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Yakir Reshef

@yakirreshef.bsky.social

Rheumatologist and computer scientist. PI at Brigham and Womens Hospital and @broadinstitute, alum of Harvard MD/PhD program. yakirr.github.io

Posts Replies Media

Reposted by Yakir Reshef

Saori Sakaue @saorisakaue.bsky.social · 27/02/2025

📣Excited to share my last postdoc paper with @soumya-boston.bsky.social on eQTL mechanisms depending on where the RNA is in the cell! @broadinstitute.org @harvardmed.bsky.social TL;DR:Early RNA eQTL variants in the nucleus and late RNA eQTL variants in the cytosol have distinct molecular mechanism🧵

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Yakir Reshef @yakirreshef.bsky.social · 12/02/2025

Excited to tell you about VIMA (Variational Inference-based Microniche Analysis), our deep learning + stats hybrid for case-control analysis of multi-sample spatial molecular datasets. 🧵👇 www.biorxiv.org/content/10.1... @soumya-boston.bsky.social @broadinstitute.org

biorxiv.org

Powerful and accurate case-control analysis of spatial molecular data with deep learning-defined tissue microniches

As spatial molecular data grow in scope and resolution, there is a pressing need to identify key spatial structures associated with disease. Current approaches often rely on hand-crafted features such...

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