Seema @molbioinfo.bsky.social · 16/09/20260.43 Angstroms x.com/Bioinfoodie/...x.comSeema (@Bioinfoodie) on XI did AlphaFold run with the same PDB 30OH, Pyrococcus abyssi rubredoxin protein sequence. RMSD between 51 pruned atom pairs is 0.345 angstroms, says ChimeraX :-) Blue 30OH, Golden: AlphaFold @embl #... 000
Reposted by SeemabioRxiv Genomics @biorxiv-genomic.bsky.social · 23/06/2026Variation and selection at predicted G-quadruplexes across the human pangenome www.biorxiv.org/content/10.64898/20… 053
Seema @molbioinfo.bsky.social · 02/06/2026RAS inhibitor Daraxonrasib binds to KRAS, HRAS, NRAS, CypA. We also studied drug sensitivity/resistance in NRAS before in the context of lncRNA MALAT1 doi.org/10.1038/s415... CD44, one of the key proteins identified in network studies shares key downstream pathways with CypA.doi.orgMALAT1 as master regulator of biomarkers predictive of pan-cancer multi-drug resistance in the context of recalcitrant NRAS signaling pathway identified using systems-oriented approach - Scientific Re...Scientific Reports - MALAT1 as master regulator of biomarkers predictive of pan-cancer multi-drug resistance in the context of recalcitrant NRAS signaling pathway identified using systems-oriented... 010
Seema @molbioinfo.bsky.social · 18/02/2026Visited BioAsia2026 Hyderabad, India. Excited to learn about keynote speakers from my lab's research domain being invited, Howard Y. Chang (lncRNAs) and Pushmeet Kohli (AlphaFold). Happy to meet alongwith my students and discuss all things lncRNAs and AI. #RNA #Computational @alphafold.bsky.social 011
Seema @molbioinfo.bsky.social · 18/02/2026Delighted and honored to get on board nature.com/npjsba/editors Thanks EiC MK Jolly for the tremendous opportunity and I look forward to working proactively towards being among the ambassadors and contributing to this journal's long-term success. @natureportfolio.nature.comnature.comAbout the Editors | npj Systems Biology and ApplicationsAbout the Editors 000
Seema @molbioinfo.bsky.social · 22/01/2026Thrilled to announce the publication of our latest research: www.sciencedirect.com/science/arti... This entails secondary structural studies on the probable mechanisms of PVT1 binding to multiple mRNAs, common DE coding & non-coding genes across pan-cancer system. #lncRNA #RNA #CancerResearchsciencedirect.comStructural basis of long non-coding RNA PVT1 interactions with select mRNAs universal in pan-cancer system: A computational studyPVT1 lncRNA can regulate multi-gene expression through diverse mechanisms, one of which is through binding interactions with mRNAs. Our previous study… 030
Seema @molbioinfo.bsky.social · 08/10/2025🧪 Thought of the day: Penned by me: "An abstract Abstract doesn't age well". Or does it? #science #NobelPrize #abstract 000
Reposted by Seemafebsopenbio.bsky.social @febsopenbio.bsky.social · 29/09/2025📣 Don't miss this new Review! Interplay between RNA-protein interactions and RNA structures in gene regulation 🔓 buff.ly/pu6TpVa 🖊️ @rnaminni.bsky.social #RBPs #RNA #RNAbiology #RNAbindingproteins #RNAbinding #RNAstructure 042
Seema @molbioinfo.bsky.social · 30/09/2025MtDNA incorporating ribonucleotides and not deoxyribonucleotides increases inflammation. Interesting article: x.com/davidasincla...x.com 010
Seema @molbioinfo.bsky.social · 19/09/2025PRC2 inhibition by sequence-specific RNA. Interesting! doi.org/10.1101/2024...doi.orgRNA-induced PRC2 inhibition depends on the sequence of bound RNAMethyltransferase PRC2 (Polycomb Repressive Complex 2) deposits histone H3K27 trimethylation to establish and maintain epigenetic gene silencing. PRC2 is precisely regulated by accessory proteins, his... 030
Seema @molbioinfo.bsky.social · 27/07/2025🧪Intellectuals, Selection for the prestigious National Academy of Sciences (India) Membership is a joy! Yours truly, Ph.D, MNASc 😀 Grateful to everyone who have stood by me rock solid in this scenic and transformative journey. Heartfelt Thank you to The National Academy of Sciences, India... 000
Seema @molbioinfo.bsky.social · 24/07/2025Happy to share our latest paper using machine-learning-QSAR on ChEMBL dataset. We identified and designed novel inhibitors for Acid Ceramidase inhibition in Glioblastoma using SHAP-based mechanistic interpretations. Thankful to proactive Reviewers and Editors. rdcu.be/exD3ardcu.beAn innovative machine learning-based QSAR approach for prediction and structural analysis of novel/repurposed acid ceramidase (ASAH1) inhibitors for glioblastoma therapy 000
Seema @molbioinfo.bsky.social · 03/01/2025Interesting, so sharing here: x.com/nlarusstone/...x.comx.com 000
Reposted by SeemaShah Selbe @shahselbe.bsky.social · 09/12/2024It is always mind boggling at how massive @agu.org is every year. This is just one session of the poster room, which changes over twice daily for the duration of the conference. #AGU24 722141
Seema @molbioinfo.bsky.social · 28/11/2024And here I was wondering RNA Capping at the first mention of the word 'cap'...caps impart efficient translation and stability to mRNA... 🤔 000
Reposted by SeemaArmand Sarlangue @armandsarlangue.bsky.social · 26/11/2024The great Matterhorn in all its glory… A classic shot from the Swiss alps, but the light was too good to not click this one. #bluesky #photography #mountains #nature #landscape #landscapephotography #naturephotography 662796165
Seema @molbioinfo.bsky.social · 23/11/2024RNA-mediated DNA damage repair: www.nature.com/articles/s41... #RNAbiology #RNAskynature.comRNA-mediated double-strand break repair by end-joining mechanisms - Nature CommunicationsDouble-strand breaks (DSBs) in DNA are challenging to repair. Here, the authors show that transcript RNAs impact the DSB repair outcomes in human and yeast cells by promoting NHEJ or MMEJ in a sequenc... 0226
Seema @molbioinfo.bsky.social · 21/11/2024RNA aficianados, Just attended my first seminar series at RNA Collaborative - The RNA Institute, SUNY University at Albany yesterday. It is awesome science and a great way to stay updated in everything RNA. Registration is free: www.rnasociety.org/rna-collabor... #rnabiology #rnasky 🧪rnasociety.orgRNA Collaborative Seminar Series 022
Seema @molbioinfo.bsky.social · 21/11/2024Any answers? Looks like this is a ResearchGate question. 😀 #rnabiology #rnasky #moleculardynamics 000
Reposted by SeemaJohn Prensner @johnprensner.bsky.social · 16/11/2024Here is a paper where I would just like to say "Thank you" to the authors. I thoroughly enjoyed this. I hope you do too. #GENESky #RNAsky #CANsky #genomics #bioinformatics 🧪 🧬💻 🔎 microproteins www.cell.com/cell-reports...cell.comRNA splicing junction landscape reveals abundant tumor-specific transcripts in human cancerLi et al. thoroughly analyzed RNA splicing junctions in 34,775 samples and identified 29,051 tumor-specific transcripts that may serve as cancer driver genes, neoantigens, and circulating biomarkers. 14212
Seema @molbioinfo.bsky.social · 20/11/2024Is 108 kb Air the longest lncRNA? Any new champion in this category?🤔 #rnabiology #rnasky 🧪 010
Seema @molbioinfo.bsky.social · 20/11/2024Molecular dynamics aficionados! Which is the most accurate RNA force-field currently? #rnabiology #computationalbiology #rnasky 🧪 100
Seema @molbioinfo.bsky.social · 19/11/2024Yes, what you really want to do is key when you have lot of time till the day you think of retirement....juggle it with playing it safe. Do the balancing act. 000
Seema @molbioinfo.bsky.social · 18/11/2024Deers and LncRNAs... www.nature.com/nsmb/volumes... #rna #rnabiologynature.com 000
Reposted by SeemaVictoria aka Blaze @burrddoh.bsky.social · 13/11/2024Got birds? Reply or quote this with your pics; we’d love to see them 📷🪶 117717018502
Reposted by SeemaIgor Ulitsky @igorulitsky.bsky.social · 13/11/2024Let's make a thread of RNA-related conferences in 2025 🧵 (add missing!) 1211846
Seema @molbioinfo.bsky.social · 13/11/2024@ijayas.bsky.social please add me to Biophysics starter pack. Thanks. 000
Seema @molbioinfo.bsky.social · 12/11/2024🧪 Transcriptome-wide CRISPR screens reveal essential lncRNAs: www.cell.com/cell/fulltex... #rnabiologycell.comTranscriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cellsMassively parallel CRISPR-Cas13 screens in multiple human cell lines uncover universally essential and context-specific essential lncRNAs that exhibit dynamic expression during development and in spec... 081
Seema @molbioinfo.bsky.social · 12/11/2024I am struck by a moment of sonder as I gaze around the @bluesky #bluesky 000
Reposted by SeemaZid Lab @zidlab.bsky.social · 09/11/2024 🎯 Our focus: TIM50, a mitochondrial import receptor with 7 consecutive prolines. When eIF5A is depleted, ribosomes get seriously stuck here - creating a traffic jam up to 300 base pairs long! 121
Seema @molbioinfo.bsky.social · 12/11/2024Hi Oded! Welcome here. Every Science post uses test-tube emoji for Science feed...so use it and vrooommmm... 021
Reposted by SeemaThiago Carvalho @cyrilpedia.bsky.social · 29/10/2024'On the evolutionary timescale, accumulation of L1 & SINEs occurred via multiple “explosions” when, during rather short evolutionary times, numerous insertions of retroelements entered genomes of our ancestors creating structurally distinct subfamilies of L1s & SINEs.' www.pnas.org/doi/10.1073/...pnas.orgThe reconstruction of evolutionary dynamics of processed pseudogenes indicates deep silencing of “retrobiome” in naked mole rat | PNASApproximately half of mammalian genomes are occupied by retrotransposons, highly repetitive interspersed genetic elements expanded through the mech... 011
Seema @molbioinfo.bsky.social · 30/10/2024I know there are prediction tools for MHC and T cell Binding. Any computational tools for predicting T cell response? 🧪 000
Reposted by SeemaZen Faulkes @doctorzen.net · 29/10/2024Two high school students wanted the cash prize 🏆 for a math contest. They discovered new profs of the Pythagorean theorem, presented it at conferences, and published it in a journal - which has an awesome “Conclusion” section with the backstory: www.tandfonline.com/doi/full/10....tandfonline.comFive or Ten New Proofs of the Pythagorean TheoremWe present five trigonometric proofs of the Pythagorean theorem, and our method for finding proofs (Section 5) yields at least five more. 47331
Reposted by SeemaMark Peifer (He, him) @peiferlabunc.bsky.social · 29/10/2024If you are interested in biological evolution in its many guises and aren't following Will, you're REALLY missing out 🧪 1185