ophirklein.bsky.social @ophirklein.bsky.social · 04/04/2026Trump Slashed Science Funding. Now the U.S. Could Face a Costly Brain Drain. www.nytimes.com/2026/04/04/b...nytimes.comTrump Slashed Science Funding. Now the U.S. Could Face a Costly Brain Drain. 000
ophirklein.bsky.social @ophirklein.bsky.social · 18/10/2025CNPY4 joins the growing list of lipid-binding regulators keeping cellular membranes balanced — exciting times for membrane & lipid biology! #lipidbiology #cellbiology #biorxiv #sphingolipids 010
ophirklein.bsky.social @ophirklein.bsky.social · 18/10/2025Why it matters 🧠 🧩 Reveals a new lipid-binding regulator in cells ⚙️ Links SAPLIP family proteins to membrane lipid regulation 🧪 Opens questions: how is CNPY4 controlled? disease relevance? 100
ophirklein.bsky.social @ophirklein.bsky.social · 18/10/2025Our work uncovers a new molecular player: CNPY4. CNPY4, a saposin-like protein, directly binds sphingolipids Loss or perturbation of CNPY4 disrupts lipid distribution + abundance → reshaping membrane architecture & possibly signaling pathways. This is a new layer of control in lipid homeostasis. 120
ophirklein.bsky.social @ophirklein.bsky.social · 18/10/2025Happy to share our new preprint in collaboration with Natalia Jura's lab! 🧬 CNPY4 is a lipid-binding regulator of sphingolipid homeostasis 👉 biorxiv.org/content/10.1101/2025.10.13.682155v1 Sphingolipids shape membranes & signaling — but how their balance is maintained is still unclear.biorxiv.orgCNPY4 is a Lipid-Binding Regulator of Sphingolipid HomeostasisSphingolipids function both as signaling molecules and as organizers of cell membranes, and their dysregulation has been linked to cancer, metabolic disorders, and neurodegeneration. A central node in... 130
ophirklein.bsky.social @ophirklein.bsky.social · 13/10/2025🔔SAVE THE DATE!🔔 Leanne Jones and I are super excited to announce the 3rd Intestinal Stem Cell conference is taking place next November in Mexico. Registration now open, ECR grants available and our Keynote, Hans Clevers, is confirmed. More info➡️ bit.ly/474De1Ebit.ly3rd Stem Cell - Niche Interactions in the Gastrointestinal Tract Conference | Fusion ConferencesOur scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros... 051
ophirklein.bsky.social @ophirklein.bsky.social · 10/10/2025www.cedars-sinai.org/newsroom/ced...cedars-sinai.orgNew Cedars-Sinai Study Aims to Improve Oral Tissue GraftsA new study at Cedars-Sinai Guerin Children’s, funded by a $5.7 million NIH grant, is exploring the use of stem cells to enhance oral tissue grafting. 030
Reposted by @ophirklein.bsky.socialSave Our Cures @saveourcures.bsky.social · 25/09/2025YOUR PHONE EXISTS because the government invested in "useless" basic research decades ago! It's the same with medical research - today's basic science leads to tomorrow's life-saving treatments. Visit FundResearch.org to tell Congress to keep funding research #SaveOurCures #PhoneForGood #FundNIH 021
Reposted by @ophirklein.bsky.socialSave Our Cures @saveourcures.bsky.social · 28/08/2025🎉 INTRODUCING #SaveOurCures🎉 Federal biomedical research represents less than 1% of the federal budget but delivers life-saving treatments for millions of American families. 93% of cancer treatments started with American government-funded research. 🧵: 1/8 122
ophirklein.bsky.social @ophirklein.bsky.social · 15/09/2025Trump Is Shutting Down the War On Cancer www.nytimes.com/2025/09/14/m...nytimes.comTrump Is Shutting Down the War On Cancer 000
ophirklein.bsky.social @ophirklein.bsky.social · 10/09/2025www.nytimes.com/2025/09/08/o...nytimes.comOpinion | We Are Watching a Scientific Superpower Destroy Itself 010
ophirklein.bsky.social @ophirklein.bsky.social · 31/08/2025We're very excited to launch a search for a founding director of our new reproductive sciences program at Cedars-Sinai! careers.cshs.org/job/los-ange...careers.cshs.orgDirector, Reproductive Sciences Program at CEDARS-SINAILearn more about applying for Director, Reproductive Sciences Program at CEDARS-SINAI 000
Reposted by @ophirklein.bsky.socialAmerican Society of Human Genetics (ASHG) @geneticssociety.bsky.social · 28/08/2025🎖️Congratulations to Carole Ober, PhD, winner of the ASHG 2025 Mentorship Award! Learn more about the award and Dr. Ober's work: www.ashg.org/membership/awards/2025… #ASHG #HumanGenetic 055
Reposted by @ophirklein.bsky.socialCamp Lab @graycamplab.bsky.social · 22/08/2025Final version @science.org "Recent evolution of the developing human intestine affects metabolic and barrier functions". Evolutionary preparation for microbiota, diet, and pathogen exposure is fascinating! Thank you @erc.europa.eu for supporting our vision! www.science.org/doi/10.1126/... 2308
Reposted by @ophirklein.bsky.socialHolly Ober @sciwri.bsky.social · 12/08/2025UCLA professor Bill Lowry: My current basic-research grant from the National Institutes of Health, which is a continuation of the work that led to this discovery on alopecia, was suspended last week. I don’t know what interesting discoveries won’t be made the longer this thing stays suspended. 🧪nymag.comThe Great Unbalding Draws NearerDecades of science have not found a way to regrow lost hair. Until, maybe, now. 5127
ophirklein.bsky.social @ophirklein.bsky.social · 04/07/2025The findings, if confirmed in humans, could one day lead to treatments that enable rapid, scarless recovery from skin wounds on other parts of the body." www.cedars-sinai.org/newsroom/pre...cedars-sinai.orgPreclinical Study Unlocks a Mystery of Rapid Mouth HealingYour mouth is a magician. Bite the inside of your cheek, and the wound may vanish without a trace in a couple of days. A preclinical study co-led by Cedars-Sinai, Stanford Medicine and the University ... 010
ophirklein.bsky.social @ophirklein.bsky.social · 04/07/2025"Your mouth is a magician. Bite the inside of your cheek, and the wound may vanish without a trace in a couple of days. A new study has discovered one secret of this disappearing act.cedars-sinai.orgPreclinical Study Unlocks a Mystery of Rapid Mouth HealingYour mouth is a magician. Bite the inside of your cheek, and the wound may vanish without a trace in a couple of days. A preclinical study co-led by Cedars-Sinai, Stanford Medicine and the University ... 110
ophirklein.bsky.social @ophirklein.bsky.social · 04/07/2025Excited to share our new paper by Jessi Cook in collaboration with Michelle Griffin from Mike Longaker's group at Stanford. www.science.org/stoken/autho... As nicely described by our communications team:urldefense.comGrowth arrest specific–6 and angiotoxin receptor–like signaling drive oral regenerative wound repairActivation of angiotoxin receptor–like signaling and suppression of focal adhesion kinase allow for regenerative healing in the oral mucosa. 162
ophirklein.bsky.social @ophirklein.bsky.social · 04/07/2025Join us in Crete in the fall to discuss stem cells! The early bird deadline has been extended to July 15th. This date will be the final deadline for abstracts being considered for short talk selection. www.aegeanconferences.org/src/App/spea... Looking forward to seeing you there!aegeanconferences.orgAegean Conferences 030
Reposted by @ophirklein.bsky.socialWaggoner Lab @labwaggoner.bsky.social · 02/07/2025Activation of angiotoxin receptor–like signaling and suppression of focal adhesion kinase allow for regenerative healing in the oral mucosa www.science.org/doi/10.1126/... @ophirklein.bsky.social 021
ophirklein.bsky.social @ophirklein.bsky.social · 23/06/2025Here Is All the Science at Risk in Trump’s Clash With Harvard www.nytimes.com/interactive/...nytimes.comHere Is All the Science at Risk in Trump’s Clash With HarvardMore than 900 research grants worth $2.6 billion are in jeopardy. So is the 80-year-old model of American science. 000
ophirklein.bsky.social @ophirklein.bsky.social · 18/06/2025Help Save the NIH www.congressweb.com/UCSF/9?frame...congressweb.comHelp Save the NIHAs the second largest recipient of NIH funding in the nation, UCSF depends on NIH funding to support our researchers in advancing health worldwide. Unfortunately, the White House's budget request pr... 000
Reposted by @ophirklein.bsky.socialArdem Patapoutian @ardemp.bskyverified.social · 03/06/2025Talked to @KateZernike at @nytimes about my journey and the current moment for scientists in the U.S. “Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.” Read the article here. No subscription required: www.nytimes.com/2025/06/03/u...nytimes.comThe U.S. Lit a Beacon for Science. Under Trump, Scientists Fear It’s Dimming 722893
ophirklein.bsky.social @ophirklein.bsky.social · 04/06/2025Sorry to read this and glad you are on the mend! 010
ophirklein.bsky.social @ophirklein.bsky.social · 03/06/2025www.nytimes.com/2025/06/03/u...nytimes.comThe U.S. Lit a Beacon for Science. Under Trump, Scientists Fear It’s Dimming 000
ophirklein.bsky.social @ophirklein.bsky.social · 20/05/2025www.nytimes.com/2025/05/19/o...nytimes.comOpinion | In the Future, China Will Be Dominant. The U.S. Will Be Irrelevant. 020
Reposted by @ophirklein.bsky.socialUrsula von der Leyen @vonderleyen.ec.europa.eu · 05/05/2025Europe’s choice is clear. To put science at the heart of its economy. To become the home of scientific freedom and collaboration. And to welcome talent from all over the world. I’m glad to present the first elements of our Choose Europe Initiative. → europa.eu/!TTbWbJ 1204021963
ophirklein.bsky.social @ophirklein.bsky.social · 03/05/2025Urge Congress to Reject the President's Budget Proposal to Cut NIH, NSF www.congressweb.com/ASHG/32?fram...congressweb.comUrge Congress to Reject the President's Budget Proposal to Cut NIH, NSFEarlier today on May 2, the Trump Administration proposed sweeping cuts across the U.S. Department of Health and Human Services (HHS), including a nearly 40% cut to the National Institutes of Health (... 020
ophirklein.bsky.social @ophirklein.bsky.social · 11/04/2025This is something I keep asking myself: www.nytimes.com/2025/04/11/o...nytimes.comOpinion | What Is Actually the Point of Treating the N.I.H. Like This?Efficiency is not being enhanced, nor is waste being eliminated at the N.I.H. Scientists are just left to wonder: Why? 020
ophirklein.bsky.social @ophirklein.bsky.social · 11/04/2025It was an honor to speak at the Shanthi Sitaraman Symposium at Emory yesterday, and to hear about Shanthi from her colleagues, friends and family. She was a remarkable physician, scientist and teacher. 010
ophirklein.bsky.social @ophirklein.bsky.social · 06/04/2025rarediseases.org/ceo-statemen...rarediseases.orgNORD CEO Statement on the Termination of the Advisory Committee on Heritable Disorders in Newborns and Children - National Organization for Rare DisordersThe sudden termination of the Advisory Committee on Heritable Disorders in Newborns and Children (ACHDNC) raises serious concerns for the rare disease community and families nationwide. 000
ophirklein.bsky.social @ophirklein.bsky.social · 04/04/2025www.nytimes.com/2025/04/03/o...nytimes.comOpinion | The Uncertain Fate of the Young American ScientistYoung researchers are choosing between staying in science and staying in the United States. 010
ophirklein.bsky.social @ophirklein.bsky.social · 03/04/2025Was great to visit @newyorkuniversity.bsky.social dental school today and to hear all the terrific science going on. A highlight of the trip was spending time with our former lab member @rkzwick.bsky.social in her beautiful new space and meet her growing group - she is off to a great start! 060
Reposted by @ophirklein.bsky.socialJeff Bush @jeffbush.bsky.social · 01/04/2025Just recruited two more grad students to be appreciated on Bluesky! @jasminegarciia.bsky.social @davidsungtooth.bsky.social @ophirklein.bsky.social 0101
ophirklein.bsky.social @ophirklein.bsky.social · 31/03/2025Killing the goose that lays the golden eggs www.nytimes.com/2025/03/31/b...nytimes.comTrump’s Science Policies Pose Long-Term Risk, Economists WarnSince World War II, U.S. research funding has led to discoveries that fueled economic gains. Now cutbacks are seen as putting that legacy in jeopardy. 020
ophirklein.bsky.social @ophirklein.bsky.social · 27/03/2025Was great to hear @ardemp.bskyverified.social 's lecture @cedars-sinai.bsky.social annual research day - amazing science and a remarkable life journey. He's so committed to understanding Piezo proteins that he got one tattooed on his arm! 080
Reposted by @ophirklein.bsky.socialCarolyn Bertozzi @carolynbertozzi.bskyverified.social · 07/03/2025Thank you for lending your voice to @standupforscience.bsky.social 🙏 052
ophirklein.bsky.social @ophirklein.bsky.social · 06/03/2025Save the date: The 6th Int’l Conference on Stem Cells will be held at the Kalimera Kriti Hotel in Sissi, Crete, Greece from October 1-6, 2025. Looking forward to our next iteration of this exciting and fun meeting! www.aegeanconferences.org/src/App/conf... 050
ophirklein.bsky.social @ophirklein.bsky.social · 06/03/2025Appreciate NIDCR highlighting our paper from last year in this nice piece: www.nidcr.nih.gov/news-events/... NIDCR support has been fundamental to our work since we began in this field, and its continued survival is essential to supporting essential dental, oral and craniofacial researchnidcr.nih.govThe Forces that Sculpt a ToothMultiplying cells create pressure that triggers the formation of command centers that direct tooth formation in mice, according to an NIDCR-funded study. 041
Reposted by @ophirklein.bsky.socialEric Topol @erictopol.bsky.social · 01/03/2025Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter www.nytimes.com/2025/03/01/u... 6131241380
ophirklein.bsky.social @ophirklein.bsky.social · 15/02/2025This is sobering: kucharski.substack.com/p/the-bigges...kucharski.substack.comThe biggest coincidence of my careerWhy we struggle to grasp how bad events will be 021
ophirklein.bsky.social @ophirklein.bsky.social · 14/02/2025www.nytimes.com/2025/02/14/o...nytimes.comOpinion | American Science is Under AttackThe Trump administration hobbles research and endangers the public health. 010
Reposted by @ophirklein.bsky.socialJAMA @jama.com · 14/02/2025Viewpoint: Recent disruptions and funding cuts at the National Institutes of Health (NIH) undermine the infrastructure and stability of US scientific research, threatening the nation's global leadership and scientific productivity. ja.ma/41hBnoc #MedSky 17348
Reposted by @ophirklein.bsky.socialAmerican Society of Human Genetics (ASHG) @geneticssociety.bsky.social · 14/02/2025ASHG is concerned about the cuts to NIH-funded research support, its impacts on biomedical research, and the effect on local, state, and national economies. We join our advocacy partners to ensure essential progress is not stalled. Read our statement: www.ashg.org/publications... #ASHG 13327
ophirklein.bsky.social @ophirklein.bsky.social · 12/02/2025Research Funding at Stake: Urgent Advocacy Needed for NIH Indirect Cost Policy www.congressweb.com/ASHG/31?fram...congressweb.comResearch Funding at Stake: Urgent Advocacy Needed for NIH Indirect Cost PolicyUPDATE: On February 10, the attorneys general of 22 states filed a lawsuit (https://www.azag.gov/press-release/attorney-general-mayes-sues-trump-administration-defunding-medical-and-public-health) aga... 001
ophirklein.bsky.social @ophirklein.bsky.social · 06/02/2025Congrats @rkzwick.bsky.social - super excited for you and I know you will do great things! Looking forward to seeing the lab in person before too long - 110
ophirklein.bsky.social @ophirklein.bsky.social · 05/02/2025February is Ectodermal Dysplasias Awareness Month! Please help to spread the word nfed.org/get-involved...nfed.orgFebruary is Ectodermal Dysplasias Awareness MonthEctodermal Dysplasia Awareness begins with YOU! Each February, we come together to celebrate Ectodermal Dysplasias Awareness Month—a time to amplify 000
