iiinova — where your digital self keeps evolving

MitoCarriers @mitocarriers.bsky.social · 06/12/2025

Here, we critically review the structures of the mitochondrial pyruvate carrier (MPC) in apo and ligand-bound states, highlighting controversies with regard to the orientation in the inner membrane, interpretation of the transport states, and modelling of the inhibitors. doi.org/10.1016/j.ti...

doi.org

Redirecting

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MitoCarriers @mitocarriers.bsky.social · 11/10/2025

Recently, I saw a sun dog next to the cupola of Trinity Hall, Cambridge. It is a natural phenomena where hexagonal ice crystals in the sky deflect the sun light at a 22 degree angle. They function as a prism, like diamond dust, separating out the different wavelengths. Big shout out to Newton!

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MitoCarriers @mitocarriers.bsky.social · 11/10/2025

A brilliant new paper by @Marilia Meira Dias and @Thomas MacVicar and others is out! It has discovered that a mitochondrial carrier SLC25A45 is involved in the uptake of methylated lysine and arginine, a key step in carnitine biosynthesis! www.sciencedirect.com/science/arti...

sciencedirect.com

SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis

Methylated amino acids accumulate upon the degradation of methylated proteins and are implicated in diverse metabolic and signaling pathways. Disturbe…

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Insta Science @instascience.bsky.social · 23/08/2025

A microscopic Tardigrade (water bear), walking across a glass slide. Extremely resilient, they can survive decades without food or water and can survive in direct exposure to space.

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New Scientist @newscientist.com · 30/07/2025

A harder form of diamond that has eluded scientists for decades can now be synthesised in the laboratory, and could be used to make extremely tough cutting and drilling tools.

newscientist.com

Extra-hard hexagonal diamonds can now be grown in a lab

Hexagonal diamond up to 60 per cent stronger than normal diamonds could be used to create super-tough drilling and cutting tools for industrial applications

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MitoCarriers @mitocarriers.bsky.social · 25/07/2025

Our review on the peculiar properties of mitochondrial carriers of the SLC25 family out: portlandpress.com/biochemj/art...

Characterised members of the human SLC25 mitochondrial family. Members of the mitochondrial carriers are shown in rainbow (blue to red) cartoon and surface representations with their primary substrates shown in sphere representations to scale. Only one paralogue is shown.

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Insta Science @instascience.bsky.social · 13/07/2025

The Queen of the Night (Epiphyllum oxypetalum) blooms once a year at night.

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eLife @elife.bsky.social · 12/07/2025

While academic publishing may not be broken, it isn’t built to serve science either. It runs on a chain of perverse incentives, but everything we need to rebuild it is already in our hands. #OpenScience #AcademicSky buff.ly/oSesI1s

Screenshot of article summary of: Toward Science-Led Publishing by Damian Pattinson, George Currie published as an opinion piece, in Learned Publishing Summary The current dynamic of scholarly publishing prioritises the wants of the publishing industry over the needs of the research community. This article explores this theme through the lens of ‘publisher-led science’ as a description of our current status quo, and through ‘science-led publishing’ as an improved future state. We argue that financial motivations central to most publishing distort how research is presented, how it is assessed and even what research is undertaken, leading to a system that hinders, rather than facilitates, scientific progress. We propose three elements of a science-led publishing approach that would accelerate research communication, incentivise collaboration between authors, editors and reviewers, and create a more transparent and equitable research landscape. We believe that research funding and research assessment are two of the primary levers for wider change in research and research culture and consider the future purpose of scholarly publishing in a world where these proposals have been widely adopted.

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Martin Enserink @martinenserink.bsky.social · 12/07/2025

The White House has concerns about allegedly risky research on viruses, bacteria, and other pathogens. In response, the National Institutes of Health is cracking down on dozens of studies it was funding. By @jocelynkaiser.bsky.social and @cohenjon.bsky.social. www.science.org/content/arti...

science.org

Exclusive: NIH suspends dozens of pathogen studies over ‘gain-of-function’ concerns

Trump executive order leads to pauses on U.S.-funded research into TB, influenza, COVID-19, and other diseases, dismaying some scientists

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Blue Travel Channel 📸 @bluetravelchannel.bsky.social · 25/05/2025

Japanese snow fairy bird 🇯🇵 😃

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Jonathan Slater @jonathanslater.bsky.social · 26/04/2025

Remember to look up

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Katherine Stiles @katherinestiles.org · 11/03/2025

🎓Higher Education🎓 The UK’s universities are beleaguered and besieged. Redundancies continue to be announced. Cardiff, Dundee, Edinburgh, Kent, Queen’s Belfast, Sheffield; the list goes on and on. Perhaps 10,000 jobs will go in this academic year, and that’s just the beginning. #AcademicSky

ft.com

The UK’s academic recession is in full swing

This university crisis is a grim scrabble for numbers

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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 23/04/2025

A colder frontier in cryo-EM 🧪🔬 Chris Russo’s group, inc. Joshua Dickerson, adapted #cryoEM to work at liquid helium temperatures (13 kelvins), where every frame captured contains more information than the equivalent using liquid nitrogen (81 kelvins). Read more: tinyurl.com/mwwcunkc #LMBResearch

The electron cryo-microscope adapted for use at liquid nitrogen temperatures within its custom-made black box.

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MitoCarriers @mitocarriers.bsky.social · 18/04/2025

Proposed pH-dependent mechanism of the mitochondrial pyruvate carrier. In the outward-open state, positively charged K49 and H86 bind pyruvate, initiating conformational changes to the inward-open state. The high matrix pH deprotonates H86, allowing pyruvate to leave. www.science.org/doi/10.1126/...

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Nereide @drnereide.bsky.social · 17/04/2025

🧵 Here is Earth's rotation realized in an unusual way: using a camera scanning the landscape of Tivoli, Namibia, Bartosz Wojczyński focused on the sky. He created a timelapse spanning 24 h that has a focal point in the sky rather than on the ground. ➡️ apod.nasa.gov/apod/ap20070... 🔭 🧪 #galactic

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Coral City Camera @coralcitycamera.bsky.social · 18/04/2025

The Caribbean reef squid out on quite the show today. Wait for the dramatic 180 color change reverse off stage! 🦑🔄👻💨 #caribbeanreefsquid #reefsquid #squid #chromatophores #colorchange #poof #cephalopod #coral #coralcitycamera #miami #portmiami #biscaynebay #bfi #noaa #aoml #coralcity

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Astronomy 🔭 @astronomy.bsky.social · 18/04/2025

Albert Einstein died on this day, April 18, 1955. It is incredible to hear Albert Einstein explain his famous formula, E=mc².

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Angie Voyles Askham @avaskham.bsky.social · 17/04/2025

A leaked HHS proposal outlines an approximately 40% cut to the NIH budget and significant changes to its organization. That would spell destruction for U.S. science, Joshua Gordon told me. My latest for @thetransmitter.bsky.social: #neuroskyence 🧪

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MitoCarriers @mitocarriers.bsky.social · 27/03/2025

Our review on Current Understanding of Pathogenic Mechanisms and Disease Models of Citrin Deficiency is out! The disease is caused by the dysfunction or absence of the mitochondrial aspartate/glutamate carrier 2, also known as citrin doi.org/10.1002/jimd... #mitochondria

The transport activity of reconstituted citrin is not regulated by calcium.

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The EMBO Journal @embojournal.org · 03/03/2025

Thought that only purine nucleotides could inhibit mitochondrial thermogenesis in brown adipose tissue? Edmund Kunji and coworkers @mitocarriers.bsky.social @mrc-mbu.bsky.social show that pyrimidines bind and inhibit UCP1 in similar manner www.embopress.org/doi/full/10....

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MitoCarriers @mitocarriers.bsky.social · 28/02/2025

It is believed that proton conductance by the mitochondrial uncoupling protein (UCP1) is inhibited specifically by purine nucleotides, but we show that pyrimidine nucleotides also inhibit UCP1 with similar affinities in a pH-dependent manner. #mitochondria www.embopress.org/doi/full/10....

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MRC MBU @mrc-mbu.bsky.social · 21/01/2025

Hello! 👋 We've joined the Bluesky community to connect again with all those interested in #mitochondria. 😎🥼🔬👩‍🔬👨‍🔬🧪

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Chris Packham @chrisgpackham.bsky.social · 02/12/2024

A beaut of a #FoxOfTheDay today , thank you @davidhateley !

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Universe @wholethings.bsky.social · 02/12/2024

The Hourglass Nebula seen by Hubble

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MitoCarriers @mitocarriers.bsky.social · 01/12/2024

Using 33 pathogenic variants of citrin we identify crucial elements of the carrier domain required for transport and show that the N-terminal domain is not involved in calcium regulation of transport, but causes a mitochondrial import defect, when mutated. www.sciencedirect.com/science/arti...

sciencedirect.com

Distinct roles for the domains of the mitochondrial aspartate/glutamate carrier citrin in organellar localization and substrate transport

Citrin, the mitochondrial aspartate/glutamate carrier isoform 2 (AGC2), is structurally and mechanistically the most complex SLC25 family member, beca…

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Universe @wholethings.bsky.social · 01/12/2024

Pluto's moon, Charon, at highest resolution so far captured by NASA

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