Nature - Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the...

Nature Metabolism, Published online: 26 June 2025; doi:10.1038/s42255-025-01315-9Epithelial cell death driven by oxidative stress is a hallmark of inflammatory bowel disease (IBD), but the upstream triggers are unclear. A new study reveals that fibroblast-derived lipids enriched with polyunsaturated fatty acids induce epithelial ferroptosis. Genetic or pharmacological inhibition of fibroblast ACSL4 alleviates intestinal inflammation and injury in IBD models.

Biological sciences; Endocrinology; Natural sciences; Physiology

Recent years have seen a growth in our understanding of the biological drivers of eating disorders and their interactions with environmental and psychosocial factors. Foldi and Griffiths consider how ...

Diets that are high in fat cause overeating and weight gain in multiple species of animals, suggesting that high dietary fat is sufficient to cause ob…

Nature Metabolism, Published online: 11 June 2025; doi:10.1038/s42255-025-01301-1The authors describe a sensory circuit involving the medial septum (MS), where MS glutamatergic neurons integrate food odours to prime satiety and regulate nutrient intake.

Astrocyte signaling pathways influence neuronal networks and behavioral responses to neuromodulators

Aus Deutschland sprechen sich 110 Wissenschaftlerinnen und Wissenschaftler öffentlich für Tierversuche aus. Frank Kirchhoff, Initiator der Aktion, sagt, warum Experimente an Mäusen, Ratten und Fischen immer noch sein müssen.

To the Editor: The review article by Fasano (Jan. 23 issue)1 concerning human nutrition and hunger regulation omits the crucial role of autophagy, a cellular recycling process vital for maintaining...

Activation of PNOCARC neurons promotes feeding. Here, Solheim et al. describe PNOC neurons in the murine ARC as mediators of leptin action in body weight maintenance. Moreover, they molecularly and fu...

Zhu et al. describe a rapid downregulation of Notch1 expression in hypothalamic blood-brain barrier (BBB) endothelial cells after high-fat diet (HFD) feeding. Notch activation prevents HFD-induced red...

BACKGROUND The strongest genetic drivers of late-onset Alzheimer's disease (AD) are apolipoprotein E4 (ApoE4) and TREM2R47H. Despite their critical roles, the mechanisms underlying their interaction.....

Short-term transition to high-fat diet (HFD) feeding causes rapid changes in the molecular architecture of the blood-brain barrier (BBB), BBB permeabi…

Brain-initiated hunger signals control circulating monocyte dynamics.

Short-term transition to high-fat diet (HFD) feeding causes rapid changes in the molecular architecture of the blood-brain barrier (BBB), BBB permeabi…