In 2015, Tim Raine and Carl Anderson had the ambitious idea of using single-cell sequencing to gain insights into the genes and cell types causally driving Inflammatory Bowel Disease (IBD), a project ...

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Patient and public involvement and engagement (PPIE) refers to the different ways those with lived experience, including patients, family, friends and carers, and the public engage with the design, de...

A trajectory-based molecular framework reveals coordinated temporal shifts in metabolic, inflammatory and fibrogenic mechanisms across the human MASLD spectrum.

A trajectory-based molecular framework reveals coordinated temporal shifts in metabolic, inflammatory and fibrogenic mechanisms across the human MASLD spectrum.

A trajectory-based molecular framework reveals coordinated temporal shifts in metabolic, inflammatory and fibrogenic mechanisms across the human MASLD spectrum.

Understanding how changes in gene function affect disease risk is central to drug development. Genetic variants are natural perturbations of gene activity and provide an opportunity to systematically ...

Lewis Evans is an Open Targets project lead and Senior Staff Scientist at the Wellcome Sanger Institute. He studies the genetics of neurodegeneration. As part of his project NeuroFlux, Lewis interacts...

"I’m a dermatologist, and my research straddles the disciplines of genomics, immunology, skin, and human development. I want to make a difference to human health, focusing on understanding how the hum...

As a platform grows in complexity, maintaining stability becomes increasingly difficult. The Open Targets Frontend Team has introduced automated end-to-end testing to ensure that core user journeys an...

The latest IBDverse study identifies the genes expressed in Crohn's disease, revealing a lasting 'molecular scar' in the gut lining.

IBDverse is a single-cell RNA atlas of terminal ileal biopsies comprising 1.1 million cells from 111 patients with Crohn’s disease and 232 healthy participants. Analysis of the data identifies genes, ...

Open Targets’ most successful collaborations are built on strong connections and regular communication between academic and industry partners at every stage of a project’s lifecycle. A decade after it...

Single-cell mapping of cis-expression quantitative trait loci in inflammatory bowel disease revealed distal, enhancer-enriched variants detected at the cell-type level more frequently co-loc...