iiinova — where your digital self keeps evolving

Leo Nicolai

@immunothrombosis.bsky.social

502 followers 1.1K following 27 posts

Junior Research Group Leader @LMU Munich, interested in vascular biology with a focus on platelets and immunothrombosis

Posts Replies Media

Leo Nicolai @immunothrombosis.bsky.social · 19/05/2025

Online now: Yacine Boulaftali, Steffen Massberg and I summarized recent key insights into the role of platelets in vascular inflammation: journals.lww.com/co-hematolog...

Leo Nicolai @immunothrombosis.bsky.social · 24/04/2025

Immune cells contribute to thrombosis in mouse models - but what about human disease? We used scRNA Sequencing, flow cytometry and histology to better understand immune cells in human stroke thrombi www.sciencedirect.com/science/arti... now online @cp-immunity.bsky.social

sciencedirect.com

Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis and correlate with thrombus resolution

Thrombotic diseases remain the major cause of death and disability worldwide, and the contribution of inflammation is increasingly recognized. Thrombo…

Reposted by Leo Nicolai

Ivan Zanoni @lozanzi.bsky.social · 24/04/2025

#TheMoreTheMerrier! Pekayvaz @immunothrombosis.bsky.social Stark &co show @cp-immunity.bsky.social that non-classical monocytes help to resolve thrombi by recruiting neutrophils that become thrombolytic following hypoxia-induced programs! www.sciencedirect.com/science/arti...

sciencedirect.com

Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis and correlate with thrombus resolution

Thrombotic diseases remain the major cause of death and disability worldwide, and the contribution of inflammation is increasingly recognized. Thrombo…

Leo Nicolai @immunothrombosis.bsky.social · 03/04/2025

Very happy to contribute another @bloodjournal.bsky.social cover with our story on aging platelets: ashpublications.org/blood/articl... Thoughtful commentary by Laura Gutiérrez in the issue as well.

ashpublications.org

Aging platelets shift their hemostatic properties to inflammatory functions

Key PointsPlatelets change their phenotype as they age in circulation, skewing toward inflammatory function over time.Genetic models of increased platelet

Leo Nicolai @immunothrombosis.bsky.social · 23/01/2025

1/x Online now: Our work on platelet aging and inflammation in @bloodjournal.bsky.social led by superstar PhD student Afra Anjum: ashpublications.org/blood/articl...

Leo Nicolai @immunothrombosis.bsky.social · 21/11/2024

Arterial thrombosis - studying platelet recruitment at the single cell level in vivo

Leo Nicolai @immunothrombosis.bsky.social · 21/11/2024

It was an immense pleasure to host our 2nd #immunothrombosis Symposium @LMU Munich together with Konstantin Stark. Talks and discussions were outstanding, and new ideas & perspectives made the meeting really special!