt.

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Simone Minnie @simone-minnie.bsky.social · 20/11/2024

Secondly, something that isn’t a big deal for you personally might still be for your trainee. I can’t give a work example for this one but just because I don’t think it matters who cut the banana doesn’t change the fact that my toddler is devastated that I did it.

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Simone Minnie @simone-minnie.bsky.social · 20/11/2024

I think one of the most important parts of mentoring is having empathy for your trainees. Firstly, things being harder now for junior people doesn’t mean that things weren’t hard for you at the time. Ie. I would NEVER have gotten into a PhD program these days with my track record back then.

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Reposted by Simone Minnie

Lee Grimes Lab @leegrimeslab.bsky.social · 20/11/2024

CHMC Division of Immunobiology is hiring Assistant Professors. You can have a lab next to mine if you like.

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Simone Minnie @simone-minnie.bsky.social · 20/11/2024

Ha! This is when I need the laughing/crying emoji 😅

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Simone Minnie @simone-minnie.bsky.social · 20/11/2024

For context: this is a broader and not at all personal question. My experience was actually fine, but that doesn’t mean it is/will be for everyone!!

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Simone Minnie @simone-minnie.bsky.social · 20/11/2024

Current postdocs have the perception that the faculty job market is insanely hard right now. Is this reality? Has it always been this hard or is it objectively particularly bad right now?

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Reposted by Simone Minnie

Thiago Carvalho @cyrilpedia.bsky.social · 17/11/2024

Putting LIPSTIC on CARTs "We reasoned that target-induced labelling of CAR molecules within the immunologic synapse, instead of surface CD8 expression levels, could be used to distinguish and characterize first-division proximal- and distal-daughter CARTs" #Immunology www.nature.com/articles/s41...

nature.com

Fate induction in CD8 CAR T cells through asymmetric cell division - Nature

We show that target-induced proximity labelling enables isolation of first-division CD8 chimeric antigen receptor T cells that asymmetrically distribute their surface proteome and transcriptome, resul...

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