Short sleepers cruise by on four to six hours a night and don’t seem to suffer ill effects. Turns out they’re genetically built to require less sleep than the rest of us

Researchers need to better address time-of-day as a critical biological variable

Gonzalez-Aponte et al. identify daily glucocorticoid receptor signaling as an intrinsic driver of glioblastoma (GBM) progression and a synchronizer of tumor clock gene expression to the host. This work provides an intrinsic circadian driver, and therapeutic target, to slow GBM growth, and offers considerations for glucocorticoid use in the clinic.