Researchers found that paired pathogenic variants can restore protein function rather than make it worse. This phenomenon could occur in four percent of human genes.

V2P predicts variant pathogenicity conditioned on disease phenotypes across top-level Human Phenotype Ontology categories. This approach shows promise for phenotype-specific estimation of variant effe...

Academic scientists and pharmaceutical companies alike are embracing artificial intelligence, even as questions linger about its value

Structures of the solute carrier transporters MCT8 and OATP1C1 reveal mechanisms of thyroid hormone transport into the brain and identify a conserved extracellular allosteric site in OATP1C1.

David Baker’s lab has successfully designed binders to disordered proteins, expanding therapeutic access to over 50% of the human proteome.

While AI-driven approaches tout increased speed and lower costs, commercial interests compromise scientific collaboration.

The astrocytic γ-aminobutyric acid (GABA) transporter, GAT3, is essential for terminating GABAergic signalling in the central nervous system. Selective inhibition of GAT3 offers a potential strategy f...

NIH’s abrupt decision to cap indirect cost reimbursement at 15% threatens the critical infrastructure supporting groundbreaking biomedical research in the United States. This policy jeopardizes Americ...

‘With the current turmoil, China could surpass the U.S. in the near future,’ Nobel Prize winner David Baker warns.

Who needs N.I.H. grants? A lot of red-state universities, for one.

Huge analysis identifies regional variations in the criteria that institutions use to move researchers up the ranks.