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Patrik Rödin Mörch

@patrikrodinmorch.bsky.social
265 followers 533 following 1 posts

Genomics, evolution, conservation. Post-doc at Uppsala University.

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Reposted by Patrik Rödin Mörch
Vertebrate Genomes Project @vertebrategenomes.bsky.social · 10/09/2026
Meet the hellbender, North America’s biggest salamander, a walking water quality test, and the owner of a genome 16x bigger than that of human beings.
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Vertebrate Genomes Project @vertebrategenomes.bsky.social · 06/08/2026
We are excited to officially share the first fully phased telomere-to-telomere (T2T) reference genome for a songbird! 🐦 www.cell.com/cell/fulltex...
manuscript alert

The Complete Genome of a Songbirda major milestone in bird genomics

This new genome closes nearly all previous gaps, including complex heterochromatic regions, microchromosomes, and sex chromosomes. Built using a combination of PacBio HiFi long reads, ONT ultra-long reads, Arima Genomics Hi-C reads for chromosome scaffolding, and Illumina parental short reads for haplotype phasing, this T2T assembly provides an unprecented view of the zebra finch genome and advances research of vocal learning and evolution.featured in a special issue in Cell

Images:
- Article title and authors
- QR code for manuscript
- Cell T2T issue cover
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Kieran Samuk @ksamuk.bsky.social · 03/08/2026
Just posted: a group paper describing major updates to my software pixy, for population genetic summary statistics. www.biorxiv.org/content/10.6... New since 2021: arbitrary ploidy, multiallelic sites, missingness-aware Watterson's θ and Tajima's D, Hudson's FST, multicore execution!
Alt text: Schematic of the pixy workflow. Left, inputs: a bgzipped, tabix- or CSI-indexed VCF with callable sites supplied as an all-sites VCF or gVCF blocks, a populations file, and optional BED and sites files. Centre, core: windowing by fixed width, BED or region; statistic selection; options for Hudson's FST, multiallelic SNPs, automatic ploidy detection and multicore execution. Right, outputs: one TSV per statistic for pi, dxy, FST, Watterson's theta and Tajima's D, with raw count columns for exact aggregation. Bottom, development: GitHub fork and pull request, local checks with ruff, mypy and pytest, continuous integration across Python 3.10 to 3.14, and distribution through conda-forge. Features new since the 2021 release are badged "new".
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Eleonore Susi @eleonoresusi.bsky.social · 23/07/2026
We are happy to share with everyone our new pre-print on the immunogenetic and microbiome diversity of two anuran species. Go check it out🐸 doi.org/10.64898/202...
doi.org
Latitudinal Patterns in Immunogenetic and Microbiome Diversity in two anuran species: Bufo bufo and Bufo spinosus
Evolutionary and demographic processes such as selection, drift and migration shape the genetic variation of populations. Genetic diversity is often lower in populations toward higher latitudes. This ...
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Joanna Masel @joannamasel.bsky.social · 03/06/2026
Our new paper doi.org/10.1098/rspb... on long-term genetic threats to small populations finds that "mutational meltdown" (bad mutations fixing) is less of a problem than "mutational drought" (too few good new mutations) @wmawass.bsky.social @uliseshmc.bsky.social @jeremyjberg.bsky.social 1/5
doi.org
Extinction vortices are driven more by a shortage of beneficial mutations than by deleterious mutation accumulation
Abstract. Habitat loss contributes to extinction risk in multiple ways. Genetically, small populations can face an ‘extinction vortex’—a positive feedback
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Katharina Hoff @katharinahoff.bsky.social · 11/04/2026
1/ BRAKER4 hatched! The Earth BioGenome Project is on track to sequence ~1.5M eukaryotic species. Every one needs a structural annotation. No Perl monolith was going to survive that. So we rewrote BRAKER from the ground up. github.com/Gaius-August...
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Centre for Palaeogenetics @cpgsthlm.bsky.social · 03/06/2026
🧬 New paper in Cell! Analysis of 12 cave lion genomes shows that cave lions and modern lions may have diverged more than three times earlier than previously thought – as early as 1.7 million years ago! AND…they interbred when temperatures dropped! Paper: www.cell.com/cell/fulltex... 🧵 1/9
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Tony Gamble @tonygamble.eurosky.social · 30/05/2026
“We demonstrate perfect concordance with minimap2, enabling its backwards compatibility as a drop-in replacement for minimap2-based workflows.” ‼️
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Dr Tiffany Kosch 👩‍🔬 🤿🐸🧬 @tiffanykosch.bsky.social · 21/11/2025
Over 41% of amphibian species are threatened with extinction. The challenges they face are huge—but so are the successes. I'm honored to contribute to this new paper offering a rare optimistic look at amphibian conservation. 👉rdcu.be/eQPL7
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Will Booker @wbooker.bsky.social · 23/03/2026
It took forever but my last paper as an academic is finally out. ironically this paper probably has the smallest audience, but I believe is my most impactful work. I think it provides some nice support for theories on polyploid origins, and has practical implications in crops and conservation
academic.oup.com
Recombination and the role of pseudo-overdominance in polyploid evolution
Abstract. Natural selection is an imperfect force that can under some conditions fail to prevent the buildup of deleterious mutations. Small population siz
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The American Genetic Association @theaga.bsky.social · 25/04/2026
Here's a genome from the Vertebrate Genomes Project (vertebrategenomespro...): a chromosome-level assembly for the false killer whale (Pseudorca crassidens)! 🐋 This resource advances cetacean research and conservation. Photo: Stefan Thiesen Buntrabe 1/2
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Mozes Blom @moosblom.bsky.social · 27/04/2026
🚨 Wanted: PhD student excited about population genomics, Natural History Collections and birds! 📍 Museum für Naturkunde, Berlin, Germany 🕒 3 Years, funded by the Leibniz Junior Researchgroup program Details and Application portal 👇 jobs.museumfuernaturkunde.berlin/jobposting/d...
jobs.museumfuernaturkunde.berlin
12/2026 PhD student (f/m/d)
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Oded Rechavi @odedrechavi.bsky.social · 27/04/2026
Super awesome paper 👇Coalescence and translation: A language model for population genetics | PNAS www.pnas.org/doi/10.1073/...
pnas.org
Coalescence and translation: A language model for population genetics | PNAS
Probabilistic models such as the sequentially Markovian coalescent have long provided a powerful framework for population genetic inference, enabli...
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Scott V. Edwards @scottvedwards.bsky.social · 22/04/2026
Ver excited to share my just-published Darwin Review with @lh3lh3.bsky.social on population-scale long-read sequencing! royalsocietypublishing.org/rspb/article...
royalsocietypublishing.org
Population-scale long-read DNA sequencing: peering under the hood of the new evolutionary genomics
Abstract. Population-scale long-read DNA sequencing (PLRS) is rapidly reshaping our understanding of genomic variation in humans and non-model species. In
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Per Alström @peralstrom.bsky.social · 17/03/2026
Check our Open Access paper on the Tokara Leaf Warbler – a previously undescribed, threatened Japanese bird: doi.org/10.1093/pnas... Thx to all coauthors: Takema Saitoh, @dariashipilina.bsky.social. Shin-Ichi Seki, Canwei Xia, Lijun Zhang & Urban Olsson. @animecol-uu.bsky.social #birds #biodiversity
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Patrícia Pečnerová @patriciachrzan.bsky.social · 16/04/2026
Can you believe that until now there were more genomes sequenced for the woolly mammoth than for living African elephants? Today, we bring you the first genomic, continent-scale analyses of 232 high-quality genomes of both species, the savanna and forest elephant. www.nature.com/articles/s41...
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Hernán E. Morales @hernmoral.bsky.social · 15/04/2026
Happy to see this one out! Not only for the science, but because it was the first project we led as a group. This paper helped us establish a collaborative culture and good relationships, shaping how we want to work together in the future. I feel lucky to work with this bunch! #popgen #consgen
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Animal Ecology Uppsala @animecol-uu.bsky.social · 08/04/2026
We have a new exiting PhD position in our program on the skin microbiome of amphibians, supervised by @cortazar-chinarro.bsky.social! Follow the link to read more and apply: www.uu.se/en/about-uu/.... Deadline the 8th of May.
uu.se
PhD in Evolutionary Ecology and genomics - Uppsala University
PhD in Evolutionary Ecology and genomics, Department of Ecology and Genetics, Uppsala University
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Elin Videvall @elinvidevall.bsky.social · 07/04/2026
New review paper on bird #microbiome methods out! Bridging the gap: improving methodologies for future avian microbiome research 🐦🦠🧬 #OA @avianbiology.bsky.social @charlisdavies.bsky.social @kbodawatta.bsky.social nsojournals.onlinelibrary.wiley.com/doi/10.1002/...
nsojournals.onlinelibrary.wiley.com
Bridging the gap: improving methodologies for future avian microbiome research
Recent advances in the field of wild avian microbiome research have significantly deepened our understanding of the eco-evolutionary dynamics of bird–microbe interactions. Consequently, the field is ...
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Hernán E. Morales @hernmoral.bsky.social · 23/03/2026
🚨 Postdoc in conservation genomics & experimental evolution (Copenhagen) Join us explore questions on gene editing for biodiversity conservation 🔬 Required: exp in experimental evolution (ideally C. elegans) 📅 1-year pos ⏰ Dline: April 6 employment.ku.dk/faculty?show... @hologenomics.bsky.social
employment.ku.dk
Postdoctoral position in conservation genomics and experimental evolution at Hologenomics Section, Globe Institute
The Hologenomics Section, Globe Institute, University at Copenhagen, is looking for a dedicated and enthusiastic postdoctoral researcher to join our team. This position is part of the research project “Back from the Brink: experimental de-extinction in a model-organism to restore lost diversity”, funded under the Villum Experiment Programme. The project explores the potential of gene editing technologies for conservation using an experimental setting, the risks and consequences for the management of genetically vulnerable populations. Duration: one year.
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Earth BioGenome Project 🌍 @ebpgenome.bsky.social · 18/02/2026
🌍✨ Why sequence amphibian genomes? 🚨 More than 40% of amphibian species are at risk of extinction. 🧬 Their genomes reveal vulnerability, resilience, and adaptive potential — helping conservation act before populations are lost. 🐸 Proteger a los anfibios es proteger el futuro de la biodiversidad. 💻🧬
Alt EN: Colorful collage of diverse amphibians including frogs, salamanders, newts, caecilians, and an axolotl arranged on a black background. Text on image: "Why sequence amphibian genomes?"
Alt ES: Collage colorido de diversos anfibios incluyendo ranas, salamandras, tritones, cecilias y un ajolote sobre un fondo negro. Texto en la imagen: "¿Por qué secuenciar los genomas de los anfibios?"Alt EN: A tiny brown frog perched on a person’s fingertip, highlighting its small size and delicate features. Text on image: "More than 40% of amphibian species are at risk of extinction. Genomes help identify genetic vulnerability, resilience, and adaptive potential for targeted conservation."
Alt ES: Una pequeña rana marrón posada sobre la yema del dedo de una persona, destacando su diminuto tamaño y fragilidad. Texto en la imagen: "Más del 40% de las especies de anfibios están en riesgo de extinción. Los genomas ayudan a identificar vulnerabilidad genética, resiliencia y potencial adaptativo para una conservación dirigida."
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Earth BioGenome Project 🌍 @ebpgenome.bsky.social · 09/01/2026
Why genome sequence nudibranchs? 🌈🧬 Because these vibrant sea slugs hide some of the ocean’s most extraordinary biological tricks. From toxin evolution and chemical defenses 🧪 to symbioses, pigmentation, and extreme metabolic adaptations, nudibranch genomes reveal how life innovates in the sea. 🌊
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Megan Dennis @mydennis.bsky.social · 08/12/2025
Excited to share our final accepted version of the CiFi method out today: www.nature.com/articles/s41...
nature.com
CiFi: accurate long-read chromosome conformation capture with low-input requirements - Nature Communications
Hi-C methods for studying 3D genome structure typically require millions of cells and struggle with repetitive regions. Here, authors develop CiFi, combining 3C with PacBio HiFi sequencing, enabling c...
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Rob Denton @rddenton.bsky.social · 26/11/2025
One month later and those 30 billion base pairs are crammed into just about 14 chromosomes. HOT DANG! This seemed impossible 4-5 years ago.
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Katerina Guschanski @kguschan.bsky.social · 05/11/2025
Just over a month left to apply for scholarships on this project. We will run internal pre-selection interviews end of November, so if you consider applying, please reach out now. I can guarantee amazing scientific and intellectual environment at the Institute for Eco Evo @edinburghup.bsky.social
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Chris Kyriazis @ckyriazis.bsky.social · 04/08/2025
I am thrilled to share this paper outlining some ideas I’ve been thinking about for a little while on a simple but powerful approach for predicting risk of inbreeding depression from long runs of homozygosity and non-ROH heterozygosity. 1/n @klohmueller.bsky.social doi.org/10.1016/j.tr...
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Hernán E. Morales @hernmoral.bsky.social · 18/07/2025
Happy to share that our Perspective on how genome editing could restore lost diversity and help species adapt to climate or disease is out in @natrevbiodiv.nature.com We discuss potential, unknowns and risks tinyurl.com/33nm48vd Free access here: rdcu.be/ewMBq #consgen #popgen #Biodiversity
tinyurl.com
Genome engineering in biodiversity conservation and restoration - Nature Reviews Biodiversity
This Perspective argues for the use of genome engineering for restoring species genetic diversity and increase species resilience to environmental change. Genome engineering could be combined with tra...
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Vincent J Lynch 🐘🦣🦥 🦇🐋🐢🐍 @devoevomed.bsky.social · 01/07/2025
Super excited for this chance to share our @biorxivpreprint.bsky.social #preprint, in wihch we ask a simple question – what were the genomic of gorillas evolving polygyny? www.biorxiv.org/content/10.1...
biorxiv.org
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Earth BioGenome Project 🌍 @ebpgenome.bsky.social · 30/06/2025
(1/2) 🦋 The Atlas Blue butterfly has a staggering 229 chromosomes—far beyond the usual 31–32 in most moths and butterflies! 🧬 Join EBP trailblazer Mark Blaxter and the @sangerinstitute.bsky.social team as they tackle the challenge of assembling them all. 👉learn more: bit.ly/3TIXLSU 📸 M. Harzallah
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ERGA - European Reference Genome Atlas @ergabiodiv.bsky.social · 30/06/2025
📢 It’s time to harmonise practices for assessing genome-wide genetic diversity 🧬 Standardisation is key to meet the needs of stakeholders in biodiversity #conservation. 🔗 New publication by #ERGA @biogeneurope.bsky.social out now in #MolecularEcology onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Biodiversity Genomics Research Practices Require Harmonising to Meet Stakeholder Needs in Conservation
Biodiversity resilience relies on genetic diversity, which sustains the evolutionary potential of organisms in dynamic ecosystems. Genomics is a powerful tool for accurately estimating genetic divers...
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Mozes Blom @moosblom.bsky.social · 09/06/2025
Only two more days to apply!! Put your name in the hat, even if you feel like you don't match all criteria listed. Happy to chat regardless!
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Becky Taylor @beckystaylor.bsky.social · 21/05/2025
Interested in measuring genetic load? We have a new paper out providing a modified version of GERP which is more user friendly in wildlife species and with scripts to automate making input files and pulling out derived alleles in your species #consgen #popgen star-protocols.cell.com/protocols/4202
star-protocols.cell.com
Cell Press: STAR Protocols
STAR Protocols is an open access, peer-reviewed journal from Cell Press. We offer structured, transparent, accessible, and repeatable step-by-step experimental and computational protocols from all are...
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David Berger @dbergerbiol.bsky.social · 16/05/2025
Finally out: Predicting adaptation to climate warming www.nature.com/articles/s41... We find that there are many genomic routes to heat-adaptation, but this can also make genomic data of limited value for prediction. A tour de force by @denovorego.bsky.social , with @stelkens.bsky.social.
nature.com
Repeatability of evolution and genomic predictions of temperature adaptation in seed beetles - Nature Ecology & Evolution
The authors compare genomic and phenotypic changes between genetic backgrounds of seed beetles evolved at hot or cold temperatures. Despite phenotypic changes being more rapid and predictable at hot t...
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Jacob Höglund @jhog.bsky.social · 16/05/2025
www.embopress.org/doi/full/10....
embopress.org
How to clone a Dire Wolf? | EMBO reports
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
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Tom Mathers @tom-mathers.bsky.social · 16/05/2025
Struggling to find the tiny microchromosomes in draft bird genome assemblies? Our new #preprint introducing MicroFinder can help: www.biorxiv.org/content/10.1... 🧵 below (1/n) @sangerinstitute.bsky.social
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Nicolas Dussex @nicolasdussex.bsky.social · 21/04/2025
Great to see our latest paper on Ngorongoro Crater lion genomics out @commsbio.bsky.social Even after a rapid post-epizootic recovery in the 1970s, habitat fragmentation and continued isolation led to an increase in genetic load and to a reduction in overall genetic variation.
Ngorongoro Crater Lion. Photo: I. Janssondemographypop. gen. indices
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Hernán E. Morales @hernmoral.bsky.social · 10/04/2025
🚨 New preprint! We analyzed 39 bird genomes—including 3 Mauritian species that bounced back from the brink of extinction—to explore genomic erosion in a comparative framework. 🧬🦜🧩 📄 www.biorxiv.org/content/10.1... #consgen #popgen @claudiafontsere.bsky.social
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Jesper Boman @jesperboman.bsky.social · 03/04/2025
I feel honored that our work: "On the origin of an insular hybrid butterfly lineage" was picked as "Editor's choice" and that my picture of a mating couple (🧡🤎) covers the latest issue of Evolution @journal-evo.bsky.social. Link to paper: academic.oup.com/evolut/artic... (1/8)
Cover: Northern brown argus (Aricia artaxerxes) mating in the wild in Uppland, Sweden. These individuals (female-left, male-right) and forty of their offspring were later whole-genome resequenced to make a linkage map.  Boman J., Nolan, Z.J. And Backström, N. On the origin of an insular hybrid butterfly lineage. Evolution 79 (4)
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Genetics Society of America @genetics-gsa.bsky.social · 03/04/2025
📢 NEW GENOME ALERT In #G3journal, Rödin-Mörch et al. generated a high-quality reference genome of the European green toad to understand the evolutionary genomics of the amphibian. Read more: buff.ly/XnaKB29
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Mafalda S Ferreira @mafaldaferreira.bsky.social · 02/04/2025
PhD position on Evolution of Seasonal Camouflage in my group. Fully funded 4 year position in Stockholm University and SciLifeLab! :-) su.varbi.com/en/what:job/...
su.varbi.com
PhD Student in Evolution of Seasonal Camouflage
The Department of Zoology at Stockholm University includes about 80 employeese, including Researchers, PhD students and administrative staff. Research and education at the department occurs in an inte
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Hernán E. Morales @hernmoral.bsky.social · 31/03/2025
The orange-bellied parrot is predicted to go extinct by 2038. We tracked >200 years of genomic erosion. Here’s what we found 🧬🦜 #ConservationGenomics #consgen #popgen onlinelibrary.wiley.com/doi/10.1111/... pic by Marc Gardner
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Hernán E. Morales @hernmoral.bsky.social · 27/03/2025
🧬🌍 Happy to see our latest paper out at @royalsocietypublishing.org We show how genetic risks in endangered species can stay hidden due to a time-lag between demographic collapse and genetic loss. Work led by amazing MSc students Xufen Liu and Ester Milesi #ConservationGenomics Pic by David Stowe
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Katerina Guschanski @kguschan.bsky.social · 25/03/2025
Dental calculus, the preserved oral microbiome, is an absolute treasure trove of information that can be interrogated across thousands of years. But how to make it work? In a new preprint, @markella-morait.bsky.social asks this questions using >30 mammalian species:
doi.org/10.1101/2025...
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Dan Schrider @samurscicop.bsky.social · 24/03/2025
stdpopsim v0.3.0 is out! You can now mix and match your simulations of different demographic histories with published distributions of fitness effects along with gene annotations, and you can even throw in sweeps for good measure. Check out the new manuscript for more info: doi.org/10.1101/2025...
doi.org
Accessible, realistic genome simulation with selection using stdpopsim
Selection is a fundamental evolutionary force that shapes patterns of genetic variation across species. However, simulations incorporating realistic selection along heterogeneous genomes in complex de...
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Heng Li @lh3lh3.bsky.social · 24/03/2025
BWA-0.7.19 released with a fix to the internal HD-line bug introduced in 0.7.18
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Joanna Masel @joannamasel.bsky.social · 19/03/2025
Our latest paper revisits Haldane 1957 on speed limits to adaptation, the paper that triggered neutral theory. We clarify and then significantly extend the theory, and apply the resulting model to @mexpositoalonso.bsky.social's data doi.org/10.1093/gene... 1/14
doi.org
Substitution load revisited: a high proportion of deaths can be selective
Abstract. Haldane's Dilemma refers to the concern that the need for many “selective deaths” to complete a substitution (i.e. selective sweep) creates a spe
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Jacob Höglund @jhog.bsky.social · 19/03/2025
A chromosome-level genome assembly of the European green toad (Bufotes viridis) Published yesterday in G3 @GeneticsGSA
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José Cerca @naturalselection.bsky.social · 19/03/2025
[Please share widely] Come work at the U. of Oslo. We are advertising a 3-year postdoc in Evolutionary and Comparative Genomics. If working with plant evolution in the Galápagos, pangenome and structural variants sounds exciting for you - this may be your chance! www.jobbnorge.no/en/available...
jobbnorge.no
Postdoctoral Research Fellow in Evolutionary and Comparative Genomics (277333) | University of Oslo
Job title: Postdoctoral Research Fellow in Evolutionary and Comparative Genomics (277333), Employer: University of Oslo, Deadline: Wednesday, April 9, 2025
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Katerina Guschanski @kguschan.bsky.social · 12/03/2025
I was recently interviewed by Maia Garde for #UppTalk, the @uu.se outreach program. We talked about the spectacular work of @axeljensen.bsky.social on guenons, the true Rebel #Monkeys, and a bit about tracking mountain gorillas. Listen in if you like #primates & #genomics youtu.be/91zFERdT3oQ?...
youtu.be
UppTalk: What can primates teach us about adaptation and survival?
YouTube video by Uppsala universitet
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