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Seema

@molbioinfo.bsky.social
736 followers 114 following 46 posts

Loves Bioinformatics and Computational biology to the 🍵. Pan-cancer systems biology, LncRNA interactions with proteins and mRNA, molecular dynamics, immunoinformatics. Member, The National Academy of Sciences, India

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Seema @molbioinfo.bsky.social · 16/09/2026
0.43 Angstroms x.com/Bioinfoodie/...
x.com
Seema (@Bioinfoodie) on X
I did AlphaFold run with the same PDB 30OH, Pyrococcus abyssi rubredoxin protein sequence. RMSD between 51 pruned atom pairs is 0.345 angstroms, says ChimeraX :-) Blue 30OH, Golden: AlphaFold @embl #...
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Seema @molbioinfo.bsky.social · 15/09/2026
Monday? It was Ganesh Chaturthi day.
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bioRxiv Genomics @biorxiv-genomic.bsky.social · 23/06/2026
Variation and selection at predicted G-quadruplexes across the human pangenome www.biorxiv.org/content/10.64898/20…
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Seema @molbioinfo.bsky.social · 02/06/2026
RAS inhibitor Daraxonrasib binds to KRAS, HRAS, NRAS, CypA. We also studied drug sensitivity/resistance in NRAS before in the context of lncRNA MALAT1 doi.org/10.1038/s415... CD44, one of the key proteins identified in network studies shares key downstream pathways with CypA.
doi.org
MALAT1 as master regulator of biomarkers predictive of pan-cancer multi-drug resistance in the context of recalcitrant NRAS signaling pathway identified using systems-oriented approach - Scientific Re...
Scientific Reports - MALAT1 as master regulator of biomarkers predictive of pan-cancer multi-drug resistance in the context of recalcitrant NRAS signaling pathway identified using systems-oriented...
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Seema @molbioinfo.bsky.social · 18/02/2026
Visited BioAsia2026 Hyderabad, India. Excited to learn about keynote speakers from my lab's research domain being invited, Howard Y. Chang (lncRNAs) and Pushmeet Kohli (AlphaFold). Happy to meet alongwith my students and discuss all things lncRNAs and AI. #RNA #Computational @alphafold.bsky.social
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Seema @molbioinfo.bsky.social · 18/02/2026
Delighted and honored to get on board nature.com/npjsba/editors Thanks EiC MK Jolly for the tremendous opportunity and I look forward to working proactively towards being among the ambassadors and contributing to this journal's long-term success. @natureportfolio.nature.com
nature.com
About the Editors | npj Systems Biology and Applications
About the Editors
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Seema @molbioinfo.bsky.social · 22/01/2026
Thrilled to announce the publication of our latest research: www.sciencedirect.com/science/arti... This entails secondary structural studies on the probable mechanisms of PVT1 binding to multiple mRNAs, common DE coding & non-coding genes across pan-cancer system. #lncRNA #RNA #CancerResearch
sciencedirect.com
Structural basis of long non-coding RNA PVT1 interactions with select mRNAs universal in pan-cancer system: A computational study
PVT1 lncRNA can regulate multi-gene expression through diverse mechanisms, one of which is through binding interactions with mRNAs. Our previous study…
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Seema @molbioinfo.bsky.social · 08/10/2025
🧪 Thought of the day: Penned by me: "An abstract Abstract doesn't age well". Or does it? #science #NobelPrize #abstract
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febsopenbio.bsky.social @febsopenbio.bsky.social · 29/09/2025
📣 Don't miss this new Review! Interplay between RNA-protein interactions and RNA structures in gene regulation 🔓 buff.ly/pu6TpVa 🖊️ @rnaminni.bsky.social #RBPs #RNA #RNAbiology #RNAbindingproteins #RNAbinding #RNAstructure
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Seema @molbioinfo.bsky.social · 02/10/2025
#rnabiology #RNA
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Seema @molbioinfo.bsky.social · 02/10/2025
Hello RNA world! Any new news?
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Seema @molbioinfo.bsky.social · 30/09/2025
MtDNA incorporating ribonucleotides and not deoxyribonucleotides increases inflammation. Interesting article: x.com/davidasincla...
x.com
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Seema @molbioinfo.bsky.social · 19/09/2025
#rnabiology #rna
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Seema @molbioinfo.bsky.social · 19/09/2025
PRC2 inhibition by sequence-specific RNA. Interesting! doi.org/10.1101/2024...
doi.org
RNA-induced PRC2 inhibition depends on the sequence of bound RNA
Methyltransferase PRC2 (Polycomb Repressive Complex 2) deposits histone H3K27 trimethylation to establish and maintain epigenetic gene silencing. PRC2 is precisely regulated by accessory proteins, his...
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Seema @molbioinfo.bsky.social · 27/07/2025
🧪Intellectuals, Selection for the prestigious National Academy of Sciences (India) Membership is a joy! Yours truly, Ph.D, MNASc 😀 Grateful to everyone who have stood by me rock solid in this scenic and transformative journey. Heartfelt Thank you to The National Academy of Sciences, India...
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Seema @molbioinfo.bsky.social · 24/07/2025
Happy to share our latest paper using machine-learning-QSAR on ChEMBL dataset. We identified and designed novel inhibitors for Acid Ceramidase inhibition in Glioblastoma using SHAP-based mechanistic interpretations. Thankful to proactive Reviewers and Editors. rdcu.be/exD3a
rdcu.be
An innovative machine learning-based QSAR approach for prediction and structural analysis of novel/repurposed acid ceramidase (ASAH1) inhibitors for glioblastoma therapy
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Seema @molbioinfo.bsky.social · 03/01/2025
Interesting, so sharing here: x.com/nlarusstone/...
x.com
x.com
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Shah Selbe @shahselbe.bsky.social · 09/12/2024
It is always mind boggling at how massive @agu.org is every year. This is just one session of the poster room, which changes over twice daily for the duration of the conference. #AGU24
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Seema @molbioinfo.bsky.social · 28/11/2024
And here I was wondering RNA Capping at the first mention of the word 'cap'...caps impart efficient translation and stability to mRNA... 🤔
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Armand Sarlangue @armandsarlangue.bsky.social · 26/11/2024
The great Matterhorn in all its glory… A classic shot from the Swiss alps, but the light was too good to not click this one. #bluesky #photography #mountains #nature #landscape #landscapephotography #naturephotography
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Seema @molbioinfo.bsky.social · 26/11/2024
E.g.?
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Seema @molbioinfo.bsky.social · 23/11/2024
RNA-mediated DNA damage repair: www.nature.com/articles/s41... #RNAbiology #RNAsky
nature.com
RNA-mediated double-strand break repair by end-joining mechanisms - Nature Communications
Double-strand breaks (DSBs) in DNA are challenging to repair. Here, the authors show that transcript RNAs impact the DSB repair outcomes in human and yeast cells by promoting NHEJ or MMEJ in a sequenc...
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Seema @molbioinfo.bsky.social · 22/11/2024
#RNABiology #RNAsky #tRNA
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Seema @molbioinfo.bsky.social · 21/11/2024
RNA aficianados, Just attended my first seminar series at RNA Collaborative - The RNA Institute, SUNY University at Albany yesterday. It is awesome science and a great way to stay updated in everything RNA. Registration is free: www.rnasociety.org/rna-collabor... #rnabiology #rnasky 🧪
rnasociety.org
RNA Collaborative Seminar Series
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Seema @molbioinfo.bsky.social · 21/11/2024
Any answers? Looks like this is a ResearchGate question. 😀 #rnabiology #rnasky #moleculardynamics
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John Prensner @johnprensner.bsky.social · 16/11/2024
Here is a paper where I would just like to say "Thank you" to the authors. I thoroughly enjoyed this. I hope you do too. #GENESky #RNAsky #CANsky #genomics #bioinformatics 🧪 🧬💻 🔎 microproteins www.cell.com/cell-reports...
cell.com
RNA splicing junction landscape reveals abundant tumor-specific transcripts in human cancer
Li et al. thoroughly analyzed RNA splicing junctions in 34,775 samples and identified 29,051 tumor-specific transcripts that may serve as cancer driver genes, neoantigens, and circulating biomarkers.
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Seema @molbioinfo.bsky.social · 20/11/2024
Is 108 kb Air the longest lncRNA? Any new champion in this category?🤔 #rnabiology #rnasky 🧪
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Seema @molbioinfo.bsky.social · 20/11/2024
#rnabiology
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Seema @molbioinfo.bsky.social · 20/11/2024
Molecular dynamics aficionados! Which is the most accurate RNA force-field currently? #rnabiology #computationalbiology #rnasky 🧪
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Seema @molbioinfo.bsky.social · 19/11/2024
Yes, what you really want to do is key when you have lot of time till the day you think of retirement....juggle it with playing it safe. Do the balancing act.
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Seema @molbioinfo.bsky.social · 18/11/2024
#rnasky
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Seema @molbioinfo.bsky.social · 18/11/2024
Deers and LncRNAs... www.nature.com/nsmb/volumes... #rna #rnabiology
nature.com
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Victoria aka Blaze @burrddoh.bsky.social · 13/11/2024
Got birds? Reply or quote this with your pics; we’d love to see them 📷🪶
One of my blue jays standing guard over a piece of dried papaya
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Seema @molbioinfo.bsky.social · 14/11/2024
Easy hai?
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Igor Ulitsky @igorulitsky.bsky.social · 13/11/2024
Let's make a thread of RNA-related conferences in 2025 🧵 (add missing!)
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Seema @molbioinfo.bsky.social · 13/11/2024
Please add me. Thanks.
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Seema @molbioinfo.bsky.social · 13/11/2024
Me✋
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Seema @molbioinfo.bsky.social · 13/11/2024
@ijayas.bsky.social please add me to Biophysics starter pack. Thanks.
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Seema @molbioinfo.bsky.social · 12/11/2024
🧪 Transcriptome-wide CRISPR screens reveal essential lncRNAs: www.cell.com/cell/fulltex... #rnabiology
cell.com
Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells
Massively parallel CRISPR-Cas13 screens in multiple human cell lines uncover universally essential and context-specific essential lncRNAs that exhibit dynamic expression during development and in spec...
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Seema @molbioinfo.bsky.social · 12/11/2024
I am struck by a moment of sonder as I gaze around the @bluesky #bluesky
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Zid Lab @zidlab.bsky.social · 09/11/2024
🎯 Our focus: TIM50, a mitochondrial import receptor with 7 consecutive prolines. When eIF5A is depleted, ribosomes get seriously stuck here - creating a traffic jam up to 300 base pairs long!
Ribosomes start to build up ~300bps upstream of a stretch of 7 proline residues and then do not seem to make it through the ribosome stall.
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Seema @molbioinfo.bsky.social · 12/11/2024
Hi Oded! Welcome here. Every Science post uses test-tube emoji for Science feed...so use it and vrooommmm...
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Seema @molbioinfo.bsky.social · 11/11/2024
Plz add me to this RNA list. Thanks.
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Seema @molbioinfo.bsky.social · 09/11/2024
Never stop learning....Bioinformatics is endearing.
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Seema @molbioinfo.bsky.social · 09/11/2024
Please add me in. Thanks.
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Thiago Carvalho @cyrilpedia.bsky.social · 29/10/2024
'On the evolutionary timescale, accumulation of L1 & SINEs occurred via multiple “explosions” when, during rather short evolutionary times, numerous insertions of retroelements entered genomes of our ancestors creating structurally distinct subfamilies of L1s & SINEs.' www.pnas.org/doi/10.1073/...
pnas.org
The reconstruction of evolutionary dynamics of processed pseudogenes indicates deep silencing of “retrobiome” in naked mole rat | PNAS
Approximately half of mammalian genomes are occupied by retrotransposons, highly repetitive interspersed genetic elements expanded through the mech...
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Seema @molbioinfo.bsky.social · 30/10/2024
I know there are prediction tools for MHC and T cell Binding. Any computational tools for predicting T cell response? 🧪
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Zen Faulkes @doctorzen.net · 29/10/2024
Two high school students wanted the cash prize 🏆 for a math contest. They discovered new profs of the Pythagorean theorem, presented it at conferences, and published it in a journal - which has an awesome “Conclusion” section with the backstory: www.tandfonline.com/doi/full/10....
tandfonline.com
Five or Ten New Proofs of the Pythagorean Theorem
We present five trigonometric proofs of the Pythagorean theorem, and our method for finding proofs (Section 5) yields at least five more.
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 29/10/2024
If you are interested in biological evolution in its many guises and aren't following Will, you're REALLY missing out 🧪
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