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Excited to share our story on how SERPINs orchestrate local immunosuppressive niches in PDAC. Now out @nature.com
Spearheaded by @chiarafalcomata.bsky.social 🚀
@bhavyasighs.bsky.social @brownlab1.bsky.social @miriammerad.bsky.social @sinaiimmuno.bsky.social
www.nature.com/articles/s41...
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nature.com
A serpin–myeloid axis in pancreatic cancer heterogeneity and immune evasion - Nature
SERPINE1 and SERPINB2-driven fibrin-rich niches locally programme immunosuppressive macrophages and exclude T cells, enabling spatially organized immune evasion in pancreatic ductal carcinoma.
