iiinova — where your digital self keeps evolving

Alexander Pietras Lab @pietraslab.bsky.social · 24/09/2026

@elinnjohansson.bsky.social's latest paper is now online in Neuro-Oncology Pediatrics: ACVR1 mutations are shared by DMG and the bone disorder FOP, where hypoxia drives disease. Turns out hypoxia signaling is up in ACVR1-mutant pediatric gliomas too. Open access here: doi.org/10.1093/neup...

doi.org

Hypoxia signaling is elevated downstream of mutant ACVR1 in pediatric high-grade glioma

AbstractBackground. Pediatric diffuse midline gliomas (pDMG) are lethal tumors, with approximately 80% harboring a lysine-to-methionine mutation in histone

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Pereira Lab @cellreprolab.bsky.social · 27/04/2026

🔬 Lund University (@lund-university.bsky.social) is hiring 3 Assistant Professors in cancer immunotherapy, immunotechnology & immune cell engineering! ✅ Start-up package | tenure track | world-class infrastructure 📅 Deadlines: 26 May & 10 June 2026 🎥 youtu.be/z-PQU9qknZc Apply links 👇

youtu.be

Lund University programme for excellence – three positions within Immunotherapy

YouTube video by Lund University

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Kristian Pietras lab @kpietraslab.bsky.social · 21/04/2026

Lund University is recruiting a tenure-track Assistant Professor in Experimental Cancer Immunotherapy, and we want the best in the world to apply 🫵 The position comes with a clear path to tenure and an attractive start-up package. Apply or share with outstanding candidates by 10. June. 🔗 in replies

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Jessica Pantaleo @jessicapantaleo.bsky.social · 17/01/2026

New paper out from the @kpietraslab.bsky.social lab. I am happy to share that my first-author paper is now published. We map the spatial and temporal dynamics of cancer-associated fibroblasts in breast cancer using integrated spatial proteomics and transcriptomics. link.springer.com/article/10.1...

link.springer.com

Spatial and temporal dynamics of cancer-associated fibroblast niches in breast cancer - Breast Cancer Research

Breast Cancer Research - Cancer-associated fibroblasts (CAFs) are the main constituents of the tumor microenvironment. Several studies have delineated CAF heterogeneity in different types of...

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Kristian Pietras lab @kpietraslab.bsky.social · 22/12/2025

Check this out👇 Our neighbors @pietraslab.bsky.social has just published a new preprint detailing high-resolution profiling of the irradiated GBM microenvironment. ❄️Cool reading for the holidays❄️ Thanks for including us!

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Kristian Pietras lab @kpietraslab.bsky.social · 09/12/2025

New paper alert 🚨 We are delighted to present our latest paper in @natcomms.nature.com through fabulous work from co-first authors Sebastian Braun and Paulina Bolivar! Big thanks to all expert collaborators for taking this long journey with us! Tweetorial in comments 🧵 www.nature.com/articles/s41...

nature.com

Pericytes orchestrate a tumor-restraining microenvironment in glioblastoma - Nature Communications

Improved understanding of the tumor ecosystem in glioblastoma is critical for developing new treatment strategies for the disease. Here, the authors identify pericytes as an active paracrine signaling...

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Alexander Pietras Lab @pietraslab.bsky.social · 05/12/2025

Really excited to see this new paper from our friends & neighbors in the other Pietras lab @kpietraslab.bsky.social, uncovering surprising (?) roles of pericytes in the GBM microenvironment. Congrats all, and thanks for including us! www.nature.com/articles/s41...

nature.com

Pericytes orchestrate a tumor-restraining microenvironment in glioblastoma - Nature Communications

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Marcus Ruscetti Lab @marcus-ruscetti.bsky.social · 29/10/2025

How can senescent cells, which are damaged and growth arrested, both block tumor initiation as well as fuel its growth? A recent study published in Cancer Discovery @aacrjournals.bsky.social from Lin Zhou in the lab uncovered some new insights into this puzzle. aacrjournals.org/cancerdiscov...

aacrjournals.org

P21-positive senescent stromal cells promote prostate cancer immune suppression and progression that can be reversed by senolytic therapy

Abstract. Cellular senescence is a well-established tumor-suppressive cell cycle arrest program. However, chronic inflammation through the senescence-associated secretory phenotype (SASP) can alternat...

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Alexander Pietras Lab @pietraslab.bsky.social · 19/09/2025

Had a blast hosting the Brain Tumor Plasticity symposium at the Royal Swedish Academy of Sciences this week! Here's @leilaakkari.bsky.social with an outstanding talk on the evolving brain tumor microenvironment 🤩

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Monica Olcina @m-olcina.bsky.social · 24/07/2025

Thrilled to share our latest work - we describe a novel and therapeutically relevant mechanism underlying dysregulation of innate immune receptor C5aR1 in the tumour microenvironment. Thanks and congratulations to all authors! www.nature.com/articles/s41...

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LizdelaGarzaG @lizdelagarzag.bsky.social · 22/07/2025

To this day, even the strongest treatments fail when the brain’s own healing turns against it. Flunarizine, a migraine drug, may help stop astrocytes from nurturing #glioblastoma back to life. Read ⤵️

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bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · 18/07/2025

Phenotypic Screening Identifies Flunarizine as an Inhibitor of Radiotherapy-Induced Astrocyte Reactivity with Therapeutic Potential in Glioblastoma www.biorxiv.org/content/10.1101/202…

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Alexander Pietras Lab @pietraslab.bsky.social · 15/05/2025

🌍 Join us in a supportive, international lab within a vibrant cancer research hub! Strong local bioinformatics community + a high quality of life in the Malmö/Lund region. Great science, great people, great place to live. 💻🧬🏡

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Silvia Remeseiro Lab @remeseiro-lab.bsky.social · 21/05/2025

📣 New pre-print from the lab: 👉 “Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis” #Glioblastoma #GB #GRNs #multiomics #GABA #CancerNeuroscience #ML #GBM 📝 Read the #BioRxiv here: doi.org/10.1101/2025...

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Alexander Pietras Lab @pietraslab.bsky.social · 15/05/2025

🚨 We’re hiring a bioinformatics-focused PhD student for our ERC-funded project on recurrent GBM! Focus: tumor-supportive microenvironment 🔬 Experience with scRNA-seq, spatial transcriptomics & Python/R a plus. Must be self-motivated & driven. DM for details! Repost=❤️ lu.varbi.com/en/what:job/...

lu.varbi.com

Doctoral Student in Tumor Biology

Description of the workplace The research group conducts experimental research on brain tumors and is led by Associate Professor Alexander Pietras. The group consists of a bioinformatician, two postdo

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Alexander Pietras Lab @pietraslab.bsky.social · 15/05/2025

lu.varbi.com

Doctoral Student in Tumor Biology

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Alexander Pietras Lab @pietraslab.bsky.social · 12/05/2025

Just a few spots left for this exciting symposium on brain tumor plasticity—grab yours (free of charge!) before they're gone! 🚨

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Ulvmar lab @ulvmarlab.bsky.social · 02/05/2025

👋We have 2 amazing projects: A) basic molecular regulation of the LN lymphatic vasculature & B) lymphatic metastasis with new models & human samples describing completely new phenomena - both projects with solid preliminary data to build on. Open for interested postdoctoral scientists 📩

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Kristian Pietras lab @kpietraslab.bsky.social · 23/04/2025

Join us for innovative explorations of the tumor microenvironment🔬 Learn cutting-edge technologies and grow in a dynamic environment💡 The postdoc will work alongside a doctoral student from @adaptmet.bsky.social, gaining access to collaborative partners across 🇪🇺. Apply now👇 tinyurl.com/4mby45hf

tinyurl.com

Postdoc in Experimental Oncology - Lund (Stad), Skåne (SE) job with Lund University | 12838990

Lunds universitet, 009999 LUNDS UNIVERSITET, 310000 MED Lund University was founded in 1666 and is repeatedly ranked among the world’s top universi...

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Alexander Pietras Lab @pietraslab.bsky.social · 08/04/2025

I'm delighted to host @ggargiul.bsky.social for a talk in the LUCC seminar series today. Medicon Village Auditorium @ 1.30 - you don't want to miss out if you're in Lund! Welcome!

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Emma R Andersson @anderssonlab.bsky.social · 04/04/2025

Hot off the press! 🧬🔬 We developed in utero nano-injection to label & trace the mouse neural plate and otic placode using next generation single cell lineage tracing. We couple progenitors to mature cell types in the CNS & resolve the lineages of cells in the hearing organ: doi.org/10.1126/scie...

doi.org

Ectoderm barcoding reveals neural and cochlear compartmentalization

Placodes and the neural crest are defining features of vertebrates. In this study, we investigate their lineages in mice using in utero approaches. We demonstrated that nanoinjection at embryonic day ...

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Alexander Pietras Lab @pietraslab.bsky.social · 10/03/2025

Huge congrats to @kpietraslab.bsky.social on this well-deserved recognition! 🙌🥳

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Gaetano Gargiulo @ggargiul.bsky.social · 06/03/2025

"EMT favours the emergence of genomic-unstable, highly fit tumour cells, which strongly supports the concept of cell-state-restricted patterns of evolution" Exceptional work addressing a classic chicken & egg paradigm in cell-state-driven tumor evolution. Congrats Gianni, Luigi & teams!

doi.org

Evolutionary fingerprints of epithelial-to-mesenchymal transition - Nature

Malignant cells with mesenchymal features display increased chromatin accessibility, particularly in the pericentromeric and centromeric regions, in turn resulting in delayed mitosis and catastrophic ...

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The Brain Prize @brainprize.org · 05/03/2025

Congratulations to winners of The Brain Prize 2025! Professors @michellemonje.bsky.social, @stanfordmedicine.bsky.social and @hhmi.org Investigator, and Frank Winkler, Heidelberg University Hospital, have pioneered the field of Cancer Neuroscience. Learn more: brainprize.org/winners/canc...

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Gaetano Gargiulo @ggargiul.bsky.social · 22/02/2025

Exciting tech advance 4 cancer research: FFPE-CUTAC enables phenotype queries from archived FFPE tissues. This finds a striking correlation between hypertranscription of histones (but not ribosomal genes) & chromosome arm losses, hence, cancer evolution.

science.org

RNA polymerase II at histone genes predicts outcome in human cancer

Genome-wide hypertranscription is common in human cancer and predicts poor prognosis. To understand how hypertranscription might drive cancer, we applied our formalin-fixed paraffin-embedded (FFPE)–cl...

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DGMB @matrixbiologie.bsky.social · 10/02/2025

Come and join us at our annual meeting in Freiburg! There is still time to submit your abstract! Deadline 21.02.! 👇 www.matrixbiologie.de/annual-meeti...

Flyer for the annual meeting of the German Society for Matrix Biology: Matrix Nexus - The Extracellular Matrix: From Molecular Foundations To Life. The flags of Germany, Belgium, Denmark, Sweden and Finland are shown on the outline of Germany, three intertwined snakes/dragons in red, yellow, and blue are looking up to the title, and a pin indicates the location of Freiburg, where the meeting will be held 26.03.-28.03.2025.

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Alexander Pietras Lab @pietraslab.bsky.social · 31/01/2025

And here's @rebeccarosberg.bsky.social (with others) accepting her poster prize to conclude a wonderful symposium in Paris 🤩🔥🧠🇫🇷

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Kristian Pietras lab @kpietraslab.bsky.social · 31/01/2025

At the Brain Tumor Microenvironment Symposium @institutducerveau.bsky.social, Sebastian Braun presented our comprehensive study of pericytes in GBM 🤩. Pericytes act as guardians of the peri-vascular niche to prevent malignant cell invasion, read more at www.biorxiv.org/content/10.1...

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Alexander Pietras Lab @pietraslab.bsky.social · 30/01/2025

...and here's Karolina Smolag @karolinasmolag.bsky.social delivering the second Pietras lab talk of the day 🤩 We also have a couple of posters so please check them out if you're with us in Paris!

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Alexander Pietras Lab @pietraslab.bsky.social · 30/01/2025

We're excited to be at the Institute du Cerveau in Paris for the brain tumor microenvironment symposium 🧠 Here's Pauline Jeannot with the first presentation of the day from the lab 🔥

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Kristian Pietras lab @kpietraslab.bsky.social · 15/01/2025

We have been waiting impatiently but can finally share our latest efforts in understanding the biology of the TGF-beta type I receptor ALK1 (gene name ACVRL1), see graphical abstract in post and the full article here: www.jci.org/articles/vie... 1/6

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Gaetano Gargiulo @ggargiul.bsky.social · 31/12/2024

End-of-the-year preprint & first 🧵 where the sky is blue! Ever wondered how a cancer driven by a single mutant oncogene becomes molecularly & cellularly heterogeneous? Why metastases share drivers w/primary tumors but are more aggressive?

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Kristian Pietras lab @kpietraslab.bsky.social · 18/12/2024

The two Pietras labs @pietraslab.bsky.social @kpietraslab.bsky.social collide in a fierce game of Ping Pong. The losers fill all pipette tip boxes the next year 😜

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Valerio Val Izzi @valerioizzi.bsky.social · 17/12/2024

I can't be more stoked to start my #scienceblue feed with this! OOPS WE DID IT AGAIN with @nabalabuic.bsky.social ! 🤩🤩🤩 And for the nerds, this is all in @rshiny.bsky.social ! #democratizescience #bigdataforall #ECMatrix

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Daniel Bexell Lab @bexell-lab.bsky.social · 27/11/2024

We are looking for future cancer researchers! The Advanced Cancer Biology course is offered at Lund University and provides both theoretical and practical preparation for doctoral studies in cancer research. Deadline for international admission: January 15, 2025. www.lucc.lu.se/education/ed...

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Anna Obenauf @obenaufa.bsky.social · 27/11/2024

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

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Alexander Pietras Lab @pietraslab.bsky.social · 26/11/2024

Delighted to see this paper from Anna Blom's group published in its final form! 🎉 Huge congrats to @karolinasmolag.bsky.social and the entire team—another fantastic collaboration unraveling the roles of complement proteins in the GBM microenvironment. 👏🧠

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Sakari Vanharanta @svanharanta.bsky.social · 25/11/2024

Hello Bluesky, we are recruiting PhD students in cancer and metastasis biology! This is a fantastic program that brings together several leading European research institutes. Details here: adaptmet.eu/recruitment/

adaptmet.eu

Recruitment

Recruitment is now open! Apply for one of the 16 positions availablein the Adaptmet network and build your futureas a researcher in metastasis! Adaptmet is offering generous three-year fellowship...

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Alexander Pietras Lab @pietraslab.bsky.social · 19/11/2024

Meet our PhD student Rebecca! This year, she beat cancer AND published her first 1st-author paper on how hypoxia induces complement signaling in GBM, alters macrophage polarization, and how the C3-C3AR1 axis can be therapeutically targeted in GBM models. Check it out! insight.jci.org/articles/vie...

insight.jci.org

JCI Insight - Hypoxia-induced complement component 3 promotes aggressive tumor growth in the glioblastoma microenvironment

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Giorgio Seano @giorgioseano.bsky.social · 19/11/2024

There are a lot of excellent Starter Packs available, but I didn’t see one focused on Neuro-oncology. If you want to be added to this list, please reply below! go.bsky.app/VgzHLtt

go.bsky.app

Neuro-oncology

Join the conversation

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Kristian Pietras lab @kpietraslab.bsky.social · 18/11/2024

We love to explore unexpected findings 🤔 Check out our two latest studies detailing the unexplored expression of ALK1 in immunosuppressive macrophages and the critical role of pericytes as a paracrine signaling hub in GBM. www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

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