iiinova — where your digital self keeps evolving

Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 10m

numinous, and so I mean that very literally: everything that makes me who I am is contained in the physical material of my body and, in this conversation, that means the molecular machinery

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 10m

as I once told a terf when I still bothered arguing with them (like a decade ago), I *am* my meat, muscle, and bone I am in most ways a materialist, in the philosophical rather than the pejorative sense of the word, although there remains a part of me that will always be spiritual and of the…

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 21m

at this point in my life I really want to know how the bartender kept 100% concentration hydrogen peroxide in his bar without blowing the place apart

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Steve Vladeck @stevevladeck.bsky.social · 12/10/2026

“The fact that we as a society have moved away from public executions would have mattered a lot for that earlier doctrinal understanding. That it wouldn’t mean nearly so much today is, in my view, a pretty telling indictment of #SCOTUS’s entirely recent jurisprudential shift.” Me on Nidal Hasan:

stevevladeck.com

257. Public Executions and the Eighth Amendment

The shift in the Court's Eighth Amendment jurisprudence would be a significant obstacle to litigation challenging the public execution of Nidal Hasan.

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David (he/him) @dkbell0.bsky.social · 11/10/2026

I finished reading the Astarion book by @tkingfisher.com this weekend and anyone who says she made Cazador a grumpy grandpa instead of a completely fucked up villain did not read the same book I did.

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Anil Dash @anildash.com · 5h

You know, the thing is, I had drafted this piece a month ago, and then never published it, because I thought maybe it was too mean.

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Jake Grumbach @jakemgrumbach.bsky.social · 17h

New working paper w/ @hannafolsz.bsky.social In 2025, Trump targeted US law firms for their political opposition Some firms resisted by suing Trump. Others folded by agreeing to support the administration w/ pro bono work Resisting firms took a short term financial hit but improved reputations

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 25m

replace the phosphate ions in our cells with something electrochemically equivalent but heavier and your mitochondria, the powerhouse of the cell, can't produce energy anymore it's the same underlying reason lithium batteries work so much better than sodium; it's literally a smaller ion

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 25m

right? like, literally *everything* about material properties and behavior is primarily a function of the molecular chemistry it's why swapping in a heavier ion with the same charge makes our biochemistry go sideways our biochemistry is contingent not just on charge but on atomic weight

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James Felton @jimmfelton.bsky.social · 1h

Man in a gilet stood on platform 12 gives up on reading the display and asks ChatGPT out loud if he is on the right platform for his train. I don’t want to be dramatic about it but Eratosthenes figured out the circumference of the Earth using a stick and knowledge of a distant well.

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 12h

I was being facetious, mostly, because I did work in tobacco policy for most of a decade and I know how deadly secondhand smoke is it's just that it's a particularly miserable death and I can't imagine it happening to nicer people

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c.e. chant/hades 💀🐊 💬 too many comics @portaltohades.bsky.social · 20h

Happy indigenous peoples day

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Ada Hoffmann @ada-hoffmann.bsky.social · 19h

Finally saw the PM announcement so I can announce this to people!!

Publishers Market Place Deal Report: The Priest of Crawling Things by Ad Hoffmann. Imprint: Wolsak & Wynn, Recorded Books. Author of Ignore All Previous Instructions Ad Hoffmann's The Priest of Crawling Things, a coming-of-age story set in a world where humans and dragons live side by side, in which a young nonbinary adult, transported to the spirit world, must prevent a war by bargaining with a trickster spirit, to Wolsak & Wynn, for publication in May 2027, by Hannah Bowman at Liza Dawson Associats (NA). Audio rights to Recorded Books. International rights: Canada Fiction. September 15, 2026

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 12h

I'm still mostly Anglo and insular Celtic, but apparently my continental ancestors really got around before they crossed the Atlantic

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 12h

I just got an update from Ancestry DNA and apparently according to their most recent data my European ancestry is summed up like this:

A political map of Europe and nearby areas with the British Isles and Ireland, France, Belgium, Switzerland, and parts of Italy and Germany circled

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 12h

… look, as long as they're not inflicting it on other people I'm okay with this

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Molly Jong-Fast @mollyjongfast.bsky.social · 13h

Just insane

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lauren @lauren.rotatingsandwiches.com · 14h

and I stand with the hectoring, pedantic weirdos. they are the thin blue line that's keeping this place unprofitable and therefore okay to look at during work hours

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lauren @lauren.rotatingsandwiches.com · 14h

twitter is a nicer and friendlier place than bluesky: false bluesky has some of the most aggressively hectoring, pedantic weirdos on the entire internet: true

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night of the living beck @anacrusisnt.bsky.social · 13h

I emailed this to another device so I could record myself playing it

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Matthew Downhour @matthewdownhour.bsky.social · 13h

Remember when we found out that our special forces had shot some DPRK fishermen for being in the wrong place at the wrong time and then stabbed them so they’d sink

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Shiv Ramdas Mens Rice Activist @nameshiv.bsky.social · 22h

nothing creepier than a guy older than trees who spends all day talking about nature and order and love and then moment the sun sets is standing there leering at you going "wanna fuck"

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Shiv Ramdas Mens Rice Activist @nameshiv.bsky.social · 22h

how did you forget the 300 year old gym bro sex pest

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juno Rylee Stump-Schultz @junoryleejournalism.com · 18h

Courage the Cowardly Dog would scream until his eyes popped out of his head and then return to the scene with a loaded gun

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Hari Kunzru @harikunzru.bsky.social · 11/10/2026

A wealth of resources here for anyone trying to understand what’s happening in India.

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The Alternate Histoween 🎃 @althistorian.bsky.social · 17h

And I should probably include the link so you can get a better look at the map! www.deviantart.com/rvbomally/ar...

deviantart.com

Monster Mash by RvBOMally on DeviantArt

Monster Mash — artwork by RvBOMally on DeviantArt. Published: 2013-10-31 · Likes: 159 · Views: 31901 · Comments: 44

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 13h

If it wasn't for a long and unfortunate history of very terrible Italians getting famous I would just have posted a picture of the country of Italy and said "pick one"

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Chise @sailorrooscout.bsky.social · 20h

The study has been published in Nature Cancer. YES, it is PEER-REVIEWED. • www.nature.com/articles/s43... 🧪🧵⬇️

Key Takeaways
• An adjuvant personalized DNA vaccine caused no serious adverse events and extended overall survival in nine patients in a phase I study compared with historical outcomes.
• Median overall survival was 16.3 months and the survival rate at 24 months was 33%, including one long-term survivor who was still alive 4 years from the time of initial surgery.
•Only about 10% to 15% of patients with this type of brain cancer survive up to 2 years.

Abstract
Glioblastoma is a fatal disease with a median prognosis of 12-18 months. Recent studies have shown encouraging results using neoantigen-based vaccines to stimulate glioblastoma-directed immune responses, but overall immunogenicity has been low.
Here, we report the results of an open-label, single-arm, phase 1 clinical trial (GT-20) to evaluate the satety and feasibility (primary endpoints) as well as immunogenicity and preliminary clinical activity (secondary endpoints) of GNOS-PV01 monotherapy, a DNA-based personalized therapeutic cancer vaccine administered following surgical resection and radiation for patients with MGMT unmethylated glioblastoma.
The GT-20 study vaccinated nine patients, using up to 40 neoantigens per patient (range, 17-40) without causing any serious adverse events, unexpected toxicities or dose-limiting toxicities.
The vaccine induced activation and expansion of circulating peripheral T cells in all evaluated patients, except one who was being treated with dexamethasone.
The secondary endpoint was to evaluate 6 month progression-free survival and 12 month overall survival; each observed in 66.7% of patients. Median progression-free survival was 8.5 months, median overall survival was 16.3 months and survival at 24 months was 33%, including one long-term survivor still alive 4 years from the time of initial surgery.
This study met the pre-specified endpoints and supports the use of GNOS-PV01 as a potentially impactful component of glioblastoma immunotherapy.
ClinicalTrials.gov: NCT04015700.

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Chise @sailorrooscout.bsky.social · 20h

The vaccine caused NO serious side effects AND prolonged patients’ overall survival compared to historical outcomes after standard-of-care surgery and chemo-radiotherapy. One long-term survivor remains recurrence-FREE nearly FIVE YEARS LATER. • www.insideprecisionmedicine.com/topics/oncol...

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Chise @sailorrooscout.bsky.social · 20h

GOOD NEWS! Phase I clinical trial results show a first-of-its-kind personalized vaccine designed to treat glioblastoma, a deadly and aggressive form of brain cancer, is safe AND elicits robust and broad immune responses that appears to INCREASE recurrence-free survival in patients after surgery.

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 19h

factory shift and was covered in dust, every day from when she was very small until she left home to go to university. This was *decades* after he retired and passed away.

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 19h

was a woman in the UK whose father had worked at an asbestos factory back in the 1960s and he died of cancer from it back in the 1980s, I think it was. Then she was diagnosed with the same cancer just a few years ago… and the exposure was him giving her a big hug every day when he got home from his…

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 19h

I mean, yes, clearly; it's going to be a problem for many trades and for residents of many cities for the foreseeable future. I'm just glad that we have a young generation for whom the main thing is "it's something you have to avoid" rather than things like a story I heard a few months ago. There …

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Gail Simone @gailsimone.bsky.social · 12/10/2026

I know. I also hate, “be sure to tip the waitresses” and “I’ll show myself out” and “_____ 2, Electric Bugaloo.” These aren’t jokes any more, they are the desiccated remains of the unwrapped corpses of the smelly fossils of jokes.

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 19h

people who were 100% committed to believing that she's a secret lesbian. I'm sure they still believe Travis Kelce is a beard to help hide her heartbreak over her breakup with Kloss.

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 19h

Day in Arrested Development murderboard on the lyrics and concert performances and public appearances and even paparazzi photos? That requires some truly next-level willful divorce from reality. I saw some people who were engaging with it while clearly not believing it, but there were absolutely…

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 19h

to give it any credence. But believing that Taylor fucking Swift, of all people, would feel compelled to hide her sexuality as of whenever this conspiracy theory started, while secretly wanting her fans to know and so putting coded messages in there only her fans can untangle by going full Charlie…

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 19h

Like, I can see how you can get to "he secretly hates the book but is unable to say so for contractual reasons", although the fact that he did the audiobook — which would have been an entirely separate contract and not one mandated by the contract for the game — makes it considerably more difficult…

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 19h

Well, the conspiracy theory part of it is about real people (the author and the voice actor), and the "he's secretly sending messages to fans with very subtle body language" is almost as unhinged as "Taylor Swift and Karlie Kloss are secretly lovers but are sending coded messages to fans".

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 20h

knowing it was both omnipresent and horribly dangerous if you've heard of mesothelioma? yeah, that's a cancer directly attributable to asbestos exposure, specifically inhaling the dust that these podcasters only know that it's bad and dangerous is a victory for public policy

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 20h

insulation and fireproofing of buildings all around the world in the course of the 20th century we learned that it's also horrendously toxic and carcinogenic, but it was still used in construction of new buildings into the 1970s and 1980s, so us GenXers and I imagine most Millennials grew up…

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 20h

for those of you who don't know: it's a silicate mineral fiber that has a long history (like, thousands of years) of being sometimes used to make things more resistant to fire, going all the way back to Stone Age pottery around the end of the 19th century it became industrially mined and used for…

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 20h

now, you might be thinking, "why is it a good thing they don't know what asbestos is?" because it means we have done such a good job at eliminating it from daily life that a couple of early Zoomers/late Millennials (I don't know for sure) are only aware that it's hazardous but don't know much more

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 20h

this morning I was happy to hear two podcasters be so unfamiliar with asbestos that they didn't even know what it was the podcast had nothing to do with asbestos, it was just mentioned in an aside, but one person heard the word and said, "what's that?" and the other said, "like mold, I think"

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 20h

what's the over/under this phrase originated on Tumblr as a fully sincere criticism of an apparently random fanfic, and if you dig back far enough you discover that it originated as a feud in the Stucky fandom and Strange Aeons did a video on it during lockdown

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Serenity "Scary Underseasoned Food" Dee 🍜 @sapphixy.bsky.social · 20h

this is approaching Gaylor levels of conspiracy bizarreness

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