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Paola GAruffo

@paolagaruffo.bsky.social
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PhD candidate @Joyce lab | Brain Tumor Microenvironment | Immunsuppression | @joycelab.bsky.social

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Reposted by Paola GAruffo
Johanna Joyce @johannajoyce.bsky.social · 25/09/2025
Celebrating our annual international lab dinner 🎉 👨🏽‍🍳 🧑🏻‍🍳 We are so fortunate to have this amazing team of motivated scientists, and very talented cooks 🤩 sharing delicious food & culture from around the world 🌍🌎🌏 Grateful for our #international #team 🇮🇹🇫🇷🇨🇦🇪🇸🇨🇭🇬🇧🇪🇬🇩🇪🇵🇹🇲🇽🇮🇪 - this truly enriches our science 🙏 🙌
Photo of all our team members at our international lab dinner, with some of the dishes at the front of the picture
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Johanna Joyce @johannajoyce.bsky.social · 12/09/2025
Dear friends at the University of Lausanne - please consider signing this petition This is to say NO to the funding cut of 24 million CHF that will negatively impact the quality of our teaching & research 🧪🧑🏼‍🎓 - and have a knock-on effect on the local economy All students, staff, faculty can sign ⏬
vaud.ssp-vpod.ch
Let’s reject budget cuts in education and research!
We, researchers, students, and members of the administrative and technical staff of the University of Lausanne (UNIL), firmly oppose the budget cuts announced for UNIL by the government of Vaud on 24t...
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EACR - European Association for Cancer Research @helloeacr.bsky.social · 18/06/2025
A record 1732 posters are being presented at #EACR2025, covering a wide range of cancer research topics. The abstracts and e-Posters are online for anyone to browse: 2025.eacr.org/abstracts
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Johanna Joyce @johannajoyce.bsky.social · 27/05/2025
Wishing our amazing postdoc @lbejarano.bsky.social continued success and happiness - as she leaves us to start her own lab in Spain 🎉🥳 Leire has been one of the most positive, creative, and kind scientists I've had the privilege to mentor - we shall all miss you so much! #NewPI 🤩 #ProudMentor 😊
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Katie Langin @klangin.bsky.social · 13/05/2025
"The lived experience of a scientist right now is terrifying." Story by @science.org's Warren Cornwall—about the fear of retaliation permeating the scientific community. www.science.org/content/arti...
science.org
Trump’s ‘fear factor’: Scientists go silent as funding cuts escalate
Many worry about retribution. But for others, speaking out is worth the risk
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Johanna Joyce @johannajoyce.bsky.social · 16/05/2025
Thanks to "The Scientist" for this great article covering a recent study from our lab where we explored why breast-to-brain metastases resist #immunotherapy — even when the same cancer type responds outside the brain.. 🧠🧪🔬 #brain #cancer #metastasis www.the-scientist.com/why-are-brea...
the-scientist.com
Why Are Breast Cancers That Metastasize to the Brain Hard to Treat?
Immunosuppressive factors prevent killer T cells from defeating brain tumors that arise from primary breast cancer.
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Johanna Joyce @johannajoyce.bsky.social · 09/05/2025
Not long after I started my lab, a prominent scientist told me it was “impossible” to be a successful PI and a mother Don’t ever let the naysayers tell you it can’t be done - of course it can! #HappyMothersDay this weekend to all the amazing scientist mamas raising their wonderful kids 🥰
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Science Magazine @science.org · 02/05/2025
President Donald Trump today asked Congress to make massive and unprecedented cuts to the 2026 budgets of major federal science agencies. scim.ag/3Yszqnm
scim.ag
Trump’s proposed budget would mean ‘disastrous’ cuts to science
Key research budgets would shrink by one-third to one-half in 2026 spending plan
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Johanna Joyce @johannajoyce.bsky.social · 08/04/2025
Excited to see our image on the cover of #Immunity today 🤩 Congrats to the amazing @lbejarano.bsky.social & all authors for our #brain #tumor #vasculature study www.cell.com/immunity/ful... Huge 🙏 🙏 to the v talented @joanagcc.bsky.social for creating this super cover 🧠🧪 @cp-immunity.bsky.social
On the cover: The blood-brain barrier is a defining feature of brain tumors, shaping their biology and therapeutic response. In this issue, Bejarano et al. use single-cell RNA sequencing and spatial analysis to construct a vascular atlas of primary and metastatic brain tumors, revealing distinct alterations in endothelial and mural cells. Glioblastomas undergo substantial vascular remodeling compared to low-grade gliomas, while brain metastases exhibit even greater permeability and increased immune cell interactions. This unveiling of vascular heterogeneity is depicted as a red pencil coloring in the intricate details of tumor-associated blood vessels within a map of the human brain wherein a tumor is surrounded by diverse immune cells. Image by Joana C. Carvalho.
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Johanna Joyce @johannajoyce.bsky.social · 31/03/2025
And if you're interested to read more 🤔 - here are some news perspectives from @ludwigcancer.bsky.social and @unil.bsky.social 🧪🧠 www.unil.ch/news/1742984... www.ludwigcancerresearch.org/news-release...
unil.ch
Why breast-to-brain metastases resist immunotherapy and radiation
Why do breast cancer metastases resist treatment in the brain? A new Cell Reports study by Prof. Joyce and Dr. Wischnewski uncovers how the brain’s tumor environment suppresses immune responses, block...
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Johanna Joyce @johannajoyce.bsky.social · 31/03/2025
Why do brain metastases resist #immunotherapy — even when the same cancer responds outside the #brain? 🧠🧪💥 We just published a study diving into this question ⏬ Led by an amazing (former) PhD student in my lab —Vladimir Wischnewski 🎉 🧵 1/ @cp-cellreports.bsky.social www.cell.com/cell-reports...
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Ludwig Cancer Research @ludwigcancer.bsky.social · 24/03/2025
Study led by Ludwig @fbm-unil.bsky.social’s @johannajoyce.bsky.social and alumnus Vladimir Wischnewski explains why brain metastases of breast cancer are likely to resist potentially synergistic combinations of radiotherapy and checkpoint blockade #immunotherapy. Learn more: bit.ly/4kZTKGo #CanSky
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fbm-unil.bsky.social @fbm-unil.bsky.social · 27/03/2025
🧬 Why do #breast-to-brain #metastases resist treatment? This study in @cp-cellreports.bsky.social shows how the brain's tumor environment suppresses immune responses and impairs therapy. 🔗 Original paper: www.cell.com/cell-reports...
cell.com
The local microenvironment suppresses the synergy between irradiation and anti-PD1 therapy in breast-to-brain metastasis
Wischnewski et al. demonstrate suppressed CD8+ T cell cytotoxicity in breast cancer brain metastases, contrasting with genetically identical extracranial tumors. Neutrophils and Trem2+ macrophages dri...
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fbm-unil.bsky.social @fbm-unil.bsky.social · 27/03/2025
🧠 Pourquoi les #métastases #cérébrales du cancer du #sein résistent-elles aux traitements? Une étude de @joycelab.bsky.social révèle que l’environnement tumoral cérébral bloque l’action des cellules immunitaires. 🔗 News: www.unil.ch/news/1742984...
unil.ch
Why breast-to-brain metastases resist immunotherapy and radiation
Why do breast cancer metastases resist treatment in the brain? A new Cell Reports study by Prof. Joyce and Dr. Wischnewski uncovers how the brain’s tumor environment suppresses immune responses, block...
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Johanna Joyce @johannajoyce.bsky.social · 20/03/2025
How does the #vasculature regulate #immune cell infiltration & function across different brain tumors? 🧠🧪 Excited to share our latest study in #Immunity where we uncover some interesting answers— led by the amazing @lbejarano.bsky.social 🤩👏🏻 🧵 @cp-immunity.bsky.social www.cell.com/immunity/ful...
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Leire Bejarano Bosque @lbejarano.bsky.social · 20/03/2025
Thrilled to see our vascular atlas across primary and metastatic brain tumors finally out in Immunity! 😍 🍾 Thanks to @johannajoyce.bsky.social for her invaluable mentorship and to all the authors involved! 🎉
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Ludwig Cancer Research @ludwigcancer.bsky.social · 19/03/2025
Researchers led by Ludwig @fbm-unil.bsky.social’s @lbejarano.bsky.social & @johannajoyce.bsky.social analyzed individual cells of the blood-brain barrier across brain tissue, primary brain tumors & brain metastases, creating a vascular atlas to guide the design of new therapies. bit.ly/4bFqwYY
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Johanna Joyce @johannajoyce.bsky.social · 19/03/2025
Well done to the first recipients of the EACR-Mark Foundation postdoc fellowships 🎉🎊 And a happy coincidence that all three awardees are women scientists in the labs of three women PIs 🙌 #WomeninSTEM #WomeninScience 👩‍🔬👩🏻‍🔬🧪 @themarkfdn.bsky.social @helloeacr.bsky.social @juliemmazet.bsky.social
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Johanna Joyce @johannajoyce.bsky.social · 10/03/2025
Cancer knows no borders, and setbacks in one part of the world can have lasting consequences for #patients everywhere The #EACR, and all co-signing national #cancer societies & foundations, stand in solidarity and offer our full support to our friends and colleagues in the US #StandUpForScience 🧪
eacr.org
EACR Statement on Threats to Cancer Research | The European Association for Cancer Research
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Johanna Joyce @johannajoyce.bsky.social · 05/03/2025
Now, more than ever, the #global #science community needs to stand together - #united against those who attack science 🧪, who seek to diminish #scientists, who destroy critical programs that advance #equality, #diversity and #inclusion Please consider to join us in signing the #MilanDeclaration ⏬
febs.org
Milan Declaration - FEBS
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Science Magazine @science.org · 21/02/2025
Rodent and monkey facilities could be imperiled by the Trump administration’s plan to slash overhead costs that the National Institutes of Health pays to institutions for medical research. scim.ag/3QvS4GC
scim.ag
‘Death by ax.’ Fate of millions of research animals at stake in NIH payments lawsuit
Rodent and monkey facilities imperiled by Trump plan to cut overhead payments
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Violeta J. Rodriguez, PhD, MSEd @vjrp.bsky.social · 21/02/2025
In my latest article for @science.org, I reflect on the current challenges faced by early-career researchers, including delays in grant reviews, uncertainty around NIH funding freezes and changes, and the critical need for continued support and advocacy. www.science.org/content/arti...
science.org
I’m an NIH-funded researcher, drowning in uncertainty
“I’ll keep doing what I can to move my research forward. But I, and so many others, can’t do this indefinitely,” this assistant professor writes
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Martin Jungkunz @martin-jk.bsky.social · 10/02/2025
Die Rektoratsmitglieder der Uni Heidelberg begrüßen die von Wissenschaftlerinnen und Wissenschaftlern bundesweit getragene Initiative, die unter der Überschrift „Demokratie braucht Fakten“ zur Wahl demokratischer Parteien aufruft. www.uni-heidelberg.de/de/bei-der-b... #aufstehenfuerdemokratie
uni-heidelberg.de
Bei der Bundestagswahl am 23. Februar vom Wahlrecht Gebrauch machen - Universität Heidelberg
Das Rektorat der Universität Heidelberg schließt sich einem gemeinsamen Aufruf der Hochschulrektorenkonferenz (HRK), des Deutschen Studierendenwerks (DSW) und
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Winkler Laboratory @winklerlab.bsky.social · 12/02/2025
#aufstehenfuerdemokratie Um 11:55 Uhr versammelte sich eine große Gruppe von Wissenschaftlern & Unterstützern, um ein Statement für faktenbasierte Entscheidungen und Demokratie abzugeben: Geht wahlen-mit Verstand! Inspirierende Worte von Prof. E. Winkler und Prof. S. Pfister - Danke an Alle!
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Johanna Joyce @johannajoyce.bsky.social · 11/02/2025
Happy International Day of Women and Girls in Science! Its been a privilege to work with these extraordinary scientists in my lab over the years - all making an incredible impact throughout the world 🙌 We must never give up on #equality #diversity & #inclusion 💪 #WomeninScience #GirlsInSTEM 🧪🔬🔭🚀
Composite image of women scientists from the Joyce lab over the past 20 years
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Johanna Joyce @johannajoyce.bsky.social · 01/02/2025
I wrote this just two weeks ago - could not have imagined how broadly #science and #researchers in the US have been impacted since then 

Science is a #global community 🌍 🌎 🌏 We're all very concerned for our friends, colleagues, and young researchers in the US right now

 #solidarityforscience 🧪
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Science Magazine @science.org · 22/01/2025
“The impact of the collective executive orders and directives appears devastating.” scim.ag/40ureTO
scim.ag
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
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Johanna Joyce @johannajoyce.bsky.social · 14/01/2025
Beautiful #Immunity cover 🤩 Congratulations to Alessandro Matera (now an amazing postdoc in our lab 🙏) for his PhD thesis 🧪 tour de force! 🥳 @ale-matera.bsky.social, Anne-Claire Compagnion, Rosa Paolicelli & all authors for fascinating insights into #microglia biology www.cell.com/immunity/ful...
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Christie Wilcox @nerdychristie.bsky.social · 26/12/2024
My holiday gift to all of you: The editors of @science.org's favorite papers of 2024, all wrapped up nicely in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪
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Cathleen O'Grady @cathleenogrady.bsky.social · 17/12/2024
It took four days from submission to publication, and nearly five years from publication to retraction. After campaigning by many, many scientists, and an investigation by Elsevier, an infamous paper on hydroxychloroquine as a COVID-19 treatment has been retracted. 🧪 www.science.org/content/arti...
science.org
Infamous paper that popularized unproven COVID-19 treatment finally retracted
Study on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds
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Johanna Joyce @johannajoyce.bsky.social · 18/12/2024
It's been a great year for #WomeninScience books - incl. the challenges faced, and the ways we can overcome historic imbalances & obstacles - as a community 🙌 Highly recommended reads by these authors 🤩 Katalin Kariko @athenedonald.bsky.social @lisampmunoz.bsky.social Kate Zernike #WomeninSTEM 🧪
Women in Science books
Women in Science Now
The Exceptions
Not just for the boys - why we need more women in science
Breaking through - my life in science
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Johanna Joyce @johannajoyce.bsky.social · 19/11/2024
Wonderful to join the annual #WomeninScience Switzerland event at Montreux Palace, including with some of the previous amazing speakers, and trainees from my lab 💜 Many thanks to Lola Grace, and all the organizing committee - and brava to Elisa Oricchio for an incredible, inspiring presentation 🙏🙏
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Johanna Joyce Lab @joycelab.bsky.social · 17/11/2024
Hi friends 👋 We are a lab of curious researchers - dedicated to understanding and ultimately helping treat cancer Our lab is led by Johanna Joyce, and we are students, postdocs & technicians from all over the world 🇮🇪🇨🇭🇪🇸🇫🇷🇵🇹🇮🇹🇨🇦🇲🇽🇪🇬🇬🇧🇩🇪 We love doing science 🧪🔬 and living in beautiful Lausanne, Switzerland!
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