We are a family of four living in a 1930's semi-detached house in Cambridge, UK. Here are the steps we've taken to reduce our ecological footprint.

Reactive oxygen species (ROS) promote genomic instability and fuel oncogenic signaling in cancer, but antioxidant therapies have so far failed to improve, or worsen, cancer outcomes. Emerging data sug...

T cell-based immunotherapies have remained ineffective against high-grade serous ovarian carcinoma (HGSOC). The metabolic environment of HGSOC suppresses the activity of cellular therapies, however, t...

It is too hard for medical researchers to launch clinical trials.

An antioxidant released by tumors dampens T cell immunity

We are a family of four living in a 1930's semi-detached house in Cambridge, UK. Here are the steps we've taken to reduce our ecological footprint.

One of three back-to-back papers to show dosage of BACH2 can modulate T cell differentiation and function and how we might apply this to enhance chimeric antigen receptor T cell therapies for cancer.

The generation of effector CD8+ T cells (TEFF) requires activation of naïve CCR7+ T cells (TN) by dendritic cells (DCs) in lymphoid tissue. How TN-DC interaction duration and signal integration are co...

The CRI Immuno-Informatics Postdoctoral Fellowship Program supports young scientists at institutions who wish to receive dual training in immunology.

In this randomized phase 3 trial, patients with treatment-naive stage III–IV nonsmall cell lung cancer who received sintilimab or pembrolizumab in combination with chemotherapy early in the day (befor...

Hijacking the energy-producing organelles from immune cells seems to help tumours in mice to infiltrate lymph nodes.

Non-Hodgkin lymphoma survivor JC Cox turned to MD Anderson when local treatment failed to keep the cancer at bay. Here, a single dose of a novel cell therapy administered through a clinical trial has put — and kept — him in remission.

A new study shows that aspirin enhances antimetastatic immunity by decreasing platelet activation, thereby releasing T cells from suppression by thromboxane A2.