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Mahesh Jethalia

@mjethalia.bsky.social
51 followers 287 following 13 posts

engineer.

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Mahesh Jethalia @mjethalia.bsky.social · 19/09/2026
From molecules to the future of predictive biology: memorial symposium for Peer Bork www.embl.org/about/info/c...
embl.org
From molecules to the future of predictive biology: memorial symposium for Peer Bork
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DAWells @sciencewells.bsky.social · 02/09/2026
Apparently biotech 🧪 has been the best performing industry in the US stock market over the last 12 months. What do you think that means for job security and opportunities? 🧬🖥️
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SETI Institute @setiinstitute.bsky.social · 01/09/2026
PRESS RELEASE: The SETI Institute and ETH Zurich are joining forces to investigate the origin and prevalence of life in the universe. The new partnership will establish an assistant professorship in Earth and Planetary Evolution at ETH Zurich... 🧪
SETI Institute logo. Text: The SETI Institute and ETH Zurich join forces to search for the origin of life. Image: President and CEO of the SETI Institute Bill Diamond (left) shakes hands with ETH President Joël Mesot in front of an abstract piece of art done in blues and white with a smattering of darker colors coming down diagonally from the top left.
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 26/06/2025
How might a quantum computer be used to understand and quantify molecular recognition? In this new interdisciplinary study we bridge from quantum algorithms via quantum chemistry and machine-learning potentials to biomolecular free-energy calculations to explore this problem doi.org/10.48550/arX...
Figure illustrating the data flow in the FreeQuantum pipeline. The database (depicted in the center) facilitates the exchange of data between the individual modules of the pipeline, which are shown on the left- and right-hand sides. The QM/MM and QM/QM/MM modules enable the calculation of accurate reference data. The ML potential module creates an ML potential from these reference data, which is then used by the NEQ module to calculate the binding free energy.
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Dr. Sandra Steingraber 🏳️‍🌈 @ssteingraber1.bsky.social · 26/08/2026
💥 🧪 149 new species* just dropped—including fish, corals, sea cucumbers, barnacles, and this super-cute sponge crab 👇—all just living their best lives in an underwater mountain range at the bottom of the Indian Ocean. Welcome, strangers 🥲 * new = newly discovered news.mongabay.com/2026/08/scie...
news.mongabay.com
Scientists discover 149 new deep-sea species at remote Indian Ocean seamounts
The Indian Ocean accounts for about a fifth of global ocean area, with 90% of it reaching deeper than 1,000 meters (3,280 feet). Yet compared to the Pacific and Atlantic, its deep-sea biodiversity is ...
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Mahesh Jethalia @mjethalia.bsky.social · 22/08/2026
Raghvendra Mall raghvendramall.substack.com?r=drmra&utm_...
raghvendramall.substack.com
Raghvendra Mall | Substack
PI working at the intersection of AI and multi-omics. Building models for biomarker discovery, drug response and repurposing, and patient stratification - mostly in cancer and computational immunology...
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David Ryan Koes @dkoes.compstruct.org · 05/12/2025
If you like to sample from the Boltzmann distribution and are in San Diego for NeurIPS, be sure to check out Rishal's (@rishalchich.bsky.social) poster (#2110). Great work with Nick Boffi (@nmboffi.bsky.social) and Jacky Chen. neurips.cc/virtual/2025... arxiv.org/abs/2507.00846
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Zoognosis with Joy! @zoognosisjoy.bsky.social · 12/08/2026
New video! Let's talk about bulldogs and brachycephalic breeds for a hot minute. 🧪#vetmed youtu.be/iWK8KEo_qjU
youtu.be
The Problem with Bulldogs: Health, Eugenics, & Fashion
YouTube video by Zoognosis with Joy!
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SMB - Society for Mathematical Biology @smbmathbiology.bsky.social · 13/08/2026
Here's a new #BullMathBio paper by Miracle Amadi, José Carlos García-Merino, and Heikki Haario on Correcting Structural Bias in Dynamical Models of Infectious Disease Using a Bayesian State-Space Framework. 🧪 link.springer.com/article/10.1...
link.springer.com
Correcting Structural Bias in Dynamical Models of Infectious Disease Using a Bayesian State-Space Framework - Bulletin of Mathematical Biology
Deterministic dynamical models are widely used in infectious disease modelling, but they often become systematically biased when key drivers such as seasonality and random environmental variation are ...
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Sergey Ovchinnikov @sokrypton.org · 13/07/2025
Alright, last one, now I need to get back to real work... 😸
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Max Fürst @maxfus.bsky.social · 16/12/2025
New preprint🚨 Imagine (re)designing a protein via inverse folding. AF2 predicts the designed sequence to a structure with pLDDT 94 & you get 1.8 Å RMSD to the input. Perfect design? What if I told u that the structure has 4 solvent-exposed Trp and 3 Pro where a Gly should be? Why to be wary🧵👇
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Elisa Fadda @elisafadda.bsky.social · 08/08/2026
Today is only #Caturday and #InternationalCatDay!! So Salem and I want to highlight Bonnie the gorgeous cat we sponsor. She is in Belfast at Cat Protection and waiting for her forever home 🥰🐱
Picture of Bonnie in her (grey) box, black and white cat, green eyes pink nose= 34 out of 10 ❤️Details about Bonnie, she is 9 yo likes toys, dislikes not having a home, she is looking for an adult only house with no other pets 😊
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Nature @nature.com · 05/08/2026
A severe bout of COVID-19 can wake up an army of dormant viruses hiding inside the body go.nature.com/4fDUY9w
go.nature.com
COVID can wake up a slew of dormant viruses inside you
Reactivation of typically harmless anelloviruses, in particular, seems to be linked with developing long COVID, study finds.
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Dr Karen Pinder 🇨🇦 🔬 @drkarenpinder.bsky.social · 05/08/2026
Yeppers. I am no longer going to conferences in the U.S. And I am not alone.
insidehighered.com
Detentions of International Scholars at Airports Raise Alarm
A Johns Hopkins University researcher was detained at an airport by immigration officials and later released. Cases like hers make travel fraught for foreign scholars.
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United Videogame Workers-CWA @videogameworkers.bsky.social · 05/08/2026
Over 150k and still 8 days to go. 🙏 Thank you everyone who has purchased the bundle. Your generosity helps us support laid off game workers who are facing eviction, have put off important medical care/treatment due to losing insurance, and the like. Your solidarity means the world.
A screenshot of the Game Industry Hardship Fund on itch that shows we have raised over 152k as of the afternoon of August 5th
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Magnus Kjærgaard @proteinmagnus.bsky.social · 03/08/2026
Why do intrinsically disordered proteins behave so weirdly during SDS-PAGE? This is the question we aim to answer in our recent paper: onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Sequence determinants of the hypomobility of intrinsically disordered proteins in <fc>SDS</fc>‐<fc>PAGE</fc>
Proteins with intrinsically disordered regions (IDRs) migrate at a higher apparent molecular weight in sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis, complicating their analysis and...
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Sergey Ovchinnikov @sokrypton.org · 09/07/2026
🍹Long weekend Project: Since Claude Fable is banned for Science, I thought it might be fun to see if it can be used for something less scientific. 😎 Introducing Age of Epochs! ⚔️ An attempted reproduction of Age of Empires II in Javascript. ageofepochs.com (1/4)
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Richard Sever @richardsever.bsky.social · 02/08/2026
"f you are hunting for a COVID villain[,] investigate crooks who promoted quack remedies...sources of anti-vaccine disinformation...No mistakes by the scientific community begin to compare with the [right's] brutal indifference to the well-being of Americans" www.theatlantic.com/ideas/2026/0...?
theatlantic.com
Anthony Fauci Is Not the Villain in This Story
The doctor was thrust into his pandemic-leadership role because of Trump’s deadly dereliction of duty.
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tony romm @tonyromm.bsky.social · 24/07/2026
NEW: In a stunning admission, the Trump administration admitted in court documents that it canceled billions in energy grants to states "based solely" on politics -- and whether that state was represented by Democrats and backed Harris in 2024. www.nytimes.com/2026/07/24/b...
nytimes.com
Trump Administration Admits Canceling Grants to States That Did Not Vote for Him
Federal officials said in court documents that they halted billions of dollars in funding for energy projects to states “based solely” on whether they backed President Trump in the 2024 election.
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Mahesh Jethalia @mjethalia.bsky.social · 17/07/2026
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Alexey Sergushichev @asergushichev.bsky.social · 17/07/2026
New preprint from my lab with a methodological follow up on our work on fast GSEA algorithm: Hash-augmented adaptive multilevel splitting Monte Carlo algorithm for accurate estimation of two-sample permutation test p-values 1/7
Preprint abstract:

Nonparametric permutation tests are widely used for statistical analysis. However, exact computation of test p-values can be algorithmically challenging, particularly for custom tests with complex test statistics. In contrast, Monte Carlo sampling can be easily applied to any test statistic, but it suffers from poor relative accuracy when estimating small p-values, interfering with multiple hypothesis testing correction and leading to other issues. In this work, we present a hash-augmented adaptive multilevel splitting Monte Carlo algorithm that enables accurate estimation of arbitrarily small p-values in two-sample permutation tests. Using the Kolmogorov-Smirnov and the Mann-Whitney U tests as examples, we highlight potential pitfalls related to the discreteness of the test statistic distribution and show how to address them. By comparing with an exact algorithm, we demonstrate the accuracy of the p-value estimates provided by the proposed algorithm and the validity of the associated confidence intervals. We provide a reference implementation of the proposed algorithm in the Python package hamstest, which allows p-value estimation for a user-defined statistic.
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Stephanie Hicks @stephaniehicks.bsky.social · 01/12/2025
Consider submitting an abstract for an invited talk or poster at STATGEN 2026 by December 15th! Amazing keynote speakers and statistical leaders in #genetics and #genomics! 👏 Hope to see you there! statgen26.emory.edu 🧪 🧬 🖥️ 🧠 #statssky #imaging #SingleCell #spatial #omics #DigitalPathology
statgen26.emory.edu
STATGEN 2026: Conference on Statistics in Genomics and Genetics
STATGEN 2026: Conference on Statistics in Genomics and Genetics, May 18-20, 2026. ASA Section on Statistics in Genomics and Genetics.
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Carl T. Bergstrom @carlbergstrom.com · 29/04/2026
This short film about one night in one city documents racial profiling and a host of other abuses by ICE using body cam footage. Issued as a video opinion by full editorial board of the New York Times, it is utterly bone-chilling. Gift link. Please take the time to watch it, then call your reps.
nytimes.com
Opinion | White Drivers Got a Warning. Latino Drivers Got Detained.
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Brandon Bishop @brandontbishop.bsky.social · 16/04/2026
Traditionally, number of grad school applicants.
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Samuel Lampa @smllmp.bsky.social · 09/04/2026
Very very important initiative, check it out #bioinformaticians!
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Bioconductor @bioconductor.bsky.social · 08/04/2026
🚨 Bioconductor and R-universe are joining forces to modernize infrastructure for bioinformatics tools while preserving the strong governance and review processes that have made Bioconductor a trusted resource for over 20 years. 🔗 Learn more: blog.bioconductor.org/posts/2026-0...
blog.bioconductor.org
Collaborating between Bioconductor and R-universe on Development of Common Infrastructure – Bioconductor community blog
R-consortium ISC top-level project R-universe is working with Bioconductor to help gradually modernize parts of its infrastructure, while accommodating the project’s scale, governance, and…
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Louise Deconinck @louisedck.bsky.social · 25/08/2025
We're excited to share that our preprint on anndataR, a new package bringing Python's AnnData to R, is now available on bioRxiv 🎉 🔗 Read the paper: www.biorxiv.org/content/10.1... 💻 Check the package in action: anndatar.data-intuitive.com
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The Journal @thejournal.ie · 19/01/2026
"What started out in 2003 was LinkedIn, a legitimately useful, if somewhat boring, social media platform aimed at professionals and jobseekers, has, in recent years, descended into nauseating levels of humblebrags." jrnl.ie/6926750
jrnl.ie
From job hunting to oversharing: How LinkedIn morphed into an embarrassing group chat
Niamh O’Reilly on how LinkedIn stopped being about jobs and became a playground for self-appointed ‘thought leaders’.
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Willem van Schaik @wvschaik.bsky.social · 16/01/2026
This is very sad news 'It is with great sadness that EMBL announces that Interim Director General Professor Peer Bork passed away from natural causes on 16 January 2026.' www.embl.org/news/embl-an...
embl.org
In remembrance of Peer Bork  | EMBL
EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General.
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Nature @nature.com · 14/01/2026
Trust in science needs researchers, journals and institutions to correct the scientific record quickly and transparently when errors are found go.nature.com/3Ld8B3e
go.nature.com
Credit in research goes hand in hand with responsibility
Trust in science needs researchers, journals and institutions to correct the scientific record quickly and transparently when errors are found.
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Peter Coles 🏳️‍🌈 🏳️‍⚧️ 🇮🇪 @telescoper.bsky.social · 30/10/2025
My name is Ozymandias, King of Kings. There's a lot more sand here than there used to be.
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Deepta Bhattacharya @deeptabhattacha.bsky.social · 30/10/2025
The UofA is hiring for a Principal Scientist in cancer immunology! This isn’t a typical academic position—we're looking for a scientist with a great idea but needs time/resources to translate and commercialize. Please repost and apply if interested! arizona.csod.com/ux/ats/caree...
arizona.csod.com
Principal Scientist, Center for Advanced Molecular and Immunological Therapies
Develop a research program in the advancement of immunological therapies.Play a crucial role in all aspects of research development, implementation, a...
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Samuel Lampa @smllmp.bsky.social · 18/07/2025
Wow, sandbox.bio now provides a tutorial for viral phylogenetics that you can run right in your browser 🙌 sandbox.bio/tutorials/vi... #microbinfie #bioinformatics #training via @robert.bio
sandbox.bio
sandbox.bio - Interactive bioinformatics tutorials
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oZgun Gokce @gokcegroup.bsky.social · 15/06/2025
Atul Butte’s talk introduced me to systems biology—I was presynapse scientist and opened my horizon to "biomedical moments, thawing frozen discoveries in data". Ideas that changed my career. Thank you for the science, the spirit, and the inspiration. You will be remembered.
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Molly Jong-Fast @mollyjongfast.bsky.social · 04/04/2025
I kind of want to go
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Furqan Shah @shahfa.bsky.social · 04/03/2025
Imposter Syndrome & The Perfectionist Trap 🎭 More in Alt Text. #ImposterSyndrome #Perfectionism #PhDLife #AcademicWriting #Research #Productivity #WorkSmart #MindsetMatters #GradSchool #ScienceCommunication 🧪
I see so many PhD students struggling with imposter syndrome, often fuelled by perfectionism. As a self-confessed former perfectionist, I’ve learned an important lesson: the effort it takes to go from 50% to 95% “perfection” is the same as it takes to go from 95% to 99%. And that last 1%? It’s nearly impossible—because there will always be room for improvement.

The key is knowing when 99% is necessary (e.g., for a thesis or scientific paper 📑, where the content matters most) and when 95% is good enough (e.g., for a formal report 📄 that just needs to be clear and complete).

One thing, however, must always be 100% accurate: your data and results 🔬.

Letting go of that last elusive 1% can make a huge difference to how you manage your workday ⏳, day after day, and help you avoid getting hyperfixated on one thing at the expense of everything else ⚖️.
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Brian Matilla @bxmatilla.bsky.social · 07/11/2024
I stand with my female friends and colleagues. I stand with the LGBTQIA+ community because we are one society. I stand for science and all of us doing great science. I stand for honesty and always seeking truth. I stand for being a decent human being, because it’s not that complicated.
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Meng-meng Fu @mengmengfu.bsky.social · 24/01/2025
If you’re a federal govt employee targeted for leave or termination on the basis of your DEI work, please file an EEO (Equal Employment Opportunity) complaint & retain legal counsel. I’m a former NIH PI. Happy to refer you to a law firm that has successfully sued the govt many times! Pls repost 🙏❤️
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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 09/01/2025
I have no words. My sister lost her house to the SoCal fire, leaving her family of four with a handful of suitcases and no home. If you are feeling particularly generous, please consider this gofundme gofund.me/3752eb40
gofund.me
Donate to Aid for Emily and Josh's Family After Fire, organized by Nina Steenwyk
My sister (Emily), her husband (Josh), and their two young daughters experien… Nina Steenwyk needs your support for Aid for Emily and Josh's Family After Fire
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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 10/01/2025
I’m so overwhelmed and so grateful for support bsky.app/profile/jlst...
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ISGlobal @isglobal.org · 18/12/2024
Today is a global day dedicated to 184 million people, 2.3% of the world's population: it's #MigrantDay. "Caring for migrant patients is an opportunity for primary care professionals to practice cultural humility and continue to learn." —Ethel Sequeira #ISGlobal www.isglobal.org/en/healthisg...
isglobal.org
Humility, Integration and Respect. Happy Migrant’s Day - Blog
Caring for migrant patients is both a challenge and an opportunity for Primary Care professionals&#8212;a chance to practice cultural humility and...
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Madhu Pai, MD, PhD @madhupai.bsky.social · 04/12/2024
www.science.org/doi/10.1126/...
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 06/05/2024
If you're interested in reading about how I got into biophysics and protein science and what I enjoy about the field, I'm profiled this month by the Biophysical Society: www.biophysics.org/profiles/kre...
biophysics.org
Kresten Lindorff-Larsen
Kresten Lindorff-Larsen, Professor at the Linderstrøm-Lang Centre for Protein Science in the De­partment of Biology, University of Copenhagen, studied biochemistry, leading him to...
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ISGlobal @isglobal.org · 26/11/2024
#ISGlobal’s #XTrem wins #i4KIDS 1st Prize! This novel approach enables healthcare professionals to rapidly evaluate the severity of infections, facilitating timely and effective treatment decisions. 🟠 www.linkedin.com/pulse/x-trem... #GlobalHealth #Innovation #ChildHealth
linkedin.com
X-Trem Prognostic Device Awarded 1st Prize in i4KIDS 2024 Acceleration Programme
X-Trem, a point-of-care (PoC) test based on sTREM-1 levels to triage the severity of children with a suspected infection, has been awarded the 1st Prize of the i4KIDS Accelerator Programme. The award ...
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ISGlobal @isglobal.org · 20/11/2024
🩺🌍 Spanish leadership in European health policy expands: #QuiqueBassat, Director General of #ISGlobal, has been appointed to the Management Board of the ECDC (@ecdc-eu.bsky.social) as a representative of the European Parliament. 🟠 www.isglobal.org/en/-/quique-...
isglobal.org
Quique Bassat, New Board Member of the European Centre for Disease Prevention and Control - ISGLOBAL
Quique Bassat, Director General of ISGlobal, has been appointed to the Management Board of the European Centre for Disease Prevention and Control (ECDC) as a representative of the European Parliament.
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Lavisha Parab @lavishaparab.bsky.social · 19/11/2024
Ok I'm so happy to see you EEB/micro folx on Bluesky! I know you didn't come because of me passionately speaking/campaigning for months 😂😂 Check if you're added to the right starter packs! Hope you'll see that it's more fun and better for science chats! Like science twitter from many many years ago
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Mahesh Jethalia @mjethalia.bsky.social · 16/04/2024
Downstream pathway enrichment identifies Epethelial to Mesenchymal transition, TGF-b signaling, Toll-like receptor signaling, cytokine & inflammatory response getting activated in highly invasive cancers creating feasible env for metastasis. More info at: rdcu.be/djYIs
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Mahesh Jethalia @mjethalia.bsky.social · 16/04/2024
I am excited to join @isglobalorg.bsky.social and get my Ph.D. It is an amazing opportunity and I hope I make the most of my time.
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