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Oscar A Peña, PhD

@oscarapena.bsky.social
599 followers 650 following 16 posts

🔬 Postdoc @bristoluni 🇬🇧, using #zebrafish 🐠 to study wound healing & scarring for a @scarfreeworld | he/him/Dr orcid.org/0000-0002-2582-0238

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Reposted by Oscar A Peña, PhD
Zebrafish Disease Models Society (ZDMS) @zdmsociety.bsky.social · 02/10/2026
That's a wrap! 'Zebrafish Infection and Immunity 9' concluded yesterday, which ends our time in the City of Dreaming Spires 🐟🦠 ICYMI, here are some photos of the event ⬇️ Conference organizers would like to thank @biologists.bsky.social for their generous sponsorship of #zii9! #ZDMS #DiseaseModels
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Reposted by Oscar A Peña, PhD
Olivia Guest · Ολίβια Γκεστ @olivia.science · 18/07/2026
OK, it's honestly very distressing and worrying and I have ADHD, so I wrote it all down to get it out of my head olivia.science/entryism/ Enjoy, I guess...
olivia.science
Entryism
AI entryism subverts anti AI critique.
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Oscar A Peña, PhD @oscarapena.bsky.social · 17/07/2026
AI in scientific publishing: Slower, worse, and more expensive | Science www.science.org/doi/10.1126/...
science.org
AI in scientific publishing: Slower, worse, and more expensive
There’s a saying in the management world, popularized by NASA administrator Daniel Goldin in the 1990s, that the goal of technological improvements is to make products faster, better, and cheaper. Alt...
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Reposted by Oscar A Peña, PhD
Javi Ibarrondo @jibarrondo.bsky.social · 15/07/2026
Editorial and peer review dynamics at elite general science journals | Science Advances www.science.org/doi/10.1126/... 🧪
science.org
Editorial and peer review dynamics at elite general science journals
Analyses of deidentified data reveal complex interactions that quantify success at elite general science journals.
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Reposted by Oscar A Peña, PhD
Richard White @whitefishlab.bsky.social · 10/07/2026
The ZDM19 meeting in Oxford is coming up soon! We have a great list of speakers, lots of early career researcher events, and an amazing location. Registration is open now but early bird pricing will end soon - so please register as soon as possible! www.zdmsociety.org/zdm19-regist...
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Reposted by Oscar A Peña, PhD
Margarita Parada-Kusz @margaritapk.bsky.social · 15/11/2024
Featuring work from my postdoc for my new friends: We have discovered a novel molecular pathway linking #tryptophan metabolism and #kainate receptors (known for their role in neuronal excitability) to protective antimicrobial #innate immune responses in #zebrafish. www.nature.com/articles/s41...
nature.com
3-Hydroxykynurenine targets kainate receptors to promote defense against infection - Nature Chemical Biology
A tryptophan metabolite was identified that acts systemically to promote defense against bacterial infection by targeting kainate receptors (KARs), revealing a novel intersection between tryptophan me...
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Reposted by Oscar A Peña, PhD
Journal of Cell Biology @jcb.org · 07/07/2026
Glover, Wilkinson, @ianofbristol.bsky.social et al. show that cells subject to mitochondrial protein import failure induce Intercellular Mitochondrial Transfer via tunnelling nanotubes. rupress.org/jcb/article/... #Organelles #Biochemistry #Mitochondria
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Reposted by Oscar A Peña, PhD
Zebrafish Rock! @zebrafishrock.bsky.social · 26/04/2026
Immune response following blood infection from Salmonella exposure (green dots 🟢) in a live zebrafish larva. Credit to @margaritapk.bsky.social. #ZebrafishZunday 🧪
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Reposted by Oscar A Peña, PhD
Cell Reports @cp-cellreports.bsky.social · 18/04/2026
Optogenetic mediated contractility enables reversible control of microglial morphology and migration in vivo
dlvr.it
Optogenetic mediated contractility enables reversible control of microglial morphology and migration in vivo
Biermeier et al. use live imaging in zebrafish to show that microglia alternate between distinct morphological states that support brain surveillance and phagocytosis. By optogenetically controlling cytoskeletal contractility, they demonstrate programmable, reversible control of microglial behavior in the living brain.
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Reposted by Oscar A Peña, PhD
Philipp Niethammer @niethammerlab.bsky.social · 06/02/2026
Zaza’s main PhD work just came out in a journal! Macrophage cell nuclei physically sense 50 um/s fast osmotic shock waves coming from wounds to mediate rapid vessel permeabilization and serum exudation - one of the hallmarks of acute inflammation. www.nature.com/articles/s41...
nature.com
Zebrafish macrophages convert physical wound signals into rapid vascular permeabilization - Nature Communications
Real-time imaging in zebrafish shows that macrophages convert fast osmotic wound signals into rapid vessel permeabilization via cPla2-dependent nuclear membrane mechanotransduction.
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Reposted by Oscar A Peña, PhD
Pedro Hernandez @zebragut.bsky.social · 03/04/2026
Very happy to share this study from our group and colleagues now out in Science! We found that in zebrafish, before the immune system is mature, gut epithelial cells perform immune functions by producing the cytokine IL-22 to shape the microbiota to promote early life gut function #Zebrafish #Gut
science.org
IL-22 from enteroendocrine cells promotes early-life gut motility in zebrafish through the microbiota
The gut microbiota, immune system, and enteric nervous system interact to regulate adult gut physiology. However, the mechanisms establishing gut physiology during development remain unknown. We repor...
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Oscar A Peña, PhD @oscarapena.bsky.social · 25/03/2026
Exactly two years ago we wrote a review on wound healing, but at the time it was posted in the site that shall not be named, so check out here if your favourite cell was featured, and leave a complaint here if I missed it 😅 www.nature.com/articles/s41...
nature.com
Cellular and molecular mechanisms of skin wound healing - Nature Reviews Molecular Cell Biology
This Review discusses the complex mechanisms of wound healing — cell migration, matrix remodelling, inflammation and angiogenesis — and the contributions of different cell types, including immune cell...
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Reposted by Oscar A Peña, PhD
Leah Greenspan @ljgreenspan.bsky.social · 24/02/2026
Excited to have started my new lab in Human Genetics at Pitt Public Health! We study wound healing in diabetes & aging using adult zebrafish. Check out this movie showing neutrophil dynamics after injury. Now recruiting research staff, grad students, and postdocs. DM me if interested.
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Reposted by Oscar A Peña, PhD
Beck Richardson @beckrichardson.bsky.social · 13/10/2025
Our new paper on valve disease in aged #zebrafish is out! onlinelibrary.wiley.com/doi/10.1111/... This has been a long running collaborative effort with contributions from lots of great people!
onlinelibrary.wiley.com
Aged Zebrafish as a Spontaneous Model of Cardiac Valvular Disease
Natural ageing in zebrafish results in spontaneous development of valvular degeneration in both the atrioventricular (AV) and bulboventricular (BV) valves. Aged zebrafish valves are larger and exhibi...
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Reposted by Oscar A Peña, PhD
Rodrigo Morales Castro @ramoralescastro.bsky.social · 14/05/2025
I'm very excited to share our latest work with #zebrafish published in @mucosalimmunol.bsky.social!! 🐟 www.sciencedirect.com/science/arti... Here, we characterized a genetic model of intestinal epithelial cell ablation to study the cellular and molecular mechanisms of intestinal #regeneration....
sciencedirect.com
A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as major modulators of mucosal healing
Promoting intestinal regeneration and enhancing mucosal healing have emerged as promising therapeutic alternatives for treating intestinal disorders t…
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Reposted by Oscar A Peña, PhD
Lauren Ross @laurennross.bsky.social · 12/02/2025
Great article by @kordinglab.bsky.social‬ on "why causal knowledge is pragmatically possible". The best arguments for causation--& only one we need--is pragmatic. Here pragmatic isn't weak/subjective, but connected to actual goals, utility & outcomes in the world. medium.com/@kording/why...
medium.com
Why Causal Knowledge Is Pragmatically Possible: Bridging Philosophical Skepticism and Scientific…
When we observe the world, we note that events consistently follow one another. As David Hume famously argued in An Enquiry Concerning…
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Reposted by Oscar A Peña, PhD
Jasmine Rowell, PhD @jasminerowell.bsky.social · 06/12/2024
Our paper has now been published @elife.bsky.social 🎉🎉🎉 Check it out, especially if you are interested in the TCR repertoire and T cell development in the thymus doi.org/10.7554/eLif...
doi.org
Distinct T-cell receptor (TCR) gene segment usage and MHC-restriction between foetal and adult thymus
The foetal thymic T-cell receptor (TCR) repertoire is distinct from adult, and it is less governed by MHC-restriction, more closely encoded by genomic sequence with distinct gene-segment usage includi...
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Reposted by Oscar A Peña, PhD
adam grieve @adamgrieve.bsky.social · 15/11/2024
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
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Reposted by Oscar A Peña, PhD
Joyce Yu @joyceyu.bsky.social · 09/11/2024
Do you work in #DevBio and want to introduce the fascinating world of developmental biology to your family and friends? You can show them this science documentary, produced by the British Society for Developmental Biology, The Company of Biologists and Cambridge Filmworks! 📽️ youtu.be/avrmIs3vPUQ?...
youtu.be
BSDB - The Fascinating World of Developmental Biology (full length)
YouTube video by The Company of Biologists
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Reposted by Oscar A Peña, PhD
eLife @elife.bsky.social · 06/09/2024
Scientists of any gender working in female-dominated disciplines receive lower scores during evaluation and are less likely to get funded. elifesciences.org/digests/9761...
elifesciences.org
Discrimination between disciplines
Scientists working in fields with a high proportion of women researchers receive lower scores during evaluation and are less likely to get funded, suggests new study.
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Reposted by Oscar A Peña, PhD
eLife @elife.bsky.social · 31/05/2024
Live imaging of zebrafish embryos reveals early differences in the genesis of the cells that become blood and immune cells, shedding light on how these precursors emerge from vessels. elifesciences.org/digests/9142...
elifesciences.org
Emerging blood and immune cells
Live imaging of zebrafish embryos reveals early differences in the genesis of the cells that become blood and immune cells, shedding light on how these precursors emerge from vessels.
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Reposted by Oscar A Peña, PhD
Zebrafish Rock! @zebrafishrock.bsky.social · 14/04/2024
Any #zebrafish friends still swimming around on here? We’d love to follow you! #ThatsHowWeShoal
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Reposted by Oscar A Peña, PhD
Margarita Parada-Kusz @margaritapk.bsky.social · 28/10/2023
For those who might be interested: We discovered a novel molecular pathway that links #tryptophan metabolism and glutamate #kainate receptors (KAR) to resistance against lethal #bacterial infections in zebrafish. www.biorxiv.org/content/10.1... Please RT!
biorxiv.org
A tryptophan metabolite modulates the host response to bacterial infection via kainate receptors
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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