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Reposted by Medical Art & Knowledge

American Society of Clinical Oncology @ascocancer.bsky.social · 27/03/2025

We are committed to supporting #CancerCare providers and patients who may be affected by public health issues. A listing of measles and vaccination resources can be found on our website and will continue to be updated: asco.org/news-initiat...

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The American Association of Immunologists @aai.org · 18/03/2025

AAI, @acpimphysicians.bsky.social, and a coalition of 34 leading scientific and medical organizations have issued a joint statement to affirm vaccine safety amid rising misinformation and declining trust. Read the full statement: ow.ly/xtoP50VjT02.

Vaccines are a cornerstone of public health, a shining example of the power of scientific research, and a vital tool in the fight against diseases. A message from 34 scientific societies and medical organizations, led by the American Association of Immunologists and the American College of Physicians.

Between 1994 and 2023, routine immunizations and adherence to current vaccine schedules for children born in the U.S. prevented an estimated 508 million cases of illness, 32 million hospitalizations, and 1+ million deaths. These efforts saved $540 billion in direct costs and $2.7 trillion in societal costs (CDC, 2024).

Globally 150 million lives saved in 50 years. Vaccination campaigns worldwide have save an estimated 154 million lives over the past 50 years, particularly through initiatives targeting diseases like smallpox, polio, and measles (WHO, 2024).

Through rigorous scientific research and extensive testing, vaccines have consistently proven their ability to save lives, prevent illness, and protect entire communities. Clinical trials and long-term post-market safety monitoring ensure that vaccines are safe, and any safety concerns that arise are swiftly investigated.

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Medical Art & Knowledge @medicalart.bsky.social · 10/03/2025

Tumor Microenvironment (TME) and the Effectivenes of mRNA Vaccines in Cancer Therapy Part 2 #science #sciart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky #immunosky

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Medical Art & Knowledge @medicalart.bsky.social · 10/03/2025

Tumor Microenvironment (TME) and the Effectivenes of mRNA Vaccines in Cancer Therapy Part 1 #science #sciart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky #immunosky

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Dr. Kristy @prophetkristy.bsky.social · 05/03/2025

NEW IMMUNE SYSTEM ANALOGY which fell out of my brain during class (hooray): You have two wheely bins for trash. One bin is for trash that you generate in your house (MHC I). If drug paraphernalia is found in that bin, your house is going to get raided and destroyed (cytotoxic T cell). (1/2)

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Medical Art & Knowledge @medicalart.bsky.social · 04/03/2025

Synthetic Spore Husk-Encased Lipid bilayer (SSHELs) mimic bacterial spores and deliver peptides to dendritic cells, showing efficient tumor regression and improved survival in mice. SSHELs require complex synthesis but avoid cell culture use, unlike VLPs. #MedSky #MedEd #medschoolsky #immunosky

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Medical Art & Knowledge @medicalart.bsky.social · 03/03/2025

Further Therapies to Enhance #IFNγ Production and #MHC I Expression in #cancer besides IL-2 mRNA #science #sciart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky #immunosky full lecture buff.ly/3XnyKPn

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Andrea Love, PhD | Biomedical Scientist @drandrealove.bsky.social · 02/03/2025

mRNA vaccines, COVID-19 or otherwise, are not gene therapy. Misconceptions & misinformation have eroded progress in science innovation. 2 main reasons: 1) misunderstanding of nuanced science 2) intentional spread of falsehoods 1/

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The American Association of Immunologists @aai.org · 27/02/2025

Measles outbreaks are not normal. Measles was eliminated in 2000 due to successful vaccination campaigns. Declining vaccination rates since have led to an increase in measles outbreaks. The good news is #measles is preventable with the MMR vaccine. Learn more: ow.ly/wmo350V7LEQ. #Immunology

Close-up image of a gloved hand holding a small vial labeled "MMR Vaccine Injection only". Accompanying text reads "Two doses of the MMR vaccine are 97% effective at preventing measles. Protect your child and get vaccinated today."

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Waggoner Lab @labwaggoner.bsky.social · 23/02/2025

Review @annualreviews.bsky.social @lucasite-lab.bsky.social Decoding Immunobiology Through Genetic Errors of Immunity www.annualreviews.org/content/jour...

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Medical Art & Knowledge @medicalart.bsky.social · 20/02/2025

A fresh and fun way to learn about our immune system! fantastically made as well!

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Medical Art & Knowledge @medicalart.bsky.social · 16/02/2025

#mRNA #vaccine production: mRNA is synthesized from plasmid DNA encoding a pathogen’s antigen. Bacteriophage polymerases transcribe it in vitro. Purified by HPLC, it is encapsulated in lipid nanoparticles, filtered, and stored in vials. #meded #medsky #publichealth DOI: 10.1186/s12943-021-01339-1

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Medical Art & Knowledge @medicalart.bsky.social · 16/02/2025

Measuring MHC-Peptide affinity via Peptide Seq: Peptides are incubated with dendritic cells to form peptide-MHC complexes. MHC-peptide complexes are extracted, separated by liquid chromatography, sequenced via mass spectrometry, and validated with transcriptome data. #vaccines #medsky #immunosky

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Medical Art & Knowledge @medicalart.bsky.social · 15/02/2025

HPV vaccines are proven safe, with no severe side effects. They do not lead to increased sexual activity, debunking a common myth. Vaccination significantly reduces the risk of HPV-related cancers in both men and women, underscoring its importance. #health #vaccination #hpv #cancer

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Medical Art & Knowledge @medicalart.bsky.social · 15/02/2025

#Measles infections weaken immunity long-term, increasing infection-related mortality. The virus replicates in immune cells, causing their death and reducing the antibody repertoire, underscoring the need for MMR #vaccination. #health #medsky #meded

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Edward Nirenberg @enirenberg.bsky.social · 14/02/2025

Also because of the times in which we live- if you have ever had a question about the HPV vaccine, I probably covered it here (and if I haven't please ask me in the replies and I will do my best to answer or find someone who can answer) #medsky #pedsky #immunosky #episky #IDsky 🧪

open.substack.com

HPV Vaccines: Separating Truth from Fiction (Originally posted on 02/27/2021)

The following was posted on my previous blog on 02/27/2021 and has not been edited since because it remains current.

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Medical Art & Knowledge @medicalart.bsky.social · 15/02/2025

Measuring MHC-Peptide affinity-competition binding assay: MHC is extracted from DC and precipitated with HLA antibodies, incubated with radioactively labeled standard and test peptides, and the radiation intensity is used to calculate IC50 values, reflecting peptide-MHC affinity. #vaccines #medsky

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Medical Art & Knowledge @medicalart.bsky.social · 15/02/2025

Vaccine production requires detecting immunogenic antigens. Immunogenicity depends on antigen-MHC affinity and presentation to immune cells. The stabilization method quantifies peptide-MHC affinity, aiding in optimizing vaccine development by selecting effective targets. #oncology #vaccines #biotech

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Medical Art & Knowledge @medicalart.bsky.social · 15/02/2025

Quantification of MHC-peptide affinity using the stabilization method: -Cells receive radiolabeled peptides -Peptides bind MHC if affinity is high -Complexes are isolated with antibodies -Complexes are purified via SDS-PAGE -Scintillation quantifies radioactivity to derive IC50 #immunosky #meded

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Medical Art & Knowledge @medicalart.bsky.social · 14/02/2025

DNA damage activates ATM-dependent apoptosis in B cells. ATM and Bcl-2 defects promote lymphomas, inhibit apoptosis, and worsen prognosis. APO-1 mutations block TNFα-induced cell destruction. #science #sciart #medsky #edusky #MedSky #MedEd #medschoolsky #cancer

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Medical Art & Knowledge @medicalart.bsky.social · 13/02/2025

The Ras protein (KRAS, NRAS, HRAS) activates MAPK and PI3K pathways. Mutations promote B-cell malignancies. MLL-1 defects increase transcription and proliferation, common in B-ALL, with poor prognosis. #science #sciart #medicaleducation #medicalschool #cancer

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Medical Art & Knowledge @medicalart.bsky.social · 12/02/2025

CD8+ T cells develop into cytotoxic T cells (CTLs) with support from antigen-presenting and CD4+ T cells. CTLs kill target cells via cytotoxins and apoptosis. Natural killer cells enhance the response by targeting low-MHC-I cells, while dendritic cells activate T cells. #science #MedEd #immunosky

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Medical Art & Knowledge @medicalart.bsky.social · 12/02/2025

Neoantigen presentation via MHC-II activates CD4+ T cells, inducing TH1/TH17 differentiation and cytokine release. CD4+ cells aid cytotoxic responses via Fas-FasL, IFN-γ, and TNF-α. Memory TH1 cells ensure adaptive immunity, reducing collateral damage. #science #sciart #medsky #MedEd #immunosky

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Medical Art & Knowledge @medicalart.bsky.social · 12/02/2025

The liver produces proteins, stores vitamins, makes bile, regulates carbs, and detoxifies. Fatty liver disease, often from alcohol, can cause organ failure, cirrhosis, liver cancer, and esophageal varices. #science #sciart #medsky #edusky #MedEd #MedicalEducation #medschoolsky

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Medical Art & Knowledge @medicalart.bsky.social · 09/02/2025

Burkitt lymphoma: In the blood smear, vacuolated blasts with very basophilic plasma, as well as round, sometimes multiple cell nuclei alongside bright macrophages can be seen. #science #skiart #medsky #edusky #MedEd #MedicalEducation #medschoolsky

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Medical Art & Knowledge @medicalart.bsky.social · 08/02/2025

Multiple enlarged plasma cells in bood smear indicating a multiple myeloma. #science #skiart #medsky #MedEd #MedicalEducation #medschoolsky

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