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Ruixuan Gao

@ruixuan3.bsky.social
156 followers 113 following 32 posts

Assistant Professor of Chemistry and Biological Sciences @UIC Studying Neurobiology, Chemistry, Microscopy, and Nanoelectronics Lab website: www.gaogroup.site

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Reposted by Ruixuan Gao
David Solecki @so-lets-kilab70.bsky.social · 24/09/2026
Georgios Skiniotis and I are announce a unique St. Jude faculty search: a joint effort between the CoE for Structural Cell Biology an intellectual community advancing structural imaging & the Division of Neuronal Cell Biology. CryoET/vEM + neuron cell biology = 🚀 talent.stjude.org/careers/JobD...
talent.stjude.org
Faculty position, Neuronal Cell Biology and Cryo-ET/vEM
Department of Developmental NeurobiologyCenter of Excellence for Structural Cell Biology and Neuronal Cell Biology DivisionSt. Jude Children’s Research HospitalThe Center of Excellence for...
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Reposted by Ruixuan Gao
Chad Hobson @cmhobson.bsky.social · 27/08/2026
A couple years in the making, but the preprint is finally out! We developed a pipeline for timelapse, volumetric FLIM (vFLIM) that incorporates multi-channel light sheet excitation, a SPAD array detector for widefield FLIM, and machine learning lifetime processing. www.biorxiv.org/content/10.6...
biorxiv.org
vFLIM: Machine Learning-enabled Light Sheet Fluorescence Lifetime Imaging
The lifetime of fluorescent molecules provides an orthogonal readout to fluorescence intensity, opening experimental possibilities of measuring changes in local molecular environments, mechanical tens...
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Reposted by Ruixuan Gao
Kevin Dean @kevin-dean.bsky.social · 08/06/2026
We’re hiring an optical systems engineer / scientist to help build and disseminate Altair, our open, modular light-sheet microscopy platform. Ideal for someone with serious hands-on experience in optical design, Zemax, CAD, alignment, and microscopy. Apply here: www.linkedin.com/jobs/view/44...
linkedin.com
UT Southwestern Medical Center hiring Optical Systems Engineer / Research Scientist in Dallas, TX | LinkedIn
Posted 11:44:16 AM. The Dean Lab in the Lyda Hill Department of Bioinformatics at UT Southwestern Medical Center is…See this and similar jobs on LinkedIn.
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Reposted by Ruixuan Gao
Nature Methods @natmethods.nature.com · 22/05/2026
MOSAIC: a versatile multimodal microscopy that seamlessly transitions between light-sheet, 2-photon, label-free and super-resolution modalities. @supgokul.bsky.social www.nature.com/articles/s41...
nature.com
A multimodal adaptive optical microscope for in vivo imaging from molecules to organisms - Nature Methods
MOSAIC is a versatile multimodal microscope that allows seamless transition between various light-sheet, two-photon, label-free and super-resolution modalities. It is demonstrated in various systems r...
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Reposted by Ruixuan Gao
Rita Strack @ritastrack.bsky.social · 23/05/2026
The MOSAIC paper is out in Nature Methods. For the record I went after this paper for *years* and was so happy when they sent it to me/us. www.nature.com/articles/s41...
nature.com
A multimodal adaptive optical microscope for in vivo imaging from molecules to organisms - Nature Methods
MOSAIC is a versatile multimodal microscope that allows seamless transition between various light-sheet, two-photon, label-free and super-resolution modalities. It is demonstrated in various systems r...
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Reposted by Ruixuan Gao
Itay Budin @ibudin.bsky.social · 01/05/2026
What membrane properties do cells maintain through regulation of lipid metabolism? In a new paper, we identify intrinsic curvature stress as one such parameter and show how different (eukaryotic) cell types employ different lipids to do that www.cell.com/cell-reports...
cell.com
Active regulation of intrinsic curvature by eukaryotic phospholipid metabolism
Cells maintain membrane function by actively balancing the molecular shape of their lipids. Milshteyn et al. find that, when subjected to high hydrostatic pressure, yeast and human cells, but not bact...
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Reposted by Ruixuan Gao
Leon Zhao @huailang.bsky.social · 20/04/2026
📷 Expansion microscopy turns 11 — and our comprehensive Primer is now live in @natrevmethodsprimers.nature.com ! A decade of ExM, 1000+ papers, and still accelerating. Co-authored with the father of the field, @eboyden3.bsky.social , + Ha Vo & Rong Xu. 📷 Free to read: rdcu.be/fdQPH
rdcu.be
Expansion microscopy
Nature Reviews Methods Primers - Expansion microscopy enhances conventional imaging by physically enlarging samples within a hydrogel matrix, surpassing diffraction limits. In this Primer, Vo et...
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Reposted by Ruixuan Gao
Jeremy Baskin @jeremybaskin.bsky.social · 18/03/2026
I've been leading a big project at Methods in Enzymology over the past year or so: editing three back-to-back-to-back volumes of articles describing the latest advances in methods for studying lipids and membranes — thank you to the 50 #lipidtime luminaries who contributed the 51 chapters! Details 👇
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Ruixuan Gao @ruixuan3.bsky.social · 02/02/2026
Have you wondered how alcohol affects your emotions and behavior in the long run? How does (excessive) alcohol exposure trigger changes in the brain at the molecular, cellular, and circuitry levels?
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Reposted by Ruixuan Gao
Reto Fiolka @retof.bsky.social · 27/01/2026
We have two funded postdoctoral positions available. Topics encompass: -Next gen light-sheet fluorescence microscopy instrumentation -Structured illumination microscopy and other approaches to extend the resolution limit. -Nonlinear microscopy combined with adaptive optics / phase conjugation
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Reposted by Ruixuan Gao
FocalPlane @focalplane.bsky.social · 02/12/2025
🔬🔦Check out our ‘Imaging spotlight’ on Volumetric Imaging via Photochemical Sectioning (VIPS) from @ruixuan3.bsky.social, Srigokul Upadhyayula and colleagues. VIPS helps researchers scale super resolution imaging to large whole-mount tissues. focalplane.biologists.com/2025/12/02/i...
focalplane.biologists.com
Imaging spotlight: Volumetric Imaging via Photochemical Sectioning (VIPS) - FocalPlane
Imaging spotlight: Volumetric Imaging via Photochemical Sectioning (VIPS) - Tools
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Gokul Upadhyayula @supgokul.bsky.social · 17/10/2025
Thrilled to share our Science cover! VIPS (volumetric imaging via photochemical sectioning) eliminates working-distance limits for whole-mount, nanoscale imaging. LLSM + photodegradable hydrogel + petabyte-scale compute → mapped axons & myelin across two mouse olfactory bulbs (WT vs NPC1).
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Science Magazine @science.org · 16/10/2025
A new method called VIPS enables organ-wide nanoscale reconstruction for quantitative mapping of connectivity and molecular landscape in intact tissue. Learn more this week in Science: scim.ag/4n4GKPm
This three-dimensional rendering of a mouse olfactory bulb exposes axons and myelin sheaths, the neuronal wiring that transmits odor information.
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Ruixuan Gao @ruixuan3.bsky.social · 17/10/2025
(1/x) Excited to report VIPS (Volumetric imaging of biological specimens via photochemical sectioning) @science.org! VIPS uses light-based sample sectioning to eliminate the inherent imaging depth limit of high-resolution optical microscopes @supgokul.bsky.social: www.science.org/doi/10.1126/...
science.org
Mesoscale volumetric fluorescence imaging at nanoscale resolution by photochemical sectioning
Optical nanoscopy of intact biological specimens has been transformed by recent advancements in hydrogel-based tissue clearing and expansion, enabling the imaging of cellular and subcellular structure...
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