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Prof Paul E Squires

@paulsquires.bsky.social
1K followers 257 following 17 posts

Prof of Biomedical Science with interests in diabetes, cardiorenal & kidney disease, connexins & cell-cell contact, coupling & communication. Views are my own. 👨‍🔬🔬🇬🇧 #cardiosky #nephsky #diabetes #cardiorenal

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Reposted by Prof Paul E Squires
Prof Claire Hills @chillslincoln79.bsky.social · 26/01/2026
No work in sight for the next 5 days 🥳🥳🥳. Salcombe birthday celebrations for the legend that is @paulsquires.bsky.social #Salcombe #SalcombeHarbourHotel ##AnnualLeave #Academic #Lifeofanacadenic #Academia #England #Devon
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ASN Publications @asnpublications.bsky.social · 27/11/2025
This #ASNCJASN study analyzed the effects of empagliflozin, a diabetes medication, on kidney function in young people with type 2 diabetes (T2D), suggesting that empagliflozin may help prevent early diabetic kidney disease in youth with T2D. Read more: kidney.pub/CJASN0889
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Paul A. Welling, MD @pawellingmd.bsky.social · 27/11/2025
Mechanistic target of rapamycin complex-2 (mTORc2) mediates the effect of over-night high K+ on Kir4.1/Kir4.1 in the DCT and ENaC/ROMK in ASDN. | American Journal of Physiology-Renal Physiology | American Physiological Society journals.physiology.org/doi/abs/10.1...
journals.physiology.org
Mechanistic target of rapamycin complex-2 (mTORc2) mediates the effect of over-night high K+ on Kir4.1/Kir4.1 in the DCT and ENaC/ROMK in ASDN. | American Journal of Physiology-Renal Physiology | Amer...
We examine the role of mTORc2 in mediating overnight-high-K+-(HK)-intake-induced stimulation of renal-outer-medullary-K+-channels (ROMK) in late distal-convoluted-tubule DCT2)/early connecting-tubule ...
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Niro Siriwardena @nsiriwardena.bsky.social · 27/11/2025
Power relations and role boundaries between community first responders and ambulance clinicians in England: a qualitative study - power relations, hierarchy and role boundaries, characterised by subordination of CFRs and collaborative relationships between ambulance staff and CFRs rdcu.be/eR6fK
rdcu.be
Power relations and role boundaries between community first responders and ambulance clinicians in England: a qualitative study
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Julien Ochala @droch.bsky.social · 04/07/2025
Our department @ucph.bsky.social is looking for a new faculty member! This is a nice environment for an ambitious PI with a research focus on cardiovascular system, metabolism and/or drug discovery! Happy to answer questions if you are interested!
jobportal.ku.dk
164414 Tenure Track Assistant Professor or Associate Professor of Biomedical Sciences
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Prof Claire Hills @chillslincoln79.bsky.social · 11/07/2025
Wedding Vibes 👰🤵‍♂💒💍 with @paulsquires.bsky.social ..it was a hot one ☀️☀️☀️ #ArdingtonHouse #Oxfordshire #womeninSTEM #annualleave #summertime #UK #Cotswolds #wedding
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Adam Braithwaite @braithwaiteat.bsky.social · 03/07/2025
Stimulating immune cells in vitro is a common experimental lab model. We profiled 150K blood immune cells treated with 11 different stimuli to compare the effects. The data are freely available for researchers. See the preprint for our findings and to access the data 🧪 doi.org/10.1101/2025...
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Struan Grant @struangrant.bsky.social · 24/04/2025
Delighted to have contributed to this editorial diabetesjournals.org/diabetes/art...
diabetesjournals.org
Accelerating Medicines Partnership in Type 2 Diabetes and Common Metabolic Diseases: Collaborating to Maximize the Value of Genetic and Genomic Data
In the last two decades, significant progress has been made toward understanding the genetic basis of type 2 diabetes. An important supporter of this resea
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Prof Paul E Squires @paulsquires.bsky.social · 13/03/2025
Fantastic article to celebrate the contribution of our very own @chillslincoln79.bsky.social to some amazing work on #worldkidneyday, see: news.lincoln.ac.uk/2025/03/13/l...
news.lincoln.ac.uk
Lincoln Professor Helping Shape the Future of Diabetic Kidney Disease Research | News and PressPrevious posts arrow navigation.Next posts arrow navigation.
Browse through a range of inspiring news stories from the University of Lincoln, featuring leading research, campus events, and student and alumni success stories.
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Francis Lynn 🇨🇦 @nictitate.bsky.social · 15/02/2025
I have funding through at least 2031 for postdoctoral researchers with expertise in islet biology or cell-based therapies for, or modelling of, diabetes. Bring your expertise to a country that values it. 🇨🇦 Contact info on my website.
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Bruce Verchere @bruceverchere.bsky.social · 10/02/2025
Fantastic opportunity for fellowship in an excellent T1D research training environment working in regenerative medicine and stem cells in the Breakthrough T1D Centre of Excellence at UBC. If you missed the NOI deadline, no worries, you can still apply! Reach out if you have any questions.
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Prof Claire Hills @chillslincoln79.bsky.social · 16/02/2025
Effect of #sotagliflozin on major adverse cardiovascular events: a prespecified secondary analysis of the SCORED randomised trial 👩‍🔬🥼🧪👨‍🔬 #cardiosky #SGLT2i #SGLT1/2 #cardiovascular #womeninstem #NephSky 👇👇👇 www.thelancet.com/journals/lan...
thelancet.com
Effect of sotagliflozin on major adverse cardiovascular events: a prespecified secondary analysis of the SCORED randomised trial
Sotagliflozin reduced MACE, with independent reductions in myocardial infarction and stroke, among patients with type 2 diabetes, chronic kidney disease, and additional cardiovascular risk. The ischae...
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Prof Claire Hills @chillslincoln79.bsky.social · 16/02/2025
A sunday night worth celebrating with @paulsquires.bsky.social after a busy, busy week 🥂🍾. Hopeful that good news will follow 👩‍🔬👨‍🔬🧪 #justbecause #cardiosky #NephSky #womeninSTEM #academic #weekendvibes #champagne ##KidneyResearch #CardioRenal #Cardiovascular
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Prof Claire Hills @chillslincoln79.bsky.social · 02/02/2025
Birthday boy cotswolds celebrations 🥳🥳 @DoubleRedDuke with @paulsquires.bsky.social 🥰🥰 #birthday #cotswolds #England #annualleave #womeninSTEM
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Prof Claire Hills @chillslincoln79.bsky.social · 28/01/2025
📣 Novo Nordisk announces that the FDA has granted approval to its blockbuster drug Ozempic (semaglutide) to treat chronic kidney disease (CKD) in adults with type 2 diabetes. 👩‍🔬🥼🧪👨‍🔬 #Semaglutide #diabetes #type2diabetes #nephropathy #GLP-1 👇👇 docwirenews.com/post/fda-app...
docwirenews.com
FDA Approves Ozempic for Kidney Disease | Docwire News
Based on FLOW trial results, the FDA has approved Ozempic (semaglutide) to treat chronic kidney disease (CKD) in adults with type 2 diabetes.
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Prof Claire Hills @chillslincoln79.bsky.social · 29/01/2025
📣 Semaglutide in patients with overweight or obesity and chronic kidney disease without diabetes: a randomized double-blind placebo-clinical trial @naturemedicine.bsky.social 👩‍🔬🥼🧪👨‍🔬 #Semaglutide #KidneyDisease #Obesity #kidney #NephroSky #CardioSky #NephSky 👇👇👇 pubmed.ncbi.nlm.nih.gov/39455729/
pubmed.ncbi.nlm.nih.gov
Semaglutide in patients with overweight or obesity and chronic kidney disease without diabetes: a randomized double-blind placebo-controlled clinical trial - PubMed
Semaglutide reduces albuminuria and the risk of kidney disease progression in patients with type 2 diabetes and chronic kidney disease (CKD). We conducted a randomized placebo-controlled double-blind ...
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Prof Paul E Squires @paulsquires.bsky.social · 29/01/2025
BBC News - Meon Vale mother of three who needs kidney makes donor appeal - BBC News www.bbc.co.uk/news/article...
bbc.co.uk
Meon Vale mother of three who needs kidney makes donor appeal
Amber Simmonds, 29, has lived with hereditary polycystic kidney disease (PKD) since she was 13.
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National Kidney Foundation @kidney.org · 28/01/2025
BREAKING NEWS: The FDA has approved Ozempic for patients with chronic kidney disease. This means the popular injection can be used to reduce the risk of kidney disease worsening, kidney failure and death from cardiovascular disease in patients with chronic kidney disease and diabetes.
cnbc.com
FDA approves Novo Nordisk's Ozempic to treat chronic kidney disease in those with diabetes, expanding its use
Expanded Ozempic approval in the U.S. could transform how doctors treat patients with chronic kidney disease, which involves a gradual loss of kidney function.
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Prof Claire Hills @chillslincoln79.bsky.social · 25/01/2025
Congratulations @cardiacshah.bsky.social & co-author @jo-ward08.bsky.social from team #CardioRenal on publication of this all important review - incorporating clinical guidelines with latest evidence & experience in the management of T2DM in patients with ASCVD 🥳🥳🥳🥳. #diabetes #CardioSky #NephSky
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Prof Claire Hills @chillslincoln79.bsky.social · 23/01/2025
Beautiful #Salcombe, it never disappoints. The perfect place to switch off and unwind with @paulsquires.bsky.social 🥰🥰 #Lifeofanacademic #AcademicSky ##CardioSky #WomeninSTEM #England #Devon #SalcombeHarbour #Coastal #Coastline #NephroSky
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Prof Claire Hills @chillslincoln79.bsky.social · 22/01/2025
📣 Congratulations to my PhD student @cardiacshah.bsky.social on his review 'Diagnosis & management of type 2 diabetes mellitus in patients with ischaemic heart disease & acute coronary syndromes - a review of evidence & recommendations' 👇👇 #CardioSky #diabetes www.frontiersin.org/journals/end...
frontiersin.org
Frontiers | Diagnosis and management of type 2 diabetes mellitus in patients with ischaemic heart disease and acute coronary syndromes - a review of evidence and recommendations
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Prof Claire Hills @chillslincoln79.bsky.social · 18/01/2025
Checking out of all things work for the next 9 days with @paulsquires.bsky.social. Heading to Salcombe for sea air, coastal walks and yummy food and wine 🫒🍲🥖🥂🍷. Stay tuned for glorious pictures of the English Coast 🌊🌊 #FancyPants are on 😉 #WomeninSTEM #Weekend #Salcombe #England #Coastal
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Prof Claire Hills @chillslincoln79.bsky.social · 20/01/2025
Bracing but beautiful day in Salcombe with @paulsquires.bsky.social ❤️ #Salcombe #Devon #AnnualLeave #womeninSTEM #CardioSky #NephroSky
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Prof Claire Hills @chillslincoln79.bsky.social · 16/01/2025
Our special issue for DiabeticMedicine entitled 'From Bench to Bedside: An integrated and multi-disciplinary approach to tackling diabetic kidney disease' is available online now. 👇👇 #KidneyDisease #Diabetes #NephSky #KidneyResearch #Diabetes #CardioSky onlinelibrary.wiley.com/toc/14645491...
onlinelibrary.wiley.com
<em>Diabetic Medicine</em> | Diabetes UK Journal | Wiley Online Library
Click on the title to browse this issue
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Prof Claire Hills @chillslincoln79.bsky.social · 11/01/2025
A glorious walk today, albeit a slightly freezing day in Kenilworth. ❄️❄️❄️ #academicsky #cardiosky #nephsky #Warwickshire #saturday #countrylife #womeninSTEM
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Prof Claire Hills @chillslincoln79.bsky.social · 08/01/2025
3 days back at work. Let's just say this wine is well deserved 🤣🤣. Thank heavens I have @paulsquires.bsky.social by my side to keep me sane 😬 #WomeninStem #cardiosky #Nephsky #academiclife #drama #womeninnephro
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Lee Roberts @leerobertslab.bsky.social · 03/01/2025
Metabolite-mediated inter-tissue signalling. Led by Jane Luk & Mark Kearney @unileedsnews.bsky.social in @naturecomms.bsky.social we identify malonic acid as an IGF1R-regulated endothelial-to-adipocyte metabokine mediating adipose metabolism. Great start to 2025. www.nature.com/articles/s41...
nature.com
Paracrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice - Nature Communications
Here the authors show that lowering IGF-1R levels in endothelial cells improves insulin sensitivity, boosts energy use, and supports beneficial changes in adipose tissue, offering insights into potent...
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Prof Claire Hills @chillslincoln79.bsky.social · 02/01/2025
Interested in #GLP-1 , #Semaglutide #cardiovascular and #kidneydisease ? 👩‍🔬🥼🧪🧪Just out @thelancet.bsky.social 👇👇. Thanks for sharing @paulsquires.bsky.social 👍 #CardioSky #NephSky #diabetes #kidneys #womeninSTEM
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Prof Paul E Squires @paulsquires.bsky.social · 02/01/2025
Great read to start 2025 #GLP1 #semaglutide #diabetes #diabetesuk #cardiorenal #GLP1RA www.thelancet.com/journals/lan...
thelancet.com
Effects of GLP-1 receptor agonists on kidney and cardiovascular disease outcomes: a meta-analysis of randomised controlled trials
We found evidence that GLP-1 receptor agonists significantly reduce clinically important kidney events, kidney failure, and cardiovascular events.
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Prof Paul E Squires @paulsquires.bsky.social · 24/12/2024
#BHF #diabetes #T2DM #trials #DUK Exciting use of #AI in diabetes diagnosis. BBC News - Hospitals trial AI to spot type 2 diabetes risk www.bbc.com/news/article...
bbc.com
Hospitals trial AI to spot type 2 diabetes risk
The system checks patients' ECG heart traces for subtle early warning signs.
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Prof Paul E Squires @paulsquires.bsky.social · 17/12/2024
What a Christmas present #KRUK #nephsky #kidneydiseae #kidneytransplant BBC News - 'My former work colleague gave me her kidney' www.bbc.com/news/article...
bbc.com
Manchester: 'My former work colleague gave me her kidney'
Jamie Lonsdale made a donor plea on Facebook and was delighted when Lauren Lane answered the call.
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Prof Paul E Squires @paulsquires.bsky.social · 14/12/2024
Following my last post. Inspired. Applications for small grants in #T1DM NOW OPEN. #diabetes #diabetesresearch 👀 👇👇👇 bit.ly/49zskBz
bit.ly
Breakthrough T1D UK Small Grant Awards | Breakthrough T1D UK
Our Small Grant Awards offer funding of up to £30,000 for a maximum of 12 months, for UK-based early career researchers.
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Prof Paul E Squires @paulsquires.bsky.social · 14/12/2024
An inspiring story from a brave young lady. #diabetes #womeninstem #T1DM #inspire BBC News - A life-changing device for diabetics www.bbc.com/news/article...
bbc.com
A life-changing device for diabetics
Read the winning essay from the Young Science Writer of the Year 2024 award
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Prof Paul E Squires @paulsquires.bsky.social · 13/12/2024
It's beginning to look a lot like Christmas #Cotswolds #lifeofanacademic #academicsky #Christmas #cotswoldlife
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European Association for the Study of Diabetes @easdnews.bsky.social · 11/12/2024
Applications for the inaugural EASD Diabetes Technology School are now open! This 3-day event is ideal for healthcare professionals looking to gain expertise in the latest #diabetes technology. Apply by 16 January 2025 👉https://www.easd.org/education/diabetes-tech-school.html #DiabetesCare #CGM #AID
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Aylwyn Scally @aylwyn-scally.bsky.social · 02/12/2024
Applications open for several research positions here in Cambridge including evolutionary genetics, genomics and population genetics. www.jobs.cam.ac.uk/job/49389/
jobs.cam.ac.uk
Associate Professor / Professor of Evolutionary Genomics - Job Opportunities - University of Cambridge
Associate Professor / Professor of Evolutionary Genomics in the Department of Genetics at the University of Cambridge.
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Prof Claire Hills @chillslincoln79.bsky.social · 01/12/2024
Trying to remember I've still got 3 weeks worth of work to do before the festive break (& a preliminary grant application)....feeling oh so twinkly and magical today however✨️👩‍🔬 🎄🎅🥼👨‍🔬🧪🌲🧑‍🎄 #Christmas #Christmastree #AcademicSky #WomeninSTEM #Christmasdecorations #WomeninNephro #nephrosky #cardiosky
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Prof Claire Hills @chillslincoln79.bsky.social · 29/11/2024
GRANT SUBMITTED 🥳🥳🥳. First #Snowball of the season to celebrate....tomorrow the tree goes up 🎄🌲🎅🎄. Looking forward to some festive ✨️. It's been a tough few weeks 🤪 #AcadmicSky #CardioSky #NephSky #christmas #academiclife #festive #snowball #womeninSTEM #weekendvibes #Christmastree
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Prof Claire Hills @chillslincoln79.bsky.social · 28/11/2024
Crosstalk of Hyperglycaemia and Cellular Mechanisms in the Pathogenesis of Diabetic Kidney Disease 👩‍🔬🧪🥼👨‍🔬 #diabetes #nephropathy ##nephrology #kidneydisease #NephSky #type2diabetes 👇👇👇 www.mdpi.com/1422-0067/25...
mdpi.com
Crosstalk of Hyperglycaemia and Cellular Mechanisms in the Pathogenesis of Diabetic Kidney Disease
Among all nephropathies, diabetic kidney disease (DKD) is the most common cause of kidney impairment advancement to end-stage renal disease (ESRD). Although DKD has no cure, the disease is commonly ma...
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Brendon Neuen @brendonneuen.bsky.social · 27/11/2024
In people with T2D, effects of GLP1-RA on CV, kidney & mortality outcomes are consistent irrespective of SGLT2i Our meta-analysis of the 3 GLP1RA diabetes clinical outcome trials with the largest prevalent use of SGLT2i in @ahajournals.bsky.social Circulation www.ahajournals.org/doi/10.1161/...
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Prof Paul E Squires @paulsquires.bsky.social · 27/11/2024
Younger-onset compared with later-onset type 2 diabetes: an analysis of the UK Prospective Diabetes Study (UKPDS) with up to 30 years of follow-up (UKPDS 92) #diabetes #T2DM #type2diabetes #MedSky 👇👇 www.thelancet.com/journals/lan...
thelancet.com
Young adult-onset type 2 diabetes heralds a poor prognosis
Younger-onset type 2 diabetes is rapidly increasing in prevalence, with the majority presenting in adulthood aged 18–39 years.1 This change in diabetes topography presents a challenge to health-care p...
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Henry Han @hancardiomd.bsky.social · 24/11/2024
#DAPA-HF & #DELIVER pooled analysis: #Dapagliflozin reduced new-onset diabetes by 33% (HR 0.67; P=0.012) in HF patients without DM (n=5623). Meta-analysis of 7 RCTs (n=17,855): #SGLT2i reduced new-onset DM by 26% (HR 0.74; P<0.001) in CV/kidney disease academic.oup.com/eurheartj/ad...
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Prof Claire Hills @chillslincoln79.bsky.social · 26/11/2024
Efficacy and Safety of Sotagliflozin in Patients with Type 1 Diabetes and CKD. 👩‍🔬🔬🧪🥼👨‍🔬. #Type1diabetes #kidneydisease #Nephropathy #SGLT2i #cardioseq #nephseq #cardiorenal. Full details 👇👇👇 journals.lww.com/jasn/abstrac...
journals.lww.com
Efficacy and Safety of Sotagliflozin in Patients with Type... : Journal of the American Society of Nephrology
ssess the effects of sotagliflozin (200mg [inTandem 1&2 only] or 400mg daily) versus placebo on glycated hemoglobin (HbA1c; primary endpoint), body weight, systolic blood pressure (BP), insulin dose, ...
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Prof Claire Hills @chillslincoln79.bsky.social · 26/11/2024
More coverage around Semaglutide and it's ability to reduce kidney disease progression by 22% and cardiovascular risk in an analysis involving >85,000 👩‍🔬🧪🥼👨‍🔬. #GLP-1 #semaglutide #diabetes #kidneydisease #Nephropathy #CardioSky #NephSky #MedSky 👇👇👇 www.theguardian.com/science/2024...
theguardian.com
Weight-loss drugs can improve kidney health, study finds
Analysis involving more than 85,000 people showed risk of worsening function was reduced by 22%
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Prof Claire Hills @chillslincoln79.bsky.social · 26/11/2024
Cellular atlases are unlocking the mysteries of the human body @natureportfolio.bsky.social 👩‍🔬🥼👨‍🔬🧪 #MedSky #CardioSky #proteome #CellAtlas #NephSky 👇👇👇 www.nature.com/articles/d41...
nature.com
Cellular atlases are unlocking the mysteries of the human body
Scientists reflect on insights from the Human Cell Atlas.
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Nephrology Times @nephtimes.bsky.social · 26/11/2024
The FLOW trial was still producing results at #KidneyWk last month, including findings of an analysis of data assessing #kidney outcomes by #CKD severity. #nephrology #kidneydisease
buff.ly
FLOW Trial Results Categorized by CKD Severity | Docwire News
FLOW trial data showed that semaglutide safely reduced risks of major kidney outcomes regardless of chronic kidney disease (CKD) severity.
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Prof Claire Hills @chillslincoln79.bsky.social · 26/11/2024
Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants 👩‍🔬🔬🥼 #Diabetes #Type1diabetes #Type2diabetes #MedSky #Lancet Full details 👇 www.thelancet.com/journals/lan...
thelancet.com
Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants
In most countries, especially in low-income and middle-income countries, diabetes treatment has not increased at all or has not increased sufficiently in comparison with the rise in prevalence. The bu...
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Prof Claire Hills @chillslincoln79.bsky.social · 25/11/2024
A morning mooch round glorious Bath with @paulsquires.bsky.social ❤️. The perfect mini break to recharge the batteries and the ☀️☀️ even decided to make an appearance 🙏🙌 #AcademicLife #AcademicSky #Bath #Somerset #Cotswolds #cardiosky #NephSky #AnnualLeave
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Prof Claire Hills @chillslincoln79.bsky.social · 25/11/2024
ISN Webinar: How GLP1 receptor agonist evolved from weight management drugs to kidney protective therapy? Speakers Katherine Tuttle and Peter Rossing 👩‍🔬🔬🥼🧪👨‍🔬 #NephSky #NephroSky #CardioSky #cardiorenal #cardiovascular #kidneydisease #diabetes #GLP-1 Full details 👇 www.theisn.org/blog/event/i...
theisn.org
ISN Webinar: How GLP1 receptor agonist evolved from weight management drugs to kidney protective therapy? - International Society of Nephrology
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Prof Claire Hills @chillslincoln79.bsky.social · 24/11/2024
New approaches to acute kidney injury 👩‍🔬🧪👨‍🔬🥼 #kidneydisease #kidneyinjury #AKI #NephroSeq #CardioSeq Full details of new publication 👇👇👇 academic.oup.com/ckj/article/...
academic.oup.com
New approaches to acute kidney injury
ABSTRACT. Acute kidney injury (AKI) is a common and serious clinical syndrome that involves complex interplay between different cellular, molecular, metabo
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