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Raffaele Sarnataro

@rafsarnataro.bsky.social
354 followers 968 following 50 posts

Sleep(ing) neuroscientist @crick.ac.uk 🧠 | Alumnus @SNS.it @ox.ac.uk @WellcomeTrust.bsky.social @SomervilleCollege.bsky.social | 🇮🇹🇪🇺

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Raffaele Sarnataro @rafsarnataro.bsky.social · 09/10/2026
Optogenetics made me fall in love with neuroscience. For my PhD I joined Gero Miesenböck’s lab, where it was pioneered to control neural activity & behaviour. Congrats to photobiologists, biophysicists, fly & mouse geneticists whose work turned an elegant idea into a tool that still feels like magic
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Sainsbury Wellcome Centre @sainsburywellcome.bsky.social · 21/09/2026
Applications are now open for the SWC Systems Neuroscience PhD Programme. Join us in London! 🎓 World-class neuroscience training 💰 Fully funded 4-year programme 🖥️Close links to @gatsbyucl.bsky.social Apply by 9 Nov: www.sainsburywellcome.org/web/content/...
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Raffaele Sarnataro @rafsarnataro.bsky.social · 15/09/2026
What a time for sleep science!
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Bradley Jamieson @bradleyjamieson.bsky.social · 10/08/2026
‼️OUT NOW‼️ Our new review updates the current understanding of how parental behaviour is generated across mammalian brains 🧠 from sensory processing and hypothalamic circuits to hormones, plasticity and behavioural flexibility 🧑‍🧑‍🧒 Check it out here: www.nature.com/articles/s41...
nature.com
Neural circuits for mammalian parental behaviour - Nature Reviews Neuroscience
Parental care is a conserved and robust feature of mammalian reproductive behaviour, but is highly variable, even within individuals. Jamieson and Kohl describe the neural circuits that drive parental...
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MPI for Biological Intelligence @mpiforbi.bsky.social · 26/06/2026
Curious about understanding sleep homeostasis? Find out more at our next “Emerging Scientist Talk” with Raffaele Sarnataro @rafsarnataro.bsky.social, Postdoc at the Francis Crick Institute @crick.ac.uk. 📅 July 1 at 11:00 a.m. 📍 Room NQ105, Martinsried Art by @somedonkey.bsky.social
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Julie Seibt @jseibt.bsky.social · 05/06/2026
Applications are now open for the inaugural CAJAL Advanced Neuroscience Training Course on Neurobiology of Sleep 😴🧠!!! 📅 Dates: 19 November – 8 December 2026 ⏳ Application Deadline: 3 July 🔗 Information and application: cajal-training.org/on-site/neur...
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Aeon Magazine @aeon.co · 20/04/2026
In this sharp and insightful essay, Hannah Critchlow takes us through the many ways in which our brains generate and use energy, and offers some helpful recommendations for looking after your brain health
buff.ly
How understanding bioenergetics can help our brain health | Aeon Essays
A brain fit for the 21st century is one that understands – and respects – its own bioenergetic foundations
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Raffaele Sarnataro @rafsarnataro.bsky.social · 28/03/2026
Many compliments!!
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Sainsbury Wellcome Centre @sainsburywellcome.bsky.social · 11/02/2026
Studies using fruit flies by @ox.ac.uk researchers @rafsarnataro.bsky.social & Dr Peter Hasenhuetl, are providing new insights into how sleep is controlled 💤 As two winners of the Emerging Neuroscientist Seminar Series 2025, they recently spoke at SWC ⤵️ www.sainsburywellcome.org/blog/what-fr...
Maximum intensity projection of a fly midbrain where dorsal fan-shaped body neurons have their mitochondria labelled green, overlaid with ‘SWC Speaker Series’
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fly paper broadcast @fly-broadcast.bsky.social · 30/01/2026
A neuronal population clock for interval timing in Drosophila #Drosophila
pubmed.ncbi.nlm.nih.gov
A neuronal population clock for interval timing in Drosophila #Drosophila
PubMed link
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Biozentrum, University of Basel @biozentrum.unibas.ch · 26/01/2026
Why do we feel an irresistible drive to sleep after being awake for too long? A recent study led by Prof. Anissa Kempf has revealed that, in fruit flies, a small set of neurons can sense when the fly needs rest. Learn more 👉 www.biozentrum.unibas.ch/news/detail/... @erc.europa.eu @snsf.ch #sleep
biozentrum.unibas.ch
The mystery of sleep: How does the brain know when it’s time to sleep?
Why do we feel an irresistible drive to sleep after being awake for too long? A recent study led by Prof. Anissa Kempf at the Biozentrum has revealed that in fruit flies, a small set of neurons can se...
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The Journal of Physiology @jphysiol.bsky.social · 25/11/2025
Raffaele Sarnataro of ox.ac.uk presents this #SymposiumReview examining the #neurobiology of mitochondrial dynamics in #sleep 🧠 💤 🔗 Read the article here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
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Antibodies.com @antibodies-dot-com.bsky.social · 02/12/2025
Did you know that we are offering 4 travel grants every year? That's right! 500£ for conferences and workshops. Registration is still open for the last grant of 2025! Need some inspiration? Read about the experiences of our Q3 winner, @rafsarnataro.bsky.social www.antibodies.com/promotions/t....
antibodies.com
Antibodies.com | Antibodies, Proteins, and ELISA Kits
Antibodies.com supplies high-quality antibodies, proteins, and ELISA kits to life science researchers at cost-effective prices. Discover more, for less.
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Raffaele Sarnataro @rafsarnataro.bsky.social · 20/11/2025
The Erice Statement on the Importance of Molecular Life Sciences Education (shorturl.at/BNvfv) calls for a global effort to strengthen molecular literacy through inquiry-based and evidence-driven education, for responsible citizenship💡🧬 Endorse it here: shorturl.at/PTmsh @iapartnership.bsky.social
shorturl.at
Erice Statement on the Critical Importance of Molecular Life Sciences Education- A Global Call to Action.pdf
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Antibodies.com @antibodies-dot-com.bsky.social · 18/11/2025
Congrats @rafsarnataro.bsky.social, the winner of our quarterly travel grant, who is currently at #SfN25. We are both excited and proud to support this cool research on the mitochondrial origins of the pressure to sleep! Shout out to @sfn.org!
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Raffaele Sarnataro @rafsarnataro.bsky.social · 18/11/2025
Thanks for the support!
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bioRxivpreprint @biorxivpreprint.bsky.social · 16/10/2025
Presynaptic Release Probability Determines the Need for Sleep www.biorxiv.org/content/10.1101/202…
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Greg Jefferis @jefferis.bsky.social · 15/10/2025
Excited to share our new #biorxivpreprint: “Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1... We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
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Raffaele Sarnataro @rafsarnataro.bsky.social · 14/09/2025
😂 I think metabolic reactions hate everyone
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Raffaele Sarnataro @rafsarnataro.bsky.social · 14/09/2025
Thank you, luckily it didn't put you to sleep during the reading! 💤
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The Transmitter @thetransmitter.bsky.social · 09/09/2025
Sleep might be an “inescapable consequence” of aerobic metabolism, new findings in fruit flies suggest. By @vcallier.bsky.social #neuroskyence www.thetransmitter.org/sleep/mitoch...
thetransmitter.org
Mitochondria set ‘ancient’ metabolic thermostat for sleep in flies, separate from circadian rhythms
During waking hours, a specialized set of sleep neurons in the fly brain accumulates reactive oxygen species, which eventually trigger sleep to clean up and repair the damage they do.
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Liuba Dvinskikh @ld-light.bsky.social · 02/09/2025
✨ Now out in Biomedical Optics Express: Cleared tissue dual-view oblique plane microscopy 🔬: doi.org/10.1364/BOE.... (🧵1/6)
doi.org
Optica Publishing Group
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Raffaele Sarnataro @rafsarnataro.bsky.social · 03/09/2025
Happy to have given a tiny contribution (as tiny as a fly brain!) to this new light-sheet microscopy technology. Congratulations to @ld-light.bsky.social and the whole team
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Raffaele Sarnataro @rafsarnataro.bsky.social · 02/09/2025
💡 Some open questions: ❓ Are mitochondrial state changes always causal in sleep (or other homeostatic behaviours) regulation, or secondary to altered neuronal activity? 🧠 Are there gradients of mitochondrial properties across neuron types and circuits, relevant to behaviours? #Neuroscience #Sleep
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Raffaele Sarnataro @rafsarnataro.bsky.social · 02/09/2025
Thanks also to the @physoc.bsky.social for funding it and for granting me a Conference Attendance Award supporting my participation and oral communication; P. Hasenhuetl, R. Klemm, and G. Miesenböck for feedback on the draft; and the reviewers for their helpful comments @oxforddpag.bsky.social
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Raffaele Sarnataro @rafsarnataro.bsky.social · 02/09/2025
I would like to thank Prof. Rasmus Petersen, Prof. Ricardo Maravall, and Dr Riccardo Storchi for organising the meeting "Breakthroughs in Understanding Natural Behaviour and its Neural Underpinnings" which prompted this collection of reviews.
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Raffaele Sarnataro @rafsarnataro.bsky.social · 02/09/2025
I also comment on our latest findings about mitochondria in fly sleep-control dFBNs, with my perspective on their neuroenergetic dynamics in light of the recent literature. 🪰 @medsci.ox.ac.uk @ox.ac.uk
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Raffaele Sarnataro @rafsarnataro.bsky.social · 02/09/2025
I summarise cross-species experimental findings on how mitochondrial morphology, trafficking, and turnover relate to sleep and, more broadly, to behavioural homeostasis, and I examine the underlying neurobiology.
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Raffaele Sarnataro @rafsarnataro.bsky.social · 02/09/2025
🚨 What's the interplay between sleep and mitochondrial dynamics in neurons? I am happy to share this invited review I wrote for The Journal of Physiology @jphysiol.bsky.social 👉 physoc.onlinelibrary.wiley.com/doi/full/10.... 🧵 Thread 👇 #Neuroscience #SleepResearch
physoc.onlinelibrary.wiley.com
Neurobiology of mitochondrial dynamics in sleep
Abstract figure legend In neurons, variations in sleep history are accompanied by alterations in mitochondrial dynamics, including changes in size, fission and fusion events, the emergence of extra-l...
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Scienza in rete @scienzainrete.bsky.social · 29/08/2025
Un nuovo studio condotto in D. melanogaster rivela che il bisogno di sonno potrebbe nascere direttamente dal metabolismo dei neuroni. Il sonno, insomma, sarebbe una conseguenza inevitabile della respirazione cellulare www.scienzainrete.it/articolo/cos...
scienzainrete.it
A cosa serve il sonno? La risposta può essere nel metabolismo neuronale
Perché dormiamo? La risposta a questa domanda rimane uno dei grandi misteri della biologia. Come scrisse il neurofisiologo Alan Rechtschaffen: «Se il sonno non avesse una funzione assolutamente vitale...
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Nick Petrić Howe @nickpetrichowe.bsky.social · 18/07/2025
Tired? Well that sleepy feeling may be driven by 'leaky' mitochondria, according to a new study. I spoke to Gero Miesenboeck from @ox.ac.uk for @nature.com all about the new study. It's here on the Nature Podcast at 12:11:
nature.com
‘Stealth flippers’ helped this extinct mega-predator stalk its prey
Hear the biggest stories from the world of science | 16 July 2025
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Raffaele Sarnataro @rafsarnataro.bsky.social · 28/08/2025
Thanks for pointing out this study... It really seems restorative sleep crucially engages a metabolic response!
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Raffaele Sarnataro @rafsarnataro.bsky.social · 28/08/2025
Beautiful work, congratulations!
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Sainsbury Wellcome Centre @sainsburywellcome.bsky.social · 08/08/2025
Congratulations to the SWC Emerging Neuroscientists Seminar Series winners! - Dimokratis Karamanlis, University of Geneva - @rafsarnataro.bsky.social‬ & Peter S. Hasenhuetl, @ox.ac.uk - Saurabh Vyas, @columbiauniversity.bsky.social - @sblumenstock.bsky.social‬, University of California San Diego
Photos of SWC Emerging Neuroscientists Seminar Series 2025/26 winners; Dimokratis Karamanlis, Sonja Blumenstock, Saurabh Vyas, Raffaele Sarnataro & Peter S. Hasenhuetl
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New Scientist @newscientist.com · 24/07/2025
Mitochondria may have been labelled the "energy powerhouses" of cells, but they also seem to have an underappreciated role in sleep.
newscientist.com
Our brain's mitochondria may play a crucial role in the onset of sleep
Textbooks say that mitochondria exist to supply cells with energy, but experiments in fruit flies suggest they are also involved in sleep
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Raffaele Sarnataro @rafsarnataro.bsky.social · 31/07/2025
Thanks @dereklowe.bsky.social for featuring our work in @science.org blog "The Pipeline"
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Raffaele Sarnataro @rafsarnataro.bsky.social · 31/07/2025
Thanks for featuring our work! rdcu.be/eyCv5
rdcu.be
Mitochondrial origins of the pressure to sleep
Nature - Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.
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Raffaele Sarnataro @rafsarnataro.bsky.social · 23/07/2025
Thanks for sharing our work!
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Raffaele Sarnataro @rafsarnataro.bsky.social · 23/07/2025
Thanks for sharing our work!
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Raffaele Sarnataro @rafsarnataro.bsky.social · 23/07/2025
Thanks for sharing our work!
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Raffaele Sarnataro @rafsarnataro.bsky.social · 23/07/2025
Thanks, and great way to put it!
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Raffaele Sarnataro @rafsarnataro.bsky.social · 23/07/2025
Thanks for sharing our work!
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Raffaele Sarnataro @rafsarnataro.bsky.social · 22/07/2025
Thanks, Nick! I could not have asked for better colleagues!
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Raffaele Sarnataro @rafsarnataro.bsky.social · 22/07/2025
18/ Finally, some press release: from @oxforddpag.bsky.social www.dpag.ox.ac.uk/news/why-do-...; the @economist.com www.economist.com/science-and-... @scienmag.bsky.social bsky.app/profile/scie...; on @science.org newsletter ScienceAdviser @nerdychristie.bsky.social www.science.org/content/arti...
dpag.ox.ac.uk
Why do we need sleep? Oxford researchers find the answer may lie in mitochondria
A New study uncovers how a metabolic “overload” in specialised brain cells triggers the need to sleep. Sleep may not just be rest for the mind - it may be essential maintenance for the body’s power su...
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Raffaele Sarnataro @rafsarnataro.bsky.social · 22/07/2025
17/ all the kind sharers of fly strains; reviewers for their work and suggestions improving this paper; @wellcometrust.bsky.social for my personal funding.
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Raffaele Sarnataro @rafsarnataro.bsky.social · 22/07/2025
16/ the many facilities of @medsci.ox.ac.uk the Don Mason Facility of Flow Cytometry and the Light Microscopy Facility, Micron, the Genomics Centre, @hhmijanelia.bsky.social, Zantiks, @vincentcroset.bsky.social, C. Treiber and @scottishwaddell.bsky.social for advice on scRNA-seq
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Raffaele Sarnataro @rafsarnataro.bsky.social · 22/07/2025
15/ I would like to thank C. Talbot for the invaluable support with instrumentation, all lab members, especially those who helped in tiring morning dissections; T. Calì, P. Hasenhuetl, R. Klemm, V. Savage, E. Vrontou for helpful discussions; V. Vyazovskiy for discussions on sleep beyond this work
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Raffaele Sarnataro @rafsarnataro.bsky.social · 22/07/2025
14/ Interestingly, humans with mitochondrial diseases often experience debilitating fatigue even without exertion. 
I hope you enjoy the read, we have much more in the paper! (here is the link once more rdcu.be/ewwrA)
rdcu.be
Mitochondrial origins of the pressure to sleep
Nature - Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.
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Raffaele Sarnataro @rafsarnataro.bsky.social · 22/07/2025
13/ 🧵 Finally, our findings conceptually align with known correlations between daily sleep and mass-specific oxygen consumption or brain mass (Fig from Savage et al 2007, each dot is a mammalian species), suggesting that sleep serves an ancient metabolic purpose also in mammals.
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Raffaele Sarnataro @rafsarnataro.bsky.social · 22/07/2025
12/ “If sleep indeed evolved to fulfil a metabolic need, it is not surprising that neurons controlling sleep and energy balance would be regulated by similar mechanisms”.
media.tenor.com
a cartoon of a sloth wearing glasses and a pink bow is laying in bed .
ALT: a cartoon of a sloth wearing glasses and a pink bow is laying in bed .
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