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Sini Nagpal

@nagpalsini.bsky.social
83 followers 221 following 58 posts

Assistant Professor, Koita Centre for Digital Health, IIT Bombay PhD Bioinformatics (Statistical Genetics) | MS Bioinformatics @GeorgiaTech nagpallab.github.io

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Sini Nagpal @nagpalsini.bsky.social · 06/09/2026
All About the Context - “At the extremes of the polygenic scores (PGS), context matters greatly for absolute risk assessment” - a wonderfully written and thought-provoking substack by @genomestake.bsky.social genomestake.substack.com/p/all-about-...
genomestake.substack.com
All About the Context
117th Take
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Sini Nagpal @nagpalsini.bsky.social · 24/07/2026
Excited to share our work on "Pervasive interactions between exposures and polygenic risk can inform more effective clinical and behavioral interventions" @genomestake.bsky.social @natgenet.nature.com - www.nature.com/articles/s41...
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Sini Nagpal @nagpalsini.bsky.social · 15/07/2026
Excited to share 2 important milestones in my academic journey- Our work on “Pervasive interactions between exposures & polygenic risk can inform more effective clinical & behavioral interventions,” showing PGSxC interactions & their utility, is out in #NatureGenetics @genomestake.bsky.social
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Genetics Society of America @genetics-gsa.bsky.social · 22/12/2025
In the December issue of #GENETICS, @jeremyjberg.bsky.social et al. introduce an evolutionary model of complex disease susceptibility, identifying how diseases are shaped by selection acting on other pleiotropically related traits. buff.ly/QTZPpYQ
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Reposted by Sini Nagpal
Sasha Gusev @sashagusevposts.bsky.social · 21/11/2025
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
theinfinitesimal.substack.com
The missing heritability question is now (mostly) answered
Not with a bang but with a whimper
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Sini Nagpal @nagpalsini.bsky.social · 19/11/2025
Excited to share our latest study integrating genetics with gene expression regulation to uncover sex-specific differences in Crohn’s disease recurrence - now out in Gastroenterology. @judyibd.bsky.social @genomestake.bsky.social
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Eric Topol @erictopol.bsky.social · 28/10/2025
Longer walks linked with less mortality and cardiovascular risk compared with short bouts of physical activity @annalsofim.bsky.social www.acpjournals.org/doi/10.7326/...
acpjournals.org
Step Accumulation Patterns and Risk for Cardiovascular Events and Mortality Among Suboptimally Active Adults | Annals of Internal Medicine
Background: Although physical activity recommendations increasingly consider daily step counts, it remains unclear whether step accumulation patterns—short versus sustained longer bouts—affect associa...
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Sini Nagpal @nagpalsini.bsky.social · 13/10/2025
Heading to Boston for the American Society of Human Genetics #ASHG25 @geneticssociety.bsky.social! Excited to present our work on how pervasive exposure-by-polygenic score interactions can inform more effective clinical and behavioral interventions. #B1070W www.medrxiv.org/content/10.1...
medrxiv.org
Dual exposure-by-polygenic score interactions highlight disparities across social groups in the proportion needed to benefit
The transferability of polygenic scores across population groups is a major concern with respect to the equitable clinical implementation of genomic medicine. Since genetic associations are identified...
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Reposted by Sini Nagpal
Hilary Martin @hilarycmartin.bsky.social · 02/10/2025
Pleased to have contributed to this paper out at @nature.com today from @vw1234.bsky.social and Yira (Xinhe) Zhang showing that the common variant contribution to autism varies substantially by age of diagnosis www.nature.com/articles/s41.... Critical for understanding heterogeneity in autism.
nature.com
Polygenic and developmental profiles of autism differ by age at diagnosis - Nature
A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.
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Reposted by Sini Nagpal
Nature Portfolio @natureportfolio.nature.com · 01/10/2025
The age that autism is diagnosed may partly reflect underlying biological and developmental differences among individuals with autism, according to a study in Nature. go.nature.com/4gQ5gSV 🧬 🧪
This is figure 1, which shows the trajectory analyses in three of the four birth cohorts.
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Sini Nagpal @nagpalsini.bsky.social · 01/08/2024
Excited to share our latest manuscript on "Dual exposure-by-polygenic score interactions highlight disparities across social groups in the proportion needed to benefit" with Greg Gibson (@genomestake), www.medrxiv.org/content/10.1101/202… [1/9]
medrxiv.org
Dual exposure-by-polygenic score interactions highlight d...
The transferability of polygenic scores across population...
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Sini Nagpal @nagpalsini.bsky.social · 18/10/2023
Lots of interesting discussions on polygenic risk scores and their implementation @HarvardPqg - Diversity in Genetics and Genomics. #polygenicriskscores #prs #environment #diversity #biobanks #precisionmedicine
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Sini Nagpal @nagpalsini.bsky.social · 02/09/2022
Honored to be selected as the Postdoctoral Semifinalist for 2022 Charles J. Epstein Awards for Excellence in Human Genetics Research for #ASHG22! Plus, our abstract has been selected as the Reviewer's Choice abstract 😀 #ASHG @GeneticsSociety...
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Sini Nagpal @nagpalsini.bsky.social · 23/03/2022
Very happy and excited to share the final study of my PhD out in @MolBioEvol. All results from this study can be explored through our Rshiny: canalization-gibsonlab.shinyapps.io… academic.oup.com/mbe/advance-articl…
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Sini Nagpal @nagpalsini.bsky.social · 18/12/2021
Reading @kph3k's wonderfully written "The Genetic Lottery", while beginning the journey to write my PhD thesis🙂 Any tips and suggestions as I embark on this journey are welcome!
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Sini Nagpal @nagpalsini.bsky.social · 29/08/2021
Ulcerative Colitis Study Analyzes Gene Expression to Measure Risk of Progression to Surgery www.genomeweb.com/gene-expression-r…
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Sini Nagpal @nagpalsini.bsky.social · 26/08/2021
Excited to share our work out in the @AJHGNews on "Stratification of risk of progression to colectomy in ulcerative colitis via measured and predicted gene expression" www.cell.com/ajhg/fulltext/S0002-92…
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Sini Nagpal @nagpalsini.bsky.social · 24/11/2020
Check out Greg Gibson's @genomestake interview with 11Alive about surveillance testing on GT campus. This is a great effort, congratulations ! www.11alive.com/video/news/health/c…
11alive.com
Georgia Tech's testing program proof we can cut COVID-19 ...
As the state's COVID-19 numbers started to fall, so did t...
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Sini Nagpal @nagpalsini.bsky.social · 15/07/2019
All set for the Summer Institute of Statistical Genetics at University of Washington, Seattle! Module 1: Bayesian Statistics for Genetics by Jon Wakefield and Ken Rice @UWBiostat #SISG #statgen
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Sini Nagpal @nagpalsini.bsky.social · 27/03/2019
I'm excited for #DDW19 on May 18-21, 2019. Join me in San Diego, CA for DDW's 50th anniversary event! app.ingo.me/q/grita .
app.ingo.me
Digestive Disease Week® (DDW) 2019
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Sini Nagpal @nagpalsini.bsky.social · 31/12/2018
TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits: www.biorxiv.org/content/biorxiv/ear…
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