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Blake Russell

@neurorussell.bsky.social

PhD student in Lak Lab & lecturer @ the University of Oxford. Using multiphoton optogenetics and Neuropixels simultaneously to study how perceptual signals propagate through the brain. Freelance 3D animation. DM for a quote

Posts Replies Media

Reposted by Blake Russell

Armin Lak @laklab.bsky.social · 24/04/2026

We have new a new doctor in the lab 🍾🍾🎉Congratulations @neurorussell.bsky.social for successful viva today at Oxford @oxforddpag.bsky.social

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Blake Russell @neurorussell.bsky.social · 26/01/2026

Out today in Neurophotonics, we show that cross-talk between the imaging laser and opsin in all-optical experiments can affect response dynamics beyond what has been accounted for. Imaging conditions subthreshold for evoking spikes can accelerate opsin desensitization: doi.org/10.1117/1.NP...

doi.org

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Reposted by Blake Russell

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 04/10/2025

Desensitization of opsin responses during all-optical interrogation depends on imaging parameters www.biorxiv.org/content/10.1101/202…

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Blake Russell @neurorussell.bsky.social · 15/10/2025

🚨New pre-print!🚨 Can we truly independently read and write neuronal activity at the same time using all-optical techniques? Here we show that even two-photon imaging over large fields of view with low dwell time per cell can bias neural dynamics! Read on for some potential fixes: (1/5)

biorxiv.org

Desensitization of opsin responses during all-optical interrogation depends on imaging parameters

Significance The combination of two-photon calcium imaging and two-photon optogenetic stimulation, termed all-optical interrogation, provides spatial and temporal precision when recording and manipula...

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Reposted by Blake Russell

Armin Lak @laklab.bsky.social · 12/10/2025

All-optical experiments are great but @neurorussell.bsky.social found that opsin desensitization due to cross-talk between the imaging laser and the opsin causes major issues. These can be ameleorated with long inter-stimulus intervals & short imaging doses. All here: www.biorxiv.org/content/10.1...

biorxiv.org

Desensitization of opsin responses during all-optical interrogation depends on imaging parameters

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