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ophirklein.bsky.social

@ophirklein.bsky.social
166 followers 71 following 39 posts
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ophirklein.bsky.social @ophirklein.bsky.social · 04/04/2026
Trump Slashed Science Funding. Now the U.S. Could Face a Costly Brain Drain. www.nytimes.com/2026/04/04/b...
nytimes.com
Trump Slashed Science Funding. Now the U.S. Could Face a Costly Brain Drain.
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ophirklein.bsky.social @ophirklein.bsky.social · 18/10/2025
Happy to share our new preprint in collaboration with Natalia Jura's lab! 🧬 CNPY4 is a lipid-binding regulator of sphingolipid homeostasis 👉 biorxiv.org/content/10.1101/2025.10.13.682155v1 Sphingolipids shape membranes & signaling — but how their balance is maintained is still unclear.
biorxiv.org
CNPY4 is a Lipid-Binding Regulator of Sphingolipid Homeostasis
Sphingolipids function both as signaling molecules and as organizers of cell membranes, and their dysregulation has been linked to cancer, metabolic disorders, and neurodegeneration. A central node in...
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ophirklein.bsky.social @ophirklein.bsky.social · 13/10/2025
🔔SAVE THE DATE!🔔 Leanne Jones and I are super excited to announce the 3rd Intestinal Stem Cell conference is taking place next November in Mexico. Registration now open, ECR grants available and our Keynote, Hans Clevers, is confirmed. More info➡️ bit.ly/474De1E
bit.ly
3rd Stem Cell - Niche Interactions in the Gastrointestinal Tract Conference | Fusion Conferences
Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...
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ophirklein.bsky.social @ophirklein.bsky.social · 10/10/2025
www.cedars-sinai.org/newsroom/ced...
cedars-sinai.org
New Cedars-Sinai Study Aims to Improve Oral Tissue Grafts
A new study at Cedars-Sinai Guerin Children’s, funded by a $5.7 million NIH grant, is exploring the use of stem cells to enhance oral tissue grafting.
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Save Our Cures @saveourcures.bsky.social · 25/09/2025
YOUR PHONE EXISTS because the government invested in "useless" basic research decades ago! It's the same with medical research - today's basic science leads to tomorrow's life-saving treatments. Visit FundResearch.org to tell Congress to keep funding research #SaveOurCures #PhoneForGood #FundNIH
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Save Our Cures @saveourcures.bsky.social · 28/08/2025
🎉 INTRODUCING #SaveOurCures🎉 Federal biomedical research represents less than 1% of the federal budget but delivers life-saving treatments for millions of American families. 93% of cancer treatments started with American government-funded research. 🧵: 1/8
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ophirklein.bsky.social @ophirklein.bsky.social · 15/09/2025
Trump Is Shutting Down the War On Cancer www.nytimes.com/2025/09/14/m...
nytimes.com
Trump Is Shutting Down the War On Cancer
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ophirklein.bsky.social @ophirklein.bsky.social · 10/09/2025
www.nytimes.com/2025/09/08/o...
nytimes.com
Opinion | We Are Watching a Scientific Superpower Destroy Itself
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ophirklein.bsky.social @ophirklein.bsky.social · 31/08/2025
We're very excited to launch a search for a founding director of our new reproductive sciences program at Cedars-Sinai! careers.cshs.org/job/los-ange...
careers.cshs.org
Director, Reproductive Sciences Program at CEDARS-SINAI
Learn more about applying for Director, Reproductive Sciences Program at CEDARS-SINAI
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American Society of Human Genetics (ASHG) @geneticssociety.bsky.social · 28/08/2025
🎖️Congratulations to Carole Ober, PhD, winner of the ASHG 2025 Mentorship Award! Learn more about the award and Dr. Ober's work: www.ashg.org/membership/awards/2025… #ASHG #HumanGenetic
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Camp Lab @graycamplab.bsky.social · 22/08/2025
Final version @science.org "Recent evolution of the developing human intestine affects metabolic and barrier functions". Evolutionary preparation for microbiota, diet, and pathogen exposure is fascinating! Thank you @erc.europa.eu for supporting our vision! www.science.org/doi/10.1126/...
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Holly Ober @sciwri.bsky.social · 12/08/2025
UCLA professor Bill Lowry: My current basic-research grant from the National Institutes of Health, which is a continuation of the work that led to this discovery on alopecia, was suspended last week. I don’t know what interesting discoveries won’t be made the longer this thing stays suspended. 🧪
nymag.com
The Great Unbalding Draws Nearer
Decades of science have not found a way to regrow lost hair. Until, maybe, now.
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ophirklein.bsky.social @ophirklein.bsky.social · 04/07/2025
Excited to share our new paper by Jessi Cook in collaboration with Michelle Griffin from Mike Longaker's group at Stanford. www.science.org/stoken/autho... As nicely described by our communications team:
urldefense.com
Growth arrest specific–6 and angiotoxin receptor–like signaling drive oral regenerative wound repair
Activation of angiotoxin receptor–like signaling and suppression of focal adhesion kinase allow for regenerative healing in the oral mucosa.
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ophirklein.bsky.social @ophirklein.bsky.social · 04/07/2025
Join us in Crete in the fall to discuss stem cells! The early bird deadline has been extended to July 15th. This date will be the final deadline for abstracts being considered for short talk selection. www.aegeanconferences.org/src/App/spea... Looking forward to seeing you there!
aegeanconferences.org
Aegean Conferences
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Waggoner Lab @labwaggoner.bsky.social · 02/07/2025
Activation of angiotoxin receptor–like signaling and suppression of focal adhesion kinase allow for regenerative healing in the oral mucosa www.science.org/doi/10.1126/... @ophirklein.bsky.social
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ophirklein.bsky.social @ophirklein.bsky.social · 23/06/2025
Here Is All the Science at Risk in Trump’s Clash With Harvard www.nytimes.com/interactive/...
nytimes.com
Here Is All the Science at Risk in Trump’s Clash With Harvard
More than 900 research grants worth $2.6 billion are in jeopardy. So is the 80-year-old model of American science.
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ophirklein.bsky.social @ophirklein.bsky.social · 18/06/2025
Help Save the NIH www.congressweb.com/UCSF/9?frame...
congressweb.com
Help Save the NIH
As the second largest recipient of NIH funding in the nation, UCSF depends on NIH funding to support our researchers in advancing health worldwide. Unfortunately, the White House's budget request pr...
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Ardem Patapoutian @ardemp.bskyverified.social · 03/06/2025
Talked to @KateZernike at @nytimes about my journey and the current moment for scientists in the U.S. “Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.” Read the article here. No subscription required: www.nytimes.com/2025/06/03/u...
nytimes.com
The U.S. Lit a Beacon for Science. Under Trump, Scientists Fear It’s Dimming
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ophirklein.bsky.social @ophirklein.bsky.social · 03/06/2025
www.nytimes.com/2025/06/03/u...
nytimes.com
The U.S. Lit a Beacon for Science. Under Trump, Scientists Fear It’s Dimming
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ophirklein.bsky.social @ophirklein.bsky.social · 20/05/2025
www.nytimes.com/2025/05/19/o...
nytimes.com
Opinion | In the Future, China Will Be Dominant. The U.S. Will Be Irrelevant.
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Ursula von der Leyen @vonderleyen.ec.europa.eu · 05/05/2025
Europe’s choice is clear. To put science at the heart of its economy. To become the home of scientific freedom and collaboration. And to welcome talent from all over the world. I’m glad to present the first elements of our Choose Europe Initiative. → europa.eu/!TTbWbJ
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ophirklein.bsky.social @ophirklein.bsky.social · 03/05/2025
Urge Congress to Reject the President's Budget Proposal to Cut NIH, NSF www.congressweb.com/ASHG/32?fram...
congressweb.com
Urge Congress to Reject the President's Budget Proposal to Cut NIH, NSF
Earlier today on May 2, the Trump Administration proposed sweeping cuts across the U.S. Department of Health and Human Services (HHS), including a nearly 40% cut to the National Institutes of Health (...
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ophirklein.bsky.social @ophirklein.bsky.social · 11/04/2025
This is something I keep asking myself: www.nytimes.com/2025/04/11/o...
nytimes.com
Opinion | What Is Actually the Point of Treating the N.I.H. Like This?
Efficiency is not being enhanced, nor is waste being eliminated at the N.I.H. Scientists are just left to wonder: Why?
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ophirklein.bsky.social @ophirklein.bsky.social · 11/04/2025
It was an honor to speak at the Shanthi Sitaraman Symposium at Emory yesterday, and to hear about Shanthi from her colleagues, friends and family. She was a remarkable physician, scientist and teacher.
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ophirklein.bsky.social @ophirklein.bsky.social · 06/04/2025
rarediseases.org/ceo-statemen...
rarediseases.org
NORD CEO Statement on the Termination of the Advisory Committee on Heritable Disorders in Newborns and Children - National Organization for Rare Disorders
The sudden termination of the Advisory Committee on Heritable Disorders in Newborns and Children (ACHDNC) raises serious concerns for the rare disease community and families nationwide.
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ophirklein.bsky.social @ophirklein.bsky.social · 04/04/2025
www.nytimes.com/2025/04/03/o...
nytimes.com
Opinion | The Uncertain Fate of the Young American Scientist
Young researchers are choosing between staying in science and staying in the United States.
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ophirklein.bsky.social @ophirklein.bsky.social · 03/04/2025
Was great to visit @newyorkuniversity.bsky.social dental school today and to hear all the terrific science going on. A highlight of the trip was spending time with our former lab member @rkzwick.bsky.social in her beautiful new space and meet her growing group - she is off to a great start!
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Jeff Bush @jeffbush.bsky.social · 01/04/2025
Just recruited two more grad students to be appreciated on Bluesky! @jasminegarciia.bsky.social @davidsungtooth.bsky.social @ophirklein.bsky.social
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ophirklein.bsky.social @ophirklein.bsky.social · 31/03/2025
Killing the goose that lays the golden eggs www.nytimes.com/2025/03/31/b...
nytimes.com
Trump’s Science Policies Pose Long-Term Risk, Economists Warn
Since World War II, U.S. research funding has led to discoveries that fueled economic gains. Now cutbacks are seen as putting that legacy in jeopardy.
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ophirklein.bsky.social @ophirklein.bsky.social · 27/03/2025
Was great to hear @ardemp.bskyverified.social 's lecture @cedars-sinai.bsky.social annual research day - amazing science and a remarkable life journey. He's so committed to understanding Piezo proteins that he got one tattooed on his arm!
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 07/03/2025
Thank you for lending your voice to @standupforscience.bsky.social 🙏
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ophirklein.bsky.social @ophirklein.bsky.social · 06/03/2025
Save the date: The 6th Int’l Conference on Stem Cells will be held at the Kalimera Kriti Hotel in Sissi, Crete, Greece from October 1-6, 2025. Looking forward to our next iteration of this exciting and fun meeting! www.aegeanconferences.org/src/App/conf...
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ophirklein.bsky.social @ophirklein.bsky.social · 06/03/2025
Appreciate NIDCR highlighting our paper from last year in this nice piece: www.nidcr.nih.gov/news-events/... NIDCR support has been fundamental to our work since we began in this field, and its continued survival is essential to supporting essential dental, oral and craniofacial research
nidcr.nih.gov
The Forces that Sculpt a Tooth
Multiplying cells create pressure that triggers the formation of command centers that direct tooth formation in mice, according to an NIDCR-funded study.
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Eric Topol @erictopol.bsky.social · 01/03/2025
Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter www.nytimes.com/2025/03/01/u...
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ophirklein.bsky.social @ophirklein.bsky.social · 17/02/2025
Looking forward to this!
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ophirklein.bsky.social @ophirklein.bsky.social · 15/02/2025
This is sobering: kucharski.substack.com/p/the-bigges...
kucharski.substack.com
The biggest coincidence of my career
Why we struggle to grasp how bad events will be
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ophirklein.bsky.social @ophirklein.bsky.social · 14/02/2025
www.nytimes.com/2025/02/14/o...
nytimes.com
Opinion | American Science is Under Attack
The Trump administration hobbles research and endangers the public health.
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JAMA @jama.com · 14/02/2025
Viewpoint: Recent disruptions and funding cuts at the National Institutes of Health (NIH) undermine the infrastructure and stability of US scientific research, threatening the nation's global leadership and scientific productivity. ja.ma/41hBnoc #MedSky
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American Society of Human Genetics (ASHG) @geneticssociety.bsky.social · 14/02/2025
ASHG is concerned about the cuts to NIH-funded research support, its impacts on biomedical research, and the effect on local, state, and national economies. We join our advocacy partners to ensure essential progress is not stalled. Read our statement: www.ashg.org/publications... #ASHG
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ophirklein.bsky.social @ophirklein.bsky.social · 12/02/2025
Research Funding at Stake: Urgent Advocacy Needed for NIH Indirect Cost Policy www.congressweb.com/ASHG/31?fram...
congressweb.com
Research Funding at Stake: Urgent Advocacy Needed for NIH Indirect Cost Policy
UPDATE: On February 10, the attorneys general of 22 states filed a lawsuit (https://www.azag.gov/press-release/attorney-general-mayes-sues-trump-administration-defunding-medical-and-public-health) aga...
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ophirklein.bsky.social @ophirklein.bsky.social · 05/02/2025
February is Ectodermal Dysplasias Awareness Month! Please help to spread the word nfed.org/get-involved...
nfed.org
February is Ectodermal Dysplasias Awareness Month
Ectodermal Dysplasia Awareness begins with YOU! Each February, we come together to celebrate Ectodermal Dysplasias Awareness Month—a time to amplify
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ophirklein.bsky.social @ophirklein.bsky.social · 26/01/2025
Excited that our new lab website is starting to come together - thanks to the team, particularly Pauline Marangoni and Zhulin Dixon, for assembling this, and stay tuned for additional updates ophirkleinlab.org
ophirkleinlab.org
Home - Klein Lab
We are interested in understanding how organs form in the embryo and how they renew and regenerate in the adult. We research how development and regeneration
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ophirklein.bsky.social @ophirklein.bsky.social · 24/01/2025
Happy birthday Pauline! And welcome Jose Tomas to the lab!
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ophirklein.bsky.social @ophirklein.bsky.social · 19/01/2025
The devastating wildfires in LA have taken an enormous toll on our community. Even those not directly impacted have had the air they breath affected - our colleague Dr. Dralyuk @cedars-sinai.bsky.social Guerin Children's offers some advice here: www.cedars-sinai.org/newsroom/los...
cedars-sinai.org
Los Angeles County Wildfires: Cedars-Sinai Lung Specialists
Updated Jan. 8, 2025 at 2 p.m. PST The catastrophic wildfires raging throughout Los Angeles County present special concerns for adults and children with respiratory illnesses. Irina Dralyuk, MD, a Ced...
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Development @dev-journal.bsky.social · 03/01/2025
📢Call for papers. Submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues Guest Editors: Meritxell Huch and Mansi Srivastava 📅 Deadline: 15 May 2025 buff.ly/4iItxeg #DevBio
Development Call for papers. Special Issue - Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. Guest Editors: Meritxell Huch and Mansi Srivastava. Submission deadline: 15 May 2025.
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Waggoner Lab @labwaggoner.bsky.social · 19/12/2024
Synthetic organizer cells, engineered to spatially self-assemble around stem cells, can be used to create specific morphogen gradients and systematically guide in vitro development www.cell.com/cell/fulltex... @cellcellpress.bsky.social @ophirklein.bsky.social
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Atul Butte @atulbutte.bsky.social · 06/12/2024
Very cool! One genomic test can diagnose nearly any infection! Comes out of the lab of Charles Chiu @ucsfhealth.bsky.social www.ucsf.edu/news/2024/11...
ucsf.edu
1 Genomic Test Can Diagnose Nearly Any Infection
A decade-long effort has resulted in a new, rapid genomic test to diagnose rare infectious diseases in the brain and lungs.
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Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 06/12/2024
#NCB2024 In February, @ophirklein.bsky.social & co examined transcriptional patterns across the entire mouse and human small #intestine and found that it comprises five domains of #NutrientAbsorption and three regional #StemCell populations. rdcu.be/d2FlY www.nature.com/articles/s41...
rdcu.be
Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains
Nature Cell Biology - Zwick et al. examine longitudinal transcriptional patterns across the entire mouse and human small intestine and find that, in both species, the small intestine comprises five...
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