Reposted by Dr. Phil Rivera
'These results showed that HMGB1 inhibited IFN-γ–induced PD-L1 expression, thereby enhancing the antitumor effects of T cells, and confirmed the role of HMGB1 as a prognostic indicator for lung cancer treated with chimeric antigen receptor T cells.'
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HMGB1 inhibits the IFN-γ–induced PD-L1 expression in NSCLC
Abstract. T cells are the most important cytotoxic cells involved in antitumor immune responses. After recognizing the major histocompatibility complex (MH