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Matteo Fabbri

@mfabbri.bsky.social
389 followers 310 following 5 posts

Assistant Professor Center for Functional Anatomy and Evolution Johns Hopkins University School of Medicine

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Reposted by Matteo Fabbri
Griffin Lab @griffinlabpaleo.bsky.social · 04/12/2025
Very excited to share that our latest paper is out in Science! We show that the type specimen of Nanotyrannus—an isolated skull—is fully grown, showing that it is not a juvenile Tyrannosaurus rex but a distinct species (1/12) www.science.org/doi/10.1126/...
science.org
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Gayani Senevirathne @gayani.bsky.social · 27/08/2025
Super excited and thrilled to see this work come out in Nature today. 🥹@tdcapellini.bsky.social Thank you so much for your amazing mentorship throughout the project, and to all my co-authors who helped take this work to the next level.
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tdcapellini.bsky.social @tdcapellini.bsky.social · 27/08/2025
1) I am delighted to present this terrific tour de force research conducted by my post-doc Dr. Gayani Senevirathne @gayani.bsky.social and published today in Nature - www.nature.com/articles/s41...
nature.com
The evolution of hominin bipedalism in two steps - Nature
The human pelvis exhibits distinct spatiotemporal ossification patterns and an ilium cartilage growth plate that is shifted perpendicularly compared with those of other mammals and non-human primates—...
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Matteo Fabbri @mfabbri.bsky.social · 09/07/2025
New paper today about the evolution of the wrist along the dinosaur to bird transition: a bird-like configuration appeared in predatory dinosaurs first, as suggested by new exceptionally preserved hands of oviraptors and troodontids www.nature.com/articles/s41...
nature.com
Reorganization of the theropod wrist preceded the origin of avian flight - Nature
The forelimbs of two Late Cretaceous theropod dinosaurs show the presence of the pisiform bone, previously thought to have been lost early in theropod evolution and regained in birds during the evolut...
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Guillaume Houée 🦷🔬 @guillaumehouee.bsky.social · 22/05/2025
Thrilled to have co-written a News & Views with P. Janvier on Haridy et al.’s recent Nature paper. They reveal that Anatolepis, once thought to have the oldest dental tissue, is actually Cambrian arthropod sensory armor! Paper: nature.com/articles/s41... N&V: www.nature.com/articles/d41...
nature.com
The evolutionary origin of sensitive dental structures
Fossil data shed light on a debate about when vertebrate dental tissues arose by assigning an early sensory structure to arthropods rather than to vertebrates.
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Matteo Fabbri @mfabbri.bsky.social · 21/05/2025
Glad to share a new paper led by @yara_haridy and @NeilShubin Lab on the early evolution of teeth! Modern and fossil data point at an ancestrally sensorial function for the earliest dentine www.nature.com/articles/s41...
nature.com
The origin of vertebrate teeth and evolution of sensory exoskeletons - Nature
Re-examination of the presumed Cambrian fossil fish Anatolepis reveals previous misidentification of aglaspidid sensory structures as dentine, a vertebrate sensory tissue, showing it to be a...
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Matteo Fabbri @mfabbri.bsky.social · 14/05/2025
Glad to see the formal description of the Chicago specimen of #Archaeopteryx finally out in @nature.com! Troodontid and early bird features in the palate and evidence of tertiary feathers www.nature.com/articles/s41...
nature.com
Chicago Archaeopteryx informs on the early evolution of the avian bauplan - Nature
Analysis of the 'Chicago' Archaeopteryx, a nearly complete and uncrushed specimen, reveals details of the skeleton, soft tissues and plumage of this taxon, providing information on the evolution to av...
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Neelima Sharma @neelimasharma.bsky.social · 26/02/2025
Super excited to share our @plosbiology.org paper with @neilshubin.bsky.social and Yara Haridy, “Synovial joints were present in the common ancestor of jawed fish but lacking in jawless fish” Paper: plos.io/3CTC8La Primer by @crumplab.bsky.social: plos.io/4kkhXa6 I hope you enjoy reading it!
plos.io
Synovial joints were present in the common ancestor of jawed fish but lacking in jawless fish
Synovial joints are characterized by lubricated articular surfaces separated by a cavity, providing mobility and load-bearing, but when did they evolve? This comparative and developmental study reveal...
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PLOS Biology @plosbiology.org · 25/02/2025
When did synovial joints evolve? @neelimasharma.bsky.social @neilshubin.bsky.social &co reveal that stable, mobile & lubricated joints were present in the common ancestor of jawed fishes but lacking in jawless ones 🧪 @plosbiology.org plos.io/3CTC8La
Top: Immunostaining reveals aggrecan (yellow) at the articular surfaces in the pelvic joint of an embryonic little skate (stage 33). The nucleus is stained using DAPI and is shown in red. Bottom: Phylogenetic tree adapted from Donoghue and Keating, annotated to show that synovial joints exist in extant jawed vertebrates (gnathostomes), but the study’s results do not support their existence in cyclostomes. The presence of reciprocally shaped and cavitated joints in the dermal skeleton of antiarchs suggests that joints that function by relative sliding (similar to synovial joints) first originated in stem gnathostomes.
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Neil Shubin @neilshubin.bsky.social · 25/02/2025
New paper led by @neelimasharma.bsky.social on the lab! The evolutionary origin of highly mobile joints!
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Kim Cooper @ucsdcooperlab.bsky.social · 21/02/2025
@philipcball.bsky.social gets a bit spicier in places than I did, "it can be hard to avoid the suspicion that sometimes its (omics data) collection serves to postpone the awkward time when some sense must be made of it all." And I like it :)
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Kim Cooper @ucsdcooperlab.bsky.social · 13/02/2025
With gratitude to the Keck Foundation, we get to work on a project with Dana Rashid (MSU) and Susan Chapman (Clemson U) that was inspired by Dana's studies of the dino-bird transition. today.ucsd.edu/story/uc-san...
today.ucsd.edu
UC San Diego Biologist and Collaborators Receive $1 Million Keck Award
A multi-institutional research team that includes UC San Diego biologist Kim Cooper has been awarded a $1 million grant from the W.M. Keck Foundation to study the role of inflammation in animals, whic...
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Stowers Institute @stowersinstitute.bsky.social · 12/02/2025
Ever wondered how your #genes know when to turn on or off? 🧬🔌 In our latest #BioBasics episode, @juliannahaug.bsky.social, a researcher in the Sauka-Spengler Lab, explains gene regulatory networks — the circuits that control gene activity. Watch + learn more: bit.ly/4jYJmxR
bit.ly
#BioBasics: What are Gene Regulatory Networks?
The Sauka-Spengler Lab explores the blueprint and circuitry driving cells
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Neil Shubin @neilshubin.bsky.social · 08/02/2025
Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.
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Rita Strack @ritastrack.bsky.social · 06/02/2025
"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...
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Hao Yin @haoyin.bsky.social · 02/02/2025
CellOracle In silico transcription factor KO via cell type-specific Gene-Regulatory Network modeling #Nature 2023 www.nature.com/articles/s41...
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Joe Keating @evopalaeo.bsky.social · 29/01/2025
royalsocietypublishing.org/doi/10.1098/... This looks right up my street, can't wait to read!
royalsocietypublishing.org
Quantifying the configurational complexity of biological systems in multivariate ‘complexity space’ | Journal of The Royal Society Interface
An increasing number of evolutionary studies seek to quantify the morphological complexity of organisms, particularly those comprising serially homologous elements at different hierarchical levels of ...
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Anna Allen @akallen10.bsky.social · 28/01/2025
NSF has created an Executive Order Implementation webpage to ensure the widest dissemination of information and updates. We will continue to communicate with you as we receive additional guidance. new.nsf.gov/executive-or...
new.nsf.gov
NSF Implementation of Recent Executive Orders
Information for the NSF community regarding executive orders.
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Marc Robinson-Rechavi @marcrr.ecoevo.social.ap.brid.gy · 27/01/2025
We are excited to share our work on molar #EvoDevo 🦷 in mouse and hamster 🐁, led by the amazing team of Marie Sémon and Sophie Pantalacci. We find an inverted hourglass pattern, with a maximum of evolutionary divergence at the bell stage. www.biorxiv.org/content/10.1101/202…
Top: hourglass pattern of increasing then decreasing divergence over molar development, with the stages BUD, CAP, BEL (maximum divergence), DIF and SEC. Bottom: illustration of gene processes influencing this pattern, from left to right: image of embryo with “shared: limbs, scales, glands; lung, kidney”; “immunity genes (influx of blood)”; image of embryo and of tooth with “shared: secretion; intrinsic: mineralisation”.
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Miki Ebisuya @ebisuyamiki.bsky.social · 24/01/2025
Latest from the lab! I've been seeking the ultimate modulator that regulates the tempo of multiple developmental processes simultaneously, and metabolism has been an attractive candidate for such a global tempo modulator. However, I was wrong. 1/ www.nature.com/articles/s41...
nature.com
Metabolic activities are selective modulators for individual segmentation clock processes - Nature Communications
Metabolism has been considered an attractive candidate as a global modulator of the tempo of multiple developmental processes, including somite segmentation timing. Here they demonstrate that metaboli...
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Melanie D. White @melaniedwhite.bsky.social · 24/01/2025
Happy #FluorescenceFriday to those who celebrate! Here's a beautiful quail neural tube and somites labelled for microtubules 🟠 and actin 🔵. Imaged by Power-RA Siew Zhuan Tan. #devbio 🧪🔬👩‍🔬
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Stowers Institute @stowersinstitute.bsky.social · 22/01/2025
Postdoc in @planaria1.bsky.social Lab, @rileynoceros.bsky.social, joins the 2024 class of @hhmi.bsky.social #HannaGrayFellows! Her work on how some vertebrates “pause” their development could transform our understanding of #evolution & human #medicine – listen as she explains: bit.ly/4g8xWED
youtube.com
Stowers Institute Postdoc selected as HHMI Hanna H. Gray Fellow
YouTube video by Stowers Institute for Medical Research
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Thom Sanger @thomsanger.bsky.social · 18/01/2025
I am very proud of the work that went into this new Sanger Lab publication. This paper was led by postdoc Marta Marchini and a number of my lab's undergraduate students, each of which contributed unique skills or effort to the completion of this project.
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J Pardo @jdpardo.bsky.social · 18/01/2025
Pretty neat story here by Marta Marchini, @thomsanger.bsky.social and coauthors. Our first look at the role of FGF and HH signaling in the lizard face (Anolis), with big implications for the ancestral amniote condition 1/n www.nature.com/articles/s42...
nature.com
Sonic hedgehog and fibroblast growth factor 8 regulate the evolution of amniote facial proportions - Communications Biology
The function of two genes, Sonic hedgehog and Fibroblast growth factor 8, have changed greatly during amniote facial evolution. The expression of these genes can explain variation in the proportion of...
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@LaBonneLaB @labonnelab.bsky.social · 18/01/2025
Dear #neuralcrest afficionados Please Apply for the Neural Crest and Cranial Placodes GRC - the current application numbers put it at risk for cancellation going forward. Come to beautiful Tuscany and engage with interesting science! www.grc.org/neural-crest...
grc.org
2025 Neural Crest and Cranial Placodes (GRS) Seminar GRC
The 2025 Gordon Research Seminar on Neural Crest and Cranial Placodes (GRS) will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
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Matt Friedman @friedmanlab.bsky.social · 13/01/2025
Great to see old pals and new results at #SICB2025, including Yara Haridy's deep dive into some of the earliest bony skeletons: www.science.org/content/arti...
science.org
Ancient fish fossil suggests ‘living skeletons’ evolved 460 million years ago
X-ray analysis of bony scale shows vertebrates developed ability to remodel and repair bone much earlier than thought
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Will Gearty @willgearty.bsky.social · 06/12/2024
🚨New Diamond 💎 Open Access Journal in Paleontology 🦴🐚!🚨 Send us your manuscripts 📜 and publish fully open access 🔓 entirely for free! #openacess #paleontology #free #palaeontology #diamond #open
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Aaron Griffing @aaronhgriffing.bsky.social · 06/12/2024
Eventually, we studied development of sticky toes! We found similar derived developmental patterns of convergently evolved #toepads, despite approximately 200 million years of independent evolution! @tonygamble.bsky.social @thomsanger.bsky.social #GeckoEvoDevo academic.oup.com/biolinnean/a...
academic.oup.com
Convergent developmental patterns underlie the repeated evolution of adhesive toe pads among lizards
Abstract. How developmental modifications produce key innovations, which subsequently allow for rapid diversification of a clade into new adaptive zones, h
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Eric Ekdale @eekdale.bsky.social · 04/12/2024
I have a new paper out on the evolution of hearing in toothed whales! It looks like a narrow range of high-frequency auditory sensitivity in some living dolphins and porpoises may be an ancestral physiology rather than novel specializations in select groups. onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Variation in whale (Cetacea) inner ear anatomy reveals the early evolution of “specialized” high‐frequency hearing sensitivity
Our findings support sensitivity to low-frequency sound in the archaeocete Zygorhiza kochii and an early toothed mysticete cf. Aetiocetus. Narrow-band high-frequency hearing was present in Oligocene ...
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Hao Yin @haoyin.bsky.social · 26/11/2024
TRISCO A solid step closer to 3D #SpatialTranscriptomics 😎 Optimized probe-based 3D RNA imaging in whole organs isHCR Tris 500 mM 4'C Validated probe list in Table S1 Brain Heart Lung Kidney @peruhlen.bsky.social @science.org 2024 www.science.org/doi/10.1126/...
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Neil Shubin @neilshubin.bsky.social · 24/11/2024
Your reminder that many of the muscles, nerves and bones you use to hear and talk with correspond to gill structures in fish. 🧪 #evolution #paleontology
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Professor Anjali Goswami FRS @evoswami.bsky.social · 24/11/2024
New paper! For all of you working with 3d scans (e.g. micro-CT, MRI), check out SPROUT, a rapid open-source tool for generating segmented and parcellated data, meaning your scans are separated into the individual elements without any manual labelling or training. www.biorxiv.org/content/10.1...
Figure showing diverse datasets analysed with SPROUT, including a skink skeleton, aardvark skull, human heart, concrete block, and foraminifera.
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Matteo Fabbri @mfabbri.bsky.social · 22/11/2024
Considering that turkey day is approaching, enjoy a close up of its origins for #fossilfriday. The Chicago specimen of #Archaeopteryx
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Matteo Fabbri @mfabbri.bsky.social · 22/11/2024
Picture of history being made
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Kim Cooper @ucsdcooperlab.bsky.social · 21/11/2024
Excited to share work that @ceriweber.bsky.social started and drove in my lab. Tails!! We know a lot about limb bone growth, but vertebrae have completely different embryonic and evolutionary origins. What controls growth and proportion in the vertebral skeleton? www.biorxiv.org/content/10.1...
biorxiv.org
Cellular and molecular mechanisms that shape the development and evolution of tail vertebral proportion in mice and jerboas
Despite the functional importance of the vertebral skeleton, little is known about how individual vertebrae elongate or achieve disproportionate lengths as in the giraffe neck. Rodent tails are an abu...
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Armita R. Manafzadeh @armanafzadeh.bsky.social · 20/11/2024
Thrilled to share: out in @natureportfolio.bsky.social (!) just in time for Thanksgiving, the dinosaurian history of how your turkey does the twist. Fibular reduction enabled mid-drumstick mobility, unlocking extreme knee long-axis rotation in theropods 🍗🦖🧵 www.nature.com/articles/s41586-024-08251-w
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