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ACR Journals @acr-journals.bsky.social · 14/08/2026

Arthritis & Rheumatology doi.org/10.1002/art....

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ACR Journals @acr-journals.bsky.social · 14/08/2026

New study identifies CD8⁺ HLA-DRB1⁺ T cells as a dysfunctional, disease-associated T cell population expanded in lupus. Type I IFN drives exhaustion, senescence, and impaired degranulation despite increased cytotoxic gene expression, linking chronic IFN signaling to defective T cell function

Type I interferon drives dysfunction of a distinct CD8+ HLA‐DRB1+ T cell subset in systemic lupus erythematosus. Graphical abstract created using BioRender

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asawalha.bsky.social @asawalha.bsky.social · 19/07/2026

JCI - Rheumatoid factor production is genetically and molecularly distinct from rheumatoid arthritis www.jci.org/articles/vie...

jci.org

JCI - Rheumatoid factor production is genetically and molecularly distinct from rheumatoid arthritis

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STITCHES Medicine - the Best of Medical Research @medicine.stitches.today · 09/07/2026

Rheumatoid factor production is linked to distinct genetic pathways and immune mechanisms, diverging from rheumatoid arthritis development. by Hocaoglu M and Sawalha AH in J Clin Invest #MedSky 👉 get more here 📖 read the article: www.jci.org/articles/view/208390

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ACR Journals @acr-journals.bsky.social · 02/01/2026

DNA methylation analysis of patients with childhood-onset SLE identified distinct patterns associated with disease activity, molecular subgroups, and sex Arthritis & Rheumatology doi.org/10.1002/art....

DNA methylation profiling reveals distinct epigenetic clusters and suggests epigenetic patterns associated with sex and disease activity in childhood-onset lupus. Graphical abstract created using BioRender

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ACR Journals @acr-journals.bsky.social · 10/04/2026

Among individuals in the UK Biobank cohort, gain-of-function variants in IDH1 and IDH2 conferred increased risk of incident immune-mediated rheumatic diseases, predominantly rheumatoid arthritis and polymyalgia rheumatica ACR Open Rheumatology doi.org/10.1002/acr2...

Rare Gain-of-Function Variants in IDH1 and IDH2 Confer Increased Risk of Immune-Mediated Rheumatic Diseases. Graphical abstract created using BioRender

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ACR Journals @acr-journals.bsky.social · 02/04/2026

Can blood proteins predict lupus before dx? New study using @ukbiobank.ac.uk data says yes. Machine learning models trained on serum proteomics identified lupus with ~90% sensitivity, outperformed polygenic risk scores, and flagged novel biomarkers A&R doi.org/10.1002/art.... @asawalha.bsky.social

Identifying systemic lupus erythematosus from serum proteomic profiles using machine learning and genetic risk stratification. Graphical abstract created using BioRender

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