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Mario van der Stelt @mvdstelt.bsky.social · 23/05/2026

This week in Nature Neuroscience: our study links “foamy” GPNMB⁺ microglia/macrophages, oxylipins and lipid metabolism to lesion expansion and faster progression in multiple sclerosis. MAGL emerges as a potential therapeutic target www.nature.com/articles/s41...

nature.com

Foamy microglia link oxylipins to disease progression in multiple sclerosis - Nature Neuroscience

Foamy microglia are associated with multiple sclerosis progression, linking phagocytosis, altered lipid metabolism (oxylipins) and lysosomal stress to nonclassical neuroinflammation and disease severi...

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Mario van der Stelt @mvdstelt.bsky.social · 22/08/2025

Heading home after a fantastic cannabinoid GRC meeting organised by @drjkhokhar.bsky.social and Cecilia Hillard. Hope to see you all in Dijon ICRS-meeting June 28th -July 2nd, 2026 @icrsonbluesky.bsky.social

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Stephan Hacker @stephanhacker2.bsky.social · 02/07/2025

It also highlights work by the group of @mvdstelt.bsky.social of the @led3hub.bsky.social on profiling the targets of BIA 10-2474 (www.science.org/doi/10.1126/...) as well as the work that @mads-chem.bsky.social performed in Ben Cravatt's lab on JAK1 inhibitors (www.nature.com/articles/s41...) (4/5)

science.org

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

A drug that was unexpectedly neurotoxic in a clinical trial has off-target activities in chemical proteomic assays.

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Stephan Hacker @stephanhacker2.bsky.social · 02/07/2025

A new exciting article in @natbiotech.nature.com highlights the power of chemical proteomics to find druggable pockets on difficult high-value targets. Great insights into applications in covalent and non-covalent drug discovery including clinical development. (1/5) www.nature.com/articles/s41...

nature.com

Probing the proteome - Nature Biotechnology

Chemical proteomics has brought rigor to covalent drug discovery and drugs to the clinic. Can it deliver a new generation of drug targets?

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Stephan Hacker @stephanhacker2.bsky.social · 10/04/2025

A great talk by Joel Rüegger of the group of @mvdstelt.bsky.social at #FocusOnCovalentDrugs. He talked about his amazing work in the @led3hub.bsky.social on the CellEKT platform for profiling target engagement of kinase inhibitors in living cells. (1/5) www.mcponline.org/article/S153...

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Stephan Hacker @stephanhacker2.bsky.social · 25/03/2025

Lipidation of proteins has diverse essential roles in biology. In his amazing keynote lecture at #Lunteren, Marc Baggelaar talked about his group's exciting contributions to better understand protein lipidations using #ChemicalProteomics. (1/5) #chemsky #ChemBio

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Derek Lowe @dereklowe.bsky.social · 05/03/2025

Another “Continuing Crisis” post, this one covering some larger principles and explaining why I’m doing these in general:

science.org

The Continuing Crisis, Part VII: An Overview

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Mario van der Stelt @mvdstelt.bsky.social · 21/02/2025

Congratulations and a big thank you to @verenas.bsky.social and the labs of Istvan Katona, Yulong Li, Nephi Stella, and Laura Heitman, Coen van Hasselt at @led3hub.bsky.social and @unileiden.bsky.social for a fantastic collaboration. 4/4

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Mario van der Stelt @mvdstelt.bsky.social · 21/02/2025

Mathematical modelling provided a comprehensive understanding of endocannabinoid signaling. The model addresses key questions in the field and suggests that microvesicles carrying signaling lipids in their membrane regulate neuronal functions in parallel to synaptic vesicles. n/3

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Mario van der Stelt @mvdstelt.bsky.social · 21/02/2025

Our findings led us to propose an “on demand release” model, where microvesicle formation governs endocannabinoid release. This model reconciliates three previously proposed hypotheses for endocannabinoid trafficking. n/2

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Mario van der Stelt @mvdstelt.bsky.social · 21/02/2025

Happy to announce on my first bsky post that today our manuscript “The endocannabinoid 2-arachidonoylglycerol is released and transported on demand via extracellular microvesicles” has been published in its final form in PNAS n/1

pnas.org

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