iiinova — where your digital self keeps evolving

Reposted by Luke Child Dabin

Dr Hannah M. Rowland @hannahmrowland.bsky.social · 01/10/2026

Hope your day was better than Darwin’s, on this day 165 years ago

I am very poorly today & very stupid & hate everybody &everything.

Charles Darwin
Letter to Charles Lyell
1st October 1861

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Merriam-Webster @merriam-webster.com · 31/08/2026

macabre = “muh-KAHB” Worcestershire = “WOOSS-ter-sheer” omnipotent = “ahm-NI-puh-tunt” reticent = “RET-uh-sunt” epitome = “ih-PIT-uh-mee” myriad = "MEER-ee-ud" Never make fun of someone if they mispronounce a word. It means they learned it by reading.

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Luke Child Dabin @scienceandbears.bsky.social · 27/08/2026

We've lost so much and we have so much to celebrate

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Luke Child Dabin @scienceandbears.bsky.social · 11/08/2026

🧠Proud to announce a new publication: Unique transcriptomic alterations in 5XFAD;PS19 mouse model🧬 Amyloidoisis, tauopathy & neurodegeneration are hallmarks of AD. We study these proteinopathies in separate models, but rarely study them TOGETHER. We wondered if we might be missing something.🧐 1/3

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Unique transcriptomic alterations in 5XFAD;PS19 mouse model identify glial lipid dysregulation and coordinated microglial–oligodendrocyte responses

INTRODUCTION Alzheimer's disease (AD) features amyloid beta (Aβ) plaques and tau tangles, yet how their coexistence reshapes brain transcriptomic programs remains unclear. METHODS We performed high...

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Luke Child Dabin @scienceandbears.bsky.social · 30/07/2026

Maybe we should rename "Careers in Science" panels "Survivorship Bias" panels? The LUCK factor of success is typically never discussed or alluded to.

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Luke Child Dabin @scienceandbears.bsky.social · 25/07/2026

I follow this one account here which posts dialogue from The Elder Scrolls III: Morrowind. It's a little source of joy. ☺️

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Josh Gondelman @joshgondelman.bsky.social · 15/07/2026

“I’ll pass on the salad and just have those fries. I’m trying to eat healthy.” - instant hall of fame dad joke thanks to cyclospora

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Indigo V. L. Rose @ivlrose.bsky.social · 02/07/2026

Not Claude advertising their new model to me using a left-handed helix

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Luke Child Dabin @scienceandbears.bsky.social · 27/06/2026

BBC principles "Inform, Educate, Entertain" exemplified in Horrible Science sketch where a height-averse actor playing Sir Isaac Newton has to go on a fast rollercoaster & explain atomic theory while screaming hysterically, followed by "Got to Go", a Chapell Roan parody about how pooping

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Elizabeth Lopatto @lopatto.bsky.social · 10/06/2026

this is the ideal newspaper columnist. you may not like it but this is what peak performance looks like

Pump-action soap dispensers are a disgrace -and I won't put up with them any longer
By Adrian Chiles, a perfect man

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Eric Topol @erictopol.bsky.social · 21/02/2026

Progress!

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Luke Child Dabin @scienceandbears.bsky.social · 05/06/2026

Paranormasight 2: Curse of the Mermaids is a Japanese horror mystery game about a group of people seeking a mermaid. It also features a bunch of collectable bird stickers. They are all in a polycule with each other & have their own theme tune, which is incredible. www.youtube.com/watch?v=yab3...

youtube.com

25. Flock'n'Roll from PARANORMASIGHT The Mermaid's Curse Original Soundtrack

YouTube video by channel for the paranormasight 2 soundtrack

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Luke Child Dabin @scienceandbears.bsky.social · 16/05/2026

Went to the doctor this week with a suspicious-looking mole. She said they all look that way and I should put him back in the garden.

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⛧ Mother Suspiria ⛧ (Stina Marie) @stinasdemons.com · 04/05/2026

May the 4th be with you. Here's one of my favorite Star Wars memes:

Screen shots of a scene in Star Wars' The Rise of Skywalker with the following text
-Who are you [old lady]
-I am Rey [Rey]
-Rey who? [old lady]
[Image of two ghosts dancing who are The Weather Girls]
-Ningmen [Rey]
-It's Rey Ningmen? [old lady]
-Hallelujah [Rey, w/ images of men falling from sky behind her]

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Fiona Tribe @fionatribe.bsky.social · 23/04/2026

Yes, Swiss scientist Fritz Zwicky coined the term “dark matter” which is impressive, but he also coined the term “spherical bastard” to describe people who are bastards no matter which way you look at them, and I think that should be celebrated more.

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Sooz Kempner @soozuk.bsky.social · 19/04/2026

Happy 80th Birthday to Tim Curry, a guy who treats every single part like it was the role he was born to play.

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Luke Child Dabin @scienceandbears.bsky.social · 11/04/2026

I really wish there were a bluesky setting to block strangers' posts about recently departed pets 🙃

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Luke Child Dabin @scienceandbears.bsky.social · 05/04/2026

This is a long read, but worth it to get a sense of how colossal and pointless the damage to the CDC has been and how brave the people who worked there and continue to work there are.

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Luke Child Dabin @scienceandbears.bsky.social · 01/04/2026

New Kim Lab paper! 🥳 BK lead a rigorous study of the effect of microglial knockdown of PU.1 (Spi1) in APPPS1 amyloid mice. Made multiple pathological measures worse, can be partially rescued by overexpression of target genes Syk & Fcgr1. #blueskyence #microglia www.sciencedirect.com/science/arti...

sciencedirect.com

Deletion of SPI1 in microglia exacerbates amyloid pathology by impairing microglial response in Alzheimer’s disease models

Recent human genetic studies have highlighted the potential role of microglial genes and their regulatory functions in the pathogenesis of Alzheimer’s…

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Malcolm D. @mdpb53.bsky.social · 24/03/2026

Man goes to his doctor. He says "Doc, my wife tells me my hearing is going." The Doctor says "Okay. tell me about the symptoms." Man replies "Homer is the father; his wife Marge has high blue hair........"

media.tenor.com

a cartoon of marge simpson carrying a purple laundry basket

ALT: a cartoon of marge simpson carrying a purple laundry basket

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Luke Child Dabin @scienceandbears.bsky.social · 23/03/2026

It's been on bioRxiv for a while, but delighted to share that our nuclei isolation paper is now published in Cell Reports Methods! We hope it's of use to anyone planning costly snRNAseq experiments - let's get more 🧬💻🥳 for our $$$! www.cell.com/cell-reports...

cell.com

Comparative analysis of nuclei isolation methods for brain single-nucleus RNA sequencing

Kersey et al. systematically evaluate three nuclei isolation methods for brain snRNA-seq, demonstrating that protocol choice markedly affects data quality metrics, including nuclei yield and ambient R...

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Astronomer Royal for Scotland | Catherine Heymans @astroroyalscot.bsky.social · 12/03/2026

The Science, Innovation & Tech committee have written the most amazing letter to DSIT/UKRI/STFC: "What is clear is that, despite your assertions to the contrary... widespread cuts have been proposed before adequate consultation with those affected was undertaken. This is wholly unacceptable" 💪🔭⚛️🧪

The letter reads:

We were deeply concerned by what we heard, both from witnesses representing the PPAN community and those who contacted us in advance of the hearing.
It is not clear whether the current situation is the by-product of irresponsible financial management and inadequate governance; a conscious decision to set aside the 2009 ‘Drayson partitions’ in order to deprioritise a particular area of scientific research in favour of research facilities; an unintended consequence of wholesale, rushed reforms to the way the UK funds scientific research; or a combination of all three.
What is clear is that, despite your assertions to the contrary in evidence to my committee and our counterparts in the House of Lords, widespread cuts have been proposed before adequate consultation with those affected was undertaken.

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Jerry Chen @jcsalterego.bsky.social · 07/03/2026

well i think if people aren't allowed in the hotel linen chute they should put that on a sign

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Dr. SkySkull @drskyskull.bsky.social · 03/03/2026

A new paper on falling cat science came out and I just have to draw people's attention to this image

A gray shorthair cat at the moment of release upside down, with its tongue out looking derpy

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Alasdair Beckett-King @misterabk.bsky.social · 27/02/2026

More like Matt Badloss.

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Luke Child Dabin @scienceandbears.bsky.social · 27/02/2026

www.serebii.net/pokemon30/ There're versions of the 30 year logo with all pokemon on serebii, but one design in particular goes particularly hard

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Luke Child Dabin @scienceandbears.bsky.social · 26/02/2026

THOROUGHLY well-deserved 🤩🥳 Excellence is the word

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Jeremy Berg @jeremymberg.bsky.social · 23/02/2026

Deep, well sourced, moving, and enraging story from the NYT [Gift Link] www.nytimes.com/2026/02/23/o...

nytimes.com

Opinion | The Human Cost of Trump’s War on Science

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Dr. Jean Fan @jef.works · 19/02/2026

We recently updated our paper demonstrating evidence of off-target probe binding affecting the 10x Genomics Xenium spatial transcriptomics platform with key clarifications, new quantifications, and approaches for evaluating custom gene panels: biorxiv.org/content/10.1... 🧵👇1/n

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Luke Child Dabin @scienceandbears.bsky.social · 19/02/2026

Spectacular ALT text on these two photos

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Rodger Sherman @rodger.bsky.social · 18/02/2026

DOG AT THE OLYMPICS FULL COMPETITION HIGHLIGHTS

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Luke Child Dabin @scienceandbears.bsky.social · 17/02/2026

Ian the cat is zooming and has just unknowingly activated the roomba, which he is terrified of

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Luke Child Dabin @scienceandbears.bsky.social · 16/02/2026

Me, minding my own business: MILKSHAKE ADVERT FROM WHEN I WAS SINGLE DIGITS YEARS OLD: www.youtube.com/watch?v=KRLN...

youtube.com

Shakey Jake (1999, UK)

YouTube video by The Hall of Advertising

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NY Times Pitchbot @nytpitchbot.bsky.social · 10/02/2026

RFK, Jr. says a Harvard researcher cured schizophrenia by feeding his patient a meat-heavy keto diet. The Harvard researcher says he did not. For busy schizophrenic lovers of beef tallow, it can be hard to know who to trust.

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Luke Child Dabin @scienceandbears.bsky.social · 07/02/2026

Friday evening is the least helpful time to have a hypomanic episode. I COULD HAVE USED THIS ENERGY DURING THE WORKING WEEK.

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Luke Child Dabin @scienceandbears.bsky.social · 06/02/2026

I'm on a plan 1 loan. It's bullshit, I will never pay it off & it gets wiped 30 years after I graduated, when I hit my mid-50s. I remember the Lib Dems allowing the Tory increase from 3k to 9k (the rationale for which wasn't even EXPLAINED) while I was at Uni. Oli is right to be angry.

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Luke Child Dabin @scienceandbears.bsky.social · 06/02/2026

A fantastic interview, but the closing monologue is spellbinding. Linked to with timestamp below. 400 years of the human condition is the blink of an eye, and the ugly sentiment behind the 1517 riots are worth condemning today. Ian does it with superhuman eloquence. www.youtube.com/watch?v=2l2R...

youtube.com

"There's Nothing I Enjoy More Than Acting In The Theater" - Ian McKellen EXTENDED INTERVIEW

YouTube video by The Late Show with Stephen Colbert

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Omg. WTF is Happening? @lalahaenzy.bsky.social · 05/02/2026

Sir Ian McKellen performing a monologue from Shakespeare’s Sir Thomas More on the Stephen Colbert show. Never have I heard this monologue performed with such a keen sense of prescience. Nor have I ever been in this exact historical moment.TY Sir Ian, for reaching us once again. #Pinks #ProudBlue

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Luke Child Dabin @scienceandbears.bsky.social · 04/02/2026

The p-Tau217 test and emerging immunotherapies will make a monumental difference to how we manage Alzheimer's Disease if, and ONLY if, people who need them can access them. Thank goodness for the policy advocates at Alz. Assoc.!

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Steenz! @oheysteenz.bsky.social · 02/02/2026

I write and draw the daily comic strip Heart of the City! It's a nationally syndicated strip in 100+ newspapers and has a few collections of the early strips. You can read it daily for free on www.gocomics.com/heartofthecity! Consider being a paid subscriber! Get comics directly in your inbox!

gocomics.com

Read Heart of the City by Steenz on GoComics

Heart of the City by Steenz follows 10-year-old Heart LaMarr and her adventures in Philadelphia with dreams, schemes, and big city spirit.

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Luke Child Dabin @scienceandbears.bsky.social · 26/01/2026

I'd estimate around 60% of useful answers on stackoverflow are typed in an incredibly hostile tone as a response to a previous, well-meaning but flawed answer.

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NANCY COMICS BY ERNIE BUSHMILLER @nancycomics.bsky.social · 22/01/2026

Nancy By Ernie Bushmiller January 22,1959

NANCY BY ERNIE BUSHMILLER
P1- NANCY, SLUGGO AND TWO OF THE NEIGHBORHOOD KIDS HAVE ALL MADE SNOW FORTS

SLUGGO NAMED HIS FORT..FORT BRAVE

P2- SECOND KID NAMED HIS FORT..
FORT COURAGE

P3- NANCY NAMED HER FORT…
FORT STRONG

NANCY: THAT HIGHBROW KID GIVES ME A PAIN

P4- THE HIGHBROW KID NAMED HIS FORT…

FORT
ITUDE

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Elizabeth Wrigley-Field @wrigleyfield.bsky.social · 22/01/2026

I met an absolutely lovely academic who asked whether my department back home is affected by ICE -- a question dramatizing how little info is getting out. For the record, the small example I chose: My dept has a carpool to pick up grad students of color who can't safely commute to campus alone.

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Luke Child Dabin @scienceandbears.bsky.social · 21/01/2026

Was introduced to the department as a new faculty member today! It was a very long road to this promotion and I'm so glad I attended the faculty meeting in person - it now feels REAL. 🙂 Anyway, my microglial subcluster has 12 marker genes, what on earth am I supposed to do with this

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