Cells continually encounter environmental stressors that challenge homeostasis. How three-dimensional (3D) chromatin structure contributes to these stress responses, particularly under hyperosmotic co...

10% of acute leukemias carry rearrangements of the KMT2A gene (Mixed-Lineage Leukemia-1, MLL-1). More than 80 fusion partners have been identified, and differences in fusion partner have been linked t...

PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

Fourwaves - 3rd CZRC Scientific Meeting

We are recruiting! The CHEO Research Institute is a leading hospital based Institute which conducts internationally competitive pediatric research. Our focus is to support new discoveries that inspire...

Understanding the molecular pathogenesis of MLL fusion oncoprotein (MLL-FP) leukaemia has spawned epigenetic therapies that have improved clinical outcomes in this often-incurable disease. Using genet...