Published in The American Journal of Bioethics (Ahead of Print, 2026)

Many learners are more facile with the use of large language models in medicine than their supervisors are. The authors provide an approach to clinical supervision that can mitigate the perils and ...

Institutional review boards (IRBs) play a crucial role in ensuring the ethical conduct of human subjects research, but face challenges including inconsistency, delays, and inefficiencies. We propose t...

“Suffering” is a central concept within bioethics and often a crucial consideration in medical decision making. As used in practice, however, the concept risks being uninformative, ambiguous, or ev...

Clinical researchers should help respect the autonomy and promote the well-being of prospective study participants by helping them make voluntary, informed decisions about enrollment. However, part...

We identified three strategies that PIs, RCs, SDMs and patients viewed as effective for building trust and alleviating stress in the surrogate informed consent process. Incorporating these approaches ...

Cardiac arrest of neurological cause (CA-NC) is an entity whose incidence is unknown. The main reason for this is that the medical literature is mainly concerned with cardiac arrest due to cardiac cau...

YouTube video by AP-HM - Hôpitaux Universitaires de Marseille

The development of brain organoids and use of human embryonic neural structures for research each raise distinct ethical considerations that require careful analysis. We propose that rather than attem...

We report a method for the recovery of hearts for transplantation from deceased donors after circulatory death that obviates the need for thoracoabdominal normothermic regional perfusion or ex situ...

Background Accurate microbiological documentation seems central for managing severe pneumonia. While the FilmArray® Pneumonia + panel (FA-PP) offers rapid pathogen identification, its effectiveness du...

Background Therapeutic misconception (TM) among research participants refers to the conflation of research goals (generating generalisable knowledge) with clinical care goals (making the best decision...

Critical illness threatens millions of lives annually. Electronic health record (EHR) data are a source of granular information that could generate crucial insights into the nature and optimal treatme...

Anja Unger, retrace, depuis le procès de Nuremberg, la prise en compte progressive de l’éthique en matière d’expérimentations médicales sur l’humain, en France et aux Etats-Unis.

In recent years, an old challenge to informed consent has been rediscovered: the challenge of ignorance. Several authors argue that due to the presence of irreducible ignorance in certain treatment...

Background Patients with disorders of consciousness (DoC) are unable to partake in the decision making process concerning their treatment. In the process of medical decision-making, which in DoC often...

Background The history of research involving human subjects has demonstrated the importance of offering everyone an equal opportunity to participate in research, while safeguarding those who require s...

Background Post-cardiac arrest (CA) care guidelines (GLs) have been introduced in 2010 and periodically updated every 5 years since then (in 2015 and 2021). However, the impact of these GLs on patient...

An abstract is unavailable.

Rapid multiplex molecular syndromic panels (RMMSP) (3 or more pathogens and time-to-results < 6 h) allow simultaneous detection of multiple pathogens and genotypic resistance markers. Their implementa...

Background Listening and responding to family concerns in organ and tissue donation is generally considered important, but has never been researched in real time. We aimed to explore in real time, (a)...

Background The primary objective of this study was to conduct a comprehensive questionnaire survey on the practices of research ethics committees reviewing academic research projects in Czechia. The s...

What makes a good clinical study may not be the source of a discovery that propells a medical breakthrough, but getting to to innovation may require other ways of collaboration and investigation meldi...

This Medical News article is an interview with Sarah C. Hull, MD, MBE, a cardiologist and clinical ethicist at Yale School of Medicine, about appropriate boundaries for use of artificial intelligence ...

This Viewpoint discusses the US Food and Drug Administration’s upcoming mandate on diversity actions plans for trial sponsors and the importance of developing accountability mechanisms to monitor thos...

This JAMA Special Communication presents the 2024 revision of the World Medical Association’s Declaration of Helsinki, a set of principles to guide the ethical treatment of participants in medical res...