Excited to share our recent paper on the Wnt signalosome www.nature.com/articles/s41...
nature.com
Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor - Nature Communications
Gammons et al. describe how the clustering of the Wnt receptor complex in clathrin-coated locales allows Axin and GSK3 to dock at adjacent tails of the LRP6 co-receptor to assemble a signalosome that ...