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raphmercier.bsky.social

@raphmercier.bsky.social
1.5K followers 288 following 69 posts

#Meiosis4ever. #ChromosomeBiology. Max Planck for Plant Breeding Research.

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Polina Novikova @pnovik.bsky.social · 16/09/2026
I am happy to present our work @liverworks.bsky.social @robinburns.bsky.social @alisondawnscott.bsky.social on centromeric repeat turnovers, of which we counted three in the Arabidopsis genus:
biorxiv.org
The Nature of Centromeric Repeat Turnovers in the genus Arabidopsis
Centromeres are critical for accurate segregation of chromosomes and are often composed of megabases of tandemly arranged satellite repeats. Yet, despite their conserved function, the DNA sequence of ...
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Reposted by @raphmercier.bsky.social
André Marques @amarques.bsky.social · 16/09/2026
Out today in Nature: sex without crossovers. Rhynchospora tenuis makes pollen, fertilises and sets seed, yet 0 crossovers in 10,997 pollen nuclei. Chromosome drive and ~87% seed abortion rebuild the mother's genotype, so the offspring are clones. doi.org/10.1038/s415...
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Max Planck Institute for Plant Breeding Research @mpipz.bsky.social · 17/09/2026
📣📣Paper Alert! New paper @nature.com from the Marques group @amarques.bsky.social and colleagues on Rhynchospora tenuis - 🌿a plant that reproduces sexually but has completely lost the reshuffling of DNA🧬 Congratulations! 👏 🥳 Read more👉 www.mpipz.mpg.de/pr-marques-2... www.nature.com/articles/s41...
nature.com
Sex without crossovers mimics clonal reproduction in Rhynchospora tenuis - Nature
Rhynchospora tenuis undergoes obligate, genome-wide achiasmy in both male and female meiosis.
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raphmercier.bsky.social @raphmercier.bsky.social · 24/07/2026
An impressive new paper from Kejian Wang’s lab: MiMe+HUAXU=full-penetrant apomixis www.vita-journal.com/vita/EN/10.1... Self-propagating hybrids are a reality!
vita-journal.com
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raphmercier.bsky.social @raphmercier.bsky.social · 24/07/2026
The identification of the very conserved CTF18, SGO2 and SPF2 as suppressors of centromere-proximal crossovers highlights the importance of cohesin turnover in this process and opens up new possibilities for plant breeding. rdcu.be/fvHfe
rdcu.be
The deSUMOylase SPF2 and the cohesin regulators SGO2 and CTF18 suppress crossovers near centromeres
Nature Plants - Gamboa et al. identified three proteins that restrict meiotic crossovers near centromeres. This finding suggests that cohesion regulation plays a role in this suppression and...
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raphmercier.bsky.social @raphmercier.bsky.social · 24/07/2026
and guess what, some did! The cohesion regulators CTF18 and SGO2, and the deSUMOylase SPF2 actively limit centromere proximal crossover. Their mutation allows both the formation of crossover where they were completely absent in the wild-type, and enhance their frequency where they were rare!
static.klipy.com
Women's Energetic Party Reaction
ALT: Women's Energetic Party Reaction
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raphmercier.bsky.social @raphmercier.bsky.social · 24/07/2026
We reasoned that the changes in the organization of the centromere-proximal region that affect kinetochore orientation in these mutants may also affect crossover formation near centromeres.
static.klipy.com
Confused Math Meme
ALT: Confused Math Meme
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raphmercier.bsky.social @raphmercier.bsky.social · 24/07/2026
We recently described some mutants with modified kinetochre orientation at meiosis, associated with reduced cohesins, and likely modified chromatin looping close to centromeres. www.cell.com/current-biol...
cell.com
Cohesin and its regulation promote monopolar kinetochore orientation at meiosis I in Arabidopsis
Singh et al. used a forward genetic screen in Arabidopsis to identify ten proteins that promote monopolar kinetochore orientation during meiosis I. Cohesin subunits and cohesin regulators, CENP-C, and...
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raphmercier.bsky.social @raphmercier.bsky.social · 24/07/2026
But there are genes in these regions, which are thus innacissible to recombinatiion. This creates a significant bottleneck for plant breeding.
static.klipy.com
Gladiator: Russell Crowe's Hand in Wheat Field
ALT: Gladiator: Russell Crowe's Hand in Wheat Field
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raphmercier.bsky.social @raphmercier.bsky.social · 24/07/2026
Meiotic crossover shuffle genetic information. But, they are non-uniformly distributed along chromosomes and almost universally suppressed in centromere-proximal regions. How crossover are prevented next to centromere is unclear.
static.klipy.com
Nope, No Nooo
ALT: Nope, No Nooo
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raphmercier.bsky.social @raphmercier.bsky.social · 24/07/2026
Hot off the press (so to speak)! Where we described new factors that inhibit meiotic crossovers near centromeres rdcu.be/fvHfe thread👇
rdcu.be
The deSUMOylase SPF2 and the cohesin regulators SGO2 and CTF18 suppress crossovers near centromeres
Nature Plants - Gamboa et al. identified three proteins that restrict meiotic crossovers near centromeres. This finding suggests that cohesion regulation plays a role in this suppression and...
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raphmercier.bsky.social @raphmercier.bsky.social · 04/05/2026
Congrats Kirsten!
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Reposted by @raphmercier.bsky.social
PlantEvolution 🌱🌾 @plantevolution.bsky.social · 28/04/2026
What could be better than seeing a former member of your lab elected to the US National Academy of Sciences @nasonline.org? Huge congrats to Kirsten Bomblies @ethz.ch! Here are the two of us with @thanvisrikant.bsky.social , who was first a PhD student in my lab & then a postdoc with Kirsten.
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raphmercier.bsky.social @raphmercier.bsky.social · 16/04/2026
#TodayOnMyBike
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raphmercier.bsky.social @raphmercier.bsky.social · 15/04/2026
#TodayOnMyBike
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raphmercier.bsky.social @raphmercier.bsky.social · 02/04/2026
www.sciencedirect.com/science/arti...
sciencedirect.com
Cohesin and its regulation promote monopolar kinetochore orientation at meiosis I in Arabidopsis
The first division of meiosis is unique in its capacity to halve the ploidy of future gametes. To this end, one key innovation compared with mitosis i…
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raphmercier.bsky.social @raphmercier.bsky.social · 02/04/2026
Now in current biology! www.sciencedirect.com/science/arti...
sciencedirect.com
Cohesin and its regulation promote monopolar kinetochore orientation at meiosis I in Arabidopsis
The first division of meiosis is unique in its capacity to halve the ploidy of future gametes. To this end, one key innovation compared with mitosis i…
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raphmercier.bsky.social @raphmercier.bsky.social · 05/02/2026
#TodayOnMybike #SpringIsComing
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CNRS Mathématiques @cnrs-insmi.bsky.social · 08/01/2026
Découvrez les 18 nouvelles et nouveaux membres élus à @academiesciences.bsky.social pour l'année 2026 🔎 Communiqué de presse à lire sur ➡️ www.academie-sciences.fr/sites/defaul...
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raphmercier.bsky.social @raphmercier.bsky.social · 11/01/2026
Félicitations François !
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Russ Fischer @superelastic.bsky.social · 23/12/2025
and the winner of the "2025 best thing on Internet" has just arrived neal.fun/size-of-life/ @carlbergstrom.com
neal.fun
Size of Life
From an amoeba to a blue whale
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Charlie Underwood @charlieunderwood.bsky.social · 21/12/2025
An early Christmas present from our team for all of the tomato 🍅 & recombination fans: Chromosome-scale Solanum pennellii and Solanum cheesmaniae genome assemblies reveal structural variants, repeat content and recombination barriers of the tomato clade biorxiv.org/content/10.648…
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raphmercier.bsky.social @raphmercier.bsky.social · 21/12/2025
www.biorxiv.org/content/10.6...
biorxiv.org
Chromosome-scale Solanum pennellii and Solanum cheesmaniae genome assemblies reveal structural variants, repeat content and recombination barriers of the tomato clade
Crop wild relatives are important resources for improving cultivated crops, yet the precise introgression of wild genetic material into cultivated crops is often difficult and cannot be fully defined ...
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raphmercier.bsky.social @raphmercier.bsky.social · 12/12/2025
Merry Xmas from the department of Chromosome Biology!
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CEPLAS - Cluster of Excellence on Plant Sciences @ceplas.bsky.social · 09/12/2025
‼️Please RT: The CEPLAS Graduate School call for 2026 is now open! Detailed info on our website: bit.ly/4q19JWk @hhu.de @unicologne.bsky.social @mpipz.bsky.social @fz-juelich.de @leibnizipk.bsky.social @plantsciencedbg.bsky.social
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UC Davis @ucdavis.bsky.social · 08/12/2025
Two researchers at UC Davis have been awarded a VinFuture Prize in recognition of their work developing self-cloning crops, a breakthrough for sustainable agriculture. Read more: ucdav.is/4oJ41Hx
Imtiyaz Khanday and Dr Venkatesan Sundaresan stand next to cloned rice plants in a green house.
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raphmercier.bsky.social @raphmercier.bsky.social · 07/11/2025
Congrats to Dipesh, the driver of this story. And thanks to all the contributors and in particular the collaborators Jelle Van Leene and Geert De Jaeger (amazing IP ms) and the best of all Raphaels @raphguerois.bsky.social for the structure predictions and analysis
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raphmercier.bsky.social @raphmercier.bsky.social · 07/11/2025
www.nature.com/articles/s42... Latest from the lab. The conclusion is in the title! Basically, we found that the KMN complex (outer kinetochore) is fully conserved between plants and fungi/animals, showing deep origin. (reminder, you are closer to a mushroom than a mushroom is to a plant.)
nature.com
The composition and structure of the outer kinetochore KMN complex is conserved across kingdoms - Communications Biology
Affinity purification in Arabidopsis identified all key subunits of the outer kinetochore KMN complex. Functional analyses revealed a striking conservation of its composition and organization across k...
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François Parcy @flowerwhatelse.bsky.social · 24/10/2025
On mange des OGM tous les jours depuis plusieurs décennies (les plantes obtenues par mutagénèse chimique ou radiative) et ça ne pose aucun problème
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PHD Comics @phdcomics.com · 23/10/2025
The Author List
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raphmercier.bsky.social @raphmercier.bsky.social · 21/10/2025
Only those who know🐖🎮
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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 13/10/2025
“The scientific Nobels announced this week underscore that point. All three awards — granted each year in physiology or medicine, physics and chemistry — honored achievements rooted in fundamental research…Decades of inquiry paved the way for the technology, treatments and toys of tomorrow.” 🎁
nytimes.com
Nobel Prizes This Year Offer Three Cheers for Slow Science
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Oded Rechavi @odedrechavi.bsky.social · 04/10/2025
Thanking the reviewers
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Chloe Girard, PhD @chloegirard.bsky.social · 01/10/2025
This is the work of a tremendous PhD student, Benoit Madec, who did everything in this study (genetics, molecular biology, all the bioinformatics analyses) He defended his PhD on Monday and is now Dr Madec! I am very proud of him and all the work he has accomplished!
Benoît during his PhD defense on Monday!
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Chloe Girard, PhD @chloegirard.bsky.social · 01/10/2025
🚨 First pre-print from my team !! TL;DR: presence of polymorphism (sequence differences between the homologous chromosomes) can *increase* the local rate of recombination in Arabidopsis thaliana, turning cold regions of the genome hot (purple v. grey) !
The recombination frequency (cM/Mb) along chromosome 4 of A. thaliana (female meiosis). 

In full hybrids (grey), where polymorphism is distributed all along chromosomes, most crossovers occur in the regions surrounding the Centromere (Cen), and very few at chromosome ends (Tel: telomeres). 

In lines where polymorphism is restricted to chromosome ends (purple), the local recombination rate increases drastically, at the expense of the non-polymorphic regions (yellow).
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PHD Comics @phdcomics.com · 14/09/2025
Writing: just add coffee **Hey, my new book comes out on Tuesday! 👉 amazon.com/gp/aw/d/1419764063
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Maddy Seale @maddyseale.bsky.social · 22/09/2025
Out First Release in @science.org this week: A large scale analysis of the epigenetics of transposable elements in Arabidopsis shows transgenerational stability www.science.org/doi/10.1126/... #PlantScience
science.org
Transposable elements are vectors of recurrent transgenerational epigenetic inheritance
DNA methylation loss at transposable elements (TEs) can affect neighboring genes and be epigenetically inherited in plants, yet the determinants and significance of this additional system of inheritan...
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wcrismani.bsky.social @wcrismani.bsky.social · 11/09/2025
I feel incredibly privileged to share this study on Fanconi anaemia, based on a small but important cohort. This work describes the genetics and clinical outcomes of patients in Australia and New Zealand with a diagnosis of FA. www.sciencedirect.com/science/arti...
sciencedirect.com
Clinical and genetic spectrum of Fanconi anemia in Australia and New Zealand
Fanconi anemia (FA) is a rare genetic condition that predisposes to progressive bone marrow failure, a specific spectrum of malignancies, including he…
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Zwicker Group @zwickergroup.bsky.social · 10/09/2025
This is a great opportunity to start an independent group in one of the best research environments you could think of!
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Max-Planck-Gesellschaft @maxplanck.de · 09/09/2025
Springboard for an international scientific career! 🧬🧪🔭⚛️🧠🌱 Call for #MaxPlanckResearchGroups launched; applications are possible until October 14, 2025 www.mpg.de/max-planck-r... #ScienceCareer
Call for Applications / Ausschreibung
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raphmercier.bsky.social @raphmercier.bsky.social · 08/09/2025
Idee de sujet: www.nature.com/articles/d41...
nature.com
Is this the future of food? 'Sexless' seeds that could transform farming
Scientists are tinkering with plant genes to create crops that seed their own clones, with a host of benefits for farmers.
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raphmercier.bsky.social @raphmercier.bsky.social · 08/09/2025
www.nature.com/articles/d41... Interesting journalist piece on apomixix. With pieces of MiMe inside :-)
nature.com
Is this the future of food? 'Sexless' seeds that could transform farming
Scientists are tinkering with plant genes to create crops that seed their own clones, with a host of benefits for farmers.
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Schnittger Lab @schnittger-lab.bsky.social · 25/08/2025
Six more years—plus a lot of blood, sweat, and tears—later, we are thrilled to finally share it: a cytological framework of female meiosis in Arabidopsis! www.biorxiv.org/content/10.1...
biorxiv.org
A cytological framework of female meiosis in Arabidopsis
Female and male meiosis often differ in many aspects, such as their duration and the frequency as well as the positioning of crossovers. However, studying female meiosis is often very challenging and ...
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raphmercier.bsky.social @raphmercier.bsky.social · 25/08/2025
Thank you and congrats to all contributors in Versailles @ijpb-versaillescly.bsky.social and Cologne @mpipz.bsky.social and in particular to Dipesh Singh, Alexander Mahland, Rigel Salinas, Joiselle Fernandes and Qichao Lian.
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raphmercier.bsky.social @raphmercier.bsky.social · 25/08/2025
The identification of the very conserved CTF18, SGO2 and SPF2 as suppressors of centromere-proximal crossovers highlights the importance of cohesin turnover in this process and opens up new possibilities for plant breeding. Much more in the paper : www.biorxiv.org/content/10.1...
biorxiv.org
Unlocking meiotic crossovers near plant centromeres
Crossovers (COs) ensure proper chromosome segregation during meiosis and generate genetic diversity. COs are non-uniformly distributed along chromosomes and almost universally suppressed in centromere...
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raphmercier.bsky.social @raphmercier.bsky.social · 25/08/2025
and guess what, some did! The cohesion regulators CTF18 and SGO2, and the deSUMOylase SPF2 actively limit centromere proximal crossover. Their mutation allows both the formation of crossover where they were completely absent in the wild-type, and enhance their frequency where they were rare!
media.tenor.com
two women are sitting next to each other and one is pointing at the camera
ALT: two women are sitting next to each other and one is pointing at the camera
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raphmercier.bsky.social @raphmercier.bsky.social · 25/08/2025
We reasoned that the changes in the organization of the centromere-proximal region that affect kinetochore orientation in the identified mutants (see above and the first preprint) may also affect crossover formation near centromeres.
media.tenor.com
a close up of a woman 's face with a triangle and a mathematical formula .
ALT: a close up of a woman 's face with a triangle and a mathematical formula .
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raphmercier.bsky.social @raphmercier.bsky.social · 25/08/2025
But there are genes in these regions, which are thus innacissible to recombinatiion. This creates a significant bottleneck for plant breeding.
media.tenor.com
a close up of a person 's hand touching a plant in a field .
ALT: a close up of a person 's hand touching a plant in a field .
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raphmercier.bsky.social @raphmercier.bsky.social · 25/08/2025
An now the SECOND story. Meiotic crossover shuffle genetic information. But, they are non-uniformly distributed along chromosomes and almost universally suppressed in centromere-proximal regions. How crossover are prevented next to centromere is unclear.
media.tenor.com
a little girl wearing a shirt that says " til to " is eating a snack
ALT: a little girl wearing a shirt that says " til to " is eating a snack
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raphmercier.bsky.social @raphmercier.bsky.social · 25/08/2025
Our findings demonstrate that cohesion establishment and protection, kinetochore, and deSUMOylation enforce monopolar orientation in plants. This support a cohesion-driven model of kinetochore orientation at meiosis I that is conserved across kingdoms. Take a look: www.biorxiv.org/content/10.1...
biorxiv.org
Monopolar orientation of kinetochores at meiosis is enforced by COHESINS and their regulators, CENP-C, and the deSUMOylase SPF2
The first division of meiosis is unique in its capacity to halve the ploidy of the future gametes. To this end, one key innovation compared to mitosis is the monopolar orientation of the pairs of sist...
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