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Sergio Dellepiane

@sergiodellep.bsky.social
101 followers 337 following 304 posts

Nephrologist in pharma industry.

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Reposted by Sergio Dellepiane
Johan Duchêne @johanduchene.bsky.social · 30/04/2025
Antibodies don't work. NLRP3 is by far the most studied inflammasome — yet <30% of commercial antibodies were specific. Only 4 of 14 tested antibodies detected NLRP3 specifically. Antibodies must be validated before use. Full report by @ycharos.bsky.social : zenodo.org/records/1162...
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Sergio Dellepiane @sergiodellep.bsky.social · 07/10/2026
Aging clicks have been publicized as the best prediction tools for aging. This publication questions whether that’s true
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Sergio Dellepiane @sergiodellep.bsky.social · 04/10/2026
Mafia, Fascism, Modern Populism (Berlusconi is father to so many new leaders), insane deficits, Uncontrolled aging population, tanking education.. Behold the true innovators of the last 2 centuries www.ft.com/content/a271... The US is looking more like Italy @ranaforoohar.bsky.social
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Sergio Dellepiane @sergiodellep.bsky.social · 30/09/2026
Apparently I am not alone.. (even though I forgot to mention the tiny piece of 1TLN private borrowing) www.ft.com/content/c05f... Don’t own bonds and be cautious with stocks
ft.com
Don’t own bonds and be cautious with stocks
Balance sheets have become unbalanced and growth in turn may suffer the consequences
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Sergio Dellepiane @sergiodellep.bsky.social · 29/09/2026
Un nuovo interessante punto di vista sul collasso dell’età del bronzo @lucamisculin.bsky.social open.substack.com/pub/worksinp...
open.substack.com
Why the Bronze Age collapsed
Historians like to blame drought, famine and invaders. But this can’t explain why the empires never came back.
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Sergio Dellepiane @sergiodellep.bsky.social · 28/09/2026
Did surg-sky already revolted?
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Sergio Dellepiane @sergiodellep.bsky.social · 28/09/2026
Quite shocking www.ft.com/content/4339... For once, the Fed has put Main Street before Wall Street
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Sergio Dellepiane @sergiodellep.bsky.social · 21/09/2026
Let’s say: good but not really great What having a daughter does to a boss economist.com/graphic-deta... from The Economist
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Sergio Dellepiane @sergiodellep.bsky.social · 20/09/2026
Vienna è l’esempio supremo di città che ha avuto successo nel gestire le politiche abitative. Capitale di una nazione ricca, in espansione, ma con le case a prezzi accessibili! E i politici se ne riempiono la bocca. Ma quanto è replicabile il modello Vienna? 1/6 www.ilpost.it/2026/09/20/c...
ilpost.it
Mario Calabresi: «Sì, voglio provare a impegnarmi»
Intervistato da Francesco Costa per Talk, ha risposto così sulla possibilità di una sua candidatura a sindaco di Milano
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Sergio Dellepiane @sergiodellep.bsky.social · 20/09/2026
E così il giornale del figlio di Sofri ha intervistato il figlio di Calabresi. Un lieto fine (tra l’altro la rappacificazioneera già avvenuta) www.ilpost.it/2026/09/20/c...
ilpost.it
Mario Calabresi: «Sì, voglio provare a impegnarmi»
Intervistato da Francesco Costa per Talk, ha risposto così sulla possibilità di una sua candidatura a sindaco di Milano
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Sergio Dellepiane @sergiodellep.bsky.social · 18/09/2026
I don’t watch comedy shows anymore, I just read @alphaville.ft.com
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Sergio Dellepiane @sergiodellep.bsky.social · 17/09/2026
Great piece from Robert Armstrong on the @financialtimes.com. Apple stock price is higher than expected based on “standard stock metrics” and it’s expected to remain there. Why? Because Apple provides something no other Tech company has: customers’ trust
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Sergio Dellepiane @sergiodellep.bsky.social · 16/09/2026
Absolutely true. Great read: when therapy is actually harmful bleaseondrbot.substack.com/p/part-one-i...
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Reposted by Sergio Dellepiane
Astronomer Royal for Scotland | Catherine Heymans @astroroyalscot.bsky.social · 05/09/2026
Help! Parton Community Council has 60 days to raise £70k to buy Parton Kirk (resting place of James Clerk Maxwell). They plan to turn it into a visitor centre celebrating our great hero! The other buyers could turn it into long-term storage 😬 Even £5 would help 🙏🧪⚛️ www.justgiving.com/crowdfunding...
justgiving.com
Help raise £70000 to Save Parton Kirk – JustGiving Crowdfunding
Iʼm raising money to Save Parton Kirk. Support this JustGiving Crowdfunding Page.
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Reposted by Sergio Dellepiane
Philip Ball @philipcball.bsky.social · 10/09/2026
Assuming it doesn't kill us all, could AI ever display the kind of scientific creativity we find in, say, Einstein's theory of general relativity? I explore that question in this feature for Nature. www.nature.com/articles/d41...
nature.com
The Einstein test: what happens when AI tries to rediscover relativity?
Scientists are probing whether language models trained on historical data can reproduce creative breakthroughs.
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Reposted by Sergio Dellepiane
Chris Giles @chrisgiles.ft.com · 10/09/2026
My column: I am intolerant of lazy stereotypes, accusing Europeans of being work-shy layabouts, degenerately dependent on welfare instead of doing an honest day’s work Europe doesn't need a crisis, it needs more successful gradual reform www.ft.com/content/362b...
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Sergio Dellepiane @sergiodellep.bsky.social · 08/09/2026
An eye for an eye makes the whole world blind
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Sergio Dellepiane @sergiodellep.bsky.social · 07/09/2026
Now also in children! Can we stop or we are going to try also in people with midlife crisis (and sepsis..). Spoiler: it didn’t work. (Un?)Surprisingly saline outcome was numerically better
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Sergio Dellepiane @sergiodellep.bsky.social · 07/09/2026
Way to go Glasgow, approaching violence w public health “… the Scottish Violence Reduction Unit, which aims to prevent violent crime by bringing the police, schools, hospitals and sports clubs together to identify at-risk children and direct them away from crime.” economist.com/britain/2026...
economist.com
London’s approach to knife crime is working
Sadiq Khan has implemented a public-health approach that was previously fringe
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Sergio Dellepiane @sergiodellep.bsky.social · 31/08/2026
In UK (il paese della pioggia!) c’è un sano dibattito sulla gestione delle future siccità. Svariati articoli su bacini artificiali e desalinizzatori. In Italia? Il piovoso nord ormai ha siccità regolari dal 2010. Il sud molto peggio. Quando nel 2021 Bucci parlò di desalinizzazione gli risero dietro.
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Sergio Dellepiane @sergiodellep.bsky.social · 25/08/2026
www.ft.com/content/7a9f... High asset prices, not low interest rates, are driving inflation
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Sergio Dellepiane @sergiodellep.bsky.social · 20/08/2026
Urine lipids are cats’ way to mark their territory @science.org x.com/NewsfromScie...
x.com
News from Science (@NewsfromScience) on X
Meowing aside, urine is one of the most important ways cats communicate. Both wild and domestic kitties mark their territories to tell other felines to keep out or to advertise for mates. These unique...
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Sergio Dellepiane @sergiodellep.bsky.social · 20/08/2026
A true Nephrologist would also add a bit of lasix.. just in case
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Sergio Dellepiane @sergiodellep.bsky.social · 19/08/2026
So basically consumers paid and Target double cashed? www.ft.com/content/c555... Target profits double after $1bn tariff refund
ft.com
Target profits double after $1bn tariff refund
US retailer reports higher sales as net income boosted by Washington’s tariff return programme
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Reposted by Sergio Dellepiane
Oded Rechavi @odedrechavi.bsky.social · 19/08/2026
Lab meetings can be the worst, or the best! :) Here are 22 tips for improving them (including mine) www.nature.com/articles/d41... @nature.com
nature.com
Twenty-two easy ways to power up your lab meetings
Scientists share help and advice on how they got their research discussions flowing.
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Reposted by Sergio Dellepiane
vincentholst.bsky.social @vincentholst.bsky.social · 13/08/2026
In 2023, @nature.com published 'Papers and patents are becoming less disruptive over time', receiving world-wide media attention. Our Matters Arising, published after a 32 month delay (more on that soon), shows that the reported decline can largely be attributed to dataset artefacts. 🧵
The average CD_5 index per year for Web of Science. The original Park et al. decline (top curve) becomes essentially flat (bottom curve) when removing papers with CD_5=1. Those papers largely correspond to dataset artefacts.
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Sergio Dellepiane @sergiodellep.bsky.social · 13/08/2026
Can someone explain to me this odd phenomenon. Took pictures with an iPhone (but same happened to a person next to me with a Pixel). It was close to sunset. The eclipse was somewhat projected next to the sun
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Reposted by Sergio Dellepiane
Nature Human Behaviour @nathumbehav.nature.com · 13/08/2026
Cutting a nerve of the hand alters the organization of digit maps in primary somatosensory cortex
dlvr.it
Cutting a nerve of the hand alters the organization of digit maps in primary somatosensory cortex
Nature Human Behaviour, Published online: 13 August 2026; doi:10.1038/s41562-026-02548-8Weber et al. show that the normally conserved spatial organization of the digit response maps in primary somatosensory cortex is altered in patients with surgically repaired hand nerves.
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Sergio Dellepiane @sergiodellep.bsky.social · 10/08/2026
Nice read www.nature.com/articles/s44...
nature.com
Human cooperation is strong among individuals but fragile between groups - Nature Reviews Psychology
There is ample empirical evidence that humans are cooperative, but there is also evidence that humans can be distrustful, hostile and aggressive. In this Review, Van Lange and Bergmann reconcile this ...
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Sergio Dellepiane @sergiodellep.bsky.social · 07/08/2026
Gutta cavat lapidem, non vi sed saepe cadendo (Ovid) The drop excavates the rock, not with strength but relentlessly falling @nature.com www.nature.com/articles/d41...
nature.com
How a steady drip-drip can erode the hardest stone
Measuring the deformation of a surface hit by a falling droplet offers insights into water’s erosive power.
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Sergio Dellepiane @sergiodellep.bsky.social · 03/08/2026
The 2-digit inflation crisis was blamed on COVID and Russia. IMO those were the triggers, the core reasons were the insane gvt borrowing and QE. I think we are back to square one, waiting for the next trigger
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Reposted by Sergio Dellepiane
Prof Christina Pagel @chrischirp.bsky.social · 31/07/2026
More detail with links to evidence and a nice chart in my substack post 12/12 christinapagel.substack.com/p/we-are-lea...
christinapagel.substack.com
We are learning the wrong lesson from Covid school closures
A response to yesterday's News Agents podcast...
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Reposted by Sergio Dellepiane
Prof Christina Pagel @chrischirp.bsky.social · 31/07/2026
We did in fact try lockdown with schools fully open in November 2020. It worked initially, but cases in London & SE started rising again *before* lockdown even ended, because of new variant Alpha. Lockdown with schools open was not enough! 6/12
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Sergio Dellepiane @sergiodellep.bsky.social · 31/07/2026
I was always confused on the inequality literature.. today in one of his uncountable masterpieces, @jburnmurdoch.ft.com on the @financialtimes.com gives a lot of great answers. I can share only 3 clicks! giftarticle.ft.com/giftarticle/... We’ve moved from income world to wealth world
giftarticle.ft.com
We’ve moved from income world to wealth world
Passive wealth gains increasingly matter more than earnings for one’s standing in society
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Sergio Dellepiane @sergiodellep.bsky.social · 29/07/2026
This is the single thing I miss the most since I stopped practicing. The hospital let me witness love stories that are beyond imagination, beyond any novel I ever read or movie I ever saw. I participated in the sweetest lies and the hardest truths, and I learned about the dark beauty of grief
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Reposted by Sergio Dellepiane
Kristen Kroll @kkroll.bsky.social · 26/07/2026
🧪Rita Levi-Montalcini escaped war torn Italy and had a career of incredible brilliance and resilience. I loved learning about her life and wonderful scientific interactions with embryologist Viktor Hamburger throughout her years at Washington University open.substack.com/pub/kristenk...
open.substack.com
The Woman Who Turned Her Bedroom Into a Laboratory — and Changed Neuroscience Forever
Rita Levi-Montalcini, the trailblazing scientist who kept working to survive
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Sergio Dellepiane @sergiodellep.bsky.social · 24/07/2026
At the end (?) of the long debate started by @pkrugman.bsky.social and picked by N Smith, The Economist and @financialtimes.com .. I’ll add my useless opinion by reposting this. I think that 1) data can be deceiving and 2) comparing 2 continents leaves a lot of details on the plate
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Reposted by Sergio Dellepiane
asawalha.bsky.social @asawalha.bsky.social · 19/07/2026
JCI - Rheumatoid factor production is genetically and molecularly distinct from rheumatoid arthritis www.jci.org/articles/vie...
jci.org
JCI - Rheumatoid factor production is genetically and molecularly distinct from rheumatoid arthritis
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Reposted by Sergio Dellepiane
Nature Portfolio @natureportfolio.nature.com · 21/07/2026
Approximately 6.7 million US gallons, 22 million US dollars, and 57,000 tonnes of carbon dioxide emissions could have been saved across the US every day in 2021 if all light duty vehicles had driven at or below speed limits, according to a study in Communications Sustainability. #econsky 🌎🧪
go.nature.com
Speeding incurs substantial environmental and economic costs nationwide for negligible travel time savings - Communications Sustainability
Obeying speed limits can save over six million gallons of fuel and fifty thousand metric tonnes of carbon dioxide per day with minimal delay, based on analysis of more than one hundred twenty million vehicle trajectories assessing speed limit interventions across the United States.
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Sergio Dellepiane @sergiodellep.bsky.social · 21/07/2026
Completely expected and predicted.. here the final result
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Reposted by Sergio Dellepiane
Christian Odendahl @codendahl.bsky.social · 21/07/2026
Very interesting. Build wind and solar next to hydro plants. The grid is already there and goes underutilised for much of the day.
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Reposted by Sergio Dellepiane
Alex Selby-Boothroyd @alexselbyb.bsky.social · 19/07/2026
This is this World Cup's 208th hydration break. Assuming 100m viewers per game, they have wasted 118,640 years of everyone's time
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Sergio Dellepiane @sergiodellep.bsky.social · 15/07/2026
What the hell??!?
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Sergio Dellepiane @sergiodellep.bsky.social · 15/07/2026
Great piece from M Wolf on the @financialtimes.com. I can’t agree more. Just one note.. we should stop this equation life expectancy = healthcare. The main determinant of LE are public health measures and quality of life. HC plays a relatively small role www.ft.com/content/b77c...
ft.com
Is the US or Europe better off?
Comparing the two economies is harder than it seems
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Sergio Dellepiane @sergiodellep.bsky.social · 14/07/2026
What scares me the most about AI is that historically the power has always been about people. Money, armies, kingdoms are all means to get power through the people. And on the long run it always rebalances. Now what? Power will be beyond the people
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Sergio Dellepiane @sergiodellep.bsky.social · 13/07/2026
Can someone explain to me the metrics for inequality? I keep reading 1) inequality has never been so low 2) yes inequality has raised in specific critical assets (houses, healthcare) but not others 3) inequality is worse now the Gilded age Which one? My best guess is 2
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Sergio Dellepiane @sergiodellep.bsky.social · 13/07/2026
Some investment advice from the financial times. Ask a Bonobo, you’ll definitely save on fees.. may get some excrement stains though www.ft.com/content/299b...
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Reposted by Sergio Dellepiane
Jay Van Bavel, PhD @jayvanbavel.bsky.social · 12/07/2026
Why dating apps backfire: Seeing more partner options sets off a rejection mind-set: People become increasingly likely to reject potential partners to the extent that they are presented with more options. This is especially true of women. journals.sagepub.com/doi/10.1177/...
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Henry Mance @henrymance.ft.com · 11/07/2026
Europe’s slow electrification is a ‘major mistake’ www.ft.com/content/fbeb...
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Sergio Dellepiane @sergiodellep.bsky.social · 11/07/2026
Great piece from John Burn Murdoch on the @financialtimes.com. Mental health issues are clearly rising, but there is also a systematic misconception about what is a mental illness www.ft.com/content/063b... Adding what I wrote (automatic translation available) open.substack.com/pub/sergiode...
ft.com
What’s really going on with mental health?
Changing terminology risks misleading policymakers and harming those in most need
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