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Matthias Fellner

@mfellnerlab.bsky.social
36 followers 41 following 9 posts

Understand protein structure-function relationships and use this knowledge to answer fundamental questions of chemistry/biochemistry at the University of Otago.

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Matthias Fellner @mfellnerlab.bsky.social · 13/04/2026
Check out our latest publication “Carbamoyl fluorides as serine hydrolase inhibitors: a case study on FphI from Staphylococcus aureus.” doi.org/10.1016/j.bi... Great new collaboration between Otago and University of Ljubljana driven by George Randall and Anže Meden, assisted by many co-authors.
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Matthias Fellner @mfellnerlab.bsky.social · 25/03/2026
Couple of thousand protein crystals grown and hundreds of datasets later this fun project is published “Unique structural and ligand binding properties of the Staphylococcus aureus serine hydrolase FphE" www.pnas.org/doi/10.1073/... Great collaboration with @jeyunjo.bsky.social @mbogyo.bsky.social
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Matthias Fellner @mfellnerlab.bsky.social · 13/05/2025
Great collaboration with Suzanne Warring, Hazel Sisson @peterfineran.bsky.social and others to combat kiwifruit canker via an endolysin-lipase chimera, grateful to be involved, check it out here: www.jbc.org/article/S002...
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Matthias Fellner @mfellnerlab.bsky.social · 29/12/2024
Happy to share our paper "Similar but Distinct—Biochemical Characterization of the Staphylococcus aureus Serine Hydrolases FphH and FphI" in PROTEINS doi.org/10.1002/prot... - cryo vs room temperature protein crystallography, SAXS, molecular dynamics and much more to uncover key enzyme differences.
FphH and FphI cryo and room temperature crystal structures.
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Matthias Fellner @mfellnerlab.bsky.social · 13/12/2024
Just out Comparative lipidomics profiles of planktonic and biofilms of methicillin-resistant and -susceptible Staphylococcus aureus: doi.org/10.1016/j.ab... MS & NMR to dig into lipid differences between strains, living states & media. Get in contact to investigate your lipids of interest together!
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