Reposted by Rebecca Rosberg
📣 Preprint alert! Happy to share our latest work, in which we identify Flunarizine as an inhibitor of astrocyte reactivity with therapeutic potential in glioblastoma (GBM). Details in 🧵:
www.biorxiv.org/content/10.1...
biorxiv.org
Phenotypic Screening Identifies Flunarizine as an Inhibitor of Radiotherapy-Induced Astrocyte Reactivity with Therapeutic Potential in Glioblastoma
Radiotherapy is part of the standard-of-care for glioblastoma, yet tumors invariably recur as incurable lesions post-treatment. Recent studies suggest that radiation-induced astrocyte reactivity foste...