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Fan Hag

@naphu.bsky.social
41 followers 109 following 6 posts

#biotech #drugdev #pkpd - #ertra

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Reposted by Fan Hag
Keith Hornberger @krhornberger.bsky.social · 06/06/2025
Discovery of an LSD1 PROTAC degrader
pnas.org
Discovery of an LSD1 PROTAC degrader | PNAS
Aberrant expression of lysine-specific demethylase 1 (LSD1) has been implicated in various cancers, including acute myeloid leukemia (AML). Recent ...
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Reposted by Fan Hag
NEJM.org @nejm.org · 16/03/2025
A 2-year-old boy presented with a 1-week history of itchy, red spots. Tense vesicles, erosions, and inflammatory plaques were seen. Direct immunofluorescence revealed a linear band of IgA at the dermoepidermal junction. Read the full case details: nej.md/3R6CIIA #MedSky #DermSky #PedSky
Images in Clinical Medicine 
Linear IgA Bullous Dermatosis of Childhood 

Panel A: Tense vesicles and edematous pink plaques with central erosions and crust on the patient’s legs. 
Panel B: Direct immunofluorescence revealing a linear band of IgA along the dermoepidermal junction.
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Derek Lowe @dereklowe.bsky.social · 10/03/2025
Single-base CRISPR gene editing from Beam seems to have passed its first test in human trials. This is very good news indeed, and as the year goes on we’ll see even more readouts.
science.org
Single-Base Editing Seems to Work
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BioPharmCatalyst @biopharmcatalyst.bsky.social · 10/03/2025
$MLYS announced topline results from its pivotal Phase 3 Launch-HTN and Phase 2 Advance-HTN trials for lorundrostat for hypertension, with both trials meeting primary efficacy endpoints See More Pre-market Movers 👇 www.biopharmcatalyst.com/news/2025/mi... $CKPT $QTTB $TRVI $BEAM $PSTV $PRLD $ARWR
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Fyodor Urnov @urnov.bsky.social · 10/03/2025
Spectacular news this morning for CRISPR gene editing to treat genetic disease from Beam Therapeutics. This method was developed by David Liu's lab at the Broad. = "academic" science produces innovations that enables the biotech sector to build medicines investors.beamtx.com/news-release...
investors.beamtx.com
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Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 04/03/2025
Biotech startup pulls in $187M to make ‘multi-payload’ ADCs www.biopharmadive.com/news/callio-...
biopharmadive.com
Biotech startup pulls in $187M to make ‘multi-payload’ ADCs
Callio Therapeutics is launching with an ADC technology and programs licensed from Singapore-based antibody drug developer Hummingbird Bioscience.
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Reposted by Fan Hag
News Medical @newsmedical.bsky.social · 18/02/2025
Cancer-free for 18 years: CAR-T therapy sets new milestone in neuroblastoma treatment 🎗️🔬🧬 www.news-medical.net/news/2025021... #Cancer #CARTTherapy #Neuroblastoma #MedicalBreakthrough #ChildhoodCancer #Immunotherapy #Oncology #Biotech
news-medical.net
Cancer-free for 18 years: CAR-T therapy sets new milestone in neuroblastoma treatment
A groundbreaking study in Nature Medicine reveals that GD2 CAR-T cell therapy can lead to long-term remission in children with neuroblastoma, with one patient remaining cancer-free for over 18 years.
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 09/02/2025
Cool paper using LLM to discover a protein sequence code for subcellular localization 👏 www.science.org/doi/10.1126/...
science.org
Protein codes promote selective subcellular compartmentalization
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...
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Sri Kosuri @srikosuri.bsky.social · 08/02/2025
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
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Citizen.Coping @propcazhpm.bsky.social · 31/01/2025
In 1887, African American composer Edmond Dédé was living in exile in France and completed the greatest work of his life: an opera 545 pages long telling a story of epic proportions. He knew that what he had accomplished was important. Shows 2/5 NYC, 2/7 DC #BlackSky Free link: archive.ph/g3AYv
nytimes.com
Found: A Manuscript That Unlocks a Forgotten Black Composer’s World
Almost 125 years after Edmond Dédé’s death, his magnum opus “Morgiane,” perhaps the oldest existing opera by a Black American, is to be staged for the first time.
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Luke Timmerman @luketimmerman.bsky.social · 23/01/2025
Party Like It's 2015: Celebrate the 10th Anniversary of Timmerman Report in March. Register for these free, fun events in Boston and Seattle. -- timmermanreport.com/2025/01/part...
timmermanreport.com
Party Like It’s 2015: Celebrate the 10th Anniversary of Timmerman Report - TimmermanReport.com
The Timmerman Report is gearing up for the 10th Anniversary. Time to Party! Join a stellar cast of biotech leaders at the TR10 East Coast Party. This free and fun event will celebrate the 10th anniver...
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Reposted by Fan Hag
William Barter @wjbarter.bsky.social · 21/01/2025
The value of g, the acceleration of an object under gravity at the Earth’s surface (9.81 m/s^2) is very close to pi^2 = 9.87. It’s a better approximation than g = 10 m/s^2, and this is no accident…
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Derek Lowe @dereklowe.bsky.social · 14/01/2025
How do cancer cells adapt to the stress of being cancer cells, with the constant stream of mutant and misfolded proteins? There’s more than one strategy, and therapeutically you’d like to know which is being used:
science.org
Dealing With Being a Tumor Cell
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STAT @statnews.com · 13/01/2025
Duke neuroscientist Kafui Dzirasa wants nothing less than to reengineer the brain’s electrical patterns to treat anxiety, depression, bipolar disorder, and schizophrenia.
buff.ly
‘My life’s purpose’: A neuroscientist wants to rewire mental illness treatment and remake the field he loves
Duke neuroscientist Kafui Dzirasa wants nothing less than to reengineer the brain’s electrical patterns to treat anxiety, depression, bipolar disorder, and schizophrenia.
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NEJM.org @nejm.org · 12/01/2025
𝐍𝐨𝐭𝐚𝐛𝐥𝐞 𝐀𝐫𝐭𝐢𝐜𝐥𝐞𝐬 𝐨𝐟 𝟐𝟎𝟐𝟒: Omalizumab for Multiple Food Allergies In a trial involving 180 persons with food allergies, omalizumab was effective in increasing the reaction threshold for peanut & other common food allergens. Read more: nej.md/4bLW7aS #MedSky
Notable Articles of 2024 
Omalizumab for the Treatment of Multiple Food Allergies 
R.A. Wood et al. (published February 25, 2024) 

Visual representation of omalizumab for treatment of patients with multiple food allergies 

The New England Journal of Medicine
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Saloni @scientificdiscovery.dev · 09/01/2025
Childhood cancer death rates in the United States have declined six-fold over the last seventy years. 🧵
This chart presents US cancer death rates in children under five years old, measured in reported annual death rates per 100,000 children. It consists of four graphs:

1. All Malignant Cancers Combined: This graph illustrates a decline in childhood cancer death rates from about 11 per 100,000 in 1950 to around 1.8 in 2021, indicating a six-fold decrease since the 1950s.
   
2. Leukemia: This graph shows a decrease from around 5 per 100,000 in 1950 to less than 1 in 2021, following a similar declining trend throughout the decades.

3. Brain and Nervous System Cancers: This chart shows some fluctuations but overall a decline from nearly 0.8 per 100,000 in 1950 to about 0.4 in 2021.

4. Lymphomas and Multiple Myeloma: This graph shows fluctuations and a decline from around 0.8 in the late 1950s to less than 0.2 by 2021.

The data is sourced from the WHO Mortality Database (2024), with a note indicating that figures may fluctuate year-by-year due to low numbers.
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Eric Fauman (he/him) @ericfauman.bsky.social · 09/01/2025
SLC45A2 is a melanosome-specific transporter important for maintaining proper pH and osmotic balance. It's a wonderful example of "top down" causal gene inference. From its very function we expect it to be a gwas hit for pigmentation, regardless of where it sits in the genome.
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Ming Tommy Tang @tommytang.bsky.social · 07/01/2025
AI is hyped as the future of drug development. But has it really changed the game? Let’s break down where AI stands and what’s missing. 🧵
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Lawrence Hurley @lawrencehurley.bsky.social · 07/01/2025
Two federal death row inmates don't want Biden to commute their sentences because they say it would disadvantage them in their efforts to mount innocence claims (via my colleague Erik Ortiz): www.nbcnews.com/news/us-news...
nbcnews.com
Two death row inmates reject Biden's commutation of their life sentences
Shannon Agofsky and Len Davis were among 37 of the 40 federal prisoners whose death sentences were changed to life in prison without the possibility of parole.
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MIT Technology Review @technologyreview.com · 07/01/2025
The Vera C. Rubin Observatory—one of this year’s 10 Breakthrough Technologies—will help astronomers study dark matter, explore the Milky Way, and untangle other cosmic unknowns.
technologyreview.com
Vera C. Rubin Observatory: 10 Breakthrough Technologies 2025
The telescope’s massive digital camera was built to take a lot of photos of the sky, in quick succession, for a very long time.
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Fan Hag @naphu.bsky.social · 07/01/2025
Pluto may have captured its moon Charon following a fleeting ‘kiss-and-capture’ collision, in which both bodies survived largely intact... www.nature.com/articles/s41...
nature.com
Capture of an ancient Charon around Pluto - Nature Geoscience
Numerical simulations suggest that Pluto’s moon Charon was captured intact, in a scenario in which the two bodies temporarily merged in a collision but did not coalesce due to solid strength effects.
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Reposted by Fan Hag
Derek Lowe @dereklowe.bsky.social · 05/01/2025
I think you're describing science, IMO. Everything is atop a foundation of basic research. An example: at a previous company, I worked on a series of small-molecule inhibitors of Hormone-Sensitive Lipase, a possible target for Type II diabetes and related conditions. (1/10)
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Fan Hag @naphu.bsky.social · 04/01/2025
www.thefp.com/p/sean-fisch...
thefp.com
My Mom Was Diagnosed with Alzheimer’s. Then She Got Better.
My family experienced a miracle last year. It began with a tragedy.
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Stephan Hacker @stephanhacker2.bsky.social · 03/01/2025
Very interesting to see the 50 new drugs that made it to FDA approval in 2024 in one place. A lot of really exciting small molecule chemistry with interesting functional groups, deuterations and covalent warheads. #chemsky #chembio www.linkedin.com/posts/chrisd...
linkedin.com
Chris De Savi on LinkedIn: #medicine #pharmaceuticals #healthcare | 90 comments
FDA Novel Drug Approvals 2024 #medicine That is a wrap for 2024! And another year of relentless drug discovery! There you have it, drug-hunting aficionados,… | 90 comments on LinkedIn
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Carl Zimmer @carlzimmer.com · 31/12/2024
Five years ago today, Wuhan public health officials first let the world know about a "viral pneumonia" sweeping the city. www.who.int/news/item/30...
who.int
Milestone: COVID-19 five years ago
Five years ago on 31 December 2019, WHO’s Country Office in China picked up a media statement by the Wuhan Municipal Health Commission from their website on cases of ‘viral pneumonia’ in Wuhan, China....
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Anodyne @anodynesix.bsky.social · 31/12/2024
"Youth justice researchers spoke with 21 families in Macomb County with an average of $87,000 in court debt. Among them, one parent said she had her state tax refund garnished for 10 years and still had $67,000 in debt after her son spent less than a year in detention more than a decade ago."
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Jason Ukman @jasonukman.bsky.social · 30/12/2024
The world can seem grim on that other platform, on this platform, on any platform. @matthewherper.bsky.social is here to remind us that, when it comes to health and medicine, there is plenty of reason for hope. www.statnews.com/2024/12/30/t...
statnews.com
The biggest medical advances of 2024
The biggest medical advances of 2024 will be remembered as significant long into the future.
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Steve Brown - astronomy and astrophotography @sjbastro.bsky.social · 30/12/2024
Astronomers ready for dazzling but brief celestial show after 80-year wait. When will T Corona Borealis brighten? Hopefully when we have clear skies! 😀 #Astronomy #Space www.bbc.co.uk/news/article...
bbc.co.uk
T Cor Bor: Astronomers await dazzling celestial show
Astronomers are poised to see a star system about 3,000 light years away explode into brightness.
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Shen Tian 田申 @tianshenbio.bsky.social · 05/12/2024
Our miRNA story is now in @science.org ! We found a microRNA, not a protein, that finally solved a long-standing evolutionary mystery of wing coloration in butterflies and moths. (1/n) www.science.org/doi/10.1126/...
science.org
A microRNA is the effector gene of a classic evolutionary hotspot locus
In Lepidoptera (butterflies and moths), the genomic region around the gene cortex is a “hotspot” locus, repeatedly implicated in generating intraspecific melanic wing color polymorphisms across 100 mi...
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Fan Hag @naphu.bsky.social · 11/12/2024
#Somalia. One step forward, 100 steps backwards 😞
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Paul Byrne @theplanetaryguy.com · 10/12/2024
A new JWST deep field. All the eight-sided features are local stars in the Milky Way. Everything else is a galaxy. EVERYTHING ELSE IS A GALAXY.
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BioPharmCatalyst @biopharmcatalyst.bsky.social · 10/12/2024
$QURE agreed with the FDA on an Accelerated Approval pathway for AMT-130, allowing data from ongoing Phase 1/2 studies, to serve as the basis for a BLA See More Pre-market Movers 👇 www.biopharmcatalyst.com/news/2024/ch... $CMRX $CPIX $CRDF $PBM $NAMS $CRVO $NXCT
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trebstar.bsky.social @trebstar.bsky.social · 30/11/2024
Some love spinach, but in the future, some might have hearts made of spinach: In 2017, Gershlak et al. seeded human cardiac tissue onto decellularized spinach leaves. The tissue grew and contracted on the leaf’s cellulose scaffold—bioengineering at its finest!
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Fan Hag @naphu.bsky.social · 11/11/2024
Awesome stuff... Hackathon to diagnose rare diseases www.nature.com/articles/s41...
nature.com
Pushing the boundaries of rare disease diagnostics with the help of the first Undiagnosed Hackathon - Nature Genetics
In the first-ever Undiagnosed Hackathon, nearly 100 experts from 28 countries combined advanced phenotyping and genomic techniques for 48 hours, ultimately providing diagnoses to 40% of the previously...
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Bruce Levine, Ph.D. 🇺🇦 @bllphd.bsky.social · 09/11/2024
🚨 7th CAR T Cell #immunotherapy approved by #FDA obecabtagene autoleucel for adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia www.fda.gov/drugs/resour...
fda.gov
FDA approves obecabtagene autoleucel for acute lymphoblastic leukemia
On November 8, 2024, the FDA approved obecabtagene autoleucel (Aucatzyl, Autolus Inc.) for relapsed or refractory B-cell precursor acute lymphoblastic leukemia.
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Fan Hag @naphu.bsky.social · 24/10/2024
#Eritrea
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Pearl Freier @pearlf.bsky.social · 24/10/2024
NTLA-2002 is potentially the first in vivo CRISPR drug that will be FDA-approved said $NTLA's CEO. Intellia is recruiting for a larger 60-person Phase 3 study & aims to file for FDA approval in 2026 according to the story below. Potential cure/"one & done treatment" for hereditary angiodema #biosky
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Paul Bonanos @biobonanos.bsky.social · 23/10/2024
Good morning #biosky! In a small but intriguing takeout: Merck is buying Modifi Biosciences for $30 million u/f, but milestones could push the deal's value to $1.3 billion. Preclinical Yale spinout focused on DNA repair defects had raised $10.7m in seed funding: www.globenewswire.com/en/news-rele...
globenewswire.com
Modifi Biosciences Acquired by Merck
Merck gains preclinical compounds designed to exploit DNA repair defects in difficult to treat cancers...
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Rick Livesey @ricklivesey.bsky.social · 23/10/2024
Our first preprint announcement on bluesky! Using human iPSC and Drosophila models of a frontotemporal dementia, we find that key pathologies can be corrected by targeting the NAT10 acetyltransferase #biosky www.biorxiv.org/content/10.1...
biorxiv.org
Targeting the acetyltransferase NAT10 corrects pathologies in human frontotemporal dementia neurons and extends lifespan in an in vivo Drosophila tauopathy model
Disruption of the neuronal nuclear membrane and perturbation of nucleocytoplasmic transport are features of neurodegenerative diseases, including Alzheimer's disease, that involve the microtubule-asso...
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Kai Kupferschmidt @kakape.bsky.social · 17/10/2024
No new cases of #Marburg and no deaths in Rwanda today, plus 8 patients have recovered! Looking better by the day! But remember that filoviruses are tricky and an outbreak is declared over only after 42 days with no new infections (= two incubation periods).
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Derek Lowe @dereklowe.bsky.social · 16/10/2024
Protein-degrader bifunctional molecules are heading into Phase III trials, and there are s lot more ideas where that one came from:
science.org
Induced Proximity, in the Lab and in the Clinic
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Derek Lowe @dereklowe.bsky.social · 18/10/2024
Is the FDA's accelerated approval process accomplishing what it was designed to? What do we want it to accomplish in the first place?
science.org
Accelerated Approval: What Is It Accomplishing?
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STAT @statnews.com · 07/10/2024
The oldest known survivor of progeria, his life was utterly unlike others', but he lived with the conviction he could connect with anybody. www.statnews.com/2024/10/06/s...
statnews.com
Sammy Basso, progeria advocate, has died at 28
We generally don’t think of rare-disease advocacy as funny. But Sammy Basso, who died at 28, will be remembered for his ability to find laughter in almost anything.
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Bruce Levine, Ph.D. 🇺🇦 @bllphd.bsky.social · 04/11/2023
If CAR T Cells & mRNA LNP vaccines had a baby, that would give the transformative technology of targeted LNPs encoding CARs Brad Loncar interviews Laura Shawver www.biotechtv.com/post/capstan...
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