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Rory Maizels

@rorymaizels.bsky.social
333 followers 1.8K following 7 posts

Engineering cells to understand their decisions ESPOD Fellow @ebi.embl.org & @sangerinstitute.bsky.social (Saez-Rodriguez & Bayraktar / Parts) lingering scientist @crick.ac.uk (Briscoe)

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Reposted by Rory Maizels
EMBL-EBI @ebi.embl.org · 14/09/2026
🚨Two weeks left to apply! There’s still time to apply for the EMBL-EBI-Sanger Postdoctoral (ESPOD) programme. Choose from one of our available projects or propose your own. Deadline: 27 September. www.ebi.ac.uk/research/pos...
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Reposted by Rory Maizels
British Society for Developmental Biology @bsdb.bsky.social · 25/03/2026
🎉 We are thrilled to announce the very first winner of the BSDB Marie Johansson Prize! This year’s award goes to Giulia Boezio @giulia-boezio.bsky.social, recognised for outstanding contributions to developmental biology and for embodying Marie’s scientific originality and rigour.
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Reposted by Rory Maizels
British Society for Developmental Biology @bsdb.bsky.social · 24/03/2026
Huge congratulations to James Briscoe @jamesbriscoe.bsky.social for receiving the 2026 BSDB Waddington Medal, recognising an extraordinary career of discovery, mentorship, and leadership in developmental biology. bsdb.org/2026/03/24/2...
bsdb.org
2026 Waddington Medal Winner - James Briscoe - BSDB - British Society for Developmental Biology
We are very pleased to announce that this year’s Waddington medal winner is James Briscoe. His fundamental discoveries have helped shape our understanding of of how morphogens work, and he has played ...
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Reposted by Rory Maizels
Rory Maizels @rorymaizels.bsky.social · 10/03/2026
How can we hope to understand organismal development when it is controlled by huge, complex networks of interacting genes? 
One option is to move away from molecular details and focus on learning representations and rules. Check out the new perspective from me and @jamesbriscoe.bsky.social
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Rory Maizels @rorymaizels.bsky.social · 10/03/2026
How can we hope to understand organismal development when it is controlled by huge, complex networks of interacting genes? 
One option is to move away from molecular details and focus on learning representations and rules. Check out the new perspective from me and @jamesbriscoe.bsky.social
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Rory Maizels @rorymaizels.bsky.social · 05/11/2025
Genomes? Pah, who needs them... let's delete them!
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Rory Maizels @rorymaizels.bsky.social · 24/10/2025
actually courtesy of @arjunraj.bsky.social!
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Rory Maizels @rorymaizels.bsky.social · 21/09/2025
Heroic winner of the IgNobel prize for biology: paint zebra stripes on cows to stop them getting bitten journals.plos.org/plosone/arti...
a cow painted with stripes to look like a zebra
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Reposted by Rory Maizels
Cor Wijtman @corwijtman.bsky.social · 19/09/2025
. sjablonen 11 .
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Rory Maizels @rorymaizels.bsky.social · 17/09/2025
The failures of language in biology -- and the most apt description of biology I know: it is difficult to find a black cat in a dark room, especially if there is no cat. www.sciencedirect.com/science/arti...
sciencedirect.com
Can a biologist fix a radio?—Or, what I learned while studying apoptosis
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Rory Maizels @rorymaizels.bsky.social · 10/09/2025
'It’s not the destination, it’s the journey.' As true for stem cells as for humans!
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Rory Maizels @rorymaizels.bsky.social · 03/09/2025
I said some things about my PhD, and now they've appeared here. How fun!
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Reposted by Rory Maizels
Greg Jefferis @jefferis.bsky.social · 21/08/2025
Neuronal diversity is written in transcriptional codes 🧬. But what is the logic of these codes that define cell types and wiring patterns? To find out we built a #scRNAseq developmental atlas of the Drosophila nerve cord and linked it to the #connectome 🪰🧠 #preprint thread ⬇️1/8
ALT text: A UMAP representation of a single cell RNAseq dataset from the Drosophila ventral nerve cord as well as images of the Drosophila nerve cord connectome and different stages of fly development.
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Reposted by Rory Maizels
Yogesh Goyal @goyallab.bsky.social · 07/07/2025
Excited to share our paper on deciphering the design & control principles of tissue scaling w/ Luisa Arispe! Amazing work by co-first authors Danielle Pi and Jonas Braun. We show *differentiated* endothelial cell proliferate in waves with ultrafast cell cycle time of ~5h www.cell.com/cell-systems...
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James Briscoe @jamesbriscoe.bsky.social · 17/07/2025
Just published: The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube A global temporal chromatin program, operating across the CNS, directs binding of specific spatial TFs & hence when/where neurons & glia are born authors.elsevier.com/sd/article/S...
authors.elsevier.com
ScienceDirect.com | Science, health and medical journals, full text articles and books.
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Reposted by Rory Maizels
Axel Visel @axelvisel.bsky.social · 16/07/2025
No new genes needed to fly - just rewire what you have! 🦇🧬 Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social doi.org/10.1038/s415... #EvoDevo #SingleCell #BatWings
doi.org
Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development - Nature Ecology & Evolution
Single-cell comparison of developing bat and mouse limbs reveals conservation of cell populations and gene expression patterns, and suggests repurposing of genes involved in proximal limb development ...
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PLOS Biology @plosbiology.org · 16/07/2025
Measuring properties of individual cells in relation to their neighbors in 3D tissues is challenging. @cellysally.bsky.social &co develop a computational toolkit to facilitate this, analyzing developmental patterning in mouse, chick & #Drosophila #embryo @plosbiology.org 🧪 plos.io/4lQMeNu
Patterning of cell identities in the posterior E8.5 mouse embryo. Co-expression of mesoderm marker TBXT (blue) and neural marker SOX2 (green) identifies cells in the neuromesodermal (NMP) progenitor region at the intersection of their respective gene expression gradients. TBX6 (red) marks paraxial mesoderm and also marks sporadic mesoderm-committed cells emerging within the NMP region. LAMINB1 (white) marks the nuclear envelope of all cells. Credit: Matthew French.
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Anshul Kundaje @anshulkundaje.bsky.social · 20/04/2025
genomebiology.biomedcentral.com/articles/10.... Quite an indictment of some of the current single cell "virtual cell" foundation models. Even for the relatively mundane applications, cell labeling, batch correction etc, they are poor compared to much simpler & cheaper methods.
genomebiology.biomedcentral.com
Zero-shot evaluation reveals limitations of single-cell foundation models - Genome Biology
Foundation models such as scGPT and Geneformer have not been rigorously evaluated in a setting where they are used without any further training (i.e., zero-shot). Understanding the performance of mode...
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James Briscoe @jamesbriscoe.bsky.social · 29/05/2025
Our latest "Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data" A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making Applied to ventral neural tube development www.biorxiv.org/content/10.1...
biorxiv.org
Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data
Building a mechanistic understanding of cell fate decisions remains a fundamental goal of developmental biology, with implications for stem cell therapies, regenerative medicine and understanding dise...
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James Briscoe @jamesbriscoe.bsky.social · 12/06/2025
Congratulations to Tiago Rito @ritolab.bsky.social starting his own research group at Hong Kong U
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