iiinova — where your digital self keeps evolving

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Colette Delawalla, PhD @cdelawalla.bsky.social · 37m

🚨STARTING IN ONE HOUR🚨 OUR VIRTUAL AND ACCESSIBLE NO KINGS RALLY! Come hang with the @standupamerica.com team, Michael Lewis, @staceyabrams.com, @simonwdc.bsky.social, Theo Braddy, Melly the Science Geek, AND MORE!! Let's Get Out The VOTE! #nokings events.standupforscience.net/stand-up-for...

events.standupforscience.net

Official No Kings Virtual & Accessible GOTV Rally

<b>Join us for this virtual event that ensures everyone has a way to show up and participate in the movement to defend our democracy</b>. The rally offers people across and outside of the U.S. an acce...

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The Tennessee Holler @thetnholler.bsky.social · 38m

BRAZIL 🇧🇷: A judge ordered META to stop intentionally helping Bolsonaro (son of an insurrectionist) against Progressive President Lula. Tech oligarchs meddling with elections across the globe. www.nbcnews.com/world/south-...

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Long Covid Advocacy @longcovidadvoc.com · 16/10/2026

Olympic sprinter Beth Dobbin advocates brilliantly in this article: 🔹strongly rejects CFS label 🔹states there is no specialist NHS service 🔹conveys the severity of the disease 🔹raises the issue of how athletes are more 'believed' www.bbc.co.uk/sport/athlet...

bbc.co.uk

Beth Dobbin: British Olympic sprinter in bed for 22 hours a day after ME diagnosis

Beth Dobbin ran for Great Britain at the Tokyo Olympics in 2021. Five years on, she is largely bedbound after being diagnosed with ME, a devastating illness for which there is no cure.

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Stefan Pöhlmann @snpoehlm.bsky.social · 24/09/2026

🦠 SARS-CoV-2 SURVEILLANCE RESOURCES AROUND THE WORLD An updated collection of useful dashboards and websites for tracking COVID-19, SARS-CoV-2 variants and wastewater surveillance. Bookmark/share. 🧵

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Ryan Hisner @ryanhisner.bsky.social · 14/10/2026

66 airport SARS-CoV-2 sequences from incoming travelers were uploaded today, collected Sept 21-30, and 26 (39.4%) were PJ.2.1. 20/30 (66.7%) sequences from Latin American travelers were PJ.2.1. Seems likely that PJ.2.1 is rapidly sweeping across the entire Western hemisphere.

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Ryan Hisner @ryanhisner.bsky.social · 09/10/2026

Large upload from Ontario yesterday, providing some striking revelations about the evolution of PJ.2.1. First, there is yet another strikingly divergent branch of PJ.2.1. This isn't one variant: it's four. More and more, this resembles the emergence of BA.1/2/3. What is happening? 1/

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Ryan Hisner @ryanhisner.bsky.social · 06/10/2026

Since Aug 31, 12.8% (10/78) airport surveillance seqs from international travelers to the US have been PJ.2.1. 45% (9/20) from Latin American travelers in that period are PJ.2.1: 4 from Cuba & 1 each from Chile, Colombia, the DR, Ecuador, & Guatemala. PJ.2.1 is the fastest variant in the world now.

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WIRED @wired.com · 02/10/2026

DHS agents not only tracked and intimidated people observing ICE activity in Maine, but stored information about them in a Palantir-built database, newly unsealed court filings say.

wired.com

ICE Has Been Dumping Protester Photos Into a Palantir Database

DHS agents not only tracked and intimidated people observing ICE activity in Maine, but stored information about them in a Palantir-built database, newly unsealed court filings say.

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🗽LOLGOP🗽 @lolgop.bsky.social · 03/10/2026

"The doctrine that the strong dominate the weak is the doctrine of our enemies."

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Abdul El-Sayed @abdulelsayed.bsky.social · 28/09/2026

Keep the data centers away from our Great Lakes.

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Ryan Hisner @ryanhisner.bsky.social · 29/09/2026

By far the most commonly mutated CD8 T cell-epitope site in chronic infections is ORF1a:T1638, and mutations there are now far more common in circulating lineages than they ever have been. In one case (RF.5.4.1) it's paired with another major HLA*01:01 escape mutation: ORF1b:T730I.

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Ryan Hisner @ryanhisner.bsky.social · 26/09/2026

Phenomenal 🧵 (& paper) about why Omicron is less efficient at infecting the lung than previous variants. Initial ideas on this were proven wrong, & it's been an utter mystery since. Stuart, doing work on one else is doing, has largely explained it & revealed vital aspects of the SARS-2 life cycle.

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c0nc0rdance @c0nc0rdance.bsky.social · 23/09/2026

Video from Maura Hennelly captures her sunbeam snake named 'Vespira' in all her glory. Sunbeam snakes (genus Xenopeltis) are non-venomous snakes from SE Asia that kill small prey (frogs, rodents) by constricting. They burrow through soft dirt or leaf litter in humid jungles. (📷:@maurahennelly IG)

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Get To Know Nature @gettoknownature.bsky.social · 22/09/2026

I love how Jewelweed flowers look like a big mouth, in this case chomping on a bumble bee. It’s almost like an oddly shaped Pac-Man #birds 🌿 #BeeButt #NativePlants

A large fuzzy black and light yellow bee has its back half hanging out of an orange flower like a mouth. It even looks like it has lips!

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Mark Faghy @profmarkfaghy.bsky.social · 22/09/2026

📢 Our paper is published in Oxford Open Immunology: The ERASE_LC trial evaluated whether a 5-day course of intravenous remdesivir is feasible, safe, and acceptable for people living with Long COVID. This is the first study to specifically examine remdesivir as a treatment for LC.

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Adam Jewell Photography @adamjewell.bsky.social · 19/09/2026

Here’s a double rainbow after an intense storm over what I believe is Wolf Mountain in the Two Medicine section of Glacier National Park in Northern Montana. #twomedicine #glacier #rainbows #nationalparks #photography #nature #gnp #wilderness #eastglacier Prints—> adamjewell.com/featured/two...

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Barry Cliver @barrycliver.bsky.social · 19/09/2026

74° North off the coast of Western Greenland. #greenland #travel #landscapephotography #photography #arctic

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AndyBeavisPhoto @andybeavisphoto.bsky.social · 12/09/2026

In Senja, Norway, at the iconic Segla Mountain in late afternoon light. #landscape #Landscapephotography #Norway #Senja #sunset #mountain

A very steep vertical mountain rises upwards, with the steep left sude descending to a saddle valley overlooking a fjord, while the near vertical right side drops down to water level in the fjord below. In the background are many high, multiple peaked mountains. The golden late afternoon sun is striking the right side of the mountain, painting it yellow orange. The sky is blue with whispy streaks of cloud.

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Ryan Hisner @ryanhisner.bsky.social · 11/09/2026

Great thread on the PJ.2.1 variant situation, what we do & do not know, & where it stands now. Worth emphasizing that a recent Yunlong Cao preprint found PJ.2.1 has very high ACE2 affinity, meaning that, like BA.2.75 or BA.2.86, it has plenty of space to acquire new Ab-evading spike mutations.

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Solid Evidence @solidevidence.bsky.social · 20/08/2026

I can finally reveal the rest of our World Cup surveillance. While we were working away on wastewater metagenomics, the other side of lung.fish was on the ground doing air sampling with team Canada. Preprint just out. www.medrxiv.org/content/10.6...

lung.fish

Lungfish

Dedicated to improving environmental surveillance and tackling viruses through innovative detection strategies.

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Ryan Hisner @ryanhisner.bsky.social · 12/08/2026

The truth: getting Covid early in pregnancy can cause fetal brain hemorrhaging, w/direct detection of virus in the hemorrhages. This decreased when the UK approved vaccines for pregnant women—& increased when they removed the vax recommendation for pregnant women. Hugely overlooked finding. 1/3

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🦋 MiLilith 🦋 @mililith.bsky.social · 11/08/2026

That is simultaneously interesting & reassuring. Such beneficial information to have!

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Solid Evidence @solidevidence.bsky.social · 06/08/2026

FYI, the most elevated viruses in the US last week were once again Parechovirus 6 and Coxsackievirus A9. Both are elevated nationwide.

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Ryan Hisner @ryanhisner.bsky.social · 29/07/2026

This is excellent. "The 'rogue AI' narrative helps obscure some pretty ugly truths.... Like the fact that OpenAI lost $38.5 billion last year, will likely never make a profit, & is facing total collapse or acquisition as an AI bubble looms." Also, a vision of an even dumber near future: 1/2

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Dr. Jeroen W.P. Wijnendaele @drdragases.bsky.social · 27/07/2026

Good grief, this hits home.

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Danielle Beckman @daniellebeckman.bsky.social · 27/07/2026

Our review covering the major Neuroinflammatory events in Long Covid is finally online and open access here! www.nature.com/articles/s41... #NeuroCovid #LongCovid 🤓🧠

Expert Review
Open access
Published: 21 July 2026
Understanding neuroinflammation in post-COVID-19 syndrome: biological mechanisms, diagnostic biomarkers, and therapeutic prospects

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Sho Hoshino @shophotography.bsky.social · 27/11/2024

Witnessing phenomena like this is why I can never stop capturing landscapes.

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Ryan Hisner @ryanhisner.bsky.social · 21/07/2026

This chronic-infection variant now has a name: PJ.2.1. You can see how divergent it is from other current lineages in the @neher.io/Roemer BA.2.86 tree below. It originated in Ontario but has been detected in wastewater by @solidevidence.bsky.social in New York, Florida, Alabama, & Utah I think. 1/3

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Ryan Hisner @ryanhisner.bsky.social · 18/07/2026

The full paragraph this quote comes from is gold, like the rest of the book. "Who was the first man to look at a house full of objects and immediately assess them only in terms of what he could get for them in the market? Surely, he can only have been a thief." - David Graeber

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Ryan Hisner @ryanhisner.bsky.social · 16/07/2026

Great thread here. Really looking forward to digging into this paper by @mghafari.bsky.social, @spyroslytras.bsky.social, and Sanni Översti.

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Ryan Hisner @ryanhisner.bsky.social · 16/07/2026

ORF6 is a SARS-2 protein that shuts down traffic between the nucleus & cytoplasm in host cells, inhibiting host mRNA export & immune responses. But in all variants since early 2023, ORF6's abilities are hampered by the ORF6:D61L mutation. Two newish ORF6 observations.... 1/15

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Solid Evidence @solidevidence.bsky.social · 10/07/2026

We performed a metagenomic sprint this week. Samples that arrived on Tues were prepped overnight, loaded on a 10B plate Wed (25 h run), and output today. The same summer viruses continue to surge: Parechovirus 6, Rhinovirus A54, Parainfluenzavirus 3 and Coxsackievirus A9.

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Solid Evidence @solidevidence.bsky.social · 06/07/2026

@ryanhisner.bsky.social I did some scavenging to see if it was in any other sewersheds in the last month. Found 3 more, 2 more from NYC (different sewersheds) and 1 from Utah. I can't say it's taking off, but it moving around pretty quickly.

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Solid Evidence @solidevidence.bsky.social · 05/07/2026

World Cup virus wastewater update. While I wait ‘patiently’ for the sequences from this week (which was supposed to be done already), here is a summary of the 4 lineages that have been on the rise since the games began across our 43 sampling sites. 1/

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Ryan Hisner @ryanhisner.bsky.social · 04/07/2026

A mysterious, unusually diverse saltation lineage descended from KP.3.1.1 (last seen early 2025) has circulated at a low level for ~8 months in Ontario (see 🧵 on next post). Seemed a local anomaly, but @solidevidence.bsky.social just spied a weird spike in NYC wastewater—& it's the same one! 1/14

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Carl Quintanilla @carlquintanilla.bsky.social · 04/07/2026

“.. Members of the group Patriot Front ride the metro on the 250th anniversary of U.S. independence in Washington, D.C.” @reuters.com

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Adam Cohen (My Personal Views Only) @axidentaliberal.bsky.social · 04/07/2026

“Those who profess to favor freedom, and yet depreciate agitation,are men who want..the ocean without the awful roar..This struggle may be a moral one; or it may be a physical one; or it may be both..but it must be a struggle. Power concedes nothing without a demand” Frederick Douglass America 250

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Solid Evidence @solidevidence.bsky.social · 04/07/2026

I was wrong. What I thought was a cryptic lineage from NYC was actually a new highly divergent JN.1 (branched off about a year ago). Probably derived from a persistent infection. BTW, it was in 2 different sewersheds, and the most recent one was 40% of the signal.

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Solid Evidence @solidevidence.bsky.social · 03/07/2026

This is kind of weird. A new cryptic showed up in two different NYC sewersheds this month. Low coverage. RBD piece is: 403K-405N-408S-417N-435S-439N-445P-446T-450D-452K-455S-456L. Also a deletion at 621-622. 1/

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Ryan Hisner @ryanhisner.bsky.social · 26/06/2026

Successfully appealed the biorxiv rejection and today our paper (co-authors @darrenmartin.bsky.social & Ravi Gupta) is posted. The paper's too long to do a single summary thread, but I'll do a cursory overview here, then more detailed subsection threads later. 1/16 www.biorxiv.org/content/10.6...

biorxiv.org

Coevolving Mutations in Chronic SARS-CoV-2 Infections

The SARS-CoV-2 pandemic has been marked by two outstanding features that have had major impacts on global public health: the repeated emergence and growth of highly divergent saltation variants with n...

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Solid Evidence @solidevidence.bsky.social · 24/06/2026

This is so awesome. Here's a different view of the last 6 months of wastewater metagenomics from 41 sites (color coded by site). We were able to predict the sewershed each sample came from based solely on the virome present with 99% accuracy.

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Ryan Hisner @ryanhisner.bsky.social · 24/06/2026

Cheat sheet for those wondering what the various new lineages @siamosolocani.bsky.social refers to are, or who (like me) often forget or get them mixed up. My ability to make this is utterly dependent on @angieshinrichs.bsky.social's invaluable Usher tree work. TA.1 still too new to be included.

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Solid Evidence @solidevidence.bsky.social · 19/06/2026

First World Cup wastewater metagenomics had nothing out of the ordinary. Parainfluenzavirus 3 and a couple enteric viruses are high (typical for early summer). The most exotic virus we saw was a Largemouth Bass Bunyavirus. Waiting 'patiently' for data from the second plate.

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Ryan Hisner @ryanhisner.bsky.social · 19/06/2026

55 of the last 75 outbreaks of H5N1/HPAI/avian bird flu in the US affecting at least 1000 birds have occurred in counties in Northeast Indiana with large Amish populations: Lagrange, Elkhart, Adams, and Jay. I do not know if there is a connection here, but it seems worth looking into. 1/4

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Isabel, booonyavirus wonk @isabelott.bsky.social · 19/06/2026

An interesting thread from a month ago that predicted exactly what we’re seeing in the reflecting pool now (peeling up, prolific microbial activity)

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Alyssa Harad @alyssaharad.bsky.social · 19/06/2026

Reagan forced everyone out of the psych wards and on to the streets so I guess this is some kind of demonic 1980s full circle moment.

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Ryan Hisner @ryanhisner.bsky.social · 17/06/2026

Probably the most spectacular rainbow I've ever seen showed up earlier today outside my house. Crazy how much brighter it is beneath the rainbow than above it.

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Solid Evidence @solidevidence.bsky.social · 15/06/2026

Here is the first round of games by host city. Which match will have the most exotic viral pathogen? And what viral family will it be from?

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Ryan Hisner @ryanhisner.bsky.social · 15/06/2026

BA.1/NB.1.8.1 recombinant uploaded today from Portugal, collection date January 2026. There were two BA.1 collected in Dec 2025 in Michigan uploaded last month as well. BA.1 not entirely finished with us yet, over 4 years after it disappeared from circulation.

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