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Nicole Coufal, MD, PhD

@nicolecoufal.bsky.social
32 followers 55 following 6 posts

Pediatric intensivist with research in translational neuroimmunology focused on neurodevelopmental and pediatric neurodegenerative disorders. #humanbrainmyeloidcells #microglia. Mom of 3 boys.

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Nicole Coufal, MD, PhD @nicolecoufal.bsky.social · 17/03/2026
The infrastructure for federal funding for science is crumbling - from funding opportunities to advisory councils. This will be devastating for science. elizabethginexi.substack.com/p/i-wrote-re...
elizabethginexi.substack.com
I Wrote Research Funding Announcements for NIH for 22 Years. This Year They’ve Published 14
How NIH went from 756 funding announcements to 14 in two years — and what it means for every disease that depends on federal research
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Reposted by Nicole Coufal, MD, PhD
Dorit Reiss @doritreiss.bsky.social · 27/02/2026
White House stalls release of approved US science budgets: The administration has not yet released funding Congress allocated to multiple research agencies, so they cannot provide it to funded entities/people - including NIH and NASA. www.nature.com/articles/d41...
nature.com
White House stalls release of approved US science budgets
The US Congress rejected sweeping cuts to science agencies. But the NIH, the NSF and NASA have had their spending slowed.
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Nicole Coufal, MD, PhD @nicolecoufal.bsky.social · 03/06/2025
Universities and the government: Which needs the other more?
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Reposted by Nicole Coufal, MD, PhD
John Lukens @lukensjohnr.bsky.social · 24/05/2025
STING deletion protects against amyloid β–induced Alzheimer's disease pathogenesis - Thanos - 2025 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com
STING deletion protects against amyloid β–induced Alzheimer's disease pathogenesis
INTRODUCTION While immune dysfunction has been increasingly linked to Alzheimer's disease (AD) progression, many major innate immune signaling molecules have yet to be explored in AD pathogenesis us...
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Reposted by Nicole Coufal, MD, PhD
John Lukens @lukensjohnr.bsky.social · 03/05/2025
Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. @cp-immunity.bsky.social All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...
cell.com
Inflammasome signaling in astrocytes modulates hippocampal plasticity
The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in memory...
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Reposted by Nicole Coufal, MD, PhD
Science Magazine @science.org · 02/05/2025
President Donald Trump today asked Congress to make massive and unprecedented cuts to the 2026 budgets of major federal science agencies. scim.ag/3Yszqnm
scim.ag
Trump’s proposed budget would mean ‘disastrous’ cuts to science
Key research budgets would shrink by one-third to one-half in 2026 spending plan
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Reposted by Nicole Coufal, MD, PhD
Max Kozlov @maxkozlov.bsky.social · 01/05/2025
NEW: An NIH policy coming in the next week will target — and at least temporarily stop — funding outside the US, threatening thousands of projects and collaborations on topics like infectious diseases and cancer. Some NIH staff have already been told to hold all subaward funds for foreign labs.
nature.com
Exclusive: NIH to suspend funds for research abroad as it overhauls policy
Move by US biomedical agency threatens thousands of projects on infectious diseases, cancer and more.
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Reposted by Nicole Coufal, MD, PhD
Dan Garisto @dangaristo.bsky.social · 01/05/2025
BREAKING: NSF has frozen all grant funding, as of yesterday. It's unclear when they will resume funding awards, or why the pause has been put in place. www.nature.com/articles/d41...
nature.com
Exclusive: NSF stops awarding new grants and funding existing ones
US science funder also plans to screen grant applications for compliance with ‘agency priorities’.
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Reposted by Nicole Coufal, MD, PhD
Alexander Tin @alexander-a-tin.bsky.social · 10/04/2025
Nearly half of CDC's developmental disabilities and birth defects center is now off the job Secy Kennedy's layoffs included entire team working on sickle cell disease www.cbsnews.com/news/cdc-cut...
cbsnews.com
CDC faces backlash for cutting sickle cell, adult disability programs
Nearly half of the National Center on Birth Defects and Developmental Disabilities was laid off.
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Reposted by Nicole Coufal, MD, PhD
Christian Odendahl @codendahl.bsky.social · 28/03/2025
Nobel Prizes by country and year. The dominance of Germany is striking every time. Before 1933, that is. And the utter dominance of America (and the UK) after 1945.
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Reposted by Nicole Coufal, MD, PhD
Jeremy Berg @jeremymberg.bsky.social · 28/03/2025
Powerful new Washington Post story up... wapo.st/426d9fT (Gift link) 1/n
wapo.st
Trump promised scientific breakthroughs. Researchers say he’s breaking science.
NIH funding for biomedical research has abruptly fallen by billions of dollars, with many grant decisions on hold. Trump officials say they’re reviewing the agency.
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Reposted by Nicole Coufal, MD, PhD
Joe Allen @joeallenjoe.bsky.social · 12/03/2025
In fiscal year 2024, the report found, NIH awarded more than $36.9 billion to researchers, supporting more than 408,000 jobs and generating over $94.5 billion in new economic activity nationwide. news.harvard.edu/gazette/stor...
news.harvard.edu
NIH funding delivers exponential economic returns — Harvard Gazette
Report finds all 50 states reap gains in patient health, job creation, research resources, business development.
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Reposted by Nicole Coufal, MD, PhD
Charles Jennings @chasjennings.bsky.social · 12/03/2025
This message needs to be heard widely.
news.harvard.edu
NIH funding delivers exponential economic returns — Harvard Gazette
Report finds all 50 states reap gains in patient health, job creation, research resources, business development.
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Reposted by Nicole Coufal, MD, PhD
Gregg Gonsalves @gregggonsalves.bsky.social · 09/03/2025
This is a great piece on how acting NIH Director Matthew Memoli and his MAGA cronies at HHS are twisting the story on indirect costs. @insidehighered.com www.insidehighered.com/opinion/view...
insidehighered.com
Why the NIH cuts are so wrong (opinion)
Christopher Newfield writes that higher ed has a better counternarrative to share.
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Reposted by Nicole Coufal, MD, PhD
John Lukens @lukensjohnr.bsky.social · 06/03/2025
Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease @naturemedicine.bsky.social www.nature.com/articles/s41...
nature.com
Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease - Nature Medicine
Spatial transcriptomics reveals distinct microglial mechanisms driving amyloid-β clearance in both passively and actively immunized patients with Alzheimer’s disease.
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Nicole Coufal, MD, PhD @nicolecoufal.bsky.social · 05/03/2025
Everyone should know what is happening at the NIH www.washingtonpost.com/science/2025...
washingtonpost.com
NIH reels with fear, uncertainty about future of scientific research
The Trump administration’s orders have created more turmoil and damage at the National Institutes of Health than was previously known.
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Reposted by Nicole Coufal, MD, PhD
rnatr @rnatr.com · 03/03/2025
This article about what is going on at NIH is insightful. It details why the fight over the indirect rates are existential and show how the administration is trying to seize power that is directly given to Congress by the constitution www.sensible-med.com/p/the-nih-is...
sensible-med.com
The NIH is Being Slashed and Burned, not “Reformed”
A strong and well-argued rebuttal to NIH criticism
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Reposted by Nicole Coufal, MD, PhD
David Shiffman, Ph.D. 🦈 @whysharksmatter.bsky.social · 03/03/2025
Today, a broad coalition of scientific professional societies who represent over 92,000 scientists are speaking out against the politicization and demonization of Federally funded science and government scientist jobs. It was an honor to help the Union of Concerned Scientists with this! 🧪🌎
ucsusa.org
48 Scientific Societies Representing Almost 100,000 Scientists Ask Congress to Protect the Future of Science
48 scientific societies representing almost 100,000 scientists signed on to a letter asking Congress to protect the future of science
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Reposted by Nicole Coufal, MD, PhD
John Lukens @lukensjohnr.bsky.social · 03/03/2025
CLEC16A in astrocytes promotes mitophagy and limits pathology in a multiple sclerosis mouse model @NatureNeuro www.nature.com/articles/s41...
nature.com
CLEC16A in astrocytes promotes mitophagy and limits pathology in a multiple sclerosis mouse model - Nature Neuroscience
The mechanisms of pathological astrocyte responses during multiple sclerosis remain unclear. Kadowaki et al. found in MS mouse models that CLEC16A suppresses astrocyte pathogenic activities related to...
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Reposted by Nicole Coufal, MD, PhD
Mariko Bennett @nachoriko.bsky.social · 01/03/2025
In this #rarediseaseday2025 we cannot remain silent. We must fight on the beach and the bench. Share. Tell your stories. Call your elected officials. Call your unelected officials. #fightonthebench
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Reposted by Nicole Coufal, MD, PhD
Jonathan Ladd @jonathanmladd.com · 27/02/2025
"officials at the Dept. of HHS... have pressed staff at the agency to ignore court orders, according to nearly a dozen former and current NIH officials I spoke with. Even advice from NIH lawyers to resume business as usual was dismissed by the agency’s acting director, those officials said."
theatlantic.com
Inside the Collapse at the NIH
Administration officials pressured the NIH to avoid clear advice from the agency’s own lawyers to restart grant funding now.
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Reposted by Nicole Coufal, MD, PhD
Igor Brodsky @brodskyigorlab.bsky.social · 26/02/2025
Despite court order, NIH grants remain frozen. Newly awarded grants, grants with fundable scores, & funds for a new budget cycle of a current project are all *FROZEN*🥶 and not being released. US research is being choked to death & is on life support right now www.motherjones.com/politics/202...
motherjones.com
NIH is again throttling research funding in defiance of a federal court order
A freeze on "new and continuation awards" will "remain in place" pending DEI review, states a new internal memo.
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Reposted by Nicole Coufal, MD, PhD
UCSD PICU Fellowship @ucsd-picu.bsky.social · 23/02/2025
PCCM article by Christina Rufener & team. Congratulations! #pedsICU @nicolecoufal.bsky.social @sapnakmd.bsky.social @helenharvey3.bsky.social journals.lww.com/pccmjournal/...
journals.lww.com
Extubation Practices and Outcomes During Pediatric... : Pediatric Critical Care Medicine
ional database of all ECMO centers in the ELSO registry. Patients: Patients between 30 days and 18 years old receiving pulmonary ECMO support. Interventions: None. Measurements and Main Results...
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Reposted by Nicole Coufal, MD, PhD
Science Magazine @science.org · 24/02/2025
“There’s going to be a missing age class of researchers that will reverberate for years.” scim.ag/3ERRLDo
scim.ag
U.S. early-career researchers struggling amid chaos
Uncertain funding, government firings, and distressed universities hit vulnerable groups especially hard
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Nicole Coufal, MD, PhD @nicolecoufal.bsky.social · 23/02/2025
Sent to all of HHS/NIH as well. It’s purely meant to intimidate and to make them question their self worth. apple.news/An1zUSES4QKq...
apple.news
Feds must answer email on what they did last week — or lose jobs, Musk says — The Washington Post
Musk says on X that feds must explain what they did last week — or resign
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Nicole Coufal, MD, PhD @nicolecoufal.bsky.social · 21/02/2025
Nature discussing the mess of the NIH. www.nature.com/articles/d41...
nature.com
Revealed: NIH research grants still frozen despite lawsuits challenging Trump order
The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.
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Reposted by Nicole Coufal, MD, PhD
Dr. Becca @docbecca.bsky.social · 20/02/2025
Glad to see this post getting some traction, because the Federal Register is the WHOLE ballgame, folks. To drive this point home, a recent EO declares that all posts to FR now must be approved by the White House. www.whitehouse.gov/presidential...
whitehouse.gov
Ensuring Accountability for All Agencies
By the authority vested in me as President by the Constitution and the laws of the United States of America, it is hereby ordered:
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Reposted by Nicole Coufal, MD, PhD
Meredith Wadman @meredithwadman.bsky.social · 20/02/2025
icymi, @science.org has a new tracker to keep you up to the minute: Trump Tracker: Firings, lawsuits, and U.S. science in chaos | Science | AAAS www.science.org/content/arti...
science.org
Trump Tracker: Firings, lawsuits, and U.S. science in chaos
Follow President Donald Trump’s impact on U.S. research and science globally
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Reposted by Nicole Coufal, MD, PhD
Alex Sundermann, DrPH @sundermannaj.bsky.social · 20/02/2025
41/47 (87%) of NIH study sections are cancelled this week Frustrating to see all this good research stalled (& not funded) You can search for study sections that ‘did not meet as scheduled’ here with ones with * ⤵️ www.csr.nih.gov/RevPanelsAnd...
csr.nih.gov
Review Dates
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Nicole Coufal, MD, PhD @nicolecoufal.bsky.social · 19/02/2025
Blocking study sections stops the flow of funding and is destroying science. www.thetransmitter.org/funding/fede...
thetransmitter.org
Federal Register hold makes ‘end run’ around court pause on NIH funding freeze
NIH-related updates to the Federal Register, which are required for the scheduling of study sections and advisory councils, are on hold indefinitely, according to an email reviewed by <i>The Transmitt...
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Reposted by Nicole Coufal, MD, PhD
Max Kozlov @maxkozlov.bsky.social · 13/02/2025
NEW: In a further sign of turmoil at the NIH, Mike Lauer, who oversees the agency's $39 billion extramural budget that goes to research outside the NIH, has resigned effective tomorrow. This comes after top NIH official Larry Tabak abruptly retired yesterday.
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