Reposted by Fan HagKeith Hornberger @krhornberger.bsky.social · 06/06/2025Discovery of an LSD1 PROTAC degraderpnas.orgDiscovery of an LSD1 PROTAC degrader | PNASAberrant expression of lysine-specific demethylase 1 (LSD1) has been implicated in various cancers, including acute myeloid leukemia (AML). Recent ... 032
Reposted by Fan HagNEJM.org @nejm.org · 16/03/2025A 2-year-old boy presented with a 1-week history of itchy, red spots. Tense vesicles, erosions, and inflammatory plaques were seen. Direct immunofluorescence revealed a linear band of IgA at the dermoepidermal junction. Read the full case details: nej.md/3R6CIIA #MedSky #DermSky #PedSky 1157
Reposted by Fan HagDerek Lowe @dereklowe.bsky.social · 10/03/2025Single-base CRISPR gene editing from Beam seems to have passed its first test in human trials. This is very good news indeed, and as the year goes on we’ll see even more readouts.science.orgSingle-Base Editing Seems to Work 4495
Reposted by Fan HagBioPharmCatalyst @biopharmcatalyst.bsky.social · 10/03/2025$MLYS announced topline results from its pivotal Phase 3 Launch-HTN and Phase 2 Advance-HTN trials for lorundrostat for hypertension, with both trials meeting primary efficacy endpoints See More Pre-market Movers 👇 www.biopharmcatalyst.com/news/2025/mi... $CKPT $QTTB $TRVI $BEAM $PSTV $PRLD $ARWR 001
Reposted by Fan HagFyodor Urnov @urnov.bsky.social · 10/03/2025Spectacular news this morning for CRISPR gene editing to treat genetic disease from Beam Therapeutics. This method was developed by David Liu's lab at the Broad. = "academic" science produces innovations that enables the biotech sector to build medicines investors.beamtx.com/news-release...investors.beamtx.com 17115
Reposted by Fan HagWafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 04/03/2025Biotech startup pulls in $187M to make ‘multi-payload’ ADCs www.biopharmadive.com/news/callio-...biopharmadive.comBiotech startup pulls in $187M to make ‘multi-payload’ ADCsCallio Therapeutics is launching with an ADC technology and programs licensed from Singapore-based antibody drug developer Hummingbird Bioscience. 082
Reposted by Fan HagNews Medical @newsmedical.bsky.social · 18/02/2025Cancer-free for 18 years: CAR-T therapy sets new milestone in neuroblastoma treatment 🎗️🔬🧬 www.news-medical.net/news/2025021... #Cancer #CARTTherapy #Neuroblastoma #MedicalBreakthrough #ChildhoodCancer #Immunotherapy #Oncology #Biotechnews-medical.netCancer-free for 18 years: CAR-T therapy sets new milestone in neuroblastoma treatmentA groundbreaking study in Nature Medicine reveals that GD2 CAR-T cell therapy can lead to long-term remission in children with neuroblastoma, with one patient remaining cancer-free for over 18 years. 051
Reposted by Fan HagCarolyn Bertozzi @carolynbertozzi.bskyverified.social · 09/02/2025Cool paper using LLM to discover a protein sequence code for subcellular localization 👏 www.science.org/doi/10.1126/...science.orgProtein codes promote selective subcellular compartmentalizationCells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote... 623568
Reposted by Fan HagSri Kosuri @srikosuri.bsky.social · 08/02/2025It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases. 841009846
Reposted by Fan HagCitizen.Coping @propcazhpm.bsky.social · 31/01/2025In 1887, African American composer Edmond Dédé was living in exile in France and completed the greatest work of his life: an opera 545 pages long telling a story of epic proportions. He knew that what he had accomplished was important. Shows 2/5 NYC, 2/7 DC #BlackSky Free link: archive.ph/g3AYvnytimes.comFound: A Manuscript That Unlocks a Forgotten Black Composer’s WorldAlmost 125 years after Edmond Dédé’s death, his magnum opus “Morgiane,” perhaps the oldest existing opera by a Black American, is to be staged for the first time. 9261101
Reposted by Fan HagLuke Timmerman @luketimmerman.bsky.social · 23/01/2025Party Like It's 2015: Celebrate the 10th Anniversary of Timmerman Report in March. Register for these free, fun events in Boston and Seattle. -- timmermanreport.com/2025/01/part...timmermanreport.comParty Like It’s 2015: Celebrate the 10th Anniversary of Timmerman Report - TimmermanReport.comThe Timmerman Report is gearing up for the 10th Anniversary. Time to Party! Join a stellar cast of biotech leaders at the TR10 East Coast Party. This free and fun event will celebrate the 10th anniver... 042
Reposted by Fan HagWilliam Barter @wjbarter.bsky.social · 21/01/2025The value of g, the acceleration of an object under gravity at the Earth’s surface (9.81 m/s^2) is very close to pi^2 = 9.87. It’s a better approximation than g = 10 m/s^2, and this is no accident… 1019753
Reposted by Fan HagDerek Lowe @dereklowe.bsky.social · 14/01/2025How do cancer cells adapt to the stress of being cancer cells, with the constant stream of mutant and misfolded proteins? There’s more than one strategy, and therapeutically you’d like to know which is being used:science.orgDealing With Being a Tumor Cell 33911
Reposted by Fan HagSTAT @statnews.com · 13/01/2025Duke neuroscientist Kafui Dzirasa wants nothing less than to reengineer the brain’s electrical patterns to treat anxiety, depression, bipolar disorder, and schizophrenia.buff.ly‘My life’s purpose’: A neuroscientist wants to rewire mental illness treatment and remake the field he lovesDuke neuroscientist Kafui Dzirasa wants nothing less than to reengineer the brain’s electrical patterns to treat anxiety, depression, bipolar disorder, and schizophrenia. 33918
Reposted by Fan HagNEJM.org @nejm.org · 12/01/2025𝐍𝐨𝐭𝐚𝐛𝐥𝐞 𝐀𝐫𝐭𝐢𝐜𝐥𝐞𝐬 𝐨𝐟 𝟐𝟎𝟐𝟒: Omalizumab for Multiple Food Allergies In a trial involving 180 persons with food allergies, omalizumab was effective in increasing the reaction threshold for peanut & other common food allergens. Read more: nej.md/4bLW7aS #MedSky 1195
Reposted by Fan HagSaloni @scientificdiscovery.dev · 09/01/2025Childhood cancer death rates in the United States have declined six-fold over the last seventy years. 🧵 2242855
Reposted by Fan HagEric Fauman (he/him) @ericfauman.bsky.social · 09/01/2025SLC45A2 is a melanosome-specific transporter important for maintaining proper pH and osmotic balance. It's a wonderful example of "top down" causal gene inference. From its very function we expect it to be a gwas hit for pigmentation, regardless of where it sits in the genome. 011
Reposted by Fan HagMing Tommy Tang @tommytang.bsky.social · 07/01/2025AI is hyped as the future of drug development. But has it really changed the game? Let’s break down where AI stands and what’s missing. 🧵 1147
Reposted by Fan HagLawrence Hurley @lawrencehurley.bsky.social · 07/01/2025Two federal death row inmates don't want Biden to commute their sentences because they say it would disadvantage them in their efforts to mount innocence claims (via my colleague Erik Ortiz): www.nbcnews.com/news/us-news...nbcnews.comTwo death row inmates reject Biden's commutation of their life sentencesShannon Agofsky and Len Davis were among 37 of the 40 federal prisoners whose death sentences were changed to life in prison without the possibility of parole. 510223
Reposted by Fan HagMIT Technology Review @technologyreview.com · 07/01/2025The Vera C. Rubin Observatory—one of this year’s 10 Breakthrough Technologies—will help astronomers study dark matter, explore the Milky Way, and untangle other cosmic unknowns.technologyreview.comVera C. Rubin Observatory: 10 Breakthrough Technologies 2025The telescope’s massive digital camera was built to take a lot of photos of the sky, in quick succession, for a very long time. 0136
Fan Hag @naphu.bsky.social · 07/01/2025 Pluto may have captured its moon Charon following a fleeting ‘kiss-and-capture’ collision, in which both bodies survived largely intact... www.nature.com/articles/s41...nature.comCapture of an ancient Charon around Pluto - Nature GeoscienceNumerical simulations suggest that Pluto’s moon Charon was captured intact, in a scenario in which the two bodies temporarily merged in a collision but did not coalesce due to solid strength effects. 010
Reposted by Fan HagDerek Lowe @dereklowe.bsky.social · 05/01/2025I think you're describing science, IMO. Everything is atop a foundation of basic research. An example: at a previous company, I worked on a series of small-molecule inhibitors of Hormone-Sensitive Lipase, a possible target for Type II diabetes and related conditions. (1/10) 37314
Fan Hag @naphu.bsky.social · 04/01/2025www.thefp.com/p/sean-fisch...thefp.comMy Mom Was Diagnosed with Alzheimer’s. Then She Got Better.My family experienced a miracle last year. It began with a tragedy. 010
Reposted by Fan HagStephan Hacker @stephanhacker2.bsky.social · 03/01/2025Very interesting to see the 50 new drugs that made it to FDA approval in 2024 in one place. A lot of really exciting small molecule chemistry with interesting functional groups, deuterations and covalent warheads. #chemsky #chembio www.linkedin.com/posts/chrisd...linkedin.comChris De Savi on LinkedIn: #medicine #pharmaceuticals #healthcare | 90 commentsFDA Novel Drug Approvals 2024 #medicine That is a wrap for 2024! And another year of relentless drug discovery! There you have it, drug-hunting aficionados,… | 90 comments on LinkedIn 06818
Reposted by Fan HagCarl Zimmer @carlzimmer.com · 31/12/2024Five years ago today, Wuhan public health officials first let the world know about a "viral pneumonia" sweeping the city. www.who.int/news/item/30...who.intMilestone: COVID-19 five years agoFive years ago on 31 December 2019, WHO’s Country Office in China picked up a media statement by the Wuhan Municipal Health Commission from their website on cases of ‘viral pneumonia’ in Wuhan, China.... 26315
Reposted by Fan HagAnodyne @anodynesix.bsky.social · 31/12/2024"Youth justice researchers spoke with 21 families in Macomb County with an average of $87,000 in court debt. Among them, one parent said she had her state tax refund garnished for 10 years and still had $67,000 in debt after her son spent less than a year in detention more than a decade ago." 112738
Reposted by Fan HagJason Ukman @jasonukman.bsky.social · 30/12/2024The world can seem grim on that other platform, on this platform, on any platform. @matthewherper.bsky.social is here to remind us that, when it comes to health and medicine, there is plenty of reason for hope. www.statnews.com/2024/12/30/t...statnews.comThe biggest medical advances of 2024The biggest medical advances of 2024 will be remembered as significant long into the future. 051
Reposted by Fan HagSteve Brown - astronomy and astrophotography @sjbastro.bsky.social · 30/12/2024Astronomers ready for dazzling but brief celestial show after 80-year wait. When will T Corona Borealis brighten? Hopefully when we have clear skies! 😀 #Astronomy #Space www.bbc.co.uk/news/article...bbc.co.ukT Cor Bor: Astronomers await dazzling celestial showAstronomers are poised to see a star system about 3,000 light years away explode into brightness. 1255
Reposted by Fan HagShen Tian 田申 @tianshenbio.bsky.social · 05/12/2024Our miRNA story is now in @science.org ! We found a microRNA, not a protein, that finally solved a long-standing evolutionary mystery of wing coloration in butterflies and moths. (1/n) www.science.org/doi/10.1126/...science.orgA microRNA is the effector gene of a classic evolutionary hotspot locusIn Lepidoptera (butterflies and moths), the genomic region around the gene cortex is a “hotspot” locus, repeatedly implicated in generating intraspecific melanic wing color polymorphisms across 100 mi... 12246106
Reposted by Fan HagPaul Byrne @theplanetaryguy.com · 10/12/2024A new JWST deep field. All the eight-sided features are local stars in the Milky Way. Everything else is a galaxy. EVERYTHING ELSE IS A GALAXY. 16736219
Reposted by Fan HagBioPharmCatalyst @biopharmcatalyst.bsky.social · 10/12/2024$QURE agreed with the FDA on an Accelerated Approval pathway for AMT-130, allowing data from ongoing Phase 1/2 studies, to serve as the basis for a BLA See More Pre-market Movers 👇 www.biopharmcatalyst.com/news/2024/ch... $CMRX $CPIX $CRDF $PBM $NAMS $CRVO $NXCT 001
Reposted by Fan Hagtrebstar.bsky.social @trebstar.bsky.social · 30/11/2024Some love spinach, but in the future, some might have hearts made of spinach: In 2017, Gershlak et al. seeded human cardiac tissue onto decellularized spinach leaves. The tissue grew and contracted on the leaf’s cellulose scaffold—bioengineering at its finest! 111
Fan Hag @naphu.bsky.social · 11/11/2024Awesome stuff... Hackathon to diagnose rare diseases www.nature.com/articles/s41...nature.comPushing the boundaries of rare disease diagnostics with the help of the first Undiagnosed Hackathon - Nature GeneticsIn the first-ever Undiagnosed Hackathon, nearly 100 experts from 28 countries combined advanced phenotyping and genomic techniques for 48 hours, ultimately providing diagnoses to 40% of the previously... 030
Reposted by Fan HagBruce Levine, Ph.D. 🇺🇦 @bllphd.bsky.social · 09/11/2024🚨 7th CAR T Cell #immunotherapy approved by #FDA obecabtagene autoleucel for adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia www.fda.gov/drugs/resour...fda.govFDA approves obecabtagene autoleucel for acute lymphoblastic leukemiaOn November 8, 2024, the FDA approved obecabtagene autoleucel (Aucatzyl, Autolus Inc.) for relapsed or refractory B-cell precursor acute lymphoblastic leukemia. 065
Reposted by Fan HagPearl Freier @pearlf.bsky.social · 24/10/2024NTLA-2002 is potentially the first in vivo CRISPR drug that will be FDA-approved said $NTLA's CEO. Intellia is recruiting for a larger 60-person Phase 3 study & aims to file for FDA approval in 2026 according to the story below. Potential cure/"one & done treatment" for hereditary angiodema #biosky 122
Reposted by Fan HagPaul Bonanos @biobonanos.bsky.social · 23/10/2024Good morning #biosky! In a small but intriguing takeout: Merck is buying Modifi Biosciences for $30 million u/f, but milestones could push the deal's value to $1.3 billion. Preclinical Yale spinout focused on DNA repair defects had raised $10.7m in seed funding: www.globenewswire.com/en/news-rele...globenewswire.comModifi Biosciences Acquired by MerckMerck gains preclinical compounds designed to exploit DNA repair defects in difficult to treat cancers... 094
Reposted by Fan HagRick Livesey @ricklivesey.bsky.social · 23/10/2024Our first preprint announcement on bluesky! Using human iPSC and Drosophila models of a frontotemporal dementia, we find that key pathologies can be corrected by targeting the NAT10 acetyltransferase #biosky www.biorxiv.org/content/10.1...biorxiv.orgTargeting the acetyltransferase NAT10 corrects pathologies in human frontotemporal dementia neurons and extends lifespan in an in vivo Drosophila tauopathy modelDisruption of the neuronal nuclear membrane and perturbation of nucleocytoplasmic transport are features of neurodegenerative diseases, including Alzheimer's disease, that involve the microtubule-asso... 184
Reposted by Fan HagKai Kupferschmidt @kakape.bsky.social · 17/10/2024No new cases of #Marburg and no deaths in Rwanda today, plus 8 patients have recovered! Looking better by the day! But remember that filoviruses are tricky and an outbreak is declared over only after 42 days with no new infections (= two incubation periods). 0357
Reposted by Fan HagDerek Lowe @dereklowe.bsky.social · 16/10/2024Protein-degrader bifunctional molecules are heading into Phase III trials, and there are s lot more ideas where that one came from:science.orgInduced Proximity, in the Lab and in the Clinic 1187
Reposted by Fan HagDerek Lowe @dereklowe.bsky.social · 18/10/2024Is the FDA's accelerated approval process accomplishing what it was designed to? What do we want it to accomplish in the first place?science.orgAccelerated Approval: What Is It Accomplishing? 2279
Reposted by Fan HagSTAT @statnews.com · 07/10/2024The oldest known survivor of progeria, his life was utterly unlike others', but he lived with the conviction he could connect with anybody. www.statnews.com/2024/10/06/s...statnews.comSammy Basso, progeria advocate, has died at 28We generally don’t think of rare-disease advocacy as funny. But Sammy Basso, who died at 28, will be remembered for his ability to find laughter in almost anything. 0127
Reposted by Fan HagBruce Levine, Ph.D. 🇺🇦 @bllphd.bsky.social · 04/11/2023If CAR T Cells & mRNA LNP vaccines had a baby, that would give the transformative technology of targeted LNPs encoding CARs Brad Loncar interviews Laura Shawver www.biotechtv.com/post/capstan... 031