NAD depletion in skeletal muscle does not impair tissue integrity and function or accelerate aging, as shown in a mouse model with an 85% decrease in muscle NAD+ levels. Muscle structure, metabolism, and mitochondrial function remain unaffected, suggesting that NAD depletion does not drive age-related muscle decline.

Background Oestrogen receptor alpha (ERα) plays an important role in maintaining mitochondrial function and regulating metabolism in skeletal muscle. However, its alterations and potential mechanism...

DNA end resection is crucial for most DNA double-strand break repair pathways. This Review discusses the molecular mechanisms of end resection and its regulation, focusing on the roles of post-transla...

A scientific technique that rapidly increases the body’s production of anti-inflammatory cells promoted healing from heart attacks in mice, according to a new study by investigators from the Smidt Hea...

Background Exercising with low muscle glycogen content can improve training adaptation, but the mechanisms underlying the muscular adaptation are still largely unknown. In this study, we measured subs...

Duchenne muscular dystrophy (DMD) is a progressive disease associated with functional decline. Chronic administration of cardiosphere-derived cell therapy prevents disease-related functional decline f...

Nature Reviews Molecular Cell Biology, Published online: 17 March 2025; doi:10.1038/s41580-025-00828-1Changes in nuclear and genome organization promote the repair of DNA double-strand breaks and genome stability. Processes that are involved include the…

Nature Reviews Bioengineering, Published online: 17 March 2025; doi:10.1038/s44222-025-00286-6A thorough understanding of the life cycle of extracellular vesicles is essential to unleash their full potential in biomarker identification and therapeutics…

This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...

The nuclear periphery is linked with transcriptional repression, but MyoD1 remains active during myoblast proliferation despite being in this compartment. Here, the authors show that WFS1 tethers MyoD...

Genome-wide survey of human and mouse DMD tissues suggests EZH2’s role in satellite cells; its inhibition improves prognosis.

During high-intensity exercise a lactic-acidosis occurs with raised myoplasmic and plasma concentrations of lactate− and protons ([lactate−], [H+] or pH). We critically evaluate whether this causes/co...

Muscle stem cells (satellite cells) promote adult skeletal muscle adaptation. The presence of satellite cells affects the skeletal muscle methylome response to lifelong wheel running - specifically i...

CBER, OTP is hosting a virtual scientific public workshop on February 25, 2025, titled “Cell Therapies and Tissue-based Products: A Public Workshop on Generating Scientific Evidence to Facilitate Deve...

A dual recombinase-mediated genetic system for cell-type-specific lineage tracing, ablation, and gene manipulation of senescent cells reveals distinct roles of senescence across cell types.

The detailed structure of the native dystrophin–glycoprotein complex provides mechanistic insights into mutations underlying muscular dystrophy.

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Modeling the neuromusculoskeletal (NMS) axis with organoids is challenging. Xiang and colleagues developed hPSCs-derived NNMS organoids (hNMSOs) with co-development, self-organization, and functional connection of neural, muscular, and skeletal tissues. hNMSOs revealed skeletal impacts on muscular development and neuromuscular function. These findings provide a model for studying human NMS crosstalk and disease.

Huang et al. conducted a comprehensive review of the literature on metabolomic aging clocks. They particularly emphasized how metabolomic aging clocks, as a novel tool for quantifying aging, are developed, applied, and interpreted.

BACKGROUND: Myofibroblasts are primary cells involved in chronic response-induced cardiac fibrosis. Fibroblast activation protein (FAP) is a relatively specific marker of activated myofibroblasts and ...

A population of macrophages with exclusive molecular and functional signatures in the muscle spindles express machinery for synthesizing and releasing glutamate, and a cellular component, the muscle s...

Coren et al. show that in skeletal muscles, fibroblasts diversify into distinct subpopulations during embryonic development. These subpopulations reside in distinct niches, entail different dynamics and transcriptomes, and exert opposing effects on myogenic differentiation. This diversification process is dependent on muscle contraction in the embryo.

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Gherardi et al. identify that aging and disability impair mitochondrial calcium uptake in skeletal muscle via MCUR1. Food-derived polyphenols increase the import of calcium in mitochondria by binding MICU1. The natural MCU activator oleuropein stimulates energy metabolism, ameliorates muscle performance, and reverses age-related muscle decline by increasing mitochondrial calcium.

To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...

Pathogenic signaling leads to reduced mobility of proteins with diverse functions. This proteolethargy, which is due to increased oxidation of cysteine residues, may account for diverse cellular pheno...