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Philip Ruthig

@philipruthig.bsky.social
169 followers 118 following 64 posts

Staff Scientist @erturklab.bsky.social, passionate neuroscientist, Light sheet microscopist, and Python aficionado.

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Reposted by Philip Ruthig
Prof Bill McGuire @profbillmcguire.bsky.social · 26/08/2026
A direct line can be drawn from the fossil fuel corporation CEOs in their smart suits and swanky offices, to the brutal deaths of the terrified people you can see in these films Himalayan glaciers are collapsing, and meltwater lakes breaching, due to global heating www.bbc.co.uk/news/live/c6...
bbc.co.uk
Hundreds missing, including 291 foreign tourists, after deadly flash flood on Nepal-Tibet border
In Tibet, CCTV captured a wall of mud and water hitting a border crossing. The missing in Nepal include more than 100 from India and 12 from the UK.
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Philip Ruthig @philipruthig.bsky.social · 05/08/2026
Special thanks to the @klaus-tschira-stiftung.de for supporting this initiative!
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Philip Ruthig @philipruthig.bsky.social · 04/08/2026
Got your own (mouse brain-) 3D data from clearing and light sheet imaging, but no idea how to tackle the analysis? We have just the solution for you in Munich: A two-day course on deep learning and VR-assisted segmentation, atlas registration, and so on! Take the course at @erturklab.bsky.social
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Philip Ruthig @philipruthig.bsky.social · 03/08/2026
I entered a contest for a pretty picture! And if you want to help, you can vote for my entry here 😍 awards.helmholtz-imaging.de/site/index.php ("Public Voting" at the top of the site)
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Danielle Beckman @daniellebeckman.bsky.social · 17/06/2026
Not all brains age the same🧐🧠 Using whole-brain 3D imaging combined with spatial proteomics, @erturklab.bsky.social revealed multiple trajectories of cerebrovascular aging. A fascinating new study: biorxiv.org/content/10.6... I'm always excited to share great work from my colleagues! #Neuroscience
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Nature @nature.com · 22/05/2026
Nature research paper: A deep-learning framework reveals whole-body perturbations at cell level go.nature.com/3Pjox61
go.nature.com
A deep-learning framework reveals whole-body perturbations at cell level - Nature
An analysis of diet-induced obesity using MouseMapper—a suite of foundation-model-based deep-learning algorithms—identifies structural alterations of the infraorbital branch of the trigeminal ganglia.
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Ali Maximilian Erturk @erturklab.bsky.social · 15/05/2026
🧠 Does brain aging always mean vessel loss? We found the opposite in some aged brains: maladaptive hypervascularization, linked to cognitive decline and blood-brain barrier damage. Check it out below! www.biorxiv.org/content/10.6...
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Ali Maximilian Erturk @erturklab.bsky.social · 13/05/2026
happy to share our new protocol paper on wildDISCO for whole-body immunolabeling, tissue clearing & 3D imaging of intact mice at cellular resolution using standard IgG antibodies, for mapping of neuronal, vascular, lymphatic and immune systems across the entire body. www.nature.com/articles/s41...
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Philip Ruthig @philipruthig.bsky.social · 08/05/2026
@markuselsner.bsky.social @erturklab.bsky.social
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Philip Ruthig @philipruthig.bsky.social · 07/05/2026
The Ertürk Lab and me are looking for a motivated and skilled Master's Student (with possible PhD extension)! If you are interested in addiction neurobiology, multimodal brain mapping, proteomics, tissue clearing and 3D imaging, please do not hesitate to apply! tinyurl.com/2esspas6
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Philip Ruthig @philipruthig.bsky.social · 04/05/2026
The Ertürk lab is looking for PhD students. Come work with us in Munich :)
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Philip Ruthig @philipruthig.bsky.social · 09/04/2026
New life goal: get fanmail from a student
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Philip Ruthig @philipruthig.bsky.social · 09/03/2026
Be my colleague! :)
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Reposted by Philip Ruthig
Helen Czerski @helenczerski.bsky.social · 09/03/2026
Oil prices wouldn't be all over the news today if more of our economy was powered by local, secure renewable energy. This isn't an "energy crisis". It's a fossil fuel crisis. 44% of UK electricity came from renewables in 2025. More of that plus an electrified economy => no more oil shocks.
Crude oil prices, showing a very sharp increase in the last day, from around 65 to 101 dollars per barrel..
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bryson @brysonm.bsky.social · 09/03/2026
holy shit
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Brandy A Freitas @brandy-syglass.bsky.social · 12/02/2026
❤️ A cleared guinea pig heart for #3DThursday! Clearing a heart is HARD — dense muscle, deep antibody labeling, big volume. But to understand coronary networks, you need the whole organ. 🔬: Miltenyi Ultramiscroscope 🥼: Pam Rios Coronado, @pamrc.bsky.social 🏛️: Red-Horse lab @stanford.edu 🎬: #syGlass
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PLOS Biology @plosbiology.org · 23/01/2026
For the record, an earlier version of this post, using Fig 1 from this paper, but without shorts, fell foul of BlueSky's "Adult Content" filter.
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Philip Ruthig @philipruthig.bsky.social · 23/01/2026
Come work with a great team on one of the big questions at Helmholtz Munich! @helmholtzmunich.bsky.social
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Altmetric @altmetric.com · 08/01/2026
X/Twitter's rough full volume is around 500 total million posts every day, or 182 (and a half) billion posts per year. By contracts, we found 11.2 million research posts in all of 2025 on there. In other words, 0.000006% of Twitter appears to be sharing research. Basically zero.
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Rita Strack @ritastrack.bsky.social · 23/12/2025
Very cool paper in NBT from the Dietz and Erturk labs @erturklab.bsky.social @markuselsner.bsky.social go.nature.com/4gNLjeC
go.nature.com
Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning - Nature Biotechnology
An integrated experimental and deep learning pipeline reveals cell-level targeting of nanocarriers in whole bodies.
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Ali Maximilian Erturk @erturklab.bsky.social · 08/12/2025
Congratulations to our scientist, Laurent Simons, for earning his PhD in quantum physics at just 15—an exceptional achievement. In our lab, Laurent’s work focuses on in silico biology to accelerate treatment of devastating diseases. We’re thrilled to have him on the team.
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Philip Ruthig @philipruthig.bsky.social · 17/12/2025
Super interesting concept!
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Ali Maximilian Erturk @erturklab.bsky.social · 04/11/2025
We are introducing LipiGo 🤗 A programmable DNA–lipid nanocarrier 🧬 with built-in targeting logic. It de-targets the liver and redirects mRNA delivery into lymphoid organs, enhancing therapies requiring the immune system. Precision delivery at the cell level isn't far! www.biorxiv.org/content/10.1...
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LMU Open Science Center @lmu-osc.bsky.social · 10/09/2025
💡 Explore how practices from distributed, open-source software can make science more professional, open, and collaborative! Attend the “Science as amateur software development” lecture by Prof. Dr. @rmcelreath.bsky.social on Wed 17 Sept, 9:00. 👉 Register here: www.pretix.osc.lmu.de/lmu-osc/OSSS...
Promotional poster for the LMU Open Science Center Summer School 2025 Public Lecture. The poster features a photo of speaker Prof. Dr. Richard McElreath. The text states the lecture focuses on science as amateur software development, time and date of lecture being 9:00-10:00 CEST on Wednesday September 17 2025, and instructions to register online. Logos of LMU Open Science Center, LMU, and Universitätsbibliothek München are displayed at the bottom.
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Philip Ruthig @philipruthig.bsky.social · 30/08/2025
Wrote the same thing as a tweetorial on X, got a single interaction with the tweet. I guess it is finally time to leave that place for good
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Philip Ruthig @philipruthig.bsky.social · 26/08/2025
😱
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Reposted by Philip Ruthig
PLOS Biology @plosbiology.org · 22/08/2025
#Myelination enables faster signal propagation in the brain, but takes more energy & space. @philipruthig.bsky.social &co reveal how short- & long-range #WhiteMatter fibers differ, showing how these variations affect neural communication & processing efficiency @plosbiology.org 🧪 plos.io/4mq5tOy
Arrangement of raw data, semantic, and instance segmentation of human corpus callosum fibers, acquired by transmission electron microscopy. The data used for this image were generated by Maria Morozova, David Edler von der Planitz, and Philip Ruthig. All cover Art was created by the MPI for Human Cognitive and Brain Sciences Graphics department (Andrea Sandmann)
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Philip Ruthig @philipruthig.bsky.social · 21/08/2025
That leaves me to thank my excellent co-1st author David Edler von der Planitz, and our collaborators and co-supervisors @siawooshmr.bsky.social, @nikweiskopf.bsky.social, Evgeniya Kirilina, and Markus Morawski! A collaborative project of @mpicbs.bsky.social and @unileipzig.bsky.social!
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Philip Ruthig @philipruthig.bsky.social · 21/08/2025
That concludes the skeetorial - check the full paper @plosbiology.org: plos.io/4mq5tOy
bsky.app
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Philip Ruthig @philipruthig.bsky.social · 21/08/2025
Furthermore, we supply other scientists with the necessary functions that describe our experimental data - important for anyone who might want to simulate brain-wide activity!
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Philip Ruthig @philipruthig.bsky.social · 21/08/2025
Based on this anatomical data, we estimate that corpus callosum fibers conduct signals ~25% faster than short white matter fibers, and show a higher portion of very fast fibers (>8m/s).
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Philip Ruthig @philipruthig.bsky.social · 21/08/2025
In contrast, the g-ratio distribution of both sets of fibers is almost identical!
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Philip Ruthig @philipruthig.bsky.social · 21/08/2025
Additionally, both groups of fibers seems to have a large amount of fibers near the g-ratio of 0.6. This seems to be the equilibrium for long fibers where energy expenditure by the organism, space constraints, velocity and efficiency of signal transduction meet.
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Philip Ruthig @philipruthig.bsky.social · 21/08/2025
We fitted a generalized extreme value function (GEV) to all of the distributions and found that both axon diameter and myelin thickness is downscaled in shorter fibers.
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Philip Ruthig @philipruthig.bsky.social · 21/08/2025
Using a fully automated deep learning analysis, we segmented each structure in the TEM data and analyzed the axonal diameter, myelin thickness, and g-ratio (ratio between axon radius & myelin thickness).
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Philip Ruthig @philipruthig.bsky.social · 21/08/2025
To investigate this issue, we sampled white matter tissue from body donors from a variety of superficial white matter (mostly short fibers) and corpus callosum areas (very long fibers), and prepared them for transmission electron microscopy.
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Philip Ruthig @philipruthig.bsky.social · 21/08/2025
How are human brain regions connected? Are the connecting axons thicker and more myelinated the longer these connecting fibers are? In our recent paper we find that indeed, they are! Read the skeetorial below ⬇️⬇️⬇️ plos.io/4mq5tOy #neuroscience #neuroskyence #whitematter #deeplearning
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Philip Ruthig @philipruthig.bsky.social · 21/08/2025
Out now in @plosbiology.org: our recent study on white matter myelination and axon diameters in long and short fibers of humans! Skeetorial coming soon :)
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Christophe 🔬 Leterrier @christlet.bsky.social · 14/07/2025
When a microscope facility user asks about how to make a red/green overlay
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Markus Elsner @markuselsner.bsky.social · 23/06/2025
Our spin-off company is hiring a COO. (Stay tuned for more job offers) www.linkedin.com/jobs/view/42...
linkedin.com
Deep Piction hiring Chief Operating Officer in Greater Munich Metropolitan Area | LinkedIn
Posted 10:54:20 AM. Chief Operating Officer (COO)Location: Munich, Germany (On-site) Employment Type: Full-timeAbout…See this and similar jobs on LinkedIn.
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☁️ retornam ☁️ @retornam.bsky.social · 21/06/2025
bsky.app/profile/matt...
Meme showing Principal Skinner from
The Simpsons in two frames. 

The first frame has him with the words "Am I out of touch?"

The second frame has him with the words “No it is the entire corpus of human knowledge that is wrong."
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Josh Moore @joshmoore.bsky.social · 11/06/2025
🚀 We’re hiring again! Join @gerbi-gmb.de as a Software Developer! 💻 Build scalable #bioimaging solutions 🌍 Collaborate globally 🎯 Contribute to open science through #OME #Zarr 📣 Tell your #NGFF friends. Remote, full-time. Apply by 30 June 2025: All submissions via bit.ly/gerbi-jobs-2...
Screenshot of the PDF available at https://cloud.gerbi-gmb.de/s/6LrYfMByymPnHP5/download/2025_OME-Zarr_sw_developer.pdfScreenshot of the PDF available at https://cloud.gerbi-gmb.de/s/y4rBGFM6dXn8Jkr/download/2025_OME-Zarr_web_developer.pdf
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Karl Deisseroth @deisseroth.bsky.social · 30/05/2025
Congratulations to our Human Neural Circuitry team; bit.ly/4dEyX7Z publishes today in Science! This was the hardest challenge of my career, but one of the most rewarding, after years of rebuilding– & expanding my inpatient neuropsychiatry in the service of basic discovery bsky.app/profile/deis...
bit.ly
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Philip Ruthig @philipruthig.bsky.social · 20/05/2025
Signs I am, indeed, living in Munich, pt 1: I just paid 9€ for a pretzel and croissant.
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Philip Ruthig @philipruthig.bsky.social · 18/05/2025
Definitely going to, soon!
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Blake Richards @tyrellturing.bsky.social · 12/05/2025
+1000 I think AI will help us do scientific research in numerous ways, but the bulk of the work that real scientists do is not anything that "AI scientists" will be able to do.
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Philip Ruthig @philipruthig.bsky.social · 07/05/2025
📌
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Jo Wolff @jowolff.bsky.social · 03/05/2025
Every now again it’s useful to repeat advice about accessing papers that are behind a paywall that excludes you. Email the author. My estimate is that 90% of academics are so thrilled that a living, breathing, possibly even reading, person shows interest that they will swiftly send you a copy.
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Philip Ruthig @philipruthig.bsky.social · 17/04/2025
One of the undisputed scientific wins of the last few years.
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Philip Ruthig @philipruthig.bsky.social · 10/04/2025
Can wholeheartedly recommend the city, place and people to motivated to-be phd students! Don't hesitate to apply 👏👏
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