Nanoparticles targeted to solid tumor vasculature improve the pharmacologic properties of PROTACs.

Victor Nizet, MD, discusses how students can thrive at the university’s Skaggs School of Pharmacy and Pharmaceutical Sciences. He discusses the school's features including its rigorous coursework, foc...

The diary entry of an 8-year-old girl with cystic fibrosis indicates that Aug. 25, 1989, was an important day for her (Figure 1). That was the day the research teams at the University of Michigan a...

In the United States, we’ve fought to achieve the world’s best care for children with cancer.

Medicine is now the nation’s largest employer, but its growth may be slowing.

New blood tests promise to detect malignancies before they’ve spread. But proving that these tests actually improve outcomes remains a stubborn challenge.

An analysis of millions of scientific papers and patents reveals a ‘pivot penalty’ when researchers shift direction, with the impact of studies decreasing rapidly the further they move from their previous work.

Based on a proteogenomic analysis, Perreault and colleagues report that the majority of predicted tumor antigens originate from unmutated genomic sequences in melanoma and non-small cell lung cancer.

Letter to the Editor

Fumiko Ladd Chino: Toxicity in phase III oncology clinical trials is often incompletely reported / Adina H Passy, Alexander D. Sherry, Avital M Miller,

A family whose 6-year-old is battling cancer says a move to slash funding by the National Institutes of Health (NIH) for research at universities and medical centers would be “devastating.”

The Trump administration hobbles research and endangers the public health.

Combined therapies in cancer treatment aim to enhance antitumor activity. However, delivering multiple small molecules imposes challenges, as different drugs have distinct pharmacokinetic profiles and...

AbstractPurpose:. Amplification of cyclin-dependent kinase 4 (CDK4) and CDK6 is a feature of a variety of malignancies, and preclinical evidence suggests that inhibition of CDK4/6 is a plausible treat...

Purpose Childhood and adolescent cancer survivors (CACS) experience medical and psychosocial adverse effects. Attention widens to include issues such as socio-bureaucratic hardships. This systematic r...