Reposted by HöbartnerLab UniWue
A new paper from the Hoebartner Lab @UniWue @chlab.bsky.social reports the crystal structures of the ribozyme SAMURI, revealing the mechanism of its methyltransferase activity and site-selectivity
www.nature.com/articles/s41...
nature.com
Structure and catalytic activity of the SAM-utilizing ribozyme SAMURI - Nature Chemical Biology
Crystal structures of the ribozyme SAMURI reveal the alkyltransferase mechanism and show N3-modified adenosine and dealkylated cofactor in the active site, allowing for a comparison with riboswitches ...