Reposted by @fatihaygenli.bsky.social
☕ @robles-lab.bsky.social & co map chromatin-bound CLOCK/BMAL1 protein complexes across three mouse tissues and uncover PROX1, HNF1B and HOXA5 as homeodomain cofactors that directly bind and co-occupy BMAL1 sites to establish tissue-specific circadian transcription.
www.nature.com/articles/s41...
nature.com
CLOCK/BMAL1 interactome uncovers homeodomain factors as tissue regulators - Nature Cell Biology
Aygenli et al. map chromatin-bound CLOCK/BMAL1 protein complexes across three mouse tissues and uncover PROX1, HNF1B and HOXA5 as homeodomain cofactors that directly bind and co-occupy BMAL1 sites to ...