Temporal patterning is essential for generation of neuronal diversity in the developing vertebrate nervous system. A shared sequence of temporal transcription factors (tTFs) partitions neurons by birt...

Tissue morphogenesis integrates developmental programs with cell mechanics, yet the mechanisms coupling these processes remain poorly understood. We investigated this link during neuroepithelial morph...

Apply for a PhD: Biosciences Graduate Training Assistant PhD Studentships at University College London

We are very pleased to announce that this year’s Waddington medal winner is James Briscoe. His fundamental discoveries have helped shape our understanding of of how morphogens work, and he has played ...

We are very pleased to announce that this year’s Waddington medal winner is James Briscoe. His fundamental discoveries have helped shape our understanding of of how morphogens work, and he has played ...

Molecular and functional diversification of spinal cord output neurons by a conserved sequence of transcription factors.

The European Molecular Biology Laboratory (EMBL) is one of the world’s leading life science research organisations. With sites across Europe, EMBL fosters an international, collaborative, and inclusiv...

A fundamental role for division orientation in progenitor output driving cortical and retinal growth is revealed.

The dorsal horn of the mammalian spinal cord is organized into laminae where each layer is populated by different neuron types, has distinctive circuit connections, and plays specialized roles in beha...

Benzinger et al. develop a chemo-optogenetic system for precise spatiotemporal control of morphogen production in vitro. Using light-controlled Sonic hedgehog expression, they recapitulate neural tube...

We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...

Building a mechanistic understanding of cell fate decisions remains a fundamental goal of developmental biology, with implications for stem cell therapies, regenerative medicine and understanding dise...